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Improving the Plausibility of Success with Inefficient Metrics

https://doi.org/10.1021/ml4004638
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Outgoing claims: the papers this work cites, builds on, or argues with.

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Inflation of correlation in the pursuit of drug-likeness
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The thermodynamic basis for the use of lipophilic efficiency (LipE) in enthalpic optimizations
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Medicinal chemistry matters – a call for discipline in our discipline
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Ligand efficiency: a useful metric for lead selection
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A Comparison of Physiochemical Property Profiles of Development and Marketed Oral Drugs
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Relating Molecular Properties and in Vitro Assay Results to in Vivo Drug Disposition and Toxicity Outcomes

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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