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The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO Consultation
inferredcites →https://doi.org/10.1002/1098-2272(200101)20:1<57::aid-gepi6>3.0.co;2-5openalex-snapshot
Transmission/disequilibrium tests for quantitative traits
inferredcites →https://doi.org/10.1006/bbrc.1998.9962openalex-snapshot
Pro12Ala Missense Mutation of the Peroxisome Proliferator Activated Receptor γ and Diabetes Mellitus
inferredcites →https://doi.org/10.1006/bbrc.2000.2096openalex-snapshot
Inhibitory Effect of a Proline-to-Alanine Substitution at Codon 12 of Peroxisome Proliferator-Activated Receptor-γ 2 on Thiazolidinedione-Induced Adipogenesis
inferredcites →https://doi.org/10.1006/bbrc.2000.2605openalex-snapshot
The Pro12Ala Polymorphism in PPAR γ2 May Confer Resistance to Type 2 Diabetes
inferredcites →https://doi.org/10.1007/s001250050772openalex-snapshot
A missense mutation of the muscle glycogen synthase gene (M416V) is associated with insulin resistance in the Japanese population
inferredcites →https://doi.org/10.1007/s001250050926openalex-snapshot
Tumour necrosis factor-alpha gene promoter polymorphism and decreased insulin resistance
inferredcites →https://doi.org/10.1007/s001250051098openalex-snapshot
Missense mutations in the pancreatic islet beta cell inwardly rectifying K + channel gene (KIR6.2/BIR ): a meta-analysis suggests a role in the polygenic basis of Type II diabetes mellitus in Caucasians
inferredcites →https://doi.org/10.1007/s001250051120openalex-snapshot
Association of polymorphisms in the ?2-adrenergic receptor gene with obesity, hypertriglyceridaemia, and diabetes mellitus (Short Communication)
inferredcites →https://doi.org/10.1016/0092-8674(94)90006-xopenalex-snapshot
Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
inferredcites →https://doi.org/10.1016/0140-6736(93)92694-oopenalex-snapshot
Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus
inferredcites →https://doi.org/10.1038/3099openalex-snapshot
A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
inferredcites →https://doi.org/10.1038/47254openalex-snapshot
Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension
inferredcites →https://doi.org/10.1038/ng0395-299openalex-snapshot
A missense mutation in the glucagon receptor gene is associated with non–insulin–dependent diabetes mellitus
inferredcites →https://doi.org/10.1038/sj.ijo.0801112openalex-snapshot
Impact of the Peroxisome Proliferator Activated Receptor γ2 Pro12Ala polymorphism on adiposity, lipids and non-insulin-dependent diabetes mellitus
inferredcites →https://doi.org/10.1038/sj.ijo.0801191openalex-snapshot
The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes
inferredcites →https://doi.org/10.1056/nejm199508103330604openalex-snapshot
Association of a Polymorphism in the β3-Adrenergic–Receptor Gene with Features of the Insulin Resistance Syndrome in Finns
inferredcites →https://doi.org/10.1056/nejm199810013391403openalex-snapshot
Obesity Associated with a Mutation in a Genetic Regulator of Adipocyte Differentiation
inferredcites →https://doi.org/10.1073/pnas.94.20.10756openalex-snapshot
Fluorescence energy transfer detection as a homogeneous DNA diagnostic method
inferredcites →https://doi.org/10.1074/jbc.270.22.12953openalex-snapshot
An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)
inferredcites →https://doi.org/10.1086/301714openalex-snapshot
A Sibship Test for Linkage in the Presence of Association: The Sib Transmission/Disequilibrium Test
inferredcites →https://doi.org/10.1086/301787openalex-snapshot
Genetic Association Mapping Based on Discordant Sib Pairs: The Discordant-Alleles Test
inferredcites →https://doi.org/10.1101/gr.9.5.492openalex-snapshot
Fluorescence Polarization in Homogeneous Nucleic Acid Analysis
inferredcites →https://doi.org/10.1126/science.7716547openalex-snapshot
Cloning of the β Cell High-Affinity Sulfonylurea Receptor: a Regulator of Insulin Secretion
inferredcites →https://doi.org/10.1172/jci117778openalex-snapshot
An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance.
inferredcites →https://doi.org/10.1210/jc.81.4.1657openalex-snapshot
Codon 972 polymorphism in the insulin receptor substrate-1 gene, obesity, and risk of noninsulin-dependent diabetes mellitus
inferredcites →https://doi.org/10.1210/jc.82.10.3373openalex-snapshot
Paraoxonase-2 Gene (PON2) G148 Variant Associated with Elevated Fasting Plasma Glucose in Noninsulin-Dependent Diabetes Mellitus
inferredcites →https://doi.org/10.1210/jc.84.3.1002openalex-snapshot
Prevalence of Variants in Candidate Genes for Type 2 Diabetes Mellitus in The Netherlands: The Rotterdam Study and the Hoorn Study
inferredcites →https://doi.org/10.1210/jcem.82.10.4289openalex-snapshot
Paraoxonase-2 Gene (PON2) G148 Variant Associated with Elevated Fasting Plasma Glucose in Noninsulin-Dependent Diabetes Mellitus1
inferredcites →https://doi.org/10.2337/diab.44.9.1081openalex-snapshot
Frequency of Mutations of Insulin Receptor Gene in Japanese Patients With NIDDM
inferredcites →https://doi.org/10.2337/diab.45.11.1585openalex-snapshot
Metabolic Consequences of a Family History of NIDDM (The Botnia Study): Evidence for Sex-Specific Parental Effects
inferredcites →https://doi.org/10.2337/diab.45.6.825openalex-snapshot
Sequence Variants in the Sulfonylurea Receptor (SUR) Gene Are Associated With NIDDM in Caucasians
inferredcites →https://doi.org/10.2337/diab.45.9.1279openalex-snapshot
Missense Mutation of Amylin Gene (S20G) in Japanese NIDDM Patients
inferredcites →https://doi.org/10.2337/diab.46.4.701openalex-snapshot
Predictors of Progression From Impaired Glucose Tolerance to NIDDM: An Analysis of Six Prospective Studies
inferredcites →https://doi.org/10.2337/diabetes.48.7.1466openalex-snapshot
Pro12Ala substitution in the peroxisome proliferator-activated receptor-gamma2 is not associated with type 2 diabetes.
inferredcites →https://doi.org/10.2337/diabetes.49.1.126openalex-snapshot
Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles.
inferredcites →https://doi.org/10.2337/diacare.22.3.399openalex-snapshot
Impaired fasting glucose or impaired glucose tolerance. What best predicts future diabetes in Mauritius?
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Expression of the diabetes‐associated gene TCF7L2 in adult mouse brain
inferred← citeshttps://doi.org/10.1002/dmrr.1221openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/dmrr.543openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/dmrr.546openalex-snapshot
Gly482Ser polymorphism of the peroxisome proliferator-activated receptor-γ coactivator-1 gene might be a risk factor for diabetic retinopathy in Slovene population (Caucasians) with type 2 diabetes and the Pro12Ala polymorphism of thePPARγ gene is not
inferred← citeshttps://doi.org/10.1002/dmrr.866openalex-snapshot
Association of glucose transporter 1 polymorphisms with type 2 diabetes in the Tunisian population
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A Likelihood Ratio‐Based Mann‐Whitney Approach Finds Novel Replicable Joint Gene Action for Type 2 Diabetes
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The Genetic Basis of Complex Traits
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Genetics of Type 2 Diabetes
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Genetics of Type 2 Diabetes
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Genetics of Type 2 Diabetes: From Candidate Genes to Genome-Wide Association Analysis
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Genetics of Type 2 Diabetes: From Candidate Genes to Genome-Wide Association Analysis
inferred← citeshttps://doi.org/10.1007/978-3-319-20797-1_10-2openalex-snapshot
Genetics of Type 2 Diabetes: From Candidate Genes to Genome-Wide Association Analysis
inferred← citeshttps://doi.org/10.1007/978-3-319-71812-5_1openalex-snapshot
Genetic Contributions and Personalized Medicine
inferred← citeshttps://doi.org/10.1007/978-3-642-18741-4_10openalex-snapshot
Molekulare Grundlagen altersspezifischer Erkrankungen des Endokriniums
inferred← citeshttps://doi.org/10.1007/978-3-642-18741-4_4openalex-snapshot
Besonderheiten der Arzneitherapie im Alter unter Berücksichtigung pharmakogenetischer Faktoren
inferred← citeshttps://doi.org/10.1007/978-3-642-20036-6_41openalex-snapshot
Increasing Power of Groupwise Association Test with Likelihood Ratio Test
inferred← citeshttps://doi.org/10.1007/978-3-662-06214-2_10openalex-snapshot
Insulin Resistance and Cardiovascular Disease: New Insights from Genetics
inferred← citeshttps://doi.org/10.1007/978-3-662-06214-2_6openalex-snapshot
The Genetic Basis of Essential Hypertension and Its Implications for Treatment
inferred← citeshttps://doi.org/10.1007/978-3-7091-1334-9_4openalex-snapshot
Gene Polymorphisms and Signaling Defects
inferred← citeshttps://doi.org/10.1007/978-4-431-55333-5_15openalex-snapshot
Relationship of Cardiorespiratory Fitness and Obesity Genes to Metabolic Syndrome in Adult Japanese Men
inferred← citeshttps://doi.org/10.1007/978-90-481-3303-1_10openalex-snapshot
PPARs: Important Regulators in Metabolism and Inflammation
inferred← citeshttps://doi.org/10.1007/978-981-13-3705-5_24openalex-snapshot
Physical Impairments Associated with Diseases: A Pathophysiological Approach
inferred← citeshttps://doi.org/10.1007/978-981-13-8177-5_4openalex-snapshot
Genome-Wide Association Study for Type 2 Diabetes
inferred← citeshttps://doi.org/10.1007/978-981-16-5123-6_2openalex-snapshot
Pathophysiology and Risk Factors of Diabetes
inferred← citeshttps://doi.org/10.1007/978-981-287-050-6_5openalex-snapshot
Predisposition Factors of Type II Diabetes Mellitus and Related Complications
inferred← citeshttps://doi.org/10.1007/978-981-33-6699-2_2openalex-snapshot
Single Nucleotide Polymorphisms and Pharmacogenomics
inferred← citeshttps://doi.org/10.1007/978-981-95-0575-3_20openalex-snapshot
Interactions Between Genetic and Environmental Risk Factors in Lifestyle Diseases
inferred← citeshttps://doi.org/10.1007/bf03256250openalex-snapshot
Pharmacogenetics of Glucose-Lowering Drug Treatment
inferred← citeshttps://doi.org/10.1007/bf03343914openalex-snapshot
Medical care from childhood to adulthood in Type 1 and Type 2 diabetes
inferred← citeshttps://doi.org/10.1007/bf03349241openalex-snapshot
Association of the peroxisome proliferator-activated receptor-γ2 Pro12Ala but not the C1431T gene variants with lower body mass index in Type 2 diabetes
inferred← citeshttps://doi.org/10.1007/s00005-008-0037-yopenalex-snapshot
Structure and physiological functions of the human peroxisome proliferator-activated receptor γ
inferred← citeshttps://doi.org/10.1007/s00018-002-8426-6openalex-snapshot
Recent advances in the genetics of schizophrenia
inferred← citeshttps://doi.org/10.1007/s00063-006-1090-0openalex-snapshot
Kandidatengene des Diabetes mellitus Typ 2
inferred← citeshttps://doi.org/10.1007/s00109-002-0417-4openalex-snapshot
Implications of pharmacogenetics for individualizing drug treatment and for study design
inferred← citeshttps://doi.org/10.1007/s00109-003-0466-3openalex-snapshot
Evidence for genetic epistasis in human insulin resistance: the combined effect of PC-1 (K121Q) and PPAR?2 (P12A) polymorphisms
inferred← citeshttps://doi.org/10.1007/s00109-006-0138-1openalex-snapshot
Dietary fat, genes and insulin sensitivity
inferred← citeshttps://doi.org/10.1007/s00109-007-0203-4openalex-snapshot
TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis
inferred← citeshttps://doi.org/10.1007/s001090100255openalex-snapshot
Sibling-based association study of the PPARγ2 Pro12Ala polymorphism and metabolic variables in Chinese and Japanese hypertension families: a SAPPHIRe study
inferred← citeshttps://doi.org/10.1007/s001090100282openalex-snapshot
Interaction effect between common polymorphisms in PPARγ2 (Pro12Ala) and insulin receptor substrate 1 (Gly972Arg) on insulin sensitivity
inferred← citeshttps://doi.org/10.1007/s00125-002-0793-xopenalex-snapshot
Insulin sensitivity of glucose disposal and lipolysis: no influence of common genetic variants in IRS-1 and CAPN10
inferred← citeshttps://doi.org/10.1007/s00125-002-1009-0openalex-snapshot
The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
inferred← citeshttps://doi.org/10.1007/s00125-003-1050-7openalex-snapshot
Does the −11377 promoter variant of APM1 gene contribute to the genetic risk for Type 2 diabetes mellitus in Japanese families?
inferred← citeshttps://doi.org/10.1007/s00125-003-1092-xopenalex-snapshot
No interactions between polymorphisms in the β3-adrenergic receptor gene and the PPAR-γ gene on the risk of the insulin resistance syndrome in the Danish MONICA cohort
inferred← citeshttps://doi.org/10.1007/s00125-003-1126-4openalex-snapshot
Gly972Arg variant in the insulin receptor substrate-1 gene and association with Type 2 diabetes: a meta-analysis of 27 studies
inferred← citeshttps://doi.org/10.1007/s00125-003-1136-2openalex-snapshot
Genetic epistasis of adiponectin and PPAR?2 genotypes in modulation of insulin sensitivity: a family-based association study
inferred← citeshttps://doi.org/10.1007/s00125-004-1388-5openalex-snapshot
Genotypic and phenotypic differences between Arabian and Scandinavian women with gestational diabetes mellitus
inferred← citeshttps://doi.org/10.1007/s00125-004-1395-6openalex-snapshot
Common polymorphisms in the genes regulating the early insulin signalling pathway: effects on weight change and the conversion from impaired glucose tolerance to Type 2 diabetes.
inferred← citeshttps://doi.org/10.1007/s00125-004-1400-0openalex-snapshot
Control of glycaemia: from molecules to men. Minkowski Lecture 2003
inferred← citeshttps://doi.org/10.1007/s00125-004-1406-7openalex-snapshot
Peroxisome proliferator-activated receptor γ gene polymorphisms and restenosis in diabetic patients after stenting in coronary arteries
inferred← citeshttps://doi.org/10.1007/s00125-004-1418-3openalex-snapshot
Large-scale studies of the HphI insulin gene variable-number-of-tandem-repeats polymorphism in relation to Type 2 diabetes mellitus and insulin release
inferred← citeshttps://doi.org/10.1007/s00125-004-1432-5openalex-snapshot
Single nucleotide polymorphisms of protein tyrosine phosphatase 1B gene are associated with obesity in morbidly obese French subjects
inferred← citeshttps://doi.org/10.1007/s00125-004-1557-6openalex-snapshot
The PlA1/A2 polymorphism of platelet glycoprotein IIIa is not associated with the risk of type 2 diabetes. The Ludwigshafen Risk and Cardiovascular Health Study
inferred← citeshttps://doi.org/10.1007/s00125-004-1575-4openalex-snapshot
Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism
inferred← citeshttps://doi.org/10.1007/s00125-004-1577-2openalex-snapshot
Common polymorphisms of the PPAR-?2 (Pro12Ala) and PGC-1? (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial
inferred← citeshttps://doi.org/10.1007/s00125-005-0035-0openalex-snapshot
Association of the E23K polymorphism in the KCNJ11 gene with gestational diabetes mellitus
inferred← citeshttps://doi.org/10.1007/s00125-005-0044-zopenalex-snapshot
The in vivo effects of the Pro12Ala PPARγ2 polymorphism on adipose tissue NEFA metabolism: the first use of the Oxford Biobank
inferred← citeshttps://doi.org/10.1007/s00125-005-0130-2openalex-snapshot
Meta-analysis of the Gly482Ser variant in PPARGC1A in type 2 diabetes and related phenotypes
inferred← citeshttps://doi.org/10.1007/s00125-005-1729-zopenalex-snapshot
Hypoadiponectinaemia and high risk of type 2 diabetes are associated with adiponectin-encoding (ACDC) gene promoter variants in morbid obesity: evidence for a role of ACDC in diabesity
inferred← citeshttps://doi.org/10.1007/s00125-005-1737-zopenalex-snapshot
No association between insulin gene variation and adult metabolic phenotypes in a large Finnish birth cohort
inferred← citeshttps://doi.org/10.1007/s00125-005-1807-2openalex-snapshot
Making the right associations
inferred← citeshttps://doi.org/10.1007/s00125-005-1817-0openalex-snapshot
The Pro12Ala and C–681G variants of the PPARG locus are associated with opposing growth phenotypes in young schoolchildren
inferred← citeshttps://doi.org/10.1007/s00125-005-1827-yopenalex-snapshot
Influence of Pro12Ala peroxisome proliferator-activated receptor γ2 polymorphism on glucose response to exercise training in type 2 diabetes
inferred← citeshttps://doi.org/10.1007/s00125-006-0218-3openalex-snapshot
Association study of genetic polymorphisms of SLC2A10 gene and type 2 diabetes in the Taiwanese population
inferred← citeshttps://doi.org/10.1007/s00125-006-0270-zopenalex-snapshot
Common polymorphisms of calpain-10 are associated with abdominal obesity in subjects at high risk of type 2 diabetes
inferred← citeshttps://doi.org/10.1007/s00125-006-0345-xopenalex-snapshot
Latent autoimmune diabetes in adults (LADA)—more than a name
inferred← citeshttps://doi.org/10.1007/s00125-006-0450-xopenalex-snapshot
Common variants in HNF-1 α and risk of type 2 diabetes
inferred← citeshttps://doi.org/10.1007/s00125-006-0502-2openalex-snapshot
Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population
inferred← citeshttps://doi.org/10.1007/s00125-006-0507-xopenalex-snapshot
TCF7L2: the biggest story in diabetes genetics since HLA?
inferred← citeshttps://doi.org/10.1007/s00125-007-0618-zopenalex-snapshot
Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population
inferred← citeshttps://doi.org/10.1007/s00125-007-0623-2openalex-snapshot
A variant in the transcription factor 7-like 2 (TCF7L2) gene is associated with an increased risk of gestational diabetes mellitus
inferred← citeshttps://doi.org/10.1007/s00125-007-0657-5openalex-snapshot
Association testing of common variants in the insulin receptor substrate-1 gene (IRS1) with type 2 diabetes
inferred← citeshttps://doi.org/10.1007/s00125-007-0717-xopenalex-snapshot
Transcription factor 7-like 2 polymorphisms and type 2 diabetes, glucose homeostasis traits and gene expression in US participants of European and African descent
inferred← citeshttps://doi.org/10.1007/s00125-007-0787-9openalex-snapshot
ENPP1 K121Q polymorphism and obesity, hyperglycaemia and type 2 diabetes in the prospective DESIR Study
inferred← citeshttps://doi.org/10.1007/s00125-007-0825-7openalex-snapshot
Genetic studies of diabetes following the advent of the genome-wide association study: where do we go from here?
inferred← citeshttps://doi.org/10.1007/s00125-007-0826-6openalex-snapshot
The Pro12Ala variant at the peroxisome proliferator-activated receptor γ gene and change in obesity-related traits in the Diabetes Prevention Program
inferred← citeshttps://doi.org/10.1007/s00125-008-1025-9openalex-snapshot
Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: Where are the insulin resistance genes?
inferred← citeshttps://doi.org/10.1007/s00125-008-1141-6openalex-snapshot
Positive association between variations in CDKAL1 and type 2 diabetes in Han Chinese individuals
inferred← citeshttps://doi.org/10.1007/s00125-008-1151-4openalex-snapshot
The search for putative unifying genetic factors for components of the metabolic syndrome
inferred← citeshttps://doi.org/10.1007/s00125-009-1356-1openalex-snapshot
Translating TCF7L2: from gene to function
inferred← citeshttps://doi.org/10.1007/s00125-009-1362-3openalex-snapshot
Combined analysis of 19 common validated type 2 diabetes susceptibility gene variants shows moderate discriminative value and no evidence of gene–gene interaction
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