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Metabolic Activation of Diclofenac by Human Cytochrome P450 3A4: Role of 5-Hydroxydiclofenac
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Outgoing claims: the papers this work cites, builds on, or argues with.
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Diclofenac-Associated Hepatotoxicity
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Cytotoxic activity of T cells and non-T cells from diclofenac-immunized mice against cultured syngeneic hepatocytes exposed to diclofenac
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Diclofenac Covalent Protein Binding Is Dependent on Acyl Glucuronide Formation and Is Inversely Related to P450-Mediated Acute Cell Injury in Cultured Rat Hepatocytes
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Side-Effects of Anti-Inflammatory Drugs 3
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Cytochrome P450TB (CYP2C): A major monooxygenase catalyzing diclofenac 4′-hydroxylation in human liver
inferredcites →https://doi.org/10.1016/0168-8278(90)90077-5openalex-snapshot
Diclofenac associated hepatitis
inferredcites →https://doi.org/10.1016/0378-4347(85)80079-7openalex-snapshot
High-performance liquid chromatographic determination of diclofenac and its monohydroxylated metabolites in biological fluids
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Comparative Studies on the Catalytic Roles of Cytochrome P450 2C9 and Its Cys- and Leu-Variants in the Oxidation of Warfarin, Flurbiprofen, and Diclofenac by Human Liver Microsomes
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The Carbon Monoxide-binding Pigment of Liver Microsomes
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Synthesis, decomposition kinetics, and preliminary toxicological studies of pure N-acetyl-p-benzoquinone imine, a proposed toxic metabolite of acetaminophen
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Specificity of in vitro Covalent Binding of Tienilic Acid Metabolites to Human Liver Microsomes in Relationship to the Type of Hepatotoxicity: Comparison with Two Directly Hepatotoxic Drugs
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Cytochrome P4502C9: an enzyme of major importance in human drug metabolism
inferredcites →https://doi.org/10.1093/oxfordjournals.jbchem.a122145openalex-snapshot
Nucleotide Sequence of a Human Liver Cytochrome P-450 Related to the Rat Male Specific Form1
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Reversible Hepatitis Associated with Diclofenac
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Diclofenac hepatitis
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Failure of Calcium Antagonistic Agents to Prevent Hepatotoxicity Induced by Diclofenac
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Diclofenac-induced hepatotoxicity
inferredcites →https://doi.org/10.1172/jci118936openalex-snapshot
Antigenic targets in tienilic acid hepatitis. Both cytochrome P450 2C11 and 2C11-tienilic acid adducts are transported to the plasma membrane of rat hepatocytes and recognized by human sera.
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In Vitro Methods for Assessing Human Hepatic Drug Metabolism: Their use in Drug Development
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Idiosyncratic Liver Toxicity of Nonsteroidal Antiinflammatory Drugs: Molecular Mechanisms and Pathology
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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The self‐sufficient P450 RhF expressed in a whole cell system selectively catalyses the 5‐hydroxylation of diclofenac
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In vivo and in vitro diclofenac 5-hydroxylation mediated primarily by cytochrome P450 3A enzymes in common marmoset livers genotyped for P450 2C19 variants
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Pharmacokinetics of diclofenac and inhibition of cyclooxygenases 1 and 2: no relationship to the CYP2C9 genetic polymorphism in humans
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Genetic Susceptibility to Diclofenac-Induced Hepatotoxicity: Contribution of UGT2B7, CYP2C8, and ABCC2 Genotypes
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Role of mitochondrial permeability transition in diclofenac-induced hepatocyte injury in rats
inferred← citeshttps://doi.org/10.1055/sos-sd-218-00197openalex-snapshot
2.10 C—O Bond Formation by Arene C—H Activation via Biomimetic and Organocatalytic Oxidation
inferred← citeshttps://doi.org/10.1080/01919512.2021.1898928openalex-snapshot
Identification and Quantification of Transformation Products Formed during the Ozonation of the Non-steroidal Anti-inflammatory Pharmaceuticals Ibuprofen and Diclofenac
inferred← citeshttps://doi.org/10.1080/02772248.2017.1296444openalex-snapshot
Mycoremediation of diclofenac usingMucor hiemalis
inferred← citeshttps://doi.org/10.1080/03602530902843483openalex-snapshot
Polymorphism of human cytochrome P450 enzymes and its clinical impact
inferred← citeshttps://doi.org/10.1080/03602532.2026.2620682openalex-snapshot
Relevance of reactive metabolites and covalent binding to drug candidate selection
inferred← citeshttps://doi.org/10.1080/15376510309824openalex-snapshot
Idiosyncratic Drug Hepatotoxicity Revisited: New Insights from Mechanistic Toxicology
inferred← citeshttps://doi.org/10.1081/dmr-120001392openalex-snapshot
Summary of information on human CYP enzymes: human P450 metabolism data
inferred← citeshttps://doi.org/10.1081/dmr-120015693openalex-snapshot
PREDICTING PHARMACOKINETICS AND DRUG INTERACTIONS IN PATIENTS FROM IN VITRO AND IN VIVO MODELS: THE EXPERIENCE WITH 5,6-DIMETHYLXANTHENONE-4-ACETIC ACID (DMXAA), AN ANTI-CANCER DRUG ELIMINATED MAINLY BY CONJUGATION
inferred← citeshttps://doi.org/10.1081/dmr-200028812openalex-snapshot
Drug Bioactivation Covalent Binding to Target Proteins and Toxicity Relevance
inferred← citeshttps://doi.org/10.1093/toxsci/61.1.49openalex-snapshot
Characterization of Rat and Human UDP-Glucuronosyltransferases Responsible for the in Vitro Glucuronidation of Diclofenac
inferred← citeshttps://doi.org/10.1097/00008571-200008000-00004openalex-snapshot
Relationship of polymorphism in CYP2C9 to genetic susceptibility to diclofenac-induced hepatitis
inferred← citeshttps://doi.org/10.1111/j.1472-8206.2007.00516.xopenalex-snapshot
Effect of voriconazole on the pharmacokinetics of diclofenac
inferred← citeshttps://doi.org/10.1124/dmd.104.002840openalex-snapshot
IDENTIFICATION OF A NOVEL GLUTATHIONE ADDUCT OF DICLOFENAC, 4′-HYDROXY-2′-GLUTATHION-DESCHLORO-DICLOFENAC, UPON INCUBATION WITH HUMAN LIVER MICROSOMES
inferred← citeshttps://doi.org/10.1124/dmd.104.003095openalex-snapshot
DETECTION OF A NOVEL REACTIVE METABOLITE OF DICLOFENAC: EVIDENCE FOR CYP2C9-MEDIATED BIOACTIVATION VIA ARENE OXIDES
inferred← citeshttps://doi.org/10.1124/dmd.105.004861openalex-snapshot
PATHWAYS OF CARBAMAZEPINE BIOACTIVATION IN VITRO: II. THE ROLE OF HUMAN CYTOCHROME P450 ENZYMES IN THE FORMATION OF 2-HYDROXYIMINOSTILBENE
inferred← citeshttps://doi.org/10.1124/dmd.106.011643openalex-snapshot
Rifampin Induces the in Vitro Oxidative Metabolism, but Not the in Vivo Clearance of Diclofenac in Rhesus Monkeys
inferred← citeshttps://doi.org/10.1124/dmd.107.019323openalex-snapshot
Biosynthesis of Drug Metabolites Using Microbes in Hollow Fiber Cartridge Reactors: Case Study of Diclofenac Metabolism by Actinoplanes Species
inferred← citeshttps://doi.org/10.1124/dmd.111.039396openalex-snapshot
Bioactivation of Glafenine by Human Liver Microsomes and Peroxidases: Identification of Electrophilic Iminoquinone Species and GSH Conjugates
inferred← citeshttps://doi.org/10.1124/dmd.114.057414openalex-snapshot
Metabolic Activation of the Indoloquinazoline Alkaloids Evodiamine and Rutaecarpine by Human Liver Microsomes: Dehydrogenation and Inactivation of Cytochrome P450 3A4
inferred← citeshttps://doi.org/10.1124/dmd.30.10.1143openalex-snapshot
Diclofenac-Induced Inactivation of CYP3A4 and Its Stimulation by Quinidine
inferred← citeshttps://doi.org/10.1124/dmd.31.11.1327openalex-snapshot
STUDIES ON THE CHEMICAL REACTIVITY OF DICLOFENAC ACYL GLUCURONIDE WITH GLUTATHIONE: IDENTIFICATION OF DICLOFENAC-S-ACYL-GLUTATHIONE IN RAT BILE
inferred← citeshttps://doi.org/10.1124/dmd.31.7.837openalex-snapshot
PROTEIN COVALENT BINDING OF MAXIPOST THROUGH A CYTOCHROME P450-MEDIATED ORTHO-QUINONE METHIDE INTERMEDIATE IN RATS
inferred← citeshttps://doi.org/10.1124/dmd.31.7.955openalex-snapshot
CYTOCHROME P450 INHIBITION USING RECOMBINANT PROTEINS AND MASS SPECTROMETRY/MULTIPLE REACTION MONITORING TECHNOLOGY IN A CASSETTE INCUBATION
inferred← citeshttps://doi.org/10.1134/s1990750812010143openalex-snapshot
The influence of B-group vitamins on monooxygenase activity of cytochrome P450 3A4: Pharmacokinetics and electro analysis of the catalytic properties
inferred← citeshttps://doi.org/10.1146/annurev.pharmtox.45.120403.100058openalex-snapshot
THE ROLE OF METABOLIC ACTIVATION IN DRUG-INDUCED HEPATOTOXICITY
inferred← citeshttps://doi.org/10.1163/156856001300248461openalex-snapshot
Drug metabolism and drug toxicity
inferred← citeshttps://doi.org/10.1177/1091581817700584openalex-snapshot
Involvement of Reactive Metabolites of Diclofenac in Cytotoxicity in Sandwich-Cultured Rat Hepatocytes
inferred← citeshttps://doi.org/10.1177/2042098610386281openalex-snapshot
Drug-induced liver injury in older adults
inferred← citeshttps://doi.org/10.1177/2397847319874359openalex-snapshot
Biochemical alterations in diclofenac-treated rats: Effect of selenium on oxidative stress, inflammation, and hematological changes
inferred← citeshttps://doi.org/10.1186/s13568-018-0546-yopenalex-snapshot
Enhanced laccase-mediated transformation of diclofenac and flufenamic acid in the presence of bisphenol A and testing of an enzymatic membrane reactor
inferred← citeshttps://doi.org/10.1515/dmdi.2007.22.2-3.165openalex-snapshot
BIOAVAILABILITY OF DICLOFENAC SODIUM AFTER PRETREATMENT WITH DIOSMIN IN HEALTHY VOLUNTEERS
inferred← citeshttps://doi.org/10.1517/14740338.3.6.519openalex-snapshot
Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity
inferred← citeshttps://doi.org/10.1517/17410541.1.1.63openalex-snapshot
The CYP2C9 polymorphism: from enzyme kinetics to clinical dose recommendations
inferred← citeshttps://doi.org/10.17638/00010013openalex-snapshot
In vitro and in vivo investigations into the interactions between the acyl glucuronide metabolite of diclofenac and serum albumin
inferred← citeshttps://doi.org/10.18097/pbmc20115703343openalex-snapshot
The influence of vitamin B group on monooxygenase activity of cytochrome P450 3A4: pharmacokinetics and electro analysis of catalytic properties
inferred← citeshttps://doi.org/10.18433/j3ks39openalex-snapshot
Pharmacokinetics and Pharmacodynamics of diclofenac in the presence and absence of glibenclamide in the rat
inferred← citeshttps://doi.org/10.18433/j3s597openalex-snapshot
Pharmacokinetic of Diclofenac in the Presence and Absence of Glibenclamide in the Rat
inferred← citeshttps://doi.org/10.1897/09-173.1openalex-snapshot
Pharmaceutical metabolites in the environment: Analytical challenges and ecological risks
inferred← citeshttps://doi.org/10.2131/jts.37.1143openalex-snapshot
Increase in covalent binding of 5-hydroxydiclofenac to hepatic tissues in rats co-treated with lipopolysaccharide and diclofenac: involvement in the onset of diclofenac-induced idiosyncratic hepatotoxicity
inferred← citeshttps://doi.org/10.2165/00044011-200727030-00002openalex-snapshot
Diclofenac Potassium 12.5mg Tablets for Mild to Moderate Pain and Fever
inferred← citeshttps://doi.org/10.2174/138161210791208910openalex-snapshot
In Vitro Evaluation of Potential Hepatotoxicity Induced by Drugs
inferred← citeshttps://doi.org/10.3109/00498254.2011.607196openalex-snapshot
The hepatic reductase null mouse as a model for exploring hepatic conjugation of xenobiotics: Application to the metabolism of diclofenac
inferred← citeshttps://doi.org/10.3109/00498254.2013.806837openalex-snapshot
Drug interactions of diclofenac and its oxidative metabolite with human liver microsomal cytochrome P450 1A2-dependent drug oxidation
inferred← citeshttps://doi.org/10.3109/03602532.2014.978081openalex-snapshot
Transcriptional profiling of reactive metabolites for elucidating toxicological mechanisms: a case study of quinoneimine-forming agents
inferred← citeshttps://doi.org/10.3109/9781420016697-14openalex-snapshot
Pharmacogenetics in Gastroenterology
inferred← citeshttps://doi.org/10.3109/9781420016697-17openalex-snapshot
Pharmacogenetics in Gastroenterology
inferred← citeshttps://doi.org/10.33549/physiolres.934609openalex-snapshot
Diclofenac-induced cytotoxicity in cultured carp leukocytes
inferred← citeshttps://doi.org/10.3389/fphar.2018.01033openalex-snapshot
The Modulatory Role of CYP3A4 in Dictamnine-Induced Hepatotoxicity
inferred← citeshttps://doi.org/10.3390/ph13120456openalex-snapshot
Cytochrome P450 Expression and Chemical Metabolic Activity before Full Liver Development in Zebrafish
inferred← citeshttps://doi.org/10.3797/scipharm.1003-10openalex-snapshot
Effect of Itraconazole on the Pharmacokinetics of Diclofenac in Beagle Dogs
inferred← citeshttps://doi.org/10.3923/pjbs.2008.1901.1908openalex-snapshot
Morphological Alteration in Mitochondria Following Diclofenac and Ibuprofen Administration
inferred← citeshttps://doi.org/10.4102/ojvr.v89i1.1978openalex-snapshot
Effect of cytochrome P450 inhibition on toxicity of diclofenac in chickens: Unravelling toxicity in Gyps vultures
inferred← citeshttps://doi.org/10.4103/ejpi.ejpi-d-25-00043openalex-snapshot
Antinociceptive Interaction between Diclofenac and Statins: An Isobolographic Analysis
inferred← citeshttps://doi.org/10.70675/88f06b4czc522z47dazb01fzfb4bef3db97dopenalex-snapshot
Etude de la toxicité idiosyncratique de médicaments sur cellules HepaRG et levure : influence du stress inflammatoire et de la biotransformation
inferred← citeshttps://doi.org/10.70675/8ebe0656z9dc4z4d95za9bdz3a65c5e0e868openalex-snapshot
État d'imprégnation de différents compartiments du milieu aquatique par des résidus de médicaments et leurs produits de dégradation
inferred← citeshttps://doi.org/10.70675/d053eb1ez6b24z416fzba3cz3197a19b0541openalex-snapshot
Evaluation des effets chroniques du diclofénac sur un mollusque gastéropode avec des approches physiologiques, comportementales, transcriptomiques et métabolomiques
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