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Coamorphous Drug Systems: Enhanced Physical Stability and Dissolution Rate of Indomethacin and Naproxen
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Pharmaceutical Applications of Solid Dispersion Systems
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Comparison of polyethylene glycol and polyoxyethylene stearate as excipients for solid dispersion systems of griseofulvin and tolbutamide II
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The effects of co-lyophilized polymeric additives on the glass transition temperature and crystallization of amorphous sucrose
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Refinement of the structure of naproxen, (+)-6-methoxy-α-methyl-2-naphthaleneacetic acid
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Non-crystalline solids: glasses and amorphous solids
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Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs
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Understanding the solid-state forms of fenofibrate – A spectroscopic and computational study
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Physical characterization and stability of amorphous indomethacin and ranitidine hydrochloride binary systems prepared by mechanical activation
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Characterization of the molecular distribution of drugs in glassy solid dispersions at the nano-meter scale, using differential scanning calorimetry and gravimetric water vapour sorption techniques
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Perspectives in the use of spectroscopy to characterise pharmaceutical solids
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Enhanced dissolution rate and synchronized release of drugs in binary systems through formulation: Amorphous naproxen–cimetidine mixtures prepared by mechanical activation
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Synthesis and characterization of layered double hydroxides (LDH) intercalated with non-steroidal anti-inflammatory drugs (NSAID)
inferredcites →https://doi.org/10.1016/s0378-5173(02)00195-3openalex-snapshot
Physicochemical properties of amorphous salt of cimetidine and diflunisal system
inferredcites →https://doi.org/10.1016/s0928-0987(00)00173-1openalex-snapshot
Physical stabilisation of amorphous ketoconazole in solid dispersions with polyvinylpyrrolidone K25
inferredcites →https://doi.org/10.1016/s0939-6411(00)00060-6openalex-snapshot
Physicochemical properties of amorphous precipitates of cimetidine–indomethacin binary system
inferredcites →https://doi.org/10.1016/s0939-6411(02)00061-9openalex-snapshot
Melt extrusion: from process to drug delivery technology
inferredcites →https://doi.org/10.1021/js9601896openalex-snapshot
Characteristics and Significance of the Amorphous State in Pharmaceutical Systems
inferredcites →https://doi.org/10.1021/js9704801openalex-snapshot
Mixing Behavior of Colyophilized Binary Systems
inferredcites →https://doi.org/10.1021/js9800174openalex-snapshot
Sugar–polymer hydrogen bond interactions in lyophilized amorphous mixtures
inferredcites →https://doi.org/10.1021/js980403lopenalex-snapshot
Solid dispersion of poorly water‐soluble drugs: Early promises, subsequent problems, and recent breakthroughs
inferredcites →https://doi.org/10.1021/la070050iopenalex-snapshot
Inhibiting Surface Crystallization of Amorphous Indomethacin by Nanocoating
inferredcites →https://doi.org/10.1021/mp050004gopenalex-snapshot
Role of Molecular Interaction in Stability of Celecoxib−PVP Amorphous Systems
inferredcites →https://doi.org/10.1023/a:1007516718048openalex-snapshot
What is the True Solubility Advantage for Amorphous Pharmaceuticals?
inferredcites →https://doi.org/10.1023/a:1012167410376openalex-snapshot
Spectroscopic Characterization of Interactions Between PVP and Indomethacin in Amorphous Molecular Dispersions
inferredcites →https://doi.org/10.1081/ddc-100105180openalex-snapshot
The Potential of Small-Scale Fusion Experiments and the Gordon-Taylor Equation to Predict the Suitability of Drug/Polymer Blends for Melt Extrusion
inferredcites →https://doi.org/10.1081/pdt-120002236openalex-snapshot
Mechanism for Further Enhancement in Drug Dissolution from Solid-Dispersion Granules upon Storage
inferredcites →https://doi.org/10.1211/0022357011775532openalex-snapshot
Characterization of glass solutions of poorly water-soluble drugs produced by melt extrusion with hydrophilic amorphous polymers
inferredcites →https://doi.org/10.1211/jpp.59.2.0012openalex-snapshot
A theoretical and spectroscopic study of γ-crystalline and amorphous indometacin
inferredcites →https://doi.org/10.14227/dt160209p47openalex-snapshot
Commentary: Towards Physico-Relevant Dissolution Testing: The Importance of Solid-State Analysis in Dissolution
inferredcites →https://doi.org/10.1615/critrevtherdrugcarriersyst.v21.i3.10openalex-snapshot
Amorphous Drug Delivery Systems: Molecular Aspects, Design, and Performance
inferredcites →https://doi.org/10.2174/156720109787048258openalex-snapshot
Design, Optimization, Preparation and Evaluation of Dispersion Granules of Valsartan and Formulation into Tablets
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Co amorphous systems: A product development perspective
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2017.04.007openalex-snapshot
Effects of wet-granulation process parameters on the dissolution and physical stability of a solid dispersion
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2017.04.011openalex-snapshot
Improvement of the physicochemical properties of Co-amorphous naproxen-indomethacin by naproxen-sodium
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2017.08.123openalex-snapshot
Supersaturating drug delivery systems: The potential of co-amorphous drug formulations
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2017.09.015openalex-snapshot
Spray drying of poorly soluble drugs from aqueous arginine solution
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2017.09.020openalex-snapshot
Facile formation of co-amorphous atenolol and hydrochlorothiazide mixtures via cryogenic-milling: Enhanced physical stability, dissolution and pharmacokinetic profile
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2017.09.063openalex-snapshot
Performance comparison between crystalline and co-amorphous salts of indomethacin-lysine
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2017.10.049openalex-snapshot
The natural bile acid surfactant sodium taurocholate (NaTC) as a coformer in coamorphous systems: Enhanced physical stability and dissolution behavior of coamorphous drug-NaTc systems
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2018.04.026openalex-snapshot
Undesired co-amorphisation of indomethacin and arginine during combined storage at high humidity conditions
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2018.04.045openalex-snapshot
Engineering fast dissolving sodium acetate mediated crystalline solid dispersion of docetaxel
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2018.07.063openalex-snapshot
Aspartame as a co-former in co-amorphous systems
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2018.09.069openalex-snapshot
Enhanced dissolution of naproxen from pure-drug, crystalline nanoparticles: A case study formulated into spray-dried granules and compressed tablets
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2018.12.036openalex-snapshot
Co-former selection for co-amorphous drug-amino acid formulations
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2018.12.084openalex-snapshot
Effects of pH of processing-medium on re-dispersion of spray dried, crystalline nanoparticles of pure naproxen
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2019.02.027openalex-snapshot
Involvement of metabolism-permeability in enhancing the oral bioavailability of curcumin in excipient-free solid dispersions co-formed with piperine
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2019.118653openalex-snapshot
The effect of co-amorphization of glibenclamide on its dissolution properties and permeability through an MDCKII-MDR1 cell layer
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2020.119232openalex-snapshot
Characterization and therapeutic efficacy evaluation of glimepiride and L-arginine co-amorphous formulation prepared by supercritical antisolvent process: Influence of molar ratio and preparation methods
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2020.119284openalex-snapshot
Tannic acid as a co-former in co-amorphous systems: Enhancing their physical stability, solubility and dissolution behavior
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2020.119662openalex-snapshot
Formulation of co-amorphous systems from naproxen and naproxen sodium and in situ monitoring of physicochemical state changes during dissolution testing by Raman spectroscopy
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2020.119716openalex-snapshot
Measurement of the amorphous fraction of olanzapine incorporated in a co-amorphous formulation
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2020.119768openalex-snapshot
Influence of polymer addition on the amorphization, dissolution and physical stability of co-amorphous systems
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2020.119793openalex-snapshot
Coamorphization combined with complexation enhances dissolution of lurasidone hydrochloride and puerarin with synchronized release
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2021.120448openalex-snapshot
Indomethacin co-amorphous drug-drug systems with improved solubility, supersaturation, dissolution rate and physical stability
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2021.120649openalex-snapshot
Considerations for the selection of co-formers in the preparation of co-amorphous formulations
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2021.120894openalex-snapshot
Co-amorphous systems of sinomenine with nonsteroidal anti-inflammatory drugs: A strategy for solubility improvement, sustained release, and drug combination therapy against rheumatoid arthritis
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2021.121042openalex-snapshot
Improving chemical stability of resveratrol in hot melt extrusion based on formation of eutectic with nicotinamide
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2022.121475openalex-snapshot
Design and molecular insights of drug-active metabolite based co-amorphous formulation: A case study of toltrazuril-ponazuril co-amorphous
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2022.121799openalex-snapshot
Amino acids improve aerosolization and chemical stability of potential inhalable amorphous Spray-dried ceftazidime for Pseudomonas aeruginosa lung infection
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2022.121855openalex-snapshot
API solubility in semi-crystalline polymer: Kinetic and thermodynamic phase behavior of PVA-based solid dispersions
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2022.122551openalex-snapshot
High drug loading nanosized amorphous solid dispersion (NASD) with enhanced in vitro solubility and permeability: Benchmarking conventional ASD
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2023.122840openalex-snapshot
Co-amorphous systems consisting of indomethacin and the chiral co-former tryptophan: Solid-state properties and molecular mobilities
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2023.123555openalex-snapshot
Molecular complexes of drug combinations: A review of cocrystals, salts, coamorphous systems and amorphous solid dispersions
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2024.123807openalex-snapshot
Molecular interactions of hydrated co-amorphous systems of prilocaine and lidocaine
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2024.124673openalex-snapshot
Amphiphilic disodium glycyrrhizin as a co-former for ketoconazole co-amorphous systems: Biopharmaceutical properties and underlying molecular mechanisms
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2024.124738openalex-snapshot
Excipient effects on supersaturation, particle size dynamics, and thermodynamic activity of multidrug amorphous formulations
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2024.124943openalex-snapshot
“Aging” in co-amorphous systems: Dissolution decrease and non-negligible dissolution increase during storage without recrystallization
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2025.125870openalex-snapshot
The hidden impact of wet and dry milling processes on pharmaceutical surfaces
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2025.126199openalex-snapshot
Supramolecular synthonic portions in heat-treated indomethacin-carbamazepine mixture: a singular value decomposition approach for Fourier-Transform infrared spectral analysis
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2026.126674openalex-snapshot
Tailoring poly(2-oxazoline)s for drug delivery: predicting API compatibility via COSMO-RS
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2026.126887openalex-snapshot
A co-amorphous salt of ursodeoxycholic acid and matrine incorporated into dissolving microneedles for combined antibacterial and anti-inflammatory treatment of acne vulgaris
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2026.127068openalex-snapshot
Solvent-free engineering of a co-amorphous efavirenz–ritonavir system by hot-melt extrusion: Solid-state stabilisation and improved bioavailability
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2026.127099openalex-snapshot
Designing inhalable amorphous solid dispersions to mitigate crystallization risks in atropisomer development
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2026.127189openalex-snapshot
Clarification of the scaling-factor role of the first singular vector in singular value decomposition analysis of Fourier-transform infrared spectra: detection of solid-state intermolecular interactions in indomethacin–cimetidine mixtures via the λ2/λ1 ratio
inferred← citeshttps://doi.org/10.1016/j.ijpx.2019.100035openalex-snapshot
Amorphous solid dispersion formation via solvent granulation – A case study with ritonavir and lopinavir
inferred← citeshttps://doi.org/10.1016/j.jconrel.2016.03.028openalex-snapshot
Compromised in vitro dissolution and membrane transport of multidrug amorphous formulations
inferred← citeshttps://doi.org/10.1016/j.jcou.2023.102518openalex-snapshot
Supercritical Solution Impregnation of naproxen into mesoporous SiO2 SBA-15
inferred← citeshttps://doi.org/10.1016/j.jddst.2016.02.003openalex-snapshot
Glass solution formation in water - In situ amorphization of naproxen and ibuprofen with Eudragit® E PO
inferred← citeshttps://doi.org/10.1016/j.jddst.2020.102209openalex-snapshot
Pharmaceutical Co-crystals, Salts, and Co-amorphous Systems: A novel opportunity of hot-melt extrusion
inferred← citeshttps://doi.org/10.1016/j.jddst.2021.102350openalex-snapshot
Pellets containing quercetin amino acid co-amorphous mixture for the treatment of pain: Formulation, optimization, in-vitro and in-vivo study
inferred← citeshttps://doi.org/10.1016/j.jddst.2021.102410openalex-snapshot
The formation of an amorphous composite between flavonoid compounds: Enhanced solubility in both oil components and aqueous media
inferred← citeshttps://doi.org/10.1016/j.jddst.2021.102508openalex-snapshot
Effect of mechanochemical grinding conditions on the formation of pharmaceutical cocrystals and co-amorphous solid forms of ketoconazole – Dicarboxylic acid
inferred← citeshttps://doi.org/10.1016/j.jddst.2022.103296openalex-snapshot
Characterization of co-amorphous sinomenine-tranilast systems with strong intermolecular interactions and sustained release profiles
inferred← citeshttps://doi.org/10.1016/j.jddst.2022.103980openalex-snapshot
Polymeric solid dispersion Vs co-amorphous technology: A critical comparison
inferred← citeshttps://doi.org/10.1016/j.jddst.2023.104746openalex-snapshot
Development, recent advances, and updates in binary, ternary co-amorphous systems, and ternary solid dispersions
inferred← citeshttps://doi.org/10.1016/j.jddst.2024.106232openalex-snapshot
Novel drug-drug co-amorphous systems of olaparib with nonsteroidal anti-inflammatory drugs with improved solubility, physical stability, antitumor activity and pharmacokinetics
inferred← citeshttps://doi.org/10.1016/j.jpba.2017.02.005openalex-snapshot
Solid state characterization of azelnidipine–oxalic acid co-crystal and co-amorphous complexes: The effect of different azelnidipine polymorphs
inferred← citeshttps://doi.org/10.1016/j.matchemphys.2019.121973openalex-snapshot
Biocompatible locust bean gum as mesoporous carriers for naproxen delivery
inferred← citeshttps://doi.org/10.1016/j.molliq.2019.111469openalex-snapshot
Molecular simulation driven experiment for formulation of fixed dose combination of Darunavir and Ritonavir as anti-HIV nanosuspension
inferred← citeshttps://doi.org/10.1016/j.molliq.2025.127225openalex-snapshot
Enhancing solubility, bioavailability and anti-cancer efficacy of aprepitant through a naringin-based co-amorphous system
inferred← citeshttps://doi.org/10.1016/j.molstruc.2023.137045openalex-snapshot
Design, development and characterization of the Apremilast and Indomethacin coamorphous system
inferred← citeshttps://doi.org/10.1016/j.mtcomm.2023.107411openalex-snapshot
A review on stabilization mechanism of amorphous form based drug delivery system
inferred← citeshttps://doi.org/10.1016/j.tca.2025.180112openalex-snapshot
Thermoanalytical investigation of valsartan binary eutectic forming systems and low transition temperature mixtures (LTTM)
inferred← citeshttps://doi.org/10.1016/j.trac.2020.116097openalex-snapshot
Current research trends in dielectric relaxation studies of amorphous pharmaceuticals: Physical stability, tautomerism, and the role of hydrogen bonding
inferred← citeshttps://doi.org/10.1016/j.xphs.2016.01.001openalex-snapshot
Preparation and Physical Characterization of a Diclofenac-Ranitidine Co-precipitate for Improving the Dissolution of Diclofenac
inferred← citeshttps://doi.org/10.1016/j.xphs.2016.07.009openalex-snapshot
Co-amorphous Formation Induced by Combination of Tranilast and Diphenhydramine Hydrochloride
inferred← citeshttps://doi.org/10.1016/j.xphs.2016.12.008openalex-snapshot
Molecular Dynamics of Amorphous Sulfamethazine With Structurally Related Sulfonamide Impurities Evaluated Using Thermal Analysis
inferred← citeshttps://doi.org/10.1016/j.xphs.2017.03.006openalex-snapshot
Visualization of Protonation/Deprotonation of Active Pharmaceutical Ingredient in Solid State by Vapor Phase Amine-Selective Alkyne Tagging and Raman Imaging
inferred← citeshttps://doi.org/10.1016/j.xphs.2017.09.024openalex-snapshot
Coamorphous Active Pharmaceutical Ingredient–Small Molecule Mixtures: Considerations in the Choice of Coformers for Enhancing Dissolution and Oral Bioavailability
inferred← citeshttps://doi.org/10.1016/j.xphs.2018.10.038openalex-snapshot
An Examination of Water Vapor Sorption by Multicomponent Crystalline and Amorphous Solids and Its Effects on Their Solid-State Properties
inferred← citeshttps://doi.org/10.1016/j.xphs.2019.04.031openalex-snapshot
Improving the Solubility, Dissolution, and Bioavailability of Ibrutinib by Preparing It in a Coamorphous State With Saccharin
inferred← citeshttps://doi.org/10.1016/j.xphs.2019.06.019openalex-snapshot
Kinetics Study of Cocrystal Formation Between Indomethacin and Saccharin Using High-Shear Granulation With In Situ Raman Spectroscopy
inferred← citeshttps://doi.org/10.1016/j.xphs.2019.09.013openalex-snapshot
Molecular Dynamics and Physical Stability of Pharmaceutical Co-amorphous Systems: Correlation Between Structural Relaxation Times Measured by Kohlrausch-Williams-Watts With the Width of the Glass Transition Temperature (ΔTg) and the Onset of Crystallization
inferred← citeshttps://doi.org/10.1016/j.xphs.2021.02.005openalex-snapshot
Coamorphous System of Florfenicol-Oxymatrine for Improving the Solubility and Dissolution Rate of Florfenicol: Preparation, Characterization and Molecular Dynamics Simulation
inferred← citeshttps://doi.org/10.1016/j.xphs.2021.05.020openalex-snapshot
Injection-Molded Coamorphous Tablets: Analysis of Intermolecular Interaction and Crystallization Propensity
inferred← citeshttps://doi.org/10.1016/j.xphs.2024.02.009openalex-snapshot
Insight into Formation, Synchronized Release and Stability of Co-Amorphous Curcumin-Piperine by Integrating Experimental-Modeling Techniques
inferred← citeshttps://doi.org/10.1016/j.xphs.2024.04.006openalex-snapshot
Hydrolysis of cellulose acetate phthalate and hydroxypropyl methylcellulose phthalate in amorphous solid dispersions
inferred← citeshttps://doi.org/10.1016/s1773-2247(13)50057-8openalex-snapshot
Amorphous drugs and dosage forms
inferred← citeshttps://doi.org/10.1016/s1773-2247(13)50058-xopenalex-snapshot
Characterization during storage and dissolution of solid dispersions containing furosemide and hydroxypropyl methylcellulose
inferred← citeshttps://doi.org/10.1021/acs.cgd.0c01427openalex-snapshot
Advanced Methodologies for Pharmaceutical Salt Synthesis
inferred← citeshttps://doi.org/10.1021/acs.cgd.1c00015openalex-snapshot
Co-amorphization Story of Furosemide-Amino Acid Systems: Protonation and Aromatic Stacking Insights for Promoting Compatibility and Stability
inferred← citeshttps://doi.org/10.1021/acs.cgd.1c01352openalex-snapshot
Insights into Cocrystallization and Coamorphization Engineering Techniques in the Delivery of Traditional Chinese Medicine: Formation Mechanism, Solid-State Characterization, and Improved Pharmaceutical Properties
inferred← citeshttps://doi.org/10.1021/acs.cgd.1c01442openalex-snapshot
Intelligent Mechanochemical Design of Co-Amorphous Mixtures
inferred← citeshttps://doi.org/10.1021/acs.cgd.2c01092openalex-snapshot
Co-Former Selection for Coamorphous Amino Acid/Spironolactone Formulations and Exploration of the Amorphization Kinetics of Systems
inferred← citeshttps://doi.org/10.1021/acs.cgd.3c00565openalex-snapshot
Amorphous Solid Forms of Ranolazine and Tryptophan and Their Relaxation to Metastable Polymorphs
inferred← citeshttps://doi.org/10.1021/acs.cgd.4c01558openalex-snapshot
Innovative Strategies in Generic Drug Development: The Role of Polymorph, Amorphous, Pseudopolymorph, and Cocrystal Solid Forms
inferred← citeshttps://doi.org/10.1021/acs.cgd.5b00349openalex-snapshot
Coamorphous Lurasidone Hydrochloride–Saccharin with Charge-Assisted Hydrogen Bonding Interaction Shows Improved Physical Stability and Enhanced Dissolution with pH-Independent Solubility Behavior
inferred← citeshttps://doi.org/10.1021/acs.cgd.5b01619openalex-snapshot
Crystal Engineering of Pharmaceutical Co-crystals: “NMR Crystallography” of Niclosamide Co-crystals
inferred← citeshttps://doi.org/10.1021/acs.cgd.7b00947openalex-snapshot
Co-amorphous Form of Curcumin–Folic Acid Dihydrate with Increased Dissolution Rate
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