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Validity of Ligand Efficiency Metrics

https://doi.org/10.1021/ml500146d
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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/s10822-011-9435-zopenalex-snapshot
Assessing the lipophilicity of fragments and early hits
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Setting expectations in molecular optimizations: Strengths and limitations of commonly used composite parameters
inferredcites →https://doi.org/10.1016/s0169-409x(00)00129-0openalex-snapshot
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1
inferredcites →https://doi.org/10.1016/s1359-6446(04)03069-7openalex-snapshot
Ligand efficiency: a useful metric for lead selection
inferredcites →https://doi.org/10.1021/ci900094mopenalex-snapshot
Simple Size-Independent Measure of Ligand Efficiency
inferredcites →https://doi.org/10.1021/jm701255bopenalex-snapshot
Ligand Binding Efficiency: Trends, Physical Basis, and Implications
inferredcites →https://doi.org/10.1021/ml4004638openalex-snapshot
Improving the Plausibility of Success with Inefficient Metrics
inferredcites →https://doi.org/10.1038/nrd2445openalex-snapshot
The influence of drug-like concepts on decision-making in medicinal chemistry
inferredcites →https://doi.org/10.1038/nrd2796openalex-snapshot
The influence of lead discovery strategies on the properties of drug candidates
inferredcites →https://doi.org/10.1038/nrd4163openalex-snapshot
The role of ligand efficiency metrics in drug discovery
inferredcites →https://doi.org/10.1073/pnas.96.18.9997openalex-snapshot
The maximal affinity of ligands

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Fragment‐Based Lead Generation
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Ligand Efficiency Metrics and their Use in Fragment Optimizations
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Fragment Screening in Complex Systems
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Faculty Opinions recommendation of Target-Based Evaluation of "Drug-Like" Properties and Ligand Efficiencies.
inferred← citeshttps://doi.org/10.4155/fmc-2018-0230openalex-snapshot
Ligand Potency – An Essential Estimator for Drug Design: Between intuition, Misinterpretation and Serendipity
inferred← citeshttps://doi.org/10.4155/fmc-2019-0060openalex-snapshot
Carboranylanilinoquinazoline EGFR-Inhibitors: Toward ‘Lead-to-Candidate’ Stage in the Drug-Development Pipeline
inferred← citeshttps://doi.org/10.4155/fmc-2022-0252openalex-snapshot
Recent Advances in ATM Inhibitors As Potential Therapeutic Agents
inferred← citeshttps://doi.org/10.4155/fmc.15.63openalex-snapshot
The Impact of Binding Thermodynamics on Medicinal Chemistry Optimizations
inferred← citeshttps://doi.org/10.4155/fmc.15.70openalex-snapshot
Ligand Efficiency Metrics: Why All the Fuss?
inferred← citeshttps://doi.org/10.47749/t/unicamp.2018.1102653openalex-snapshot
Aplicação da técnica FBDD ¨fragment based drug discovery¨ para a enzima DHFR da via de biossíntese de folatos em Mycobacterium tuberculosis
Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.