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Search for Hsp90 Inhibitors with Potential Anticancer Activity: Isolation and SAR Studies of Radicicol and Monocillin I from Two Plant-Associated Fungi of the Sonoran Desert
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/ijc.20611openalex-snapshot
Hsp90 inhibitors deplete key anti‐apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin
inferredcites →https://doi.org/10.1006/bbrc.1997.7527openalex-snapshot
Geldanamycin-Induced Destabilization of Raf-1 Involves the Proteasome
inferredcites →https://doi.org/10.1016/0742-8413(89)90133-3openalex-snapshot
Measurement of the relative binding affinity of zearalenone, α-zearalenol and β-zearalenol for uterine and oviduct estrogen receptors in swine, rats and chickens: An indicator of estrogenic potencies
inferredcites →https://doi.org/10.1016/j.toxlet.2005.05.017openalex-snapshot
Investigations on cellular proliferation induced by zearalenone and its derivatives in relation to the estrogenic parameters
inferredcites →https://doi.org/10.1016/s0007-1536(66)80004-9openalex-snapshot
Radicicolin and radicicol, two new antibiotics produced by Cylindrocarpon radicicola
inferredcites →https://doi.org/10.1016/s0021-9258(17)36908-9openalex-snapshot
ATP-dependent chaperoning activity of reticulocyte lysate
inferredcites →https://doi.org/10.1016/s0031-9422(98)00187-3openalex-snapshot
Studies in natural products chemistry
inferredcites →https://doi.org/10.1016/s0092-8674(00)81588-3openalex-snapshot
Repression of Heat Shock Transcription Factor HSF1 Activation by HSP90 (HSP90 Complex) that Forms a Stress-Sensitive Complex with HSF1
inferredcites →https://doi.org/10.1016/s0163-7258(98)00013-8openalex-snapshot
The 90-kDa Molecular Chaperone Family
inferredcites →https://doi.org/10.1016/s1471-4914(02)02316-xopenalex-snapshot
Hsp90 inhibitors as novel cancer chemotherapeutic agents
inferredcites →https://doi.org/10.1021/ja011364+openalex-snapshot
Concise Asymmetric Syntheses of Radicicol and Monocillin I
inferredcites →https://doi.org/10.1021/ja043101wopenalex-snapshot
Design, Synthesis, and Biological Evaluation of HSP90 Inhibitors Based on Conformational Analysis of Radicicol and Its Analogues
inferredcites →https://doi.org/10.1021/ja0484348openalex-snapshot
New Efficient Synthesis of Resorcinylic Macrolides via Ynolides: Establishment of Cycloproparadicicol as Synthetically Feasible Preclinical Anticancer Agent Based on Hsp90 as the Target
inferredcites →https://doi.org/10.1021/jm980403yopenalex-snapshot
Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin
inferredcites →https://doi.org/10.1021/np020556vopenalex-snapshot
Pochonins A−F, New Antiviral and Antiparasitic Resorcylic Acid Lactones from Pochonia chlamydosporia var. catenulata
inferredcites →https://doi.org/10.1021/np50004a004openalex-snapshot
Isolation of Radicicol from Penicillium luteo-aurantium, and Meleagrin, A New Metabolite from Penicillium meleagrinum
inferredcites →https://doi.org/10.1021/ol0063252openalex-snapshot
Efficient Asymmetric Synthesis of Radicicol Dimethyl Ether: A Novel Application of Ring-Forming Olefin Metathesis
inferredcites →https://doi.org/10.1038/sj.onc.1201443openalex-snapshot
Suppression of morphological transformation by radicicol is accompanied by enhanced gelsolin expression
inferredcites →https://doi.org/10.1071/ch9661265openalex-snapshot
Some metabolites of Nectria radicicola Gerlach & Nilsson (syn. Cylindrocarpon radicicola Wr.): The structure of radicicol (monorden)
inferredcites →https://doi.org/10.1073/pnas.91.18.8324openalex-snapshot
Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.
inferredcites →https://doi.org/10.1074/jbc.272.38.23843openalex-snapshot
The Amino-terminal Domain of Heat Shock Protein 90 (hsp90) That Binds Geldanamycin Is an ATP/ADP Switch Domain That Regulates hsp90 Conformation
inferredcites →https://doi.org/10.1074/jbc.m105931200openalex-snapshot
Evidence for a Mechanism of Repression of Heat Shock Factor 1 Transcriptional Activity by a Multichaperone Complex
inferredcites →https://doi.org/10.1093/jnci/82.13.1113openalex-snapshot
Comparison of In Vitro Anticancer-Drug-Screening Data Generated With a Tetrazolium Assay Versus a Protein Assay Against a Diverse Panel of Human Tumor Cell Lines
inferredcites →https://doi.org/10.1093/jnci/82.13.1118openalex-snapshot
Two-Year Carcinogenicity Study of Sodium Fluoride in Rats
inferredcites →https://doi.org/10.1128/mcb.16.10.5839openalex-snapshot
Destabilization of Raf-1 by Geldanamycin Leads to Disruption of the Raf-1–MEK–Mitogen-Activated Protein Kinase Signalling Pathway
inferredcites →https://doi.org/10.1158/1535-7163.1021.3.8openalex-snapshot
Altered Hsp90 function in cancer: A unique therapeutic opportunity
inferredcites →https://doi.org/10.1158/1535-7163.mct-05-0050openalex-snapshot
The anticancer activity of the fungal metabolite terrecyclic acid A is associated with modulation of multiple cellular stress response pathways
inferredcites →https://doi.org/10.1200/jco.2005.00.612openalex-snapshot
Phase I Pharmacokinetic and Pharmacodynamic Study of 17-Allylamino, 17-Demethoxygeldanamycin in Patients With Advanced Malignancies
inferredcites →https://doi.org/10.1517/14712598.2.1.3openalex-snapshot
HSP90 as a new therapeutic target for cancer therapy: the story unfolds
inferredcites →https://doi.org/10.2174/1568009033481813openalex-snapshot
The Clinical Applications of Heat Shock Protein Inhibitors in Cancer - Present and Future
inferredcites →https://doi.org/10.2174/1568009033481859openalex-snapshot
Development of Radicicol Analogues
inferredcites →https://doi.org/10.3181/00379727-217-44252openalex-snapshot
The hsp90-based Chaperone System: Involvement in Signal Transduction from a Variety of Hormone and Growth Factor Receptors
inferredcites →https://doi.org/10.7164/antibiotics.56.526openalex-snapshot
New Monordens Produced by Amidepsine-producing Fungus Humicola sp. FO-2942
inferredcites →https://doi.org/10.7164/antibiotics.57.541openalex-snapshot
Isolation, Optimization of Production and Structure-Activity Relationship Studies of Monocillin I, the Cytotoxic Constituent of Paraphaeosphaeria quadriseptata
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Specific inhibition of the halogenase for radicicol biosynthesis by bromide at the transcriptional level in Pochonia chlamydosporia
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The HSP90 and DNA topoisomerase VI inhibitor radicicol also inhibits human type II DNA topoisomerase
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A fungal metabolite zearalenone as a CFTR inhibitor and potential therapy of secretory diarrheas
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A new dihydroxanthenone from a plant-associated strain of the fungus Chaetomium globosum demonstrates anticancer activity
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2,3-Dihydrowithaferin A-3β-O-sulfate, a new potential prodrug of withaferin A from aeroponically grown Withania somnifera
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ATPase inhibitors of heat-shock protein 90, second season
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Five new isocoumarins from Sonoran desert plant-associated fungal strains Paraphaeosphaeria quadriseptata and Chaetomium chiversii
inferred← citeshttps://doi.org/10.1021/acs.jafc.9b01977openalex-snapshot
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Sorbifolivaltrates A−D, Diene Valepotriates from Valeriana sorbifolia1
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Smardaesidins A–G, Isopimarane and 20-nor-Isopimarane Diterpenoids from Smardaea sp., a Fungal Endophyte of the Moss Ceratodon purpureus
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Thielavialides A–E, Nor -Spiro-azaphilones, and a Bis-spiro-azaphilone from Thielavia sp. PA0001, An Endophytic Fungus Isolated from Aeroponically Grown Physalis alkekengi
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Concise Strategy to the Core Structure of the Macrolide Queenslandon
inferred← citeshttps://doi.org/10.1038/aps.2013.155openalex-snapshot
Recent progress regarding the bioactivities, biosynthesis and synthesis of naturally occurring resorcinolic macrolides
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Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus
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Characterization and evaluation of mycosterol secreted from endophytic strain of Gymnema sylvestre for inhibition of α-glucosidase activity
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Anticancer compounds derived from fungal endophytes: their importance and future challenges
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Synthesis of carbohydrate fused chiral macrocyclic benzolactones through Sonogashira reaction
inferred← citeshttps://doi.org/10.1039/c4np00148fopenalex-snapshot
Polyketide synthase and non-ribosomal peptide synthetase thioesterase selectivity: logic gate or a victim of fate?
inferred← citeshttps://doi.org/10.1039/c8nj02534gopenalex-snapshot
Resorcylic acid lactones (RALs) and their structural congeners: recent advances in their biosynthesis, chemical synthesis and biology
inferred← citeshttps://doi.org/10.1039/d0ob00237bopenalex-snapshot
Asymmetric total syntheses of naturally occurring α,β-enone-containing RALs, L-783290 and L-783277 through intramolecular base-mediated macrolactonization reaction
inferred← citeshttps://doi.org/10.1039/d4np00050aopenalex-snapshot
Enzymatic ester bond formation strategies in fungal macrolide skeletons
inferred← citeshttps://doi.org/10.1039/d5np00033eopenalex-snapshot
The chemical and biological properties of natural resorcylic acid lactones
inferred← citeshttps://doi.org/10.1071/ma10060openalex-snapshot
Endophytes and the microbial genetics of traditional medicines
inferred← citeshttps://doi.org/10.1073/pnas.1406999111openalex-snapshot
Diversity-oriented combinatorial biosynthesis of benzenediol lactone scaffolds by subunit shuffling of fungal polyketide synthases
inferred← citeshttps://doi.org/10.1074/jbc.m709447200openalex-snapshot
Tubocapsenolide A, a Novel Withanolide, Inhibits Proliferation and Induces Apoptosis in MDA-MB-231 Cells by Thiol Oxidation of Heat Shock Proteins
inferred← citeshttps://doi.org/10.1080/07391102.2021.1891970openalex-snapshot
Molecular docking and molecular dynamics simulation identify a novel Radicicol derivative that predicts exclusive binding toPlasmodium falciparumTopoisomerase VIB
inferred← citeshttps://doi.org/10.1080/14786419.2018.1489393openalex-snapshot
Terezine E, bioactive prenylated tryptophan analogue from an endophyte ofCentaurea stoebe
inferred← citeshttps://doi.org/10.1097/cad.0b013e32834f968copenalex-snapshot
Anticancer attributes of desert plants
inferred← citeshttps://doi.org/10.1098/rsob.120138openalex-snapshot
Spotlight on the microbes that produce heat shock protein 90-targeting antibiotics
inferred← citeshttps://doi.org/10.1098/rstb.2009.0245openalex-snapshot
Symbiosis as a source of selectable epigenetic variation: taking the heat for the big guy
inferred← citeshttps://doi.org/10.1104/pp.107.101808openalex-snapshot
A Rhizosphere Fungus Enhances Arabidopsis Thermotolerance through Production of an HSP90 Inhibitor
inferred← citeshttps://doi.org/10.1126/science.1238303openalex-snapshot
Tight Coordination of Protein Translation and HSF1 Activation Supports the Anabolic Malignant State
inferred← citeshttps://doi.org/10.1155/2022/9600079openalex-snapshot
Isolation and Characterization of Antibacterial Compounds from Aspergillus fumigatus: An Endophytic Fungus from a Mangrove Plant of the Sundarbans
inferred← citeshttps://doi.org/10.1172/jci62727openalex-snapshot
Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis
inferred← citeshttps://doi.org/10.1177/1934578x1000500524openalex-snapshot
Structure Determination of Two New Monocillin I Derivatives
inferred← citeshttps://doi.org/10.1177/1934578x1100600216openalex-snapshot
Generation of two New Macrolactones through Sequential Biotransformation of Dihydroresorcylide
inferred← citeshttps://doi.org/10.1248/cpb.56.1355openalex-snapshot
8'-Hydroxyzearalanone and 2'-Hydroxyzearalanol: Resorcyclic Acid Lactone Derivatives from the Marine-Derived Fungus Penicillium sp.
inferred← citeshttps://doi.org/10.17576/jsm-2021-5009-06openalex-snapshot
Biological Activities and Chemical Profiles of Selected Soil Fungi Isolated from Sirindhorn Peat Swamp Forest of Narathiwat, Thailand
inferred← citeshttps://doi.org/10.2174/138955709787316056openalex-snapshot
Natural Product Inhibitors of Hsp90: Potential Leads for Drug Discovery
inferred← citeshttps://doi.org/10.2174/9798898810276125010010openalex-snapshot
Understanding Quinones with Reference to Biochemistry
inferred← citeshttps://doi.org/10.22146/ijc.68922openalex-snapshot
Bioactive Secondary Metabolites from the Endophytic Fungi Alternaria sp.
inferred← citeshttps://doi.org/10.33584/rps.13.2006.3061openalex-snapshot
Discovery of small molecule bioactive agents from endophytic fungi of the Sonoran Desert
inferred← citeshttps://doi.org/10.3389/fbioe.2021.649906openalex-snapshot
Current State and Future Directions of Genetics and Genomics of Endophytic Fungi for Bioprospecting Efforts
inferred← citeshttps://doi.org/10.3389/fpls.2020.00371openalex-snapshot
The Hsp90 Inhibitor, Monorden, Is a Promising Lead Compound for the Development of Novel Fungicides
inferred← citeshttps://doi.org/10.3390/jof7110918openalex-snapshot
Infection Process and Genome Assembly Provide Insights into the Pathogenic Mechanism of Destructive Mycoparasite Calcarisporium cordycipiticola with Host Specificity
inferred← citeshttps://doi.org/10.3390/md22040143openalex-snapshot
Marine-Derived Leads as Anticancer Candidates by Disrupting Hypoxic Signaling through Hypoxia-Inducible Factors Inhibition
inferred← citeshttps://doi.org/10.3390/molecules27010296openalex-snapshot
Putative Anticancer Compounds from Plant-Derived Endophytic Fungi: A Review
inferred← citeshttps://doi.org/10.3390/plants13091265openalex-snapshot
Plastid Molecular Chaperone HSP90C Interacts with the SecA1 Subunit of Sec Translocase for Thylakoid Protein Transport
inferred← citeshttps://doi.org/10.3390/toxins17050226openalex-snapshot
A Comprehensive Review of Hypotheses About the Biological Function of Zearalenone, and a New Hypothesis for the Function of Resorcylic and Dihydroxyphenylacetic Macrolactones in Fungi
inferred← citeshttps://doi.org/10.3410/f.1098604.554709openalex-snapshot
Faculty Opinions recommendation of A rhizosphere fungus enhances Arabidopsis thermotolerance through production of an HSP90 inhibitor.
inferred← citeshttps://doi.org/10.3767/003158508x286842openalex-snapshot
Novel Paraconiothyrium species on stone fruit trees and other woody hosts
inferred← citeshttps://doi.org/10.3892/ijo.2014.2791openalex-snapshot
Hsp90 inhibitor as a sensitizer of cancer cells to different therapies (Review)
inferred← citeshttps://doi.org/10.3923/rjphyto.2017.90.110openalex-snapshot
Anti-diabetic Activity of Endophytic Fungi, Penicillium Species of Tabebuia argentea; in Silico and Experimental Analysis
inferred← citeshttps://doi.org/10.4172/1948-5948.s8-004openalex-snapshot
Understanding the Biodiversity and Biological Applications of Endophytic Fungi: A Review
inferred← citeshttps://doi.org/10.5530/ijper.58.2.45openalex-snapshot
Natural and Synthetic Inhibitors of Heat Shock Protein 90 Chaperone in Cancer Treatment
inferred← citeshttps://doi.org/10.5897/ajmr12.2290openalex-snapshot
A new endophytic Paraconiothyrium brasiliens LT161 shows potential in producing antifungal metabolites against phytopathogens
inferred← citeshttps://doi.org/10.5943/sif/6/1/12openalex-snapshot
Endophytic fungi: a source of potential anticancer compounds
inferred← citeshttps://doi.org/10.70675/af2dcef0zec8az4346zbe5az321cae7fa257openalex-snapshot
Composés antimicrobiens ou cytotoxiques à partir de micro-organismes endophytes foliaires
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