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Discovery of Natural Phenols as G Protein-Coupled Receptor-35 (GPR35) Agonists

https://doi.org/10.1021/ml2003058

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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GPR35 is a novel lysophosphatidic acid receptor

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Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation

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Natural products in drug discovery

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Zaprinast, a well‐known cyclic guanosine monophosphate‐specific phosphodiesterase inhibitor, is an agonist for GPR35

inferredcites →https://doi.org/10.1016/j.febslet.2011.05.026openalex-snapshot

Tyrphostin analogs are GPR35 agonists

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GPCR functional selectivity has therapeutic impact

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Characteristics of Dynamic Mass Redistribution of Epidermal Growth Factor Receptor Signaling in Living Cells Measured with Label-Free Optical Biosensors

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Discovery of 2-(4-Methylfuran-2(5H)-ylidene)malononitrile and Thieno[3,2-b]thiophene-2-carboxylic Acid Derivatives as G Protein-Coupled Receptor 35 (GPR35) Agonists

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Natural Products as Sources of New Drugs over the Last 25 Years

inferredcites →https://doi.org/10.1038/nrd3480openalex-snapshot

How were new medicines discovered?

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Natural products to drugs: natural product-derived compounds in clinical trials

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Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13

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Kynurenic Acid as a Ligand for Orphan G Protein-coupled Receptor GPR35

inferredcites →https://doi.org/10.1111/j.1349-7006.2004.tb03193.xopenalex-snapshot

Cloning of a G‐protein‐coupled receptor that shows an activity to transform NIH3T3 cells and is expressed in gastric cancer cells

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Targeting of the Orphan Receptor GPR35 by Pamoic Acid: A Potent Activator of Extracellular Signal-Regulated Kinase and β-Arrestin2 with Antinociceptive Activity

inferredcites →https://doi.org/10.1159/000157625openalex-snapshot

5-Nitro-2-(3-Phenylpropylamino)benzoic Acid Is a GPR35 Agonist

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G-Protein-Coupled Receptor 35 Is a Target of the Asthma Drugs Cromolyn Disodium and Nedocromil Sodium

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The development of label-free cellular assays for drug discovery

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Resonant Waveguide Grating Biosensor for Living Cell Sensing

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GPR35 as a Novel Therapeutic Target

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Optical Waveguide-Based Cellular Assays

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Label-Free Cell Phenotypic Identification of d-Luciferin as an Agonist for GPR35

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Label-Free Screening Technologies

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Revisiting pharmacological actions of disodium cromoglycate in light of GPR35: New therapeutic contexts for classical drugs

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Thieno[3,2-b]thiophene-2-carboxylic acid derivatives as GPR35 agonists

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Isolation and bioactive evaluation of flavonoid glycosides from Lobelia chinensis Lour using two-dimensional liquid chromatography combined with label-free cell phenotypic assays

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Biased constitutive signaling of the G protein-coupled receptor GPR35 suppresses gut barrier permeability

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Strong electrostatic repulsive interaction used for fast and effective alkaloid enrichment from plants

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Ellagic acid alleviates ulcerative colitis in a GPR35-dependent manner associated with SDH restoration

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Spectroscopic investigations, molecular interactions, and molecular docking studies on the potential inhibitor “thiophene-2-carboxylicacid”

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Discovery of 2H-Chromen-2-one Derivatives as G Protein-Coupled Receptor-35 Agonists

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Sticklac-Derived Natural Compounds Inhibiting RNase H Activity of HIV-1 Reverse Transcriptase

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Organo Photoinduced Decarboxylative Alkylation of Coumarins with N-(Acyloxy)phthalimide

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Development and Characterization of Fluorescent Probes for the G Protein-Coupled Receptor 35

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SAR Studies of N-[2-(1H-Tetrazol-5-yl)phenyl]benzamide Derivatives as Potent G Protein-Coupled Receptor-35 Agonists

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Synthesis and Agonistic Activity at the GPR35 of 5,6-Dihydroxyindole-2-carboxylic Acid Analogues

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Label-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel

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Discovery of Two flavonoids as Agonists of G Protein-Coupled Receptor-35

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The Three Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists

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Evidence for the Existence of a CXCL17 Receptor Distinct from GPR35

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