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Optimization of 4-( N -Cycloamino)phenylquinazolines as a Novel Class of Tubulin-Polymerization Inhibitors Targeting the Colchicine Site

https://doi.org/10.1021/jm4016526
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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MT119, a new planar‐structured compound, targets the colchicine site of tubulin arresting mitosis and inhibiting tumor cell proliferation
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Glutamate-induced polymerization of tubulin: Characteristics of the reaction and application to the large-scale purification of tubulin
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SAR studies of capsazepinoid bronchodilators. Part 1: The importance of the catechol moiety and aspects of the B-ring structure
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Synthesis and biological evaluation of N-alkyl-N-(4-methoxyphenyl)pyridin-2-amines as a new class of tubulin polymerization inhibitors
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Design and synthesis of diarylamines and diarylethers as cytotoxic antitumor agents
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Multidrug resistance in oral squamous cell carcinoma: The role of vacuolar ATPases
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The unique characteristics of tumor vasculature and preclinical evidence for its selective disruption by Tumor-Vascular Disrupting Agents
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N-Aryl-6-methoxy-1,2,3,4-tetrahydroquinolines: A novel class of antitumor agents targeting the colchicine site on tubulin
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The sulphorhodamine (SRB) assay and other approaches to testing plant extracts and derived compounds for activities related to reputed anticancer activity
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Synthesis of oxypropanolamine derivatives of 3,4-dihydro-2H-1,4-benzoxazine, β-adrenergic affinity, inotropic, chronotropic and coronary vasodilating activities
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Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin
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Synthesis of D-oxa tricyclic partial ergolines as dopamine agonists
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Optimization of Cellular Activity of G9a Inhibitors 7-Aminoalkoxy-quinazolines
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Antitumor Agents. 293. Nontoxic Dimethyl-4,4′-dimethoxy-5,6,5′,6′-dimethylenedioxybiphenyl-2,2′-dicarboxylate (DDB) Analogues Chemosensitize Multidrug-Resistant Cancer Cells to Clinical Anticancer Drugs
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Design, Synthesis, and Preclinical Evaluations of Novel 4-Substituted 1,5-Diarylanilines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Drug Candidates
inferredcites →https://doi.org/10.1021/jm800876bopenalex-snapshot
Discovery of Quinazolines as Histamine H 4 Receptor Inverse Agonists Using a Scaffold Hopping Approach
inferredcites →https://doi.org/10.1021/jm801315bopenalex-snapshot
Discovery of N-(4-Methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a Potent Apoptosis Inducer and Efficacious Anticancer Agent with High Blood Brain Barrier Penetration
inferredcites →https://doi.org/10.1021/jm901370mopenalex-snapshot
Design and Synthesis of Novel Diaminoquinazolines with in Vivo Efficacy for β-Catenin/T-Cell Transcriptional Factor 4 Pathway Inhibition
inferredcites →https://doi.org/10.1021/jm960734fopenalex-snapshot
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The First Intermolecular Friedel−Crafts Acylation with β-Lactams
inferredcites →https://doi.org/10.1038/nature02393openalex-snapshot
Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain
inferredcites →https://doi.org/10.1038/nrc1628openalex-snapshot
Disrupting tumour blood vessels
inferredcites →https://doi.org/10.1038/nrd3253openalex-snapshot
Microtubule-binding agents: a dynamic field of cancer therapeutics
inferredcites →https://doi.org/10.1039/c0ib00135jopenalex-snapshot
A perspective on vascular disrupting agents that interact with tubulin: preclinical tumor imaging and biological assessment
inferredcites →https://doi.org/10.1073/pnas.0904223106openalex-snapshot
Variations in the colchicine-binding domain provide insight into the structural switch of tubulin
inferredcites →https://doi.org/10.1073/pnas.70.3.765openalex-snapshot
Microtubule Assembly in the Absence of Added Nucleotides
inferredcites →https://doi.org/10.1073/pnas.71.7.2627openalex-snapshot
Promotion of Fluorescence upon Binding of Colchicine to Tubulin
inferredcites →https://doi.org/10.1093/jnci/82.13.1113openalex-snapshot
Comparison of In Vitro Anticancer-Drug-Screening Data Generated With a Tetrazolium Assay Versus a Protein Assay Against a Diverse Panel of Human Tumor Cell Lines
inferredcites →https://doi.org/10.1093/jnci/83.11.757openalex-snapshot
Feasibility of a High-Flux Anticancer Drug Screen Using a Diverse Panel of Cultured Human Tumor Cell Lines
inferredcites →https://doi.org/10.1124/mol.53.1.62openalex-snapshot
Structure-Activity Analysis of the Interaction of Curacin A, the Potent Colchicine Site Antimitotic Agent, with Tubulin and Effects of Analogs on the Growth of MCF-7 Breast Cancer Cells
inferredcites →https://doi.org/10.1126/science.1101637openalex-snapshot
Gefitinib-Sensitizing EGFR Mutations in Lung Cancer Activate Anti-Apoptotic Pathways
inferredcites →https://doi.org/10.1158/1535-7163.mct-05-0254openalex-snapshot
A thalidomide analogue within vitroantiproliferative, antimitotic, and microtubule-stabilizing activities
inferredcites →https://doi.org/10.1248/cpb.29.1063openalex-snapshot
A convenient synthesis of monocyclic .BETA.-lactams by means of solid-liquid phase transfer reactions.
inferredcites →https://doi.org/10.1385/cbb:38:1:1openalex-snapshot
Evaluation of Antimitotic Agents by Quantitative Comparisons of Their Effects on the Polymerization of Purified Tubulin

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Discovery of novel quinazolines as potential anti-tubulin agents occupying three zones of colchicine domain
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inferred← citeshttps://doi.org/10.1016/j.bioorg.2025.109301openalex-snapshot
Discovery of novel quinazoline analogs as tubulin inhibitors targeting the colchicine binding site for potent antitumor therapy in combination with PD-L1 inhibitors
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Optimization of N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines as tubulin polymerization inhibitors
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Synthesis, biological evaluation, and physicochemical property assessment of 4-substituted 2-phenylaminoquinazolines as Mer tyrosine kinase inhibitors
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Synthesis and screening of novel 4-N-heterocyclic-2-aryl-6,7,8-trimethoxyquinazolines as antiproliferative and tubulin polymerization inhibitors
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Molecular interactions at the colchicine binding site in tubulin: An X-ray crystallography perspective
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Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site
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Design, synthesis and bio-evaluation of novel 2-aryl-4-(3,4,5-trimethoxy-benzoyl)-5-substituted-1,2,3-triazoles as the tubulin polymerization inhibitors
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Developments of isoCombretastatin A-4 derivatives as highly cytotoxic agents
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Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities
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Discovery of novel N-aryl-2-trifluoromethyl-quinazoline-4-amine derivatives as the inhibitors of tubulin polymerization in leukemia cells
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The discovery of water-soluble indazole derivatives as potent microtubule polymerization inhibitors
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Design, synthesis, and antitumor evaluation of quinazoline-4-tetrahydroquinoline chemotypes as novel tubulin polymerization inhibitors targeting the colchicine site
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A review of recent advances in quinoline/isoquinoline based hybrids as microtubule targeted cancer therapeutics: Synthesis, binding mode, QSAR and docking studies
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Kalshiolin A, new lignan from Kalimeris shimadai
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