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The Modulatory Role of CYP3A4 in Dictamnine-Induced Hepatotoxicity

https://doi.org/10.3389/fphar.2018.01033

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Characterization of an epoxide‐derived metabolite of dictamnine using high‐performance liquid chromatography with hybrid linear trap quadrupole orbitrap mass spectrometry

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Metabolic activation of furan moiety makes Diosbulbin B hepatotoxic

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Hepatotoxicity by combination treatment of temozolomide, artesunate and Chinese herbs in a glioblastoma multiforme patient: case report review of the literature

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Tissue Distribution and Gender-Specific Protein Expression of Cytochrome P450 in five Mouse Genotypes with a Background of FVB

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Safety issues and new rapid detection methods in traditional Chinese medicinal materials

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The role of CYP3A4 in amiodarone-associated toxicity on HepG2 cells

inferredcites →https://doi.org/10.1016/j.bse.2013.03.036openalex-snapshot

Quinoline alkaloids and sesquiterpenes from the roots of Dictamnus angustifolius

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A toxicologist guide to the diagnostic interpretation of hepatic biochemical parameters

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Systematic review on herb-induced liver injury in Korea

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Hepatoprotection and hepatotoxicity of Heshouwu, a Chinese medicinal herb: Context of the paradoxical effect

inferredcites →https://doi.org/10.1016/j.jchromb.2013.10.025openalex-snapshot

Pharmacokinetics, tissue distribution and excretion study of dictamnine, a major bioactive component from the root bark of Dictamnus dasycarpus Turcz. (Rutaceae)

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The rise of traditional Chinese medicine and its materia medica: A comparison of the frequency and safety of materials and species used in Europe and China

inferredcites →https://doi.org/10.1016/j.jep.2014.10.027openalex-snapshot

Acute and sub-chronic oral toxicity profiles of the aqueous extract of Cortex Dictamni in mice and rats

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Traditional usages, botany, phytochemistry, pharmacology and toxicology of Polygonum multiflorum Thunb.: A review

inferredcites →https://doi.org/10.1016/j.jep.2015.05.053openalex-snapshot

Medicinal uses, phytochemistry and pharmacology of the genus Dictamnus (Rutaceae)

inferredcites →https://doi.org/10.1016/j.jpba.2015.11.016openalex-snapshot

Metabolism of dictamnine in liver microsomes from mouse, rat, dog, monkey, and human

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Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells

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Metabolic-induced cytotoxicity of diosbulbin B in CYP3A4-expressing cells

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Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation

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Role of Metabolic Activation in 8-Epidiosbulbin E Acetate-Induced Liver Injury: Mechanism of Action of the Hepatotoxic Furanoid

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Pyrrolizidine Alkaloid-Protein Adducts: Potential Non-invasive Biomarkers of Pyrrolizidine Alkaloid-Induced Liver Toxicity and Exposure

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Identification and Characterization of Reactive Metabolites in Natural Products-Driven Drug Discovery

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Metabolic Activation of Pyrrolizidine Alkaloids: Insights into the Structural and Enzymatic Basis

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Identification of Amino Acid and GlutathioneN-Conjugates of Toosendanin: Bioactivation of the Furan Ring Mediated by CYP3A4

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Metabolic Activation of Diclofenac by Human Cytochrome P450 3A4: Role of 5-Hydroxydiclofenac

inferredcites →https://doi.org/10.1038/srep17475openalex-snapshot

Combined DNA, toxicological and heavy metal analyses provides an auditing toolkit to improve pharmacovigilance of traditional Chinese medicine (TCM)

inferredcites →https://doi.org/10.1039/c5ra00278hopenalex-snapshot

Limonoids from the root bark of Dictamnus angustifolius: potent neuroprotective agents with biometal chelation and halting copper redox cycling properties

inferredcites →https://doi.org/10.1055/s-0042-108206openalex-snapshot

A Hexa-Herbal TCM Decoction Used to Treat Skin Inflammation: An LC-MS-Based Phytochemical Analysis

inferredcites →https://doi.org/10.1097/meg.0b013e32834f993fopenalex-snapshot

Suspected Greater Celandine hepatotoxicity

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Review article: herbal hepatotoxicity – an update on traditional Chinese medicine preparations

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An overview on adverse drug reactions to traditional Chinese medicines

inferredcites →https://doi.org/10.1111/j.1476-5381.2010.00645.xopenalex-snapshot

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inferredcites →https://doi.org/10.1517/14740338.2013.774371openalex-snapshot

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Simultaneous determination of three active compounds in root barks ofDictamnus dasycarpus by RP-HPLC

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Protection of Schisantherin a Against Dictamnine-Induced Hepatotoxicity Via Inhibiting the Metabolic Activation of Dictamnine

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Evidence for exposure biomarkers in dictamnine‐induced liver injury resulting from metabolic activation in vitro and in mice

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In Vitro and In Vivo Metabolic Activation of Obacunone, A Bioactive and Potentially Hepatotoxic Constituent of Dictamni Cortex

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