On the public citation graph

Discovery of N-(4-Methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a Potent Apoptosis Inducer and Efficacious Anticancer Agent with High Blood Brain Barrier Penetration

0 signed · 166 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.

Claim with ORCID

Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.

See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/s00280-006-0402-7openalex-snapshot

Plasma and cerebrospinal fluid pharmacokinetics of intravenously administered ABT-751 in non-human primates

inferredcites →https://doi.org/10.1016/j.bmc.2003.11.013openalex-snapshot

Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay

inferredcites →https://doi.org/10.1016/j.bmc.2006.08.002openalex-snapshot

Discovery of substituted 4-anilino-2-(2-pyridyl)pyrimidines as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. Part 1: Structure–activity relationships of the 4-anilino group

inferredcites →https://doi.org/10.1016/j.bmc.2007.09.046openalex-snapshot

Discovery and structure–activity relationship of N-phenyl-1H-pyrazolo[3,4-b]quinolin-4-amines as a new series of potent apoptosis inducers

inferredcites →https://doi.org/10.1016/j.bmc.2009.10.063openalex-snapshot

Carboxymethylated-κ-casein: A convenient tool for the identification of polyphenolic inhibitors of amyloid fibril formation

inferredcites →https://doi.org/10.1016/j.ccr.2006.08.027openalex-snapshot

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized

inferredcites →https://doi.org/10.1016/s0169-409x(02)00005-4openalex-snapshot

Computational approaches to the prediction of the blood–brain distribution

inferredcites →https://doi.org/10.1016/s0960-894x(00)00590-4openalex-snapshot

Design and synthesis of Rhodamine 110 derivative and Caspase-3 substrate for enzyme and cell-based fluorescent assay

inferredcites →https://doi.org/10.1021/cb600276qopenalex-snapshot

Design, Synthesis, and Biological Activity of a Potent Smac Mimetic That Sensitizes Cancer Cells to Apoptosis by Antagonizing IAPs

inferredcites →https://doi.org/10.1021/jm0205200openalex-snapshot

Discovery of Substituted N-Phenyl Nicotinamides as Potent Inducers of Apoptosis Using a Cell- and Caspase-Based High Throughput Screening Assay

inferredcites →https://doi.org/10.1021/jm049640topenalex-snapshot

Discovery of 4-Aryl-4H-chromenes as a New Series of Apoptosis Inducers Using a Cell- and Caspase-based High-Throughput Screening Assay. 1. Structure−Activity Relationships of the 4-Aryl Group

inferredcites →https://doi.org/10.1021/jm050292kopenalex-snapshot

Discovery and Structure−Activity Relationship of 3-Aryl-5-aryl-1,2,4-oxadiazoles as a New Series of Apoptosis Inducers and Potential Anticancer Agents

inferredcites →https://doi.org/10.1021/jm060642iopenalex-snapshot

Structure−Brain Exposure Relationships

inferredcites →https://doi.org/10.1021/jm070216copenalex-snapshot

Discovery of 4-Aryl-4H-chromenes as a New Series of Apoptosis Inducers Using a Cell- and Caspase-Based High-Throughput Screening Assay. 3. Structure−Activity Relationships of Fused Rings at the 7,8-Positions

inferredcites →https://doi.org/10.1021/jm7010657openalex-snapshot

Discovery of 4-Aryl-4H-chromenes as a New Series of Apoptosis Inducers Using a Cell- and Caspase-Based High Throughput Screening Assay. 4. Structure–Activity Relationships of N-Alkyl Substituted Pyrrole Fused at the 7,8-Positions

inferredcites →https://doi.org/10.1021/jm8003653openalex-snapshot

Discovery of 2-Chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine (EP128265, MPI-0441138) as a Potent Inducer of Apoptosis with High In Vivo Activity

inferredcites →https://doi.org/10.1021/jo049195+openalex-snapshot

Preparation and Resolution of a Modular Class of Axially Chiral Quinazoline-Containing Ligands and Their Application in Asymmetric Rhodium-Catalyzed Olefin Hydroboration

inferredcites →https://doi.org/10.1023/a:1009677307458openalex-snapshot

Caspase-dependent and -independent death pathways in cancer therapy

inferredcites →https://doi.org/10.1038/nrc1736openalex-snapshot

Promoting apoptosis as a strategy for cancer drug discovery

inferredcites →https://doi.org/10.1038/sj.bjc.6603669openalex-snapshot

Gefitinib in patients with progressive high-grade gliomas: a multicentre phase II study by Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO)

inferredcites →https://doi.org/10.1073/pnas.0708917105openalex-snapshot

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

inferredcites →https://doi.org/10.1124/dmd.107.018374openalex-snapshot

The Role of Efflux and Uptake Transporters in N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine (GW572016, Lapatinib) Disposition and Drug Interactions

inferredcites →https://doi.org/10.1124/mol.107.039750openalex-snapshot

Induction of Apoptosis by Vinblastine via c-Jun Autoamplification and p53-Independent Down-Regulation of p21

inferredcites →https://doi.org/10.1124/mol.108.039750openalex-snapshot

Induction of Apoptosis by Vinblastine via c-Jun Autoamplification and p53-Independent Down-Regulation of p21WAF1/CIP1

inferredcites →https://doi.org/10.1124/pr.57.2.6openalex-snapshot

New Approaches and Therapeutics Targeting Apoptosis in Disease

inferredcites →https://doi.org/10.1126/science.1125951openalex-snapshot

Targeting Tyrosine Kinases in Cancer: The Second Wave

inferredcites →https://doi.org/10.1126/science.1126758openalex-snapshot

The New Era in Cancer Research

inferredcites →https://doi.org/10.1158/0008-5472.can-07-0127openalex-snapshot

MPC-6827: A Small-Molecule Inhibitor of Microtubule Formation That Is Not a Substrate for Multidrug Resistance Pumps

inferredcites →https://doi.org/10.1158/1078-0432.ccr-03-0155openalex-snapshot

Plasma and Cerebrospinal Fluid Pharmacokinetics of Imatinib after Administration to Nonhuman Primates

inferredcites →https://doi.org/10.1158/1078-0432.ccr-04-1807openalex-snapshot

Plasma and Cerebrospinal Fluid Pharmacokinetics of Intravenous Oxaliplatin, Cisplatin, and Carboplatin in Nonhuman Primates

inferredcites →https://doi.org/10.1158/1078-0432.ccr-06-2372openalex-snapshot

Plasma and Cerebrospinal Fluid Pharmacokinetics of Erlotinib and Its Active Metabolite OSI-420

inferredcites →https://doi.org/10.1158/1078-0432.ccr-06-2854openalex-snapshot

The Blood-Brain Barrier and Cancer: Transporters, Treatment, and Trojan Horses

inferredcites →https://doi.org/10.1158/1078-0432.ccr-07-1810openalex-snapshot

Epidermal Growth Factor Receptor Inhibitors in Neuro-oncology: Hopes and Disappointments

inferredcites →https://doi.org/10.1158/1078-0432.ccr-07-4719openalex-snapshot

Temsirolimus, an Inhibitor of Mammalian Target of Rapamycin

inferredcites →https://doi.org/10.1188/07.cjon.649-656openalex-snapshot

Sorafenib: A Promising New Targeted Therapy for Renal Cell Carcinoma

inferredcites →https://doi.org/10.1200/jco.2004.08.110openalex-snapshot

Phase II Trial of Gefitinib in Recurrent Glioblastoma

inferredcites →https://doi.org/10.1517/14656566.8.14.2359openalex-snapshot

Sunitinib

inferredcites →https://doi.org/10.1586/14737140.7.12s.s29openalex-snapshot

Emerging therapies for malignant glioma

inferredcites →https://doi.org/10.2165/00003495-200767170-00013openalex-snapshot

Imatinib

inferredcites →https://doi.org/10.2174/092986706778201521openalex-snapshot

A Chemical Genetics Approach for the Discovery of Apoptosis Inducers:From Phenotypic Cell Based HTS Assay and Structure-Activity Relationship Studies, to Identification of Potential Anticancer Agents and Molecular Targets.

inferredcites →https://doi.org/10.2174/1568009033482038openalex-snapshot

Survivin: Role in Normal Cells and in Pathological Conditions

inferredcites →https://doi.org/10.2174/156802606776743156openalex-snapshot

Lessons from the Drug Discovery of Lapatinib, a Dual ErbB1/2 Tyrosine Kinase Inhibitor

inferredcites →https://doi.org/10.2174/157489206778776925openalex-snapshot

Bortezomib in the Treatment of Cancer

inferredcites →https://doi.org/10.3727/096504005776449680openalex-snapshot

Irinotecan/5-Fluorouracil Combination Induces Alterations in Mitochondrial Membrane Potential and Caspases on Colon Cancer Cell Lines

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4798514openalex-extracted

Discovery and Mechanistic Insights into Thieno[3,2-D]Pyrimidine and Heterocyclic Fused Pyrimidines Inhibitors Targeting Tubulin for Cancer Therapy

inferred← citeshttps://doi.org/10.1002/cmdc.201300531openalex-snapshot

Effects of the Tumor‐Vasculature‐Disrupting Agent Verubulin and Two Heteroaryl Analogues on Cancer Cells, Endothelial Cells, and Blood Vessels

inferred← citeshttps://doi.org/10.1002/cmdc.201500069openalex-snapshot

Iso CombretaQuinazolines: Potent Cytotoxic Agents with Antitubulin Activity

inferred← citeshttps://doi.org/10.1002/slct.201801322openalex-snapshot

Graphene Oxide: An Efficient Carbocatalyst for the Facile Synthesis of Isoindolo[2, 1‐ a ]quinazoline‐5,11‐diones via Domino Condensation under Solvent‐Free Conditions

inferred← citeshttps://doi.org/10.1007/s00109-019-01843-4openalex-snapshot

Co-delivery of GOLPH3 siRNA and gefitinib by cationic lipid-PLGA nanoparticles improves EGFR-targeted therapy for glioma

inferred← citeshttps://doi.org/10.1007/s00706-016-1783-xopenalex-snapshot

Synthesis and study of the electronic properties of pyrazolo[1,5-c]pyrrolo[1,2-a]quinazoline and pyrazolo[1,5-c]pyrido[1,2-a]quinazoline derivatives

inferred← citeshttps://doi.org/10.1007/s10593-021-02913-7openalex-snapshot

The Dimroth Rearrangement in the Synthesis of Condensed Pyrimidines – Structural Analogs of Antiviral Compounds

inferred← citeshttps://doi.org/10.1007/s11060-014-1437-yopenalex-snapshot

A phase 2 trial of verubulin for recurrent glioblastoma: a prospective study by the brain tumor investigational consortium (BTIC)

inferred← citeshttps://doi.org/10.1007/s11094-024-03095-0openalex-snapshot

Step-Wise, Tandem One-Pot Syntheses and Antifungal Evaluation of 2-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-arylbenzamides in Water – a Green Protocol

inferred← citeshttps://doi.org/10.1016/j.bioorg.2018.10.027openalex-snapshot

Discovery of novel quinazolines as potential anti-tubulin agents occupying three zones of colchicine domain

inferred← citeshttps://doi.org/10.1016/j.bioorg.2020.103755openalex-snapshot

Potent colchicine-site ligands with improved intrinsic solubility by replacement of the 3,4,5-trimethoxyphenyl ring with a 2-methylsulfanyl-6-methoxypyridine ring

inferred← citeshttps://doi.org/10.1016/j.bioorg.2021.104765openalex-snapshot

Cinnamide derived pyrimidine-benzimidazole hybrids as tubulin inhibitors: Synthesis, in silico and cell growth inhibition studies

inferred← citeshttps://doi.org/10.1016/j.bioorg.2025.109301openalex-snapshot

Discovery of novel quinazoline analogs as tubulin inhibitors targeting the colchicine binding site for potent antitumor therapy in combination with PD-L1 inhibitors

inferred← citeshttps://doi.org/10.1016/j.bmc.2010.07.004openalex-snapshot

Design, synthesis, and evaluation of quinazoline T cell proliferation inhibitors

inferred← citeshttps://doi.org/10.1016/j.bmc.2015.07.016openalex-snapshot

Optimization of N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines as tubulin polymerization inhibitors

inferred← citeshttps://doi.org/10.1016/j.bmc.2016.07.056openalex-snapshot

In vitro cytotoxicity of novel 2,5,7-tricarbo-substituted indoles derived from 2-amino-5-bromo-3-iodoacetophenone

inferred← citeshttps://doi.org/10.1016/j.bmc.2021.116061openalex-snapshot

Potential of substituted quinazolines to interact with multiple targets in the treatment of cancer

inferred← citeshttps://doi.org/10.1016/j.bmc.2021.116376openalex-snapshot

Design, synthesis and biological evaluation of novel acridine and quinoline derivatives as tubulin polymerization inhibitors with anticancer activities

inferred← citeshttps://doi.org/10.1016/j.bmc.2022.117098openalex-snapshot

Design, synthesis, and bioevaluation of imidazo [1,2–a] pyrazine derivatives as tubulin polymerization inhibitors with potent anticancer activities

inferred← citeshttps://doi.org/10.1016/j.bmc.2024.117660openalex-snapshot

Design, synthesis and antitumor activity of 2-substituted quinazoline-4-amine derivatives

inferred← citeshttps://doi.org/10.1016/j.bmcl.2008.09.110openalex-snapshot

Discovery of 1-benzoyl-3-cyanopyrrolo[1,2-a]quinolines as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. Part 1: Structure–activity relationships of the 1- and 3-positions

inferred← citeshttps://doi.org/10.1016/j.bmcl.2009.04.009openalex-snapshot

Discovery of N-aryl-9-oxo-9H-fluorene-1-carboxamides as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 1. Structure–activity relationships of the carboxamide group

inferred← citeshttps://doi.org/10.1016/j.bmcl.2009.04.145openalex-snapshot

Discovery of 4-anilino-N-methylthieno[3,2-d]pyrimidines and 4-anilino-N-methylthieno[2,3-d]pyrimidines as potent apoptosis inducers

inferred← citeshttps://doi.org/10.1016/j.bmcl.2009.05.012openalex-snapshot

Discovery of 1-benzoyl-3-cyanopyrrolo[1,2-a]quinolines as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2: Structure–activity relationships of the 4-, 5-, 6-, 7- and 8-positions

inferred← citeshttps://doi.org/10.1016/j.bmcl.2009.05.052openalex-snapshot

Discovery of 3-aryl-5-aryl-1,2,4-oxadiazoles as a new series of apoptosis inducers. 2. Identification of more aqueous soluble analogs as potential anticancer agents

inferred← citeshttps://doi.org/10.1016/j.bmcl.2009.11.025openalex-snapshot

Discovery of N-aryl-9-oxo-9H-fluorene-1-carboxamides as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure–activity relationships of the 9-oxo-9H-fluorene ring

inferred← citeshttps://doi.org/10.1016/j.bmcl.2010.01.112openalex-snapshot

Antiproliferative activity of novel benzo[b][1,6]naphthyridines in human solid tumor cell lines

inferred← citeshttps://doi.org/10.1016/j.bmcl.2010.01.155openalex-snapshot

Discovery of N-methyl-4-(4-methoxyanilino)quinazolines as potent apoptosis inducers. Structure–activity relationship of the quinazoline ring

inferred← citeshttps://doi.org/10.1016/j.bmcl.2013.03.107openalex-snapshot

Synthesis, single crystal and antitumor activities of benzimidazole–quinazoline hybrids

inferred← citeshttps://doi.org/10.1016/j.bmcl.2016.03.016openalex-snapshot

Synthesis, in vitro and in vivo evaluation of novel substituted N-(4-(2-(4-benzylpiperazin-1-yl)ethoxy)phenyl)-N-methyl-quinazolin-4-amines as potent antitumor agents

inferred← citeshttps://doi.org/10.1016/j.bmcl.2016.07.003openalex-snapshot

DABCO-catalyzed one-pot three component synthesis of dihydropyrano[3,2-c]chromene substituted quinazolines and their evaluation towards anticancer activity

inferred← citeshttps://doi.org/10.1016/j.bmcl.2017.05.038openalex-snapshot

Design, synthesis and evaluation of antitumor acylated monoaminopyrroloquinazolines

inferred← citeshttps://doi.org/10.1016/j.bmcl.2019.126785openalex-snapshot

In vivo comparison of N-11CH3 vs O-11CH3 radiolabeled microtubule targeted PET ligands

inferred← citeshttps://doi.org/10.1016/j.bmcl.2024.130037openalex-snapshot

Recent advances of selenized tubulin inhibitors in cancer therapy

inferred← citeshttps://doi.org/10.1016/j.drudis.2009.06.005openalex-snapshot

Orally bioavailable proteasome inhibitors: preclinical development of PR-047

inferred← citeshttps://doi.org/10.1016/j.drudis.2014.02.007openalex-snapshot

Small-molecule clinical trial candidates for the treatment of glioma

inferred← citeshttps://doi.org/10.1016/j.ejmech.2010.07.012openalex-snapshot

Design, synthesis and pro-apoptotic antitumour properties of indole-based 3,5-disubstituted oxadiazoles

inferred← citeshttps://doi.org/10.1016/j.ejmech.2011.10.056openalex-snapshot

Sulfur and selenium derivatives of quinazoline and pyrido[2,3-d]pyrimidine: Synthesis and study of their potential cytotoxic activity in vitro

inferred← citeshttps://doi.org/10.1016/j.ejmech.2012.05.039openalex-snapshot

Synthesis and biological evaluation of novel 2-(2-arylmethylene)hydrazinyl-4-aminoquinazoline derivatives as potent antitumor agents

inferred← citeshttps://doi.org/10.1016/j.ejmech.2014.06.066openalex-snapshot

The synthesis and biological evaluation of new DNA-directed alkylating agents, phenyl N-mustard-4-anilinoquinoline conjugates containing a urea linker

inferred← citeshttps://doi.org/10.1016/j.ejmech.2014.09.093openalex-snapshot

Synthesis and antiproliferative activity of 6-phenylaminopurines

inferred← citeshttps://doi.org/10.1016/j.ejmech.2016.11.012openalex-snapshot

Design, synthesis and anticancer properties of IsoCombretaQuinolines as potent tubulin assembly inhibitors

inferred← citeshttps://doi.org/10.1016/j.ejmech.2016.12.037openalex-snapshot

Facile synthesis and antiproliferative activity of 7H-benzo[7,8]chromeno[2,3-d]pyrimidin-8-amines

inferred← citeshttps://doi.org/10.1016/j.ejmech.2018.10.026openalex-snapshot

Synthesis and biological evaluation of quinazoline derivatives – A SAR study of novel inhibitors of ABCG2

inferred← citeshttps://doi.org/10.1016/j.ejmech.2018.11.070openalex-snapshot

Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site

inferred← citeshttps://doi.org/10.1016/j.ejmech.2018.12.012openalex-snapshot

The p53 stabilizing agent CP-31398 and multi-kinase inhibitors. Designing, synthesizing and screening of styrylquinazoline series

inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.112110openalex-snapshot

Developments of isoCombretastatin A-4 derivatives as highly cytotoxic agents

inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.112933openalex-snapshot

Methylsulfanylpyridine based diheteroaryl isocombretastatin analogs as potent anti-proliferative agents

inferred← citeshttps://doi.org/10.1016/j.ejmech.2021.113316openalex-snapshot

Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities

inferred← citeshttps://doi.org/10.1016/j.ejmech.2021.113826openalex-snapshot

Design, synthesis and bioevaluation of 6-aryl-1-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazoles as tubulin polymerization inhibitors

inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.114573openalex-snapshot

Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors

inferred← citeshttps://doi.org/10.1016/j.ejmech.2023.115470openalex-snapshot

Discovery of novel N-aryl-2-trifluoromethyl-quinazoline-4-amine derivatives as the inhibitors of tubulin polymerization in leukemia cells

inferred← citeshttps://doi.org/10.1016/j.ejmech.2024.116309openalex-snapshot

Structure-based approaches for the design of 6-aryl-1-(3,4,5-trimethoxyphenyl)-1H-benzo[d][1,2,3]triazoles as tubulin polymerization inhibitors

inferred← citeshttps://doi.org/10.1016/j.ejmech.2024.116649openalex-snapshot

Discovery and mechanistic insights into thieno[3,2-d]pyrimidine and heterocyclic fused pyrimidines inhibitors targeting tubulin for cancer therapy

inferred← citeshttps://doi.org/10.1016/j.ejmech.2025.117399openalex-snapshot

Medicinal chemistry applications of the Dimroth Rearrangement to the synthesis of biologically active compounds

inferred← citeshttps://doi.org/10.1016/j.ejmech.2025.118112openalex-snapshot

Verubulin and its derivatives: Progress and promise in tubulin-targeted cancer therapy

inferred← citeshttps://doi.org/10.1016/j.jphotobiol.2015.11.014openalex-snapshot

UVA-induced effects of 2,6-disubstituted 4-anilinoquinazolines on cancer cell lines

inferred← citeshttps://doi.org/10.1016/j.mencom.2021.04.003openalex-snapshot

N-(4-Methoxyphenyl)-substituted bicyclic isothioureas: effect on morphology of cancer cells

inferred← citeshttps://doi.org/10.1016/j.molliq.2015.03.012openalex-snapshot

Quantum mechanical study of solvation analysis on some nitrogen containing heterocyclic compounds

inferred← citeshttps://doi.org/10.1016/j.tet.2010.04.066openalex-snapshot

Microwave-accelerated Dimroth rearrangement for the synthesis of 4-anilino-6-nitroquinazolines. Application to an efficient synthesis of a microtubule destabilizing agent

inferred← citeshttps://doi.org/10.1016/j.tet.2010.12.067openalex-snapshot

An efficient HCCP-mediated direct amination of quinazolin-4(3H)-ones

inferred← citeshttps://doi.org/10.1016/j.tet.2014.02.066openalex-snapshot

Copper-catalyzed domino reaction between 1-(2-halophenyl)methanamines and amidines or imidates for the synthesis of 2-substituted quinazolines

inferred← citeshttps://doi.org/10.1016/j.tet.2014.06.071openalex-snapshot

Assembly of 4H-chromenes, imidazobenzothiazines and quinazolines via copper-catalyzed domino reactions using 2-halobenzyl tosylates as substrates

inferred← citeshttps://doi.org/10.1016/j.tet.2022.133073openalex-snapshot

Synthesis of heterocycles by utilizing phthalaldehydic acid: An overview

inferred← citeshttps://doi.org/10.1016/j.tetlet.2009.11.133openalex-snapshot

Mild and efficient ligand-free copper-catalyzed condensation for the synthesis of quinazolines

inferred← citeshttps://doi.org/10.1016/j.tetlet.2010.03.076openalex-snapshot

Synthesis of 4-allylquinazolines from N-(2-cyanoaryl)amides via the In-mediated allylation of nitrile and dehydrative cyclization cascade

inferred← citeshttps://doi.org/10.1016/j.tetlet.2016.04.101openalex-snapshot

Iodine-catalyzed synthesis of 5H-phthalazino[1,2-b]quinazoline and isoindolo[2,1-a]quinazoline derivatives via a chemoselective reaction of 2-aminobenzohydrazide and 2-formylbenzoic acid in ionic liquids

inferred← citeshttps://doi.org/10.1016/j.tube.2013.04.002openalex-snapshot

A novel quinoline derivative that inhibits mycobacterial FtsZ

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c01202openalex-snapshot

X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.2c02115openalex-snapshot

Design, Synthesis, and Biological Evaluation of Heterocyclic-Fused Pyrimidine Chemotypes Guided by X-ray Crystal Structure with Potential Antitumor and Anti-multidrug Resistance Efficacy Targeting the Colchicine Binding Site

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c02226openalex-snapshot

Novel Triazoloquinoxaline-Based Tubulin Polymerization Inhibitor Induces Necroptosis and Significantly Inhibits Metastatic Melanoma Tumor Growth

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b00463openalex-snapshot

Blocking Blood Flow to Solid Tumors by Destabilizing Tubulin: An Approach to Targeting Tumor Growth

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.8b00028openalex-snapshot

Radiosynthesis and in Vivo Evaluation of [11C]MPC-6827, the First Brain Penetrant Microtubule PET Ligand

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.8b01755openalex-snapshot

Discovery of Novel Quinoline–Chalcone Derivatives as Potent Antitumor Agents with Microtubule Polymerization Inhibitory Activity

inferred← citeshttps://doi.org/10.1021/acs.joc.1c03008openalex-snapshot

[4 + 1 + 1] Tandem Cyclization Reaction Involving Isocyanides: Access to 2-(Trifluoromethyl)quinazolin-4(3H)-imines

inferred← citeshttps://doi.org/10.1021/acs.joc.3c00418openalex-snapshot

Electrochemically Enabled C4–H and C3–H Functionalization of 2-Phenyl Quinazoline and Quinoxaline through Dehydrogenative C–H/C–H, C–H/P–H, and C–H/O–H Cross-Coupling

inferred← citeshttps://doi.org/10.1021/acs.orglett.8b00314openalex-snapshot

Triflates-Triggered Intermolecular Cyclization of Carbodiimides Leading to 2-Aminoquinazolinone and 2,4-Diaminoquinazoline Derivatives

inferred← citeshttps://doi.org/10.1021/acsmedchemlett.0c00119openalex-snapshot

Discovery of a Potent Anticancer Agent PVHD303 with in Vivo Activity

inferred← citeshttps://doi.org/10.1021/acsomega.6c01857openalex-snapshot

Gallium/Indium-Promoted [4 + 2] Annulation of 2-Aminobenzonitriles with Alkynes and Dimerization of 2-Aminobenzonitriles: One-Pot Access to 4-Aminoquinolines and 4-Amino-2-Arylquinazolines

inferred← citeshttps://doi.org/10.1021/co200100zopenalex-snapshot

Pyrano[4,3-b]quinolines Library Generation via Iodocyclization and Palladium-Catalyzed Coupling Reactions

inferred← citeshttps://doi.org/10.1021/jm100659vopenalex-snapshot

Synthesis and Pharmacological Evaluation of N-(3-(1H-Indol-4-yl)-5-(2-methoxyisonicotinoyl)phenyl)methanesulfonamide (LP-261), a Potent Antimitotic Agent

inferred← citeshttps://doi.org/10.1021/jm101010nopenalex-snapshot

Synthesis and Discovery of Water-Soluble Microtubule Targeting Agents that Bind to the Colchicine Site on Tubulin and Circumvent Pgp Mediated Resistance

inferred← citeshttps://doi.org/10.1021/jm4016526openalex-snapshot

Optimization of 4-( N -Cycloamino)phenylquinazolines as a Novel Class of Tubulin-Polymerization Inhibitors Targeting the Colchicine Site

inferred← citeshttps://doi.org/10.1021/ml400176nopenalex-snapshot

Discovery of ML314, a Brain Penetrant Nonpeptidic β-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor

inferred← citeshttps://doi.org/10.1021/ml5004684openalex-snapshot

Synthesis and Structure–Activity Relationship Study of 1-Phenyl-1-(quinazolin-4-yl)ethanols as Anticancer Agents

inferred← citeshttps://doi.org/10.1021/ol201807nopenalex-snapshot

Palladium-Catalyzed Intramolecular C(sp2)–H Amidination by Isonitrile Insertion Provides Direct Access to 4-Aminoquinazolines from N-Arylamidines

inferred← citeshttps://doi.org/10.1039/c0ob00500bopenalex-snapshot

Tubulin-binding dibenz[c,e]oxepines as colchinol analogues for targeting tumour vasculature

inferred← citeshttps://doi.org/10.1039/c4ob00700jopenalex-snapshot

Synthesis of 4-alkynylquinazolines: Pd–Cu-cocatalyzed coupling of quinazoline-4-tosylates with terminal alkynes using N-heterocyclic carbenes as ligands

inferred← citeshttps://doi.org/10.1055/a-1647-5978openalex-snapshot

Palladium-Catalyzed Cross-Coupling of 4-(Tosyloxy)quinazolines with H-Phosphonates and Phosphine Oxides: An Efficient Access to 2-(Hetero)aryl-4-phosphorylated Quinazolines

inferred← citeshttps://doi.org/10.1080/1062936x.2020.1827030openalex-snapshot

Pharmacophore-based identification and in vitro validation of apoptosis inducers as anticancer agents

inferred← citeshttps://doi.org/10.1080/14756366.2018.1510919openalex-snapshot

Benzofuran–appended 4-aminoquinazoline hybrids as epidermal growth factor receptor tyrosine kinase inhibitors: synthesis, biological evaluation and molecular docking studies

inferred← citeshttps://doi.org/10.1080/17518253.2012.742142openalex-snapshot

PEG-600-mediated, green and efficient, tandem syntheses of N-subtituted-2-styrylquinazolin-4- ones

inferred← citeshttps://doi.org/10.1111/cbdd.12706openalex-snapshot

Synthesis and Biological Evaluation of Novel Substituted 4‐Anilinoquinazolines as Antitumor Agents

inferred← citeshttps://doi.org/10.1134/s1068162023030044openalex-snapshot

Design, Synthesis, and Anticancer Activity of New Quinazoline Derivatives Containing Acetylhydrazide Moiety as EGFR Inhibitors and Apoptosis Inducers

inferred← citeshttps://doi.org/10.1134/s107036322210019xopenalex-snapshot

Design, Synthesis, and Anticancer Activity of New Quinazoline Derivatives as VEGFR-2 Inhibitors and Apoptosis Inducers

inferred← citeshttps://doi.org/10.1134/s1070428023020124openalex-snapshot

Eco-friendly, Water Mediated, One-Pot Synthesis of 2-(5,6-Dicyano-1H-benzo[d]imidazol-2-yl)-N-arylbenzamides and Their Antifungal Activity Testing

inferred← citeshttps://doi.org/10.1134/s1070428023030144openalex-snapshot

Stepwise, Tandem, and One-Pot Syntheses of N-Aryl-2-(4-oxo-3,4-dihydroquinazolin-2-yl)benzamides in Water: A Green Protocol

inferred← citeshttps://doi.org/10.1134/s1070428024090203openalex-snapshot

Efficient Synthesis of 8-Fluoro-10-methyl-3,4-dihydrobenzo[b][1,6]naphthyridine-2(1H)-carboxamides and Their Cytotoxic Activity

inferred← citeshttps://doi.org/10.1155/2022/8424838openalex-snapshot

A Review on Current Synthetic Methods of 4-Aminoquinazoline Derivatives

inferred← citeshttps://doi.org/10.1186/2191-2858-1-13openalex-snapshot

2D and 3D-QSAR study on 4-anilinoquinozaline derivatives as potent apoptosis inducer and efficacious anticancer agent

inferred← citeshttps://doi.org/10.1515/hc-2014-0181openalex-snapshot

Synthesis of quinazolines and quinazolinones via palladium-mediated approach

inferred← citeshttps://doi.org/10.1517/17460441.2010.486829openalex-snapshot

Cell-based apoptosis assays in oncology drug discovery

inferred← citeshttps://doi.org/10.2174/092986732311160420104823openalex-snapshot

Pyridine Based Antitumour Compounds Acting at the Colchicine Site

inferred← citeshttps://doi.org/10.2174/1389203724666230227115305openalex-snapshot

Caspase-3 Activators as Anticancer Agents

inferred← citeshttps://doi.org/10.3109/14756366.2011.601302openalex-snapshot

Design, synthesis and biological evaluation of novel quinazoline derivatives as potential anti-cancer agents

inferred← citeshttps://doi.org/10.31788/rjc.2022.1516468openalex-snapshot

BIOACTIVE COMPOUNDS OF INDONESIAN RED BETEL (PIPER CROCATUM) EXTRACT AND ITS INHIBITORY ACTIVITY IN MCF-7 CELL LINE

inferred← citeshttps://doi.org/10.3390/ijms19082232openalex-snapshot

Synthesis, Biological Evaluation and Molecular Docking of Novel Indole-Aminoquinazoline Hybrids for Anticancer Properties

inferred← citeshttps://doi.org/10.3390/molecules15129473openalex-snapshot

A General Synthetic Procedure for 2-chloromethyl-4(3H)-quinazolinone Derivatives and Their Utilization in the Preparation of Novel Anticancer Agents with 4-Anilinoquinazoline Scaffolds

inferred← citeshttps://doi.org/10.3390/molecules18055580openalex-snapshot

Hexachlorocyclotriphosphazene (HCCP)-Mediated Direct Formation of Thioethers and Ethers from Quinazolin-4(3H)-ones

inferred← citeshttps://doi.org/10.3390/molecules21101366openalex-snapshot

Synthesis and In Vitro Cytotoxic Properties of Polycarbo-Substituted 4-(Arylamino)quinazolines

inferred← citeshttps://doi.org/10.3390/molecules27185799openalex-snapshot

Facile Access to 2-Selenoxo-1,2,3,4-tetrahydro-4-quinazolinone Scaffolds and Corresponding Diselenides via Cyclization between Methyl Anthranilate and Isoselenocyanates: Synthesis and Structural Features

inferred← citeshttps://doi.org/10.3390/ph13090202openalex-snapshot

Microwave-Assisted Synthesis of Potential Bioactive Benzo-, Pyrido- or Pyrazino-thieno[3,2-d]pyrimidin-4-amine Analogs of MPC-6827

inferred← citeshttps://doi.org/10.3390/ph16101499openalex-snapshot

Verubulin (Azixa) Analogues with Increased Saturation: Synthesis, SAR and Encapsulation in Biocompatible Nanocontainers Based on Ca2+ or Mg2+ Cross-Linked Alginate

inferred← citeshttps://doi.org/10.4155/fmc-2017-0100openalex-snapshot

Tubulin Inhibitors Targeting the Colchicine Binding Site: A Perspective of Privileged Structures

inferred← citeshttps://doi.org/10.4155/fmc-2023-0151openalex-snapshot

Design, Synthesis and Bioevaluation of Novel Trifluoromethylquinoline Derivatives As Tubulin Polymerization Inhibitors

inferred← citeshttps://doi.org/10.4155/fmc.12.141openalex-snapshot

Indole Molecules As Inhibitors Of Tubulin Polymerization: Potential New Anticancer Agents

inferred← citeshttps://doi.org/10.5530/ijper.52.4s.107openalex-snapshot

Novel Quinolone Substituted Quinazolin-4(3H)-Ones as Anti-Inflammatory, Anticancer Agents: Synthesis and Biological Screening

inferred← citeshttps://doi.org/10.5582/ddt.2012.v6.3.133openalex-snapshot

Synthesis and anticancer activity of novel 5-(indole-2-yl)-3-substituted 1,2,4-oxadiazoles

inferred← citeshttps://doi.org/10.5772/intechopen.89203openalex-snapshot

Quinazolinone and Quinazoline Derivatives: Synthesis and Biological Application

inferred← citeshttps://doi.org/10.70675/5db18680zb2faz41b6zad91za2fb3d6f8d1aopenalex-snapshot

Concept, synthesis, biological evaluation of tubulin and HDAC dual inhibitory molecules and development of an efficient catalytic system of alkyne hydration

inferred← citeshttps://doi.org/10.70675/cb4b0dd4z634bz4299z96a9z469b89375839openalex-snapshot

Étude de la restauration de la réponse immunitaire antitumorale dans un modèle murin de cancer pulmonaire induit par une molécule multicible inhibitrice de HDAC et du splicéosome

inferred← citeshttps://doi.org/10.70675/dac16ddbzbfdaz4537zaf42zaa27364e3799openalex-snapshot

Nouveaux dérivés de la combrétastatine A-4 à visée antivasculaire

Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.