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Coupling N-Methylated Amino Acids Using PyBroP and PyCloP Halogenophosphonium Salts: Mechanism and Fields of Application

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Extensive Targeting of Chemical Space at the Prime Side of Ketoamide Inhibitors of Rhomboid Proteases by Branched Substituents Empowers Their Selectivity and Potency
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2-Chloro-1,3-dimethylimidazolidium Hexafluorophosphate
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Bromotripyrrolidinophosphonium Hexafluorophosphate
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Chlorotripyrrolidinophosphonium Hexafluorophosphate
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(1H-Benzotriazol-1-yloxy)tripyrrolidino-phosphonium Hexafluorophosphate
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2-Bromo-1-ethyl Pyridinium Tetrafluoroborate (BEP)
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Fine Tuning of the Cation Affinity of Artificial Receptors Based on Cyclic Peptides by Intramolecular Conformational Control
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Inverconversion of Nitriles, Carboxylic Acids, and Derivatives
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Methods for the Peptide Synthesis and Analysis
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Peptide‐Coupling Reagents
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Solution‐Phase Peptide Synthesis
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Rationales Design neuer Rezeptor‐Ligand‐Kombinationen
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Palladiumkatalysierte Addition von Alkenylepoxiden an Pronucleophile: eine Synthese des Makrolactam‐Aglycons von Fluviricin B1
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Fmoc Solid‐Phase Synthesis of C‐Terminal Peptide Thioesters by Formation of a Backbone Pyroglutamyl Imide Moiety
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N‐Methylated Peptide Synthesis via Generation of an Acyl N‐Methylimidazolium Cation Accelerated by a Brønsted Acid
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Rational Design of Orthogonal Receptor–Ligand Combinations
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Palladium‐Catalyzed Additions of Alkenyl Epoxides to Pronucleophiles: A Synthesis of the Macrolactam Aglycone of Fluviricin B1
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Fmoc Solid‐Phase Synthesis of C‐Terminal Peptide Thioesters by Formation of a Backbone Pyroglutamyl Imide Moiety
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N‐Methylated Peptide Synthesis via Generation of an Acyl N‐Methylimidazolium Cation Accelerated by a Brønsted Acid
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N‐methylation in amino acids and peptides: Scope and limitations
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The First Total Synthesis of the PeptaibolHypomurocin A1 and Its Conformation Analysis: an Application of the ‘Azirine/Oxazolone Method’
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A New Enzyme Model For Enantioselective Esterases Based On Molecularly Imprinted Polymers
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Cyclic RGD‐Peptidomimetics Containing Bifunctional Diketopiperazine Scaffolds as New Potent Integrin Ligands
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Cyclic RGD Peptidomimetics Containing Bifunctional Diketopiperazine Scaffolds as New Potent Integrin Ligands
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C‐Terminal Functionalization Methods of Amino Acids, Peptides, and Proteins
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Magnetic‐Field‐Dependent 1H Relaxivity Behavior of Biotin/Avidin‐Based Magnetic Resonance Imaging Probes
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Sequence‐Selective Peptide Recognition with Designed Modules
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An Enantioselective Fluorescence Sensor for Glucose Based on a Cyclic Tetrapeptide Containing Two Boronic Acid Binding Sites
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(9H‐Fluoren‐9‐yl)methanesulfonyl (Fms): An Amino Protecting Group Complementary to Fmoc
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Regioselective Synthesis of 2,4‐Substituted Pyrido[1′,2′:1,5]pyrazolo[3,4‐ d ]pyrimidines through Sequential Pd‐Catalyzed Arylation and S N Ar Reactions
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Assessment of new 6-Cl-HOBt based coupling reagents for peptide synthesis. Part 2: Racemization studies
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Thirteen decades of peptide synthesis: key developments in solid phase peptide synthesis and amide bond formation utilized in peptide ligation
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Progress of transition metal-catalyzed cross-coupling mediated by PyBroP
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Synthesis of surrogate structures related to the herbicidal agent hydantocidin
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A new synthesis of α-methylserine by nucleophilic ring-opening of N-sulfonyl aziridines
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CF3-NO2-PyBOP1: A new and highly efficient coupling reagent for N-methyl amino acids
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Kainic acid as conformationally constrained glutamic acid analog in peptide synthesis
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Reaction of N-trityl amino acids with BOP: Efficient synthesis of t-butyl esters as well as N-trityl serine- and threonine-β-lactones
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6.11 N-Acylation Reactions of Amines
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Side Reactions on Amino Groups in Peptide Synthesis
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Peptide Racemization
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Macrolactonizations in the Total Synthesis of Natural Products
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N-Acylation Reactions of Amines
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Pyrano-[2,3b]-pyridines as potassium channel antagonists
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General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases
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Novel cationic polyene glycol phospholipids as DNA transfer reagents—Lack of a structure–activity relationship due to uncontrolled self-assembling processes
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Recent development of peptide coupling reagents in organic synthesis
inferred← citeshttps://doi.org/10.1016/j.tet.2004.07.014openalex-snapshot
Synthesis and conformational investigation of tetrapeptide analogues of the fragment B23-B26 of insulin
inferred← citeshttps://doi.org/10.1016/j.tet.2004.10.001openalex-snapshot
Recent advances in the total syntheses of oxazole-containing natural products
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1,3-Dimethyl-2-(3-nitro-1,2,4-triazol-1-yl)-2-pyrrolidin-1-yl-1,3,2-diazaphospholidinium hexafluorophosphate (MNTP): a powerful condensing reagent for phosphate and phosphonate esters
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Total synthesis of amphidinolide E and amphidinolide E stereoisomers
inferred← citeshttps://doi.org/10.1016/j.tet.2007.04.045openalex-snapshot
Toward breast cancer resistance protein (BCRP) inhibitors: design, synthesis of a series of new simplified fumitremorgin C analogues
inferred← citeshttps://doi.org/10.1016/j.tet.2008.10.049openalex-snapshot
Parallel synthesis and spectroscopic analysis of a collection of heterocycles based on the diazabenz[e]aceanthrylene core structure
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A novel strategy towards the atorvastatin lactone
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Synthesis and biological evaluation of triazole analogues of antillatoxin
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Synthesis of arginine-containing hydroxamate dipeptidomimetics
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Synthesis of a (+)-anatoxin-a analogue for monoclonal antibodies production
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A discovery tool at work: the unexpected properties of a two-carbon residue
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2-Mercaptopyridine-1-oxide-based peptide coupling reagents
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Synthesis of the host-selective phytotoxin destruxin B. Avoiding diketopiperazine formation from an N-methyl amino acid dipeptide by use of the Boc-hydrazide derivative
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Solid phase synthesis of fumitremorgin, verruculogen and tryprostatin analogs based on a cyclization/cleavage strategy
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Design and synthesis of a novel cyclo-β-tetrapeptide
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A novel thiazolium type peptide coupling reagent for hindered amino acids
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[7] Coupling reagents and activation
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Structure-activity relationships in 2-aminodiphenylsulfides against trypanothione reductase from Trypanosoma cruzi
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Potent and specific inhibitors of trypanothione reductase from Trypanosoma cruzi
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Combinatorial synthesis and biological evaluation of Library of small-molecule Ser/Thr-protein phosphatase inhibitors
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Comprehensive Structure–Activity Relationship Studies of Macrocyclic Natural Products Enabled by Their Total Syntheses
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Chemical Blockage of the Mitochondrial Rhomboid Protease PARL by Novel Ketoamide Inhibitors Reveals Its Role in PINK1/Parkin-Dependent Mitophagy
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Glutamic Acid Selective Chemical Cleavage of Peptide Bonds
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Total Synthesis of Nannocystin Ax
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Antimicrobial Peptides with Stability toward Tryptic Degradation
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A Targeted Library of Small-Molecule, Tyrosine, and Dual-Specificity Phosphatase Inhibitors Derived from a Rational Core Design and Random Side Chain Variation
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Macrolactonizations in the Total Synthesis of Natural Products
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Peptide Coupling Reagents, More than a Letter Soup
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Update 1 of: Macrolactonizations in the Total Synthesis of Natural Products
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Synthesis of seco -B-Ring Bryostatin Analogue WN-1 via C–C Bond-Forming Hydrogenation: Critical Contribution of the B-Ring in Determining Bryostatin-like and Phorbol 12-Myristate 13-Acetate-like Properties
inferred← citeshttps://doi.org/10.1021/ja961374oopenalex-snapshot
Syntheses of Discodermolides Useful for Investigating Microtubule Binding and Stabilization
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Chemical Synthesis of Oligodeoxyribonucleotides Using N-Unprotected H-Phosphonate Monomers and Carbonium and Phosphonium Condensing Reagents: O-Selective Phosphonylation and Condensation
inferred← citeshttps://doi.org/10.1021/ja983970jopenalex-snapshot
Large Increase in Cation Binding Affinity of Artificial Cyclopeptide Receptors by an Allosteric Effect
inferred← citeshttps://doi.org/10.1021/jacs.5b05327openalex-snapshot
Enantiopure Peptide-Functionalized Metal–Organic Frameworks
inferred← citeshttps://doi.org/10.1021/jacs.6b08695openalex-snapshot
Evaluation of Chromane-Based Bryostatin Analogues Prepared via Hydrogen-Mediated C–C Bond Formation: Potency Does Not Confer Bryostatin-like Biology
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Rational Design of an Organocatalyst for Peptide Bond Formation
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Antiplasmodial Activity and Cytotoxicity of Bis-, Tris-, and Tetraquinolines with Linear or Cyclic Amino Linkers
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Solid Phase Synthesis and Evaluation of Tyr-Tic-Phe-Phe(p-NHCOCH2Br) ([Phe(p-bromoacetamide)4]TIPP), a Potent Affinity Label for δ Opioid Receptors
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Iterative Approach to the Discovery of Novel Degarelix Analogues: Substitutions at Positions 3, 7, and 8. Part II
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Novel Analogues of Degarelix Incorporating Hydroxy-, Methoxy-, and Pegylated-Urea Moieties at Positions 3, 5, 6 and the N-Terminus. Part III
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Albumin Binding of Short Cationic Antimicrobial Micropeptides and Its Influence on the in Vitro Bactericidal Effect
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Thiazolides as Novel Antiviral Agents. 1. Inhibition of Hepatitis B Virus Replication
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Design, Synthesis, and Dopamine Receptor Modulating Activity of Spiro Bicyclic Peptidomimetics of l -Prolyl- l -leucyl-glycinamide
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Antimalarial, Antitrypanosomal, and Antileishmanial Activities and Cytotoxicity of Bis(9-amino-6-chloro-2-methoxyacridines): Influence of the Linker
inferred← citeshttps://doi.org/10.1021/jo0156161openalex-snapshot
Optimization of a Synthetic Arginine Receptor. Systematic Tuning of Noncovalent Interactions
inferred← citeshttps://doi.org/10.1021/jo030358oopenalex-snapshot
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Curtin–Hammett and Steric Effects in HOBt Acylation Regiochemistry
inferred← citeshttps://doi.org/10.1021/jo200994zopenalex-snapshot
Validation of the Distal Effect of Electron-Withdrawing Groups on the Stability of Peptide Enolates and Its Exploitation in the Controlled Stereochemical Inversion of Amino Acid Derivatives
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The Scope and Mechanism of Phosphonium-Mediated SNAr Reactions in Heterocyclic Amides and Ureas
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One-Pot Synthesis of Amides and Esters from 2,2,2-Trihaloethyl Esters Using Phosphorus(III) Reagents
inferred← citeshttps://doi.org/10.1021/jo990660qopenalex-snapshot
2-Mercaptopyridone 1-Oxide-Based Uronium Salts: New Peptide Coupling Reagents1,2
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inferred← citeshttps://doi.org/10.1021/jo991523wopenalex-snapshot
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inferred← citeshttps://doi.org/10.1021/jo991687copenalex-snapshot
Total Synthesis of Cyclosporin O Both in Solution and in the Solid Phase Using Novel Thiazolium-, Immonium-, and Pyridinium-Type Coupling Reagents: BEMT, BDMP, and BEP1
inferred← citeshttps://doi.org/10.1021/jo991711mopenalex-snapshot
Direct Transacylation of 2,2,2-Trihaloethyl Esters with Amines and Alcohols Using Phosphorus(III) Reagents for Reductive Fragmentation and in Situ Activation
inferred← citeshttps://doi.org/10.1021/np0680735openalex-snapshot
Antineoplastic Agents. 561. Total Synthesis of Respirantin1a
inferred← citeshttps://doi.org/10.1021/ol020235aopenalex-snapshot
Complex Polyfluoride Additives in Fmoc-Amino Acid Fluoride Coupling Processes. Enhanced Reactivity and Avoidance of Stereomutation
inferred← citeshttps://doi.org/10.1021/ol027044sopenalex-snapshot
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inferred← citeshttps://doi.org/10.1021/ol0272390openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/ol102112zopenalex-snapshot
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inferred← citeshttps://doi.org/10.1021/ol102273uopenalex-snapshot
Bis(2-sulfanylethyl)amino Native Peptide Ligation
inferred← citeshttps://doi.org/10.1021/ol2020362openalex-snapshot
Concise, Stereocontrolled Synthesis of the Citrinadin B Core Architecture
inferred← citeshttps://doi.org/10.1021/ol990573kopenalex-snapshot
3-(Diethoxyphosphoryloxy)-1,2,3- benzotriazin-4(3H)-one (DEPBT): A New Coupling Reagent with Remarkable Resistance to Racemization
inferred← citeshttps://doi.org/10.1021/op400285yopenalex-snapshot
PAT Application in the Expedited Development of a Three-Step, One-Stage Synthesis of the Dipeptide Intermediate of HCV Protease Inhibitor Faldaprevir
inferred← citeshttps://doi.org/10.1023/a:1008806907085openalex-snapshot
Nα-Fmoc-O,O-(dimethylphospho)-L-tyrosine fluoride: A convenient building block for the solid-phase synthesis of phosphotyrosyl peptides
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(1H‐Benzotriazol‐1‐yloxy)‐N,N‐dimethylmethaniminium hexachloroantimonate (BOMI), a novel coupling reagent for solution and solid‐phase peptide synthesis
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The development of highly efficient onium‐type peptide coupling reagents based upon rational molecular design
inferred← citeshttps://doi.org/10.1034/j.1399-3011.2003.00041.xopenalex-snapshot
A convenient incorporation of conformationally constrained 5,5‐dimethylproline into the ribonuclease A 89–124 sequence by condensation of synthetic peptide fragments
inferred← citeshttps://doi.org/10.1039/a801472hopenalex-snapshot
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inferred← citeshttps://doi.org/10.1039/b920193aopenalex-snapshot
Facile and rapid access to linear and truncated microcystin analogues for the implementation of immunoassays
inferred← citeshttps://doi.org/10.1039/c3nj41093eopenalex-snapshot
The first comparative study of the ability of different hydrophilic groups to water-solubilise fluorescent BODIPY dyes
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HBTU mediated 1-hydroxybenzotriazole (HOBt) conjugate addition: synthesis and stereochemical analysis of β-benzotriazole N-oxide substituted γ-amino acids and hybrid peptides
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Proline-functionalized metal–organic frameworks and their use in asymmetric catalysis: pitfalls in the MOFs rush
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Total synthesis and biological activity of dolastatin 16
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Three successive and regiocontroled palladium cross-coupling reactions to easily synthesize novel series of 2,4,6-tris(het)aryl pyrido[1′,2′:1,5]pyrazolo[3,4- d ]pyrimidines
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Amines and amides
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Identification of 2-arylquinazolines with alkyl-polyamine motifs as potent antileishmanial agents: synthesis and biological evaluation studies
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Advances in solid-phase peptide synthesis in aqueous media (ASPPS)
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Sustainable synthesis of heteroaryl ethers from azine N -oxides via phosphoramide catalysis
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Total Synthesis of Cordyheptapeptide A
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NEW TRENDS IN PEPTIDE COUPLING REAGENTS
inferred← citeshttps://doi.org/10.1081/scc-200063953openalex-snapshot
MW‐Enhanced High‐Speed Deprotection of Boc Group Usingp‐TsOH and Concommitant Formation ofN‐Me‐Amino Acid Benzyl Esterp‐TsOH Salts
inferred← citeshttps://doi.org/10.1111/j.1399-3011.1997.tb01128.xopenalex-snapshot
Urethane‐protected N‐carboxyanhydrides (UNCAs) as unique reactants for the study of intrinsic racemization tendencies in peptide synthesis
inferred← citeshttps://doi.org/10.1134/s1070428021050018openalex-snapshot
Methods for Macrolactonization of Seco Acids in the Synthesis of Natural and Biologically Active Compounds
inferred← citeshttps://doi.org/10.1246/cl.2000.1052openalex-snapshot
Easy Preparation of Bioactive Peptides from the Novel Nα-Trifluoroethyl Amino Acids
inferred← citeshttps://doi.org/10.1246/cl.2000.204openalex-snapshot
2-Bromo-1-ethyl Pyridinium Tetrafluoroborate (BEP): A Powerful Coupling Reagent for N-Methylated Peptide Synthesis
inferred← citeshttps://doi.org/10.1366/0003702991947955openalex-snapshot
Infrared Investigation of Acid Activation by PyBOP in Polystyrene/Divinylbenzene Supported Solid-Phase Synthesis
inferred← citeshttps://doi.org/10.3390/molecules22060864openalex-snapshot
Exploring Anti-Prion Glyco-Based and Aromatic Scaffolds: A Chemical Strategy for the Quality of Life
inferred← citeshttps://doi.org/10.3987/com-02-s(m)60openalex-snapshot
Thiazoline Ring Formation from 2- Methylcysteines and 2-Halomethylalanines
inferred← citeshttps://doi.org/10.70675/1e962d74zfb6cz4e6dz9de8z6b2f7d761819openalex-snapshot
Single-chain technology using sequence-controlled precursors
inferred← citeshttps://doi.org/10.70675/352c1792ze761z43daza999zd5a8825d2d8dopenalex-snapshot
Synthèse et fonctionnalisation de nouveaux hétérocycles fusionnés à motif quinuclidine
inferred← citeshttps://doi.org/10.70675/70599ebdzae74z4c3cza458zd687d73592ccopenalex-snapshot
Mise au point et industrialisation de la synthèse de peptides complexes
inferred← citeshttps://doi.org/10.7164/antibiotics.51.872openalex-snapshot
A Novel Glycopeptide Carrying a 3-Oxazolin-5-one Ring Obtained by Intra-molecular Cyclization.
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