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Antiparasitic, Antineuroinflammatory, and Cytotoxic Polyketides from the Marine Sponge Plakortis angulospiculatus Collected in Brazil

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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/978-1-4613-1575-9_90openalex-snapshot
From Lysosomes to Cells, From Cells to Leishmania: Amino Acid Esters, Potential Chemotherapeutic Agents?
inferredcites →https://doi.org/10.1007/s005990050076openalex-snapshot
Inducible nitric oxide synthase and nitric oxide production inLeishmania infantum-infected human macrophages stimulated with interferon-γ and bacterial lipopolysaccharide
inferredcites →https://doi.org/10.1016/0022-1759(86)90183-3openalex-snapshot
An improved colorimetric assay for interleukin 2
inferredcites →https://doi.org/10.1016/j.ijpara.2005.07.001openalex-snapshot
The current status of zoonotic leishmaniases and approaches to disease control
inferredcites →https://doi.org/10.1016/j.micinf.2005.07.007openalex-snapshot
Infection-induced respiratory burst in BALB/c macrophages kills Leishmania guyanensis amastigotes through apoptosis: possible involvement in resistance to cutaneous leishmaniasis
inferredcites →https://doi.org/10.1016/j.peptides.2006.08.005openalex-snapshot
Isolation and biochemical characterization of peptides presenting antimicrobial activity from the skin of Phyllomedusa hypochondrialis
inferredcites →https://doi.org/10.1016/j.pt.2003.09.008openalex-snapshot
Leishmaniasis– current chemotherapy and recent advances in the search for novel drugs
inferredcites →https://doi.org/10.1016/j.pt.2003.11.006openalex-snapshot
Drugs against leishmaniasis: a synergy of technology and partnerships
inferredcites →https://doi.org/10.1016/j.pt.2005.08.026openalex-snapshot
Chemotherapy of trypanosomiases and leishmaniasis
inferredcites →https://doi.org/10.1016/s0040-4020(01)00947-4openalex-snapshot
Plakortides I–L, four new cyclic peroxides from an undescribed Jamaican sponge Plakortis sp. (Homosclerophorida, Plakinidae)
inferredcites →https://doi.org/10.1016/s0040-4020(97)10414-8openalex-snapshot
New polyketide peroxides from Okinawan marine sponge Plakortis sp.
inferredcites →https://doi.org/10.1016/s0040-4020(98)00055-6openalex-snapshot
Antileishmanial cyclic peroxides from the Palauan sponge Plakortis aff. angulospiculatus
inferredcites →https://doi.org/10.1016/s0040-4020(99)00332-4openalex-snapshot
Metabolites from the sponge Plakortis simplex. Determination of absolute stereochemistry of plakortin. Isolation and stereostructure of three plakortin related compounds
inferredcites →https://doi.org/10.1016/s0040-4039(96)01474-8openalex-snapshot
Absolute configuration of methyl (2Z,6R,8R,9E)-3,6-epoxy-4,6,8-triethyl-2,4,9-dodecatrienoate from the sponge Plakortis halichondrioides
inferredcites →https://doi.org/10.1016/s0140-6736(05)67381-3openalex-snapshot
Advances and challenges in management of invasive mycoses
inferredcites →https://doi.org/10.1016/s0968-0896(03)00030-0openalex-snapshot
A New α,β,γ,δ-Unsaturated carboxylic acid and three new cyclic peroxides from the marine sponge, Monotria japonica, which selectively lyse starfish oocytes without affecting nuclear morphology
inferredcites →https://doi.org/10.1016/s1473-3099(02)00347-xopenalex-snapshot
Visceral leishmaniasis: current status of control, diagnosis, and treatment, and a proposed research and development agenda
inferredcites →https://doi.org/10.1021/jm060899gopenalex-snapshot
Endoperoxide Derivatives from Marine Organisms: 1,2-Dioxanes of the Plakortin Family as Novel Antimalarial Agents
inferredcites →https://doi.org/10.1021/jo00412a006openalex-snapshot
Plakortin, an antibiotic from Plakortis halichondrioides
inferredcites →https://doi.org/10.1021/jo01305a005openalex-snapshot
Metabolites of three marine sponges of the genus Plakortis
inferredcites →https://doi.org/10.1021/jo060295kopenalex-snapshot
Sulfated Meroterpenoids from the Brazilian Sponge Callyspongia sp. Are Inhibitors of the Antileishmaniasis Target Adenosine Phosphoribosyl Transferase
inferredcites →https://doi.org/10.1021/np010216uopenalex-snapshot
Isolation and Biological Evaluation of Filiformin, Plakortide F, and Plakortone G from the Caribbean Sponge Plakortis sp.
inferredcites →https://doi.org/10.1021/np030021hopenalex-snapshot
Plakortides M and N, Bioactive Polyketide Endoperoxides from the Caribbean Marine Sponge Plakortis halichondrioides
inferredcites →https://doi.org/10.1021/np040043jopenalex-snapshot
Antineoplastic Agents. 535. Isolation and Structure of Plakorstatins 1 and 2 from the Indo-Pacific Sponge Plakortis nigra
inferredcites →https://doi.org/10.1021/np049665vopenalex-snapshot
Cyclic Peroxides Derived from the Marine Sponge Plakortis simplex
inferredcites →https://doi.org/10.1021/np50100a027openalex-snapshot
Three New Cytotoxic Metabolites from the Marine Sponge Plakortis halichondrioides
inferredcites →https://doi.org/10.1021/np990555bopenalex-snapshot
A New Bioactive Sesterterpene and Antiplasmodial Alkaloids from the Marine Sponge Hyrtios cf. erecta
inferredcites →https://doi.org/10.1055/s-2005-916239openalex-snapshot
Antimycobacterial Brominated Metabolites from Two Species of Marine Sponges
inferredcites →https://doi.org/10.1071/ch04234openalex-snapshot
Spongosoritin A: A New Polyketide from a Fijian Marine Sponge, Spongosorites sp.
inferredcites →https://doi.org/10.1097/00024382-199903000-00005openalex-snapshot
ESCHERICHIA COLI LIPOPOLYSACCHARIDE POTENTIATION AND INHIBITION OF RAT NEONATAL MICROGLIA SUPEROXIDE ANION GENERATION
inferredcites →https://doi.org/10.1111/j.1550-7408.1958.tb02565.xopenalex-snapshot
An Eight‐day Method for Screening Compounds against Leishmania donovani in the Golden Hamster*
inferredcites →https://doi.org/10.1128/aac.49.3.1076-1080.2005openalex-snapshot
Synthesis and Antileishmanial Activities of Novel 3-Substituted Quinolines
inferredcites →https://doi.org/10.1128/aac.50.5.1788-1797.2006openalex-snapshot
Sodium Antimony Gluconate Induces Generation of Reactive Oxygen Species and Nitric Oxide via Phosphoinositide 3-Kinase and Mitogen-Activated Protein Kinase Activation inLeishmania donovani-Infected Macrophages
inferredcites →https://doi.org/10.1590/s0074-02761985000100011openalex-snapshot
Morbidade da doença de Chagas: IV. Estudo longitudinal de dez anos em Pains e Iguatama, Minas Gerais, Brasil
inferredcites →https://doi.org/10.1590/s0102-695x2007000300002openalex-snapshot
Antibiotic, cytotoxic and enzyme inhibitory activity of crude extracts from Brazilian marine invertebrates
inferredcites →https://doi.org/10.1590/s0103-50532005000800010openalex-snapshot
Polyketides from the marine sponge Plakortis angulospiculatus
inferredcites →https://doi.org/10.2174/187152507781058726openalex-snapshot
Natural Products to Anti-trypanosomal Drugs: An Overview of New Drug Prototypes for American Trypanosomiasis
inferredcites →https://doi.org/10.3109/01913129209057832openalex-snapshot
A Fast Method for Processing Biologic Material for Electron Microscopic Diagnosis in Infectious Disease
inferredcites →https://doi.org/10.4269/ajtmh.1996.55.263openalex-snapshot
In Vitro Trypanocidal Activity of Tetraethylthiuram Disulfide and Sodium Diethylamine-N-Carbodithioate on Trypanosoma cruzi

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.11646/zootaxa.3718.6.2zenodo-depositor-declared
Four new species of Plakinidae (Porifera: Homoscleromorpha) from Brazil
inferred← citeshttps://doi.org/10.1002/9783527335855.marprod019openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/9783527335855.marprod195openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/cbdv.202100838openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/7081_2021_56openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/978-981-13-8763-0_27openalex-snapshot
Modulation of the Host-Parasite Redox Metabolism to Potentiate Antimalarial Drug Efficiency
inferred← citeshttps://doi.org/10.1007/978-981-15-5017-1_20openalex-snapshot
Marine Pharmacognosy: An Overview of Marine-Derived Pharmaceuticals
inferred← citeshttps://doi.org/10.1007/978-981-19-9605-4_19openalex-snapshot
Pathogenesis and Immune Response in T. cruzi Infection: Quest for Natural Compound-Based Drugs
inferred← citeshttps://doi.org/10.1007/978-981-99-6770-4_14openalex-snapshot
Neuroactive Peptides and Neuroprotective Molecules from Marine Sponges and Associated Bacteria: An Untapped Resource for Systemic Drug Development
inferred← citeshttps://doi.org/10.1007/s00343-021-0466-6openalex-snapshot
Integration of metabolomics and transcriptomics revealed the biosynthetic mechanism of anti-parasitic compounds in Salinivibrio proteolyticus strain YCSC6
inferred← citeshttps://doi.org/10.1007/s11101-016-9455-3openalex-snapshot
Natural products from marine invertebrates against Leishmania parasites: a comprehensive review
inferred← citeshttps://doi.org/10.1007/s11418-015-0920-xopenalex-snapshot
Manadodioxans A−E: polyketide endoperoxides from the marine sponge Plakortis bergquistae
inferred← citeshttps://doi.org/10.1007/s13659-013-0042-7openalex-snapshot
Peroxy natural products
inferred← citeshttps://doi.org/10.1016/b978-0-12-819489-8.00013-2openalex-snapshot
The structure–activity relationship of marine products for neuroinflammatory disorders
inferred← citeshttps://doi.org/10.1016/b978-0-323-91942-5.00019-7openalex-snapshot
Marine organisms as natural drug leads in combating vector-borne diseases
inferred← citeshttps://doi.org/10.1016/j.bioorg.2019.103002openalex-snapshot
Antitrypanosomal activity of isololiolide isolated from the marine hydroid Macrorhynchia philippina (Cnidaria, Hydrozoa)
inferred← citeshttps://doi.org/10.1016/j.bmc.2014.07.030openalex-snapshot
2-Phenylaminonaphthoquinones and related compounds: Synthesis, trypanocidal and cytotoxic activities
inferred← citeshttps://doi.org/10.1016/j.cbpc.2010.08.008openalex-snapshot
Marine pharmacology in 2007–8: Marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous system, and other miscellaneous mechanisms of action
inferred← citeshttps://doi.org/10.1016/j.copbio.2010.09.015openalex-snapshot
The structural diversity and promise of antiparasitic marine invertebrate-derived small molecules
inferred← citeshttps://doi.org/10.1016/j.tet.2012.04.025openalex-snapshot
Simplexolides A–E and plakorfuran A, six butyrate derived polyketides from the marine sponge Plakortis simplex
inferred← citeshttps://doi.org/10.1016/j.tet.2012.09.106openalex-snapshot
Gracilioethers E–J, new oxygenated polyketides from the marine sponge Plakinastrella mamillaris
inferred← citeshttps://doi.org/10.1016/j.tet.2013.03.006openalex-snapshot
New antimalarial polyketide endoperoxides from the marine sponge Plakinastrella mamillaris collected at Fiji Islands
inferred← citeshttps://doi.org/10.1016/j.tetlet.2010.02.161openalex-snapshot
Antitrypanosomal pyridoacridine alkaloids from the Australian ascidian Polysyncraton echinatum
inferred← citeshttps://doi.org/10.1017/s0025315415000375openalex-snapshot
Overview of the biodiversity and distribution of the Class Homoscleromorpha in the Tropical Western Atlantic
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.5b00070openalex-snapshot
Anti-parasitic Guanidine and Pyrimidine Alkaloids from the Marine Sponge Monanchora arbuscula
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.7b00876openalex-snapshot
Isolation, Derivative Synthesis, and Structure–Activity Relationships of Antiparasitic Bromopyrrole Alkaloids from the Marine Sponge Tedania brasiliensis
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.8b00159openalex-snapshot
Active Natural Product Scaffolds against Trypanosomatid Parasites: A Review
inferred← citeshttps://doi.org/10.1021/acsinfocus.7e9022openalex-snapshot
The Mosher Method in the Study of Natural Products
inferred← citeshttps://doi.org/10.1021/acsomega.2c03395openalex-snapshot
Mitochondrial Imbalance of Trypanosoma cruzi Induced by the Marine Alkaloid 6-Bromo-2′-de-N-Methylaplysinopsin
inferred← citeshttps://doi.org/10.1021/cr500365fopenalex-snapshot
Recent Developments in Drug Discovery for Leishmaniasis and Human African Trypanosomiasis
inferred← citeshttps://doi.org/10.1021/jm300911gopenalex-snapshot
Plakilactones from the Marine SpongePlakinastrella mamillaris. Discovery of a New Class of Marine Ligands of Peroxisome Proliferator-Activated Receptor γ
inferred← citeshttps://doi.org/10.1021/np100461topenalex-snapshot
Bioactive Cycloperoxides Isolated from the Puerto Rican Sponge Plakortis halichondrioides
inferred← citeshttps://doi.org/10.1021/np100620xopenalex-snapshot
Configurational Assignment of Cyclic Peroxy Metabolites Provides an Insight into Their Biosynthesis: Isolation of Plakortolides, seco-Plakortolides, and Plakortones from the Australian Marine Sponge Plakinastrella clathrata
inferred← citeshttps://doi.org/10.1021/np100868topenalex-snapshot
Lehualides E−K, Cytotoxic Metabolites from the Tongan Marine Sponge Plakortis sp.
inferred← citeshttps://doi.org/10.1021/np5008944openalex-snapshot
Cytotoxic Plakortides from the Brazilian Marine Sponge Plakortis angulospiculatus
inferred← citeshttps://doi.org/10.1021/np800711aopenalex-snapshot
The Marine Sponge Diacarnus bismarckensis as a Source of Peroxiterpene Inhibitors of Trypanosoma brucei, the Causative Agent of Sleeping Sickness
inferred← citeshttps://doi.org/10.1021/np900535zopenalex-snapshot
Antitrypanosomal Cyclic Polyketide Peroxides from the Australian Marine Sponge Plakortis sp.
inferred← citeshttps://doi.org/10.1021/ol201055wopenalex-snapshot
Simplextones A and B, Unusual Polyketides from the Marine Sponge Plakortis simplex
inferred← citeshttps://doi.org/10.1038/aps.2014.114openalex-snapshot
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inferred← citeshttps://doi.org/10.1039/b906091jopenalex-snapshot
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inferred← citeshttps://doi.org/10.1039/c0np00017eopenalex-snapshot
Bringing natural products into the fold – exploring the therapeutic lead potential of secondary metabolites for the treatment of protein-misfolding-related neurodegenerative diseases
inferred← citeshttps://doi.org/10.1039/c2ob26124copenalex-snapshot
Manadoperoxides, a new class of potent antitrypanosomal agents of marine origin
inferred← citeshttps://doi.org/10.1039/c4ob00448eopenalex-snapshot
Asymmetric synthesis of 3,3,5,5-tetrasubstituted 1,2-dioxolanes: total synthesis of epiplakinic acid F
inferred← citeshttps://doi.org/10.1039/c5np00142kopenalex-snapshot
Structural diversity and chemical synthesis of peroxide and peroxide-derived polyketide metabolites from marine sponges
inferred← citeshttps://doi.org/10.1039/c5ra02669eopenalex-snapshot
Antileishmanial drug discovery: comprehensive review of the last 10 years
inferred← citeshttps://doi.org/10.1039/c6ra27026copenalex-snapshot
Alkaloids and polyketides from the South China Sea sponge Agelas aff. nemoechinata
inferred← citeshttps://doi.org/10.1039/c7ob03150eopenalex-snapshot
Total synthesis and structural elucidation of spongosoritin A
inferred← citeshttps://doi.org/10.1039/c9ob02010aopenalex-snapshot
Stereochemistry of spongosoritins: beyond optical rotation
inferred← citeshttps://doi.org/10.1039/d1np00037copenalex-snapshot
The isolation of water-soluble natural products – challenges, strategies and perspectives
inferred← citeshttps://doi.org/10.1055/a-1257-8402openalex-snapshot
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inferred← citeshttps://doi.org/10.1071/ch09665openalex-snapshot
Polyketide-peroxides from a Species of Jamaican Plakortis (Porifera: Demospongiae)
inferred← citeshttps://doi.org/10.1155/2013/572859openalex-snapshot
Marine Invertebrate Natural Products for Anti-Inflammatory and Chronic Diseases
inferred← citeshttps://doi.org/10.11606/d.75.2016.tde-01042016-094114openalex-snapshot
Terpenos rearranjados da esponja Darwinella cf. oxeata com potencial leishmanicida
inferred← citeshttps://doi.org/10.1177/1934578x0900400707openalex-snapshot
Saturated Ceramides from the Sponge Dysidea Robusta
inferred← citeshttps://doi.org/10.1186/2193-1801-3-629openalex-snapshot
In vitro screening of antifungal activity of marine sponge extracts against five phytopathogenic fungi
inferred← citeshttps://doi.org/10.1201/b19081-12openalex-snapshot
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inferred← citeshttps://doi.org/10.13005/bbra/3391openalex-snapshot
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inferred← citeshttps://doi.org/10.1371/journal.pone.0174816openalex-snapshot
Sponge symbioses between Xestospongia deweerdtae and Plakortis spp. are not motivated by shared chemical defense against predators
inferred← citeshttps://doi.org/10.1590/0001-3765202220211090openalex-snapshot
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inferred← citeshttps://doi.org/10.2174/1874421401004010178openalex-snapshot
Contributions of Ultrastructural Studies to the Cell Biology of Trypanosmatids: Targets for Anti-Parasitic Drugs
inferred← citeshttps://doi.org/10.3354/meps08747openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/app14010281openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/jof12080614openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/md11104058openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/md12031169openalex-snapshot
Chemoinformatic Analysis as a Tool for Prioritization of Trypanocidal Marine Derived Lead Compounds
inferred← citeshttps://doi.org/10.3390/md15030063openalex-snapshot
Cytotoxicity of Endoperoxides from the Caribbean Sponge Plakortis halichondrioides towards Sensitive and Multidrug-Resistant Leukemia Cells: Acids vs. Esters Activity Evaluation
inferred← citeshttps://doi.org/10.3390/md15050129openalex-snapshot
Chemistry and Selective Tumor Cell Growth Inhibitory Activity of Polyketides from the South China Sea Sponge Plakortis sp.
inferred← citeshttps://doi.org/10.3390/md17050282openalex-snapshot
Oceans as a Source of Immunotherapy
inferred← citeshttps://doi.org/10.3390/md8030429openalex-snapshot
Inhibition of Nitric Oxide (NO) Production in Lipopolysaccharide (LPS)-Activated Murine Macrophage RAW 264.7 Cells by the Norsesterterpene Peroxide, Epimuqubilin A
inferred← citeshttps://doi.org/10.3390/molecules16087105openalex-snapshot
Chemical Profile and Biological Potential of Non-Polar Fractions from Centroceras clavulatum (C. Agardh) Montagne (Ceramiales, Rhodophyta)
inferred← citeshttps://doi.org/10.3390/molecules170911146openalex-snapshot
Antitrypanosomal Alkaloids from the Marine Bacterium Bacillus pumilus
inferred← citeshttps://doi.org/10.3390/molecules28114317openalex-snapshot
Organocatalytic Asymmetric Peroxidation of γ,δ-Unsaturated β-Keto Esters—A Novel Route to Chiral Cycloperoxides
inferred← citeshttps://doi.org/10.4018/978-1-6684-6737-4.ch013openalex-snapshot
Marine Bioactive Products as Potential Antileishmanial Therapeutics
inferred← citeshttps://doi.org/10.4062/biomolther.2016.067openalex-snapshot
Marine Sponges as a Drug Treasure
inferred← citeshttps://doi.org/10.4322/2675-133x.2023.014openalex-snapshot
Poríferos e suas toxinas: revisão narrativa
inferred← citeshttps://doi.org/10.64187/mm.2026.v2.i2.002openalex-snapshot
Peroxide-Containing Polyketides from Plakortis insularis: Structural Elucidation and Cytotoxic Activity
inferred← citeshttps://doi.org/10.70675/892a61b4zb599z48c5z8ae8z29de20318e9fopenalex-snapshot
Synthetic studies toward plakortolides : asymmetric synthesis of ent-plakortolide I and seco-plakortolide E
inferred← citeshttps://doi.org/10.70675/e1f90413z5e0dz40c6zbd12zfb9360e627bbopenalex-snapshot
Recherche de molecules naturelles bioactives issues de la biodiversite marine de la zone sud-ouest de l'ocean Indien
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