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Investigation of Bioactivation of Ticlopidine Using Linear Ion Trap/Orbitrap Mass Spectrometry and an Improved Mass Defect Filtering Technique
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Agranlocytosis caused by ticlopindine and its mechanism
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An algorithm for thorough background subtraction from high‐resolution LC/MS data: application to the detection of troglitazone metabolites in rat plasma, bile, and urine
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Mass defect filter technique and its applications to drug metabolite identification by high‐resolution mass spectrometry
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A software filter to remove interference ions from drug metabolites in accurate mass liquid chromatography/mass spectrometric analyses
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A generic method to detect electrophilic intermediates using isotopic pattern triggered data‐dependent high‐resolution accurate mass spectrometry
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Mass defect profiles of biological matrices and the general applicability of mass defect filtering for metabolite detection
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Rapid detection and characterization of reactive drug metabolites in vitro using several isotope‐labeled trapping agents and ultra‐performance liquid chromatography/time‐of‐flight mass spectrometry
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Metabolism of triclopidine in rats: Identification and quantitative determination of some its metabolites in plasma, urine and bile
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First evidence that cytochrome P450 may catalyze both S-oxidation and epoxidation of thiophene derivatives
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Selection of new chemical entities with decreased potential for adverse drug reactions
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Patient characteristics in ticlopidine hydrochloride-induced liver injury: Case–control study
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Metabolism of Ticlopidine by Activated Neutrophils: Implications for Ticlopidine-Induced Agranulocytosis
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THE CANADIAN AMERICAN TICLOPIDINE STUDY (CATS) IN THROMBOEMBOLIC STROKE
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Detection and Structural Characterization of Glutathione-Trapped Reactive Metabolites Using Liquid Chromatography−High-Resolution Mass Spectrometry and Mass Defect Filtering
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High-Throughput Screening and Characterization of Reactive Metabolites Using Polarity Switching of Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry
inferredcites →https://doi.org/10.1021/bi010254copenalex-snapshot
Ticlopidine as a Selective Mechanism-Based Inhibitor of Human Cytochrome P450 2C19
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Metabolic Oxidative Cleavage of Thioesters: Evidence for the Formation of Sulfenic Acid Intermediates in the Bioactivation of the Antithrombotic Prodrugs Ticlopidine and Clopidogrel
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Thiophene Sulfoxides as Reactive Metabolites: Formation upon Microsomal Oxidation of a 3-Aroylthiophene and Fate in the Presence of Nucleophilesin Vitroandin Vivo
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Potential Metabolic Bioactivation Pathways Involving Cyclic Tertiary Amines and Azaarenes
inferredcites →https://doi.org/10.1038/clpt.1987.39openalex-snapshot
Ticlopidine-theophylline interaction
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Ticlopidine-induced hepatotoxicity is associated with specific human leukocyte antigen genomic subtypes in Japanese patients: a preliminary case–control study
inferredcites →https://doi.org/10.1053/jhep.2001.20645openalex-snapshot
Comparison of Two Clinical Scales for Causality Assessment in Hepatotoxicity
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A Randomized Trial Comparing Ticlopidine Hydrochloride with Aspirin for the Prevention of Stroke in High-Risk Patients
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Toxic Erythroderma Due to Ticlopidine
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Detection and Characterization of Metabolites in Biological Matrices Using Mass Defect Filtering of Liquid Chromatography/High Resolution Mass Spectrometry Data
inferredcites →https://doi.org/10.1124/dmd.107.018002openalex-snapshot
Markers of Electrophilic Stress Caused by Chemically Reactive Metabolites in Human Hepatocytes
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Metabolism of Ticlopidine in Rats: Identification of the Main Biliary Metabolite as a Glutathione Conjugate of Ticlopidine S-Oxide
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MECHANISM-BASED INACTIVATION OF HUMAN RECOMBINANT P450 2C9 BY THE NONSTEROIDAL ANTI-INFLAMMATORY DRUG SUPROFEN
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CHARACTERIZATION OF NOVEL DIHYDROTHIENOPYRIDINIUM AND THIENOPYRIDINIUM METABOLITES OF TICLOPIDINE IN VITRO: ROLE OF PEROXIDASES, CYTOCHROMES P450, AND MONOAMINE OXIDASES
inferredcites →https://doi.org/10.1124/jpet.107.135483openalex-snapshot
Identification of the Thiophene Ring of Methapyrilene as a Novel Bioactivation-Dependent Hepatic Toxicophore
inferredcites →https://doi.org/10.1172/jci111705openalex-snapshot
Functionally thrombasthenic state in normal platelets following the administration of ticlopidine.
inferredcites →https://doi.org/10.1177/106002809302700915openalex-snapshot
Ticlopidine and Antiplatelet Therapy
inferredcites →https://doi.org/10.1177/1721727x0600400107openalex-snapshot
Ticlopidine-Induced Cholestatic Inflammatory Hepatitis: New Insights into Pathogenetic Mechanisms of Drug-Related Hepatotoxicity
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Mechanisms of drug-induced liver injury
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Cytochrome P450s and other enzymes in drug metabolism and toxicity
inferredcites →https://doi.org/10.1345/aph.1a406openalex-snapshot
Ticlopidine-Induced Cholestatic Hepatitis
inferredcites →https://doi.org/10.1592/phco.19.3.228.30916openalex-snapshot
Rash in Patients Receiving Ticlopidine after Intracoronary Stent Placement
inferredcites →https://doi.org/10.2133/dmpk.24.100openalex-snapshot
Quantitative Assessment of Reactive Metabolite Formation using 35S-labeled Glutathione
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Adverse Haematological Effects of Ticlopidine
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Clinical Pharmacokinetics of Ticlopidine
inferredcites →https://doi.org/10.33588/rn.3311.2001285openalex-snapshot
Hepatitis aguda por ticlopidina. Presentación de 12 casos y revisión de la literatura
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Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Equine Science - Applications and Implications of New Technologies [Working Title]
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