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Synthesis and Biological Evaluation of Hyperforin Analogues. Part I. Modification of the Enolized Cyclohexanedione Moiety

https://doi.org/10.1021/np0105681
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/archinte.160.2.152openalex-snapshot
St John's Wort for Depression
inferredcites →https://doi.org/10.1002/ardp.19953281007openalex-snapshot
Peroxides as Constituents of Plants, Part 19: A C50‐Hydroperoxide from Hypericum perforatum
inferredcites →https://doi.org/10.1007/s002109900073openalex-snapshot
Hypericum perforatum L. extract does not inhibit 5-HT transporter in rat brain cortex
inferredcites →https://doi.org/10.1016/s0024-3205(98)00299-9openalex-snapshot
Hyperforin as a possible antidepressant component of hypericum extracts
inferredcites →https://doi.org/10.1016/s0024-3205(98)00302-6openalex-snapshot
Melatonin, a pineal hormone with antioxidant property, protects against adriamycin cardiomyopathy in rats
inferredcites →https://doi.org/10.1016/s0024-3205(99)00506-8openalex-snapshot
Hyperforin attenuates various ionic conductance mechanisms in the isolated hippocampal neurons of rat
inferredcites →https://doi.org/10.1016/s0031-9422(97)00903-5openalex-snapshot
Oxidation products of hyperforin from Hypericum perforatum
inferredcites →https://doi.org/10.1016/s0040-4039(00)75241-5openalex-snapshot
The structure of hyperforin
inferredcites →https://doi.org/10.1016/s0140-6736(99)00214-7openalex-snapshot
Antibacterial activity of hyperforin from St John's wort, against multiresistant Staphylococcus aureus and gram-positive bacteria
inferredcites →https://doi.org/10.1016/s0140-6736(99)02991-8openalex-snapshot
School-based hepatitis B vaccination programme and adolescent multiple sclerosis
inferredcites →https://doi.org/10.1016/s0140-6736(99)05467-7openalex-snapshot
Acute heart transplant rejection due to Saint John's wort
inferredcites →https://doi.org/10.1021/np9903752openalex-snapshot
Hyperforin Analogues from St. John's Wort (Hypericum perforatum)
inferredcites →https://doi.org/10.1055/s-2007-979340openalex-snapshot
Antidepressant Activity of Hypericum Perforatum and Hyperforin: the Neglected Possibility
inferredcites →https://doi.org/10.1136/bmj.313.7052.253openalex-snapshot
St John's wort for depression—an overview and meta-analysis of randomised clinical trials
inferredcites →https://doi.org/10.1136/bmj.313.7052.258openalex-snapshot
Double blind randomised controlled trial of effect of metoprolol on myocardial ischaemia during endoscopic cholangiopancreatography
inferredcites →https://doi.org/10.1345/aph.18252openalex-snapshot
Potential Metabolic Interaction between St. John's Wort and Theophylline
inferredcites →https://doi.org/10.3109/10799899909036637openalex-snapshot
Extracts and Constituents ofHypericum PerforatumInhibit the Binding of Various Ligands to Recombinant Receptors Expressed with the Semliki Forest Virus System

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.phytochem.2022.113526zenodo-depositor-declared
Hyperforin: A natural lead compound with multiple pharmacological activities
inferred← citeshttps://doi.org/10.1002/ajoc.202100293openalex-snapshot
DBU‐Catalyzed Regioselective α‐Alkylation of Enones Using the Vinylogous Strategy
inferred← citeshttps://doi.org/10.1002/ange.201103873openalex-snapshot
Die Chemie der polycyclischen polyprenylierten Acylphloroglucine
inferred← citeshttps://doi.org/10.1002/ange.201403939openalex-snapshot
Total Syntheses of Hyperforin and Papuaforins A–C, and Formal Synthesis of Nemorosone through a Gold(I)‐Catalyzed Carbocyclization
inferred← citeshttps://doi.org/10.1002/ange.202116136openalex-snapshot
Enantioselective Total Synthesis of Hyperforin and Pyrohyperforin
inferred← citeshttps://doi.org/10.1002/anie.201103873openalex-snapshot
The Chemistry of the Polycyclic Polyprenylated Acylphloroglucinols
inferred← citeshttps://doi.org/10.1002/anie.201403939openalex-snapshot
Total Syntheses of Hyperforin and Papuaforins A–C, and Formal Synthesis of Nemorosone through a Gold(I)‐Catalyzed Carbocyclization
inferred← citeshttps://doi.org/10.1002/anie.202116136openalex-snapshot
Enantioselective Total Synthesis of Hyperforin and Pyrohyperforin
inferred← citeshttps://doi.org/10.1002/cctc.201200332openalex-snapshot
Highly Selective Synthesis of Ortho‐Prenylated Phenols and Chromans by using a New Bimetallic CuAl‐KIT‐5 with a 3D‐Cage‐type Mesoporous Structure
inferred← citeshttps://doi.org/10.1002/ejoc.200300568openalex-snapshot
Oxidative Fragmentation of the Bridged β‐Triketone Core of Hyperforin
inferred← citeshttps://doi.org/10.1002/ejoc.201300815openalex-snapshot
Chemistry and Biology of the Polycyclic Polyprenylated Acylphloroglucinol Hyperforin
inferred← citeshttps://doi.org/10.1002/ejoc.201403264openalex-snapshot
Isolation and Structure Elucidation of Hyperibine J [Revised Structure of Adhyperfirin (7‐Deprenyl‐13‐methylhyperforin)]: Synthesis of Hyperibone J
inferred← citeshttps://doi.org/10.1002/pca.718openalex-snapshot
Structural investigations of isomeric oxidised forms of hyperforin by HPLC‐NMR and HPLC‐MS n
inferred← citeshttps://doi.org/10.1007/3-7643-7338-5_2openalex-snapshot
Phytochemistry
inferred← citeshttps://doi.org/10.1007/978-3-319-32004-5_13-1openalex-snapshot
Challenges for the Cultivation of Plant Cells on the Example of Hypericum Perforatum and Taxus Chinensis
inferred← citeshttps://doi.org/10.1007/978-3-319-54600-1_13openalex-snapshot
Challenges for the Cultivation of Plant Cells on the Example of Hypericum perforatum and Taxus chinensis
inferred← citeshttps://doi.org/10.1007/s00213-002-1229-5openalex-snapshot
Role of hyperforin in the antidepressant-like activity of Hypericum perforatum extracts
inferred← citeshttps://doi.org/10.1007/s11030-015-9644-9openalex-snapshot
Tuning the Lewis acid phenol $$\varvec{ortho}$$ o r t h o -prenylation as a molecular diversity tool
inferred← citeshttps://doi.org/10.1016/b0-08-044655-8/00070-2openalex-snapshot
Functions Bearing Two Oxygens, R12C(OR2)2
inferred← citeshttps://doi.org/10.1016/b978-0-443-15628-1.00005-2openalex-snapshot
Acylphloroglucinols with anticancer and/or antimalarial activities—An overview
inferred← citeshttps://doi.org/10.1016/j.bmcl.2006.12.100openalex-snapshot
In vitro antimalarial activity of hyperforin, a prenylated acylphloroglucinol. A structure–activity study
inferred← citeshttps://doi.org/10.1016/j.cca.2007.02.022openalex-snapshot
Matrix proteases, green tea, and St. John's wort: Biomedical research catches up with folk medicine
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2013.11.073openalex-snapshot
Hyperforin and deoxycohumulone as a larvicidal agent against Culex pipiens (Diptera: Culicidae)
inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.112646openalex-snapshot
Bicyclic polyprenylated acylphloroglucinols and their derivatives: structural modification, structure-activity relationship, biological activity and mechanism of action
inferred← citeshttps://doi.org/10.1016/j.ejpb.2017.08.009openalex-snapshot
Stabilization of hyperforin dicyclohexylammonium salt with dissolved albumin and albumin nanoparticles for studying hyperforin effects on 2D cultivation of keratinocytes in vitro
inferred← citeshttps://doi.org/10.1016/j.fct.2018.05.009openalex-snapshot
Prenylated β-diketones, two new additions to the family of biologically active Hypericum perforatum L. (Hypericaceae) secondary metabolites
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2016.02.016openalex-snapshot
Hyperforin production in Hypericum perforatum root cultures
inferred← citeshttps://doi.org/10.1016/j.mcna.2005.08.002openalex-snapshot
Toxicity and Drug Interactions Associated with Herbal Products: Ephedra and St. John's Wort
inferred← citeshttps://doi.org/10.1016/j.phytochem.2006.08.017openalex-snapshot
Hyperforin
inferred← citeshttps://doi.org/10.1016/j.phytochem.2006.09.018openalex-snapshot
Hyperforin and its analogues inhibit CYP3A4 enzyme activity
inferred← citeshttps://doi.org/10.1016/j.phytochem.2025.114450openalex-snapshot
Hypertums A−J, bioactive polycyclic polyprenylated acylphloroglucinols with diverse skeletons from Hypericum perforatum L. (St. John's wort)
inferred← citeshttps://doi.org/10.1016/j.phytochem.2025.114561openalex-snapshot
Hyperwilsol A, a highly modified 2-nor-polycyclic polyprenylated acylphloroglucinol possessing an unusual 6/6/5/5 spirotetracyclic skeleton from Hypericum wilsonii
inferred← citeshttps://doi.org/10.1016/j.tetlet.2003.10.119openalex-snapshot
Investigation of the Montmorillonite clay-catalyzed [1,3] shift reaction of 3-methyl-2-butenyl phenyl ether
inferred← citeshttps://doi.org/10.1016/s1572-5995(05)80043-2openalex-snapshot
A Survey on the Hypericum Genus: Secondary Metabolites and Bioactivity
inferred← citeshttps://doi.org/10.1021/acs.joc.8b00426openalex-snapshot
Modular Total Syntheses of Hyperforin, Papuaforins A, B, and C via Gold(I)-Catalyzed Carbocyclization
inferred← citeshttps://doi.org/10.1021/acs.orglett.5b01121openalex-snapshot
Total Synthesis of (−)-Nemorosone and (+)-Secohyperforin
inferred← citeshttps://doi.org/10.1021/cr0500582openalex-snapshot
Polycyclic Polyprenylated Acylphloroglucinols
inferred← citeshttps://doi.org/10.1021/ja312150dopenalex-snapshot
Enantioselective Total Synthesis of Hyperforin
inferred← citeshttps://doi.org/10.1021/jo801595yopenalex-snapshot
Construction of the Adamantane Core of Plukenetione-Type Polycyclic Polyprenylated Acylphloroglucinols
inferred← citeshttps://doi.org/10.1021/np0200515openalex-snapshot
Challenges and Opportunities Confronting the Botanical Dietary Supplement Industry†
inferred← citeshttps://doi.org/10.1021/np050462wopenalex-snapshot
Antibacterial Galloylated Alkylphloroglucinol Glucosides from Myrtle (Myrtus communis)
inferred← citeshttps://doi.org/10.1021/ol1013069openalex-snapshot
Enantioselective Wacker-Type Cyclization of 2-Alkenyl-1,3-diketones Promoted by Pd-SPRIX Catalyst
inferred← citeshttps://doi.org/10.1021/ol4020909openalex-snapshot
An Unusual Michael-Induced Skeletal Rearrangement of a Bicyclo[3.3.1]nonane Framework of Phloroglucinols to a Novel Bioactive Bicyclo[3.3.0]octane
inferred← citeshttps://doi.org/10.1021/ol901781nopenalex-snapshot
A Short Biomimetic Approach to the Fully Functionalized Bicyclic Framework of Type A Acylphloroglucinols
inferred← citeshttps://doi.org/10.1023/a:1026069624278openalex-snapshot
Are acylphloroglucinols lead structures for the treatment of degenerative diseases?
inferred← citeshttps://doi.org/10.1038/sj.leu.2404301openalex-snapshot
Hyperforin, a new lead compound against the progression of cancer and leukemia?
inferred← citeshttps://doi.org/10.1039/c8ob01640bopenalex-snapshot
Organobase catalyzed straightforward synthesis of phosphinyl functionalized 2 H -pyran cores from allenylphosphine oxides and 1,3-diones
inferred← citeshttps://doi.org/10.1055/s-2003-36234openalex-snapshot
Strategies for the Preparation of Differentially Protectedortho-Prenylated Phenols
inferred← citeshttps://doi.org/10.1080/10286020.2011.584532openalex-snapshot
In-vitroantitumor activity evaluation of hyperforin derivatives
inferred← citeshttps://doi.org/10.1111/j.1527-3458.2004.tb00022.xopenalex-snapshot
Role of Hyperforin in the Pharmacological Activities of St. John's Wort
inferred← citeshttps://doi.org/10.1124/dmd.32.1.28openalex-snapshot
IN VITRO METABOLISM OF HYPERFORIN IN RAT LIVER MICROSOMAL SYSTEMS
inferred← citeshttps://doi.org/10.1124/jpet.106.116459openalex-snapshot
Hyperforin Blocks Neutrophil Activation of Matrix Metalloproteinase-9, Motility and Recruitment, and Restrains Inflammation-Triggered Angiogenesis and Lung Fibrosis
inferred← citeshttps://doi.org/10.1124/mol.109.057513openalex-snapshot
Simple 2,4-Diacylphloroglucinols as Classic Transient Receptor Potential-6 Activators—Identification of a Novel Pharmacophore
inferred← citeshttps://doi.org/10.1158/0008-5472.can-04-0280openalex-snapshot
Hyperforin Inhibits Cancer Invasion and Metastasis
inferred← citeshttps://doi.org/10.12677/ijpn.2012.13006openalex-snapshot
The Progress of Chinese Traditional Medicine Hypericum perforatum L. for the Treatment of Depression
inferred← citeshttps://doi.org/10.1371/journal.pone.0009558openalex-snapshot
Tetrahydrohyperforin and Octahydrohyperforin Are Two New Potent Inhibitors of Angiogenesis
inferred← citeshttps://doi.org/10.2174/156800913804486601openalex-snapshot
Mechanistic Insights into the Antileukemic Activity of Hyperforin
inferred← citeshttps://doi.org/10.3390/ijms22010146openalex-snapshot
Antiproliferative Effects of St. John’s Wort, Its Derivatives, and Other Hypericum Species in Hematologic Malignancies
inferred← citeshttps://doi.org/10.3390/ijms25158023openalex-snapshot
Antimicrobial Evaluation of Two Polycyclic Polyprenylated Acylphloroglucinol Compounds: PPAP23 and PPAP53
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