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Ursodeoxycholic acid and 4-phenylbutyrate prevent endoplasmic reticulum stress-induced podocyte apoptosis in diabetic nephropathy

https://doi.org/10.1038/labinvest.2016.44

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1159/000488231openalex-snapshot

High Glucose-Induced Podocyte Injury Involves Activation of Mammalian Target of Rapamycin (mTOR)-Induced Endoplasmic Reticulum (ER) Stress

inferred← citeshttps://doi.org/10.1186/s10020-023-00745-zopenalex-snapshot

The potential mechanism of gut microbiota-microbial metabolites-mitochondrial axis in progression of diabetic kidney disease

inferred← citeshttps://doi.org/10.1186/s12882-025-03977-9openalex-snapshot

Ursodeoxycholic acid protects against sepsis-induced acute kidney injury by activating Nrf2/HO-1 and inhibiting NF-κB pathway

inferred← citeshttps://doi.org/10.1186/s12967-025-06076-3openalex-snapshot

Targeting endoplasmic reticulum stress: an innovative therapeutic strategy for podocyte-related kidney diseases

inferred← citeshttps://doi.org/10.1186/s13020-026-01423-yopenalex-snapshot

Ureic clearance granule ameliorates chronic kidney disease by reshaping microbial dysbiosis via modulating bile acid metabolism

inferred← citeshttps://doi.org/10.1371/journal.pone.0201481openalex-snapshot

Effect of sodium 4-phenylbutyrate on Clenbuterol-mediated muscle growth

inferred← citeshttps://doi.org/10.1507/endocrj.ej22-0544openalex-snapshot

The role of bile acids in regulating glucose and lipid metabolism

inferred← citeshttps://doi.org/10.1515/dine-2023-0006openalex-snapshot

Research progress of autophagy in pathogenesis of diabetes nephropathy

inferred← citeshttps://doi.org/10.1681/asn.2021040431openalex-snapshot

CHOP-ASO Ameliorates Glomerular and Tubular Damage on Top of ACE Inhibition in Diabetic Kidney Disease

inferred← citeshttps://doi.org/10.17179/excli2018-1353openalex-snapshot

Is autophagy associated with diabetes mellitus and its complications? A review

inferred← citeshttps://doi.org/10.18632/oncotarget.24295openalex-snapshot

Notoginsenoside R1 ameliorates diabetic encephalopathy by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation

inferred← citeshttps://doi.org/10.21203/rs.3.rs-53219/v1openalex-snapshot

Network Pharmacology-based Prediction of Mechanism of Shenzhuo Formula for Application to DN

inferred← citeshttps://doi.org/10.21518/2079-701x-2019-6-86-94openalex-snapshot

Non-alcoholic fatty liver disease associated with obesity: features ursodeoxycholic acid

inferred← citeshttps://doi.org/10.3389/fendo.2023.1139444openalex-snapshot

Autophagy and its therapeutic potential in diabetic nephropathy

inferred← citeshttps://doi.org/10.3389/fendo.2023.1182848openalex-snapshot

Endoplasmic reticulum homeostasis: a potential target for diabetic nephropathy

inferred← citeshttps://doi.org/10.3389/fendo.2026.1908356openalex-snapshot

The effects of ursodeoxycholic acid on albuminuria in people with type 1 diabetes and diabetic kidney disease: a proof-of-concept study

inferred← citeshttps://doi.org/10.3389/fimmu.2022.1090989openalex-snapshot

Epigenetics and endoplasmic reticulum in podocytopathy during diabetic nephropathy progression

inferred← citeshttps://doi.org/10.3389/fmmed.2022.971247openalex-snapshot

The IRE1α pathway in glomerular diseases: The unfolded protein response and beyond

inferred← citeshttps://doi.org/10.3389/fphar.2016.00500openalex-snapshot

Astragaloside IV Attenuates Podocyte Apoptosis Mediated by Endoplasmic Reticulum Stress through Upregulating Sarco/Endoplasmic Reticulum Ca2+-ATPase 2 Expression in Diabetic Nephropathy

inferred← citeshttps://doi.org/10.3389/fphar.2022.977410openalex-snapshot

The critical role of dysregulated autophagy in the progression of diabetic kidney disease

inferred← citeshttps://doi.org/10.3389/fphar.2023.1097206openalex-snapshot

Therapeutic potential of artemisinin and its derivatives in managing kidney diseases

inferred← citeshttps://doi.org/10.3389/fphar.2023.1174415openalex-snapshot

The role of Chinese herbal medicine in the treatment of diabetic nephropathy by regulating endoplasmic reticulum stress

inferred← citeshttps://doi.org/10.3389/fphar.2025.1586333openalex-snapshot

Exploration of the renoprotective effect of Yi-Shen-Hua-Shi granules on db/db mice and the mechanism of podocyte apoptosis based on the GRP78/CHOP signaling pathway

inferred← citeshttps://doi.org/10.3389/fphar.2025.1621590openalex-snapshot

Broad-spectrum therapeutic potential of 4-phenylbutyrate in neurological and systemic diseases of viral and non-viral origin

inferred← citeshttps://doi.org/10.3389/fphar.2026.1875777openalex-snapshot

The dysregulated unfolded protein response in diabetic kidney disease: mechanisms and crosstalk with cell death pathways

inferred← citeshttps://doi.org/10.3390/antiox11071355openalex-snapshot

Demethylation of H3K9 and H3K27 Contributes to the Tubular Renal Damage Triggered by Endoplasmic Reticulum Stress

inferred← citeshttps://doi.org/10.3390/ijms24087209openalex-snapshot

Ursodeoxycholic Acid Binds PERK and Ameliorates Neurite Atrophy in a Cellular Model of GM2 Gangliosidosis

inferred← citeshttps://doi.org/10.3390/ijms27052491openalex-snapshot

Identification of Common Genes Regulated by ER Stress During the Development of Diabetic Nephropathy Based on Human Transcriptome Datasets and an In Vivo Mouse Model

inferred← citeshttps://doi.org/10.3390/life12091301openalex-snapshot

The Role of 4-Phenylbutyric Acid in Gut Microbial Dysbiosis in a Mouse Model of Simulated Microgravity

inferred← citeshttps://doi.org/10.3390/molecules23030522openalex-snapshot

Inhibiting the NLRP3 Inflammasome Activation with MCC950 Ameliorates Diabetic Encephalopathy in db/db Mice

inferred← citeshttps://doi.org/10.3390/nu8100589openalex-snapshot

Tauroursodeoxycholic Acid Attenuates Renal Tubular Injury in a Mouse Model of Type 2 Diabetes

inferred← citeshttps://doi.org/10.3748/wjg.v22.i39.8698openalex-snapshot

Improved glucose metabolism following bariatric surgery is associated with increased circulating bile acid concentrations and remodeling of the gut microbiome

inferred← citeshttps://doi.org/10.3892/etm.2019.7524openalex-snapshot

Identification of potential therapeutic target genes in mouse mesangial cells associated with diabetic nephropathy using bioinformatics analysis

inferred← citeshttps://doi.org/10.3892/mmr.2017.7388openalex-snapshot

Epigallocatechin-3-gallate protects from high glucose induced podocyte apoptosis via suppressing endoplasmic reticulum stress

inferred← citeshttps://doi.org/10.52756/ijerr.2024.v45spl.017openalex-snapshot

Role of 4-Phenylbutyric Acid in DNA and Protein Binding and its Functional Analysis

inferred← citeshttps://doi.org/10.53846/goediss-6492openalex-snapshot

Dysferlin in skeletal and heart muscle: from trafficking to therapy

inferred← citeshttps://doi.org/10.53941/hm.2025.100002openalex-snapshot

Gut Microbiota and Their Metabolites as Modulators of Vascular Complications in Diabetes

inferred← citeshttps://doi.org/10.70675/36e8b2eezb42ez4ac4zac09z6f519c78839aopenalex-snapshot

Étude du rôle des calpaïnes dans les complications microvasculaires du diabète

inferred← citeshttps://doi.org/10.70675/d49db0dfz905cz4a5dz8148z6c7e4e79cbb2openalex-snapshot

Régulation des fonctions des myofibroblastes portaux par le stress du réticulum endoplasmique

inferred← citeshttps://doi.org/10.71193/jcid.20250009openalex-snapshot

Evaluation of anti-obesogenic and anti-diabetic effects of tauroursodeoxycholic acid in Swiss albino rats: possible blockage of CHOP-dependent mitochondrial shuttling of TBP-2 and antagonism of streptozotocin-induced type 2 diabetes

inferred← citeshttps://doi.org/10.71193/jmct.20260012openalex-snapshot

Tauroursodeoxycholic Acid Protect Against Type 2 Diabetes Through Suppression of Pancreatic TBP-2 and Preservation of Thioredoxin Activity

inferred← citeshttps://doi.org/10.7150/ijbs.100394openalex-snapshot

Mechanisms of hepatic and renal injury in lipid metabolism disorders in metabolic syndrome

inferred← citeshttps://doi.org/10.7150/ijbs.83040openalex-snapshot

Inhibition of BRD4 Attenuates ER Stress-induced Renal Ischemic-Reperfusion Injury

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