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Extensive Targeting of Chemical Space at the Prime Side of Ketoamide Inhibitors of Rhomboid Proteases by Branched Substituents Empowers Their Selectivity and Potency

https://doi.org/10.2139/ssrn.4798512
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The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking
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Two Plasmodium Rhomboid Proteases Preferentially Cleave Different Adhesins Implicated in All Invasive Stages of Malaria
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Substrate binding and specificity of rhomboid intramembrane protease revealed by substrate–peptide complex structures
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PARL partitions the lipid transfer protein STARD7 between the cytosol and mitochondria
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Rhomboid intramembrane protease YqgP licenses bacterial membrane protein quality control as adaptor of FtsH AAA protease
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Rhomboid-Like-2 Intramembrane Protease Mediates Metalloprotease-Independent Regulation of Cadherins
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