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Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson’s disease
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1 of the 44 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-28): 10.1523/jneurosci.3878-11.2011 (notice 2013-12-11).
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/jnr.20315openalex-snapshot(−)‐Epigallocatechin gallate inhibits lipopolysaccharide‐induced microglial activation and protects against inflammation‐mediated dopaminergic neuronal injury
inferredcites →https://doi.org/10.1002/syn.20768openalex-snapshotHippocampal epigenetic modification at the doublecortin gene is involved in the impairment of neurogenesis with aging
inferredcites →https://doi.org/10.1007/s004010050792openalex-snapshotEnlarged and phagocytic, but not primed, interleukin-1α-immunoreactive microglia increase with age in normal human brain
inferredcites →https://doi.org/10.1016/j.yexmp.2008.10.004openalex-snapshotRole of nuclear transcription factor kappa B (NF-kappaB) for MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahyropyridine)-induced apoptosis in nigral neurons of mice
inferredcites →https://doi.org/10.1038/70978openalex-snapshotInducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease
inferredcites →https://doi.org/10.1038/ni.1920openalex-snapshotThe Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection
inferredcites →https://doi.org/10.1038/nn1997openalex-snapshotMicroglia: active sensor and versatile effector cells in the normal and pathologic brain
inferredcites →https://doi.org/10.1038/sj.cdd.4401989openalex-snapshotCharacterization of LPS and interferon-γ triggered activation-induced cell death in N9 and primary microglial cells: induction of the mitochondrial gateway by nitric oxide
inferredcites →https://doi.org/10.4049/jimmunol.0901088openalex-snapshotCompound A, a Plant Origin Ligand of Glucocorticoid Receptors, Increases Regulatory T Cells and M2 Macrophages to Attenuate Experimental Autoimmune Neuritis with Reduced Side Effects
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/cpdd.761openalex-snapshotPharmacokinetics, Pharmacodynamics, and Safety of a Single Escalating Dose and Repeated Doses of Rasagiline Transdermal Patch in Healthy Chinese Subjects
inferred← citeshttps://doi.org/10.1002/glia.23826openalex-snapshotNurr1 Cd11bcre conditional knockout mice display inflammatory injury to nigrostriatal dopaminergic neurons
inferred← citeshttps://doi.org/10.1002/glia.70035openalex-snapshotSpatial Transcriptomic Analysis Reveals HDAC Inhibition Modulates Microglial Dynamics to Protect Against Ischemic Stroke in Mice
inferred← citeshttps://doi.org/10.1002/jcp.26497openalex-snapshotHistone methylation and acetylation in macrophages as a mechanism for regulation of inflammatory responses
inferred← citeshttps://doi.org/10.1002/tox.23863openalex-snapshotHistone methyltransferase enzyme enhancer of zeste homolog 2 counteracts ischemic brain injury via H3K27me3 ‐mediated regulation of PI3K / AKT / mTOR signaling pathway
inferred← citeshttps://doi.org/10.1007/s00018-022-04536-3openalex-snapshotThe heterogeneity of microglial activation and its epigenetic and non-coding RNA regulations in the immunopathogenesis of neurodegenerative diseases
inferred← citeshttps://doi.org/10.1007/s00213-021-05912-wopenalex-snapshotHuman umbilical cord mesenchymal stem cells ameliorate depression by regulating Jmjd3 and microglia polarization in myocardial infarction mice
inferred← citeshttps://doi.org/10.1007/s11064-020-03210-zopenalex-snapshotUnlocking the Recovery Potential: JMJD3 Inhibition-Mediated SAPK/JNK Signaling Inactivation Supports Endogenous Oligodendrocyte-Lineage Commitment Post Mammalian Spinal Cord Injury
inferred← citeshttps://doi.org/10.1007/s12264-015-1539-3openalex-snapshotHistone deacetylase 6 delays motor neuron degeneration by ameliorating the autophagic flux defect in a transgenic mouse model of amyotrophic lateral sclerosis
inferred← citeshttps://doi.org/10.1016/j.bbr.2025.115703openalex-snapshotLow-grade chronic inflammatory stimulation alleviates α‑syn accumulation in Parkinson's disease by activating autophagy to promote neuronal survival in the Thy1-h[A30P]α-syn mouse model
inferred← citeshttps://doi.org/10.1016/j.bcp.2020.113932openalex-snapshotSmall-molecule arone protects from neuroinflammation in LPS-activated microglia BV-2 cells by targeting histone-remodeling chaperone ASF1a
inferred← citeshttps://doi.org/10.1016/j.cbi.2023.110387openalex-snapshotRevisiting the intersection of microglial activation and neuroinflammation in Alzheimer's disease from the perspective of ferroptosis
inferred← citeshttps://doi.org/10.1016/j.expneurol.2025.115518openalex-snapshotMicroglial hyperactivation and NLRP3 methylation mediated by SETD3 after anesthesia/surgery: Unraveling new mechanisms of perioperative neurocognitive disorders
inferred← citeshttps://doi.org/10.1016/j.intimp.2021.107896openalex-snapshotPseudoginsenoside-F11 promotes functional recovery after transient cerebral ischemia by regulating the microglia/macrophage polarization in rats
inferred← citeshttps://doi.org/10.1016/j.jad.2020.03.154openalex-snapshotEZH2 is involved in vulnerability to neuroinflammation and depression-like behaviors induced by chronic stress in different aged mice
inferred← citeshttps://doi.org/10.1038/mp.2017.167openalex-snapshotDHEA inhibits acute microglia-mediated inflammation through activation of the TrkA-Akt1/2-CREB-Jmjd3 pathway
inferred← citeshttps://doi.org/10.1042/an20130050openalex-snapshotCell-Type-Specific Jumonji Histone Demethylase Gene Expression in the Healthy Rat CNS: Detection by a Novel Flow Cytometry Method
inferred← citeshttps://doi.org/10.1089/scd.2018.0258openalex-snapshotInhibition of Ezh2 In Vitro and the Decline of Ezh2 in Developing Midbrain Promote Dopaminergic Neurons Differentiation Through Modifying H3K27me3
inferred← citeshttps://doi.org/10.1089/scd.2019.0216openalex-snapshotRNA-Seq Reveals Underlying Transcriptomic Mechanisms of Bone Marrow-Derived Mesenchymal Stem Cells in the Regulation of Microglia-Mediated Neuroinflammation After Subarachnoid Hemorrhage
inferred← citeshttps://doi.org/10.1093/hmg/ddad115openalex-snapshotJMJD3 and SNAI2 synergistically protect against Parkinson’s disease by mediating the YAP/HIF1α signaling pathway in a mouse model
inferred← citeshttps://doi.org/10.1093/hmg/ddz110openalex-snapshotRNA editing alterations in a multi-ethnic Alzheimer disease cohort converge on immune and endocytic molecular pathways
inferred← citeshttps://doi.org/10.1111/adb.12816openalex-snapshotDysregulation of the histone demethylase KDM6B in alcohol dependence is associated with epigenetic regulation of inflammatory signaling pathways
inferred← citeshttps://doi.org/10.1111/bpa.13028openalex-snapshotChronic sleep deprivation altered the expression of circadian clock genes and aggravated Alzheimer's disease neuropathology
inferred← citeshttps://doi.org/10.1111/neup.12180openalex-snapshotShort‐, middle‐ and long‐term safety of superparamagnetic iron oxide‐labeled allogeneic bone marrow stromal cell transplantation in rat model of lacunar infarction
inferred← citeshttps://doi.org/10.1113/jp271502openalex-snapshotMechanisms of microglial activation in models of inflammation and hypoxia: Implications for chronic intermittent hypoxia
inferred← citeshttps://doi.org/10.1155/2016/4854378openalex-snapshotCannabinoid CB2 Receptor Mediates Nicotine-Induced Anti-Inflammation in N9 Microglial Cells Exposed toβAmyloid via Protein Kinase C
inferred← citeshttps://doi.org/10.1186/s12967-025-07388-0openalex-snapshotSingle-cell transcriptome analysis reveals mechanisms by which hippocampal deep brain stimulation promotes neurorepair and microglial subpopulation remodeling in ischemic stroke
inferred← citeshttps://doi.org/10.1186/s12974-017-0866-xopenalex-snapshotYY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodegenerative changes induced by β-amyloid (1-42) or double transgenic overexpression of APP and PS1 via inhibition of cyclooxygenase-2
inferred← citeshttps://doi.org/10.1186/s12974-021-02209-9openalex-snapshotActivation of GPR40 attenuates neuroinflammation and improves neurological function via PAK4/CREB/KDM6B pathway in an experimental GMH rat model
inferred← citeshttps://doi.org/10.1186/s12987-025-00690-5openalex-snapshotImatinib prevents blood-spinal cord barrier disruption by inhibiting PDGFR-mediated JMJD3 expression and activation after spinal cord injury
inferred← citeshttps://doi.org/10.1186/s41232-024-00320-xopenalex-snapshotRapid and high-purity differentiation of human medium spiny neurons reveals LMNB1 hypofunction and subtype necessity in modeling Huntington’s disease
inferred← citeshttps://doi.org/10.18632/aging.100740openalex-snapshotCoronary artery calcifications predict long term cardiovascular events in non diabetic Caucasian hemodialysis patients
inferred← citeshttps://doi.org/10.3389/fendo.2019.00719openalex-snapshotOverexpression of miR-146a Might Regulate Polarization Transitions of BV-2 Cells Induced by High Glucose and Glucose Fluctuations
inferred← citeshttps://doi.org/10.3389/fnagi.2017.00282openalex-snapshotAcute Hypoxia Induced an Imbalanced M1/M2 Activation of Microglia through NF-κB Signaling in Alzheimer’s Disease Mice and Wild-Type Littermates
inferred← citeshttps://doi.org/10.3389/fnins.2016.00061openalex-snapshotInterleukin-4 Ameliorates the Functional Recovery of Intracerebral Hemorrhage Through the Alternative Activation of Microglia/Macrophage
inferred← citeshttps://doi.org/10.3389/fnut.2024.1425839openalex-snapshotNeurodegenerative diseases and catechins: (−)-epigallocatechin-3-gallate is a modulator of chronic neuroinflammation and oxidative stress
inferred← citeshttps://doi.org/10.3390/antiox12061281openalex-snapshotAnti-Neuroinflammatory Effects of the Human Milk Oligosaccharide, 2′-Fucosyllactose, Exerted via Modulation of M2 Microglial Activation in a Mouse Model of Ischemia–Reperfusion Injury
inferred← citeshttps://doi.org/10.3390/biology14080955openalex-snapshotExercise Ameliorates Dopaminergic Neurodegeneration in Parkinson’s Disease Mice by Suppressing Microglia-Regulated Neuroinflammation Through Irisin/AMPK/Sirt1 Pathway
inferred← citeshttps://doi.org/10.3390/ijms21239074openalex-snapshotSynthesis, Molecular Modeling and Biological Evaluation of Metabolically Stable Analogues of the Endogenous Fatty Acid Amide Palmitoylethanolamide
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