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Characterization of Selective Exosite-Binding Inhibitors of Matrix Metalloproteinase 13 That Prevent Articular Cartilage Degradation in Vitro
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models
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Cartilage degradation biomarkers predict efficacy of a novel, highly selective matrix metalloproteinase 13 inhibitor in a dog model of osteoarthritis: Confirmation by multivariate analysis that modulation of type ii collagen and aggrecan degradation peptides parallels pathologic changes
inferredcites →https://doi.org/10.1006/prep.1998.0972openalex-snapshot
The Expression, Refolding, and Purification of the Catalytic Domain of Human Collagenase-3 (MMP-13)
inferredcites →https://doi.org/10.1006/scdb.2000.0241openalex-snapshot
Heparan sulfate proteoglycans in invasion and metastasis
inferredcites →https://doi.org/10.1007/s00011-009-0112-9openalex-snapshot
Novel selective MMP-13 inhibitors reduce collagen degradation in bovine articular and human osteoarthritis cartilage explants
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Structural properties of matrix metalloproteinases
inferredcites →https://doi.org/10.1016/j.ab.2003.12.035openalex-snapshot
Characterization of Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2, a fluorogenic substrate with increased specificity constants for collagenases and tumor necrosis factor converting enzyme
inferredcites →https://doi.org/10.1016/j.bbrc.2006.03.098openalex-snapshot
Crystal structures of the catalytic domain of human stromelysin-1 (MMP-3) and collagenase-3 (MMP-13) with a hydroxamic acid inhibitor SM-25453
inferredcites →https://doi.org/10.1016/j.bmc.2008.03.004openalex-snapshot
High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate
inferredcites →https://doi.org/10.1016/j.bmc.2008.03.018openalex-snapshot
Ranking the selectivity of PubChem screening hits by activity-based protein profiling: MMP13 as a case study
inferredcites →https://doi.org/10.1016/j.bmc.2008.08.058openalex-snapshot
Specific targeting of metzincin family members with small-molecule inhibitors: Progress toward a multifarious challenge
inferredcites →https://doi.org/10.1016/j.bmc.2014.07.025openalex-snapshot
Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: Highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1″ binding site
inferredcites →https://doi.org/10.1016/j.bmcl.2005.02.038openalex-snapshot
Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14
inferredcites →https://doi.org/10.1016/j.bmcl.2005.06.019openalex-snapshot
Identification of potent and selective MMP-13 inhibitors
inferredcites →https://doi.org/10.1016/j.bmcl.2006.08.066openalex-snapshot
Potent, selective pyrimidinetrione-based inhibitors of MMP-13
inferredcites →https://doi.org/10.1016/j.bmcl.2009.07.151openalex-snapshot
Improving potency and selectivity of a new class of non-Zn-chelating MMP-13 inhibitors
inferredcites →https://doi.org/10.1016/j.bmcl.2010.07.036openalex-snapshot
SAR studies of non-zinc-chelating MMP-13 inhibitors: Improving selectivity and metabolic stability
inferredcites →https://doi.org/10.1016/j.bmcl.2011.08.087openalex-snapshot
Potent and selective 2-naphthylsulfonamide substituted hydroxamic acid inhibitors of matrix metalloproteinase-13
inferredcites →https://doi.org/10.1016/j.bmcl.2011.09.077openalex-snapshot
Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds
inferredcites →https://doi.org/10.1016/j.cardiores.2005.11.032openalex-snapshot
The importance of estimating the therapeutic index in the development of matrix metalloproteinase inhibitors
inferredcites →https://doi.org/10.1016/j.chembiol.2004.11.014openalex-snapshot
Structural Basis for the Highly Selective Inhibition of MMP-13
inferredcites →https://doi.org/10.1016/j.mam.2008.06.001openalex-snapshot
Synthetic active site-directed inhibitors of metzincins: Achievement and perspectives
inferredcites →https://doi.org/10.1016/j.semcdb.2007.06.006openalex-snapshot
MMPs as therapeutic targets—Still a viable option?
inferredcites →https://doi.org/10.1016/s0092-8674(00)80064-1openalex-snapshot
MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover
inferredcites →https://doi.org/10.1016/s0092-8674(00)81169-1openalex-snapshot
MMP-9/Gelatinase B Is a Key Regulator of Growth Plate Angiogenesis and Apoptosis of Hypertrophic Chondrocytes
inferredcites →https://doi.org/10.1016/s0945-053x(00)00078-0openalex-snapshot
Mechanisms involved in cartilage proteoglycan catabolism
inferredcites →https://doi.org/10.1016/s1359-6446(05)03386-6openalex-snapshot
Ligand efficiency indices as guideposts for drug discovery
inferredcites →https://doi.org/10.1021/ja001547gopenalex-snapshot
Structure-Based Design of a Novel, Potent, and Selective Inhibitor for MMP-13 Utilizing NMR Spectroscopy and Computer-Aided Molecular Design
inferredcites →https://doi.org/10.1021/jm201152uopenalex-snapshot
Discovery and Evaluation of a Non-Zn Chelating, Selective Matrix Metalloproteinase 13 (MMP-13) Inhibitor for Potential Intra-articular Treatment of Osteoarthritis
inferredcites →https://doi.org/10.1021/jm500312xopenalex-snapshot
Design, Synthesis, and Structure–Activity Relationship Studies of Novel Thioether Pleuromutilin Derivatives as Potent Antibacterial Agents
inferredcites →https://doi.org/10.1021/jm701274vopenalex-snapshot
Quinazolinones and Pyrido[3,4- d ]pyrimidin-4-ones as Orally Active and Specific Matrix Metalloproteinase-13 Inhibitors for the Treatment of Osteoarthritis
inferredcites →https://doi.org/10.1021/tx700079zopenalex-snapshot
Cytochrome P450 and Chemical Toxicology
inferredcites →https://doi.org/10.1038/6657openalex-snapshot
Crystal structures of MMP-1 and -13 reveal the structural basis for selectivity of collagenase inhibitors.
inferredcites →https://doi.org/10.1038/90100openalex-snapshot
Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome
inferredcites →https://doi.org/10.1038/nrc1821openalex-snapshot
Validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy
inferredcites →https://doi.org/10.1038/nrd1470openalex-snapshot
Can the pharmaceutical industry reduce attrition rates?
inferredcites →https://doi.org/10.1038/sj.bjc.6603043openalex-snapshot
Towards third generation matrix metalloproteinase inhibitors for cancer therapy
inferredcites →https://doi.org/10.1038/sj.emboj.7600318openalex-snapshot
Collagenase unwinds triple‐helical collagen prior to peptide bond hydrolysis
inferredcites →https://doi.org/10.1042/bj3290689openalex-snapshot
Analysis of the combined effect of two linear inhibitors on a single enzyme
inferredcites →https://doi.org/10.1053/joca.2001.0427openalex-snapshot
The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation
inferredcites →https://doi.org/10.1074/jbc.271.3.1544openalex-snapshot
Biochemical Characterization of Human Collagenase-3
inferredcites →https://doi.org/10.1074/jbc.m004039200openalex-snapshot
Identification of the 183RWTNNFREY191Region as a Critical Segment of Matrix Metalloproteinase 1 for the Expression of Collagenolytic Activity
inferredcites →https://doi.org/10.1074/jbc.m303737200openalex-snapshot
Aggrecan Protects Cartilage Collagen from Proteolytic Cleavage
inferredcites →https://doi.org/10.1074/jbc.m606004200openalex-snapshot
The Roles of Substrate Thermal Stability and P2 and P1′ Subsite Identity on Matrix Metalloproteinase Triple-helical Peptidase Activity and Collagen Specificity
inferredcites →https://doi.org/10.1074/jbc.m703286200openalex-snapshot
Discovery and Characterization of a Novel Inhibitor of Matrix Metalloprotease-13 That Reduces Cartilage Damage in Vivo without Joint Fibroplasia Side Effects
inferredcites →https://doi.org/10.1107/97809553602060000865openalex-snapshot
PHENIX: a comprehensive Python-based system for macromolecular structure solution
inferredcites →https://doi.org/10.1107/s0021889807021206openalex-snapshot
Phaser crystallographic software
inferredcites →https://doi.org/10.1107/s0907444909029436openalex-snapshot
electronic Ligand Builder and Optimisation Workbench (eLBOW): A tool for ligand coordinate and restraint generation
inferredcites →https://doi.org/10.1107/s0907444909052925openalex-snapshot
PHENIX : a comprehensive Python-based system for macromolecular structure solution
inferredcites →https://doi.org/10.1107/s0907444910007493openalex-snapshot
Features and development of Coot
inferredcites →https://doi.org/10.1110/ps.073130208openalex-snapshot
Characterization of an exosite binding inhibitor of matrix metalloproteinase 13
inferredcites →https://doi.org/10.1124/dmd.32.3.333openalex-snapshot
IN VITRO SULFOXIDATION OF THIOETHER COMPOUNDS BY HUMAN CYTOCHROME P450 AND FLAVIN-CONTAINING MONOOXYGENASE ISOFORMS WITH PARTICULAR REFERENCE TO THE CYP2C SUBFAMILY
inferredcites →https://doi.org/10.1136/ard.2008.106021openalex-snapshot
Effect of the oral application of a highly selective MMP-13 inhibitor in three different animal models of rheumatoid arthritis
inferredcites →https://doi.org/10.1172/jci10564openalex-snapshot
Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice
inferredcites →https://doi.org/10.1172/jci113929openalex-snapshot
Immunohistochemical detection and immunochemical analysis of type II collagen degradation in human normal, rheumatoid, and osteoarthritic articular cartilages and in explants of bovine articular cartilage cultured with interleukin 1.
inferredcites →https://doi.org/10.1371/journal.pone.0029615openalex-snapshot
An MMP13-Selective Inhibitor Delays Primary Tumor Growth and the Onset of Tumor-Associated Osteolytic Lesions in Experimental Models of Breast Cancer
inferredcites →https://doi.org/10.1385/mb:22:1:051openalex-snapshot
Molecular Determinants of Metalloproteinase Substrate Specificity: Matrix Metalloproteinase Substrate Binding Domains, Modules, and Exosites
inferredcites →https://doi.org/10.1515/bc.2002.118openalex-snapshot
Triple-Helical Peptide Analysis of Collagenolytic Protease Activity
inferredcites →https://doi.org/10.2174/138161207779313551openalex-snapshot
Matrix Metalloproteinases as Valid Clinical Target
inferredcites →https://doi.org/10.2174/138920108783497659openalex-snapshot
Joint Diseases and Matrix Metalloproteinases: A Role for MMP-13
inferredcites →https://doi.org/10.2741/1817openalex-snapshot
Matrix Metalloproteinases: Role In Arthritis
inferredcites →https://doi.org/10.4155/fmc.14.16openalex-snapshot
Alternative Variables in Drug Discovery: Promises and Challenges
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Development of a Zn2+-Chelating But Highly Selective Matrix Metalloproteinase 13 Inhibitor
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Design and Structural Evolution of Matrix Metalloproteinase Inhibitors
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Recent Research Advances in Selective Matrix Metalloproteinase‐13 Inhibitors as Anti‐Osteoarthritis Agents
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inferred← citeshttps://doi.org/10.1016/j.matbio.2015.01.002openalex-snapshot
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Thioredoxin fusion construct enables high-yield production of soluble, active matrix metalloproteinase-8 (MMP-8) in Escherichia coli
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Isolation, synthesis and medicinal chemistry of biphenyl analogs – A review
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Matrix Metalloproteinases as New Targets in Alzheimer’s Disease: Opportunities and Challenges
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SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.7b00018openalex-snapshot
Second Generation Triple-Helical Peptide Inhibitors of Matrix Metalloproteinases
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.7b00514openalex-snapshot
Structure-Based Design and Synthesis of Potent and Selective Matrix Metalloproteinase 13 Inhibitors
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Novel matrix metalloproteinase inhibitors: an updated patent review (2014 - 2020)
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Articular cartilage: injury, healing, and regeneration
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A New Pleuromutilin Derivative: Synthesis, Crystal Structure and Antibacterial Evaluation
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Design, Synthesis and in vitro Evaluation of Phthalimide-Anhydride Derivatives as MMP-9 Suppressors in Breast Cancer Therapy
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Physiological Properties, Functions, and Trends in the Matrix Metalloproteinase Inhibitors in Inflammation-Mediated Human Diseases
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Molecular Dynamics Simulations of Matrix Metalloproteinase 13 and the Analysis of the Specificity Loop and the S1′−Site
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