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Evaluating the Effect of Dual GIPR/GLP-1R Agonists on Non-Alcoholic Fatty Liver Disease and Metabolic Risk Abnormalities: A Drug-Target Mendelian Randomization Study

https://doi.org/10.2139/ssrn.4771342
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Nonalcoholic steatohepatitis versus steatosis: Adipose tissue insulin resistance and dysfunctional response to fat ingestion predict liver injury and altered glucose and lipoprotein metabolism
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Peripheral insulin resistance predicts liver damage in nondiabetic subjects with nonalcoholic fatty liver disease
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Electronic health record-based genome-wide meta-analysis provides insights on the genetic architecture of non-alcoholic fatty liver disease
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Resmetirom (MGL-3196) for the treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial
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Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer
inferredcites →https://doi.org/10.1038/nrgastro.2013.41openalex-extracted
Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis
inferredcites →https://doi.org/10.1038/s41588-018-0099-7openalex-extracted
Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases
inferredcites →https://doi.org/10.1038/s41588-018-0241-6openalex-extracted
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
inferredcites →https://doi.org/10.1038/s41588-021-00913-zopenalex-extracted
Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression
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Efruxifermin in non-alcoholic steatohepatitis: a randomized, double-blind, placebo-controlled, phase 2a trial
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Activation of Lipoprotein Lipase by Glucose-dependent Insulinotropic Polypeptide in Adipocytes
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Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
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Sensitivity Analyses for Robust Causal Inference from Mendelian Randomization Analyses with Multiple Genetic Variants
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The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review
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The MRC IEU OpenGWAS data infrastructure
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The GTEx Consortium atlas of genetic regulatory effects across human tissues
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Accuracy of MR Imaging–estimated Proton Density Fat Fraction for Classification of Dichotomized Histologic Steatosis Grades in Nonalcoholic Fatty Liver Disease
inferredcites →https://doi.org/10.1161/jaha.120.020331openalex-extracted
Genetic Evidence for Repurposing of GLP1R (Glucagon‐Like Peptide‐1 Receptor) Agonists to Prevent Heart Failure
inferredcites →https://doi.org/10.1194/jlr.m006841openalex-extracted
GIP increases human adipocyte LPL expression through CREB and TORC2-mediated trans-activation of the LPL gene
inferredcites →https://doi.org/10.12688/wellcomeopenres.15555.1openalex-extracted
Guidelines for performing Mendelian randomization investigations
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Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics
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Coexpression of the Type 2 Diabetes Susceptibility Gene Variants KCNJ11 E23K and ABCC8 S1369A Alter the ATP and Sulfonylurea Sensitivities of the ATP-Sensitive K+ Channel
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SGLT2 Inhibition, Choline Metabolites, and Cardiometabolic Diseases: A Mediation Mendelian Randomization Study
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