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SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/cbic.201000246openalex-snapshot
Modulation of Shank3 PDZ Domain Ligand‐Binding Affinity by Dimerization
inferredcites →https://doi.org/10.1006/bbrc.1999.1489openalex-snapshot
Proline-Rich Synapse-Associated Proteins ProSAP1 and ProSAP2 Interact with Synaptic Proteins of the SAPAP/GKAP Family
inferredcites →https://doi.org/10.1006/mcne.2000.0940openalex-snapshot
Sharpin, a Novel Postsynaptic Density Protein That Directly Interacts with the Shank Family of Proteins
inferredcites →https://doi.org/10.1016/j.ajhg.2009.10.004openalex-snapshot
CNTNAP2 and NRXN1 Are Mutated in Autosomal-Recessive Pitt-Hopkins-like Mental Retardation and Determine the Level of a Common Synaptic Protein in Drosophila
inferredcites →https://doi.org/10.1016/j.cell.2004.07.019openalex-snapshot
Lamellipodial Versus Filopodial Mode of the Actin Nanomachinery
inferredcites →https://doi.org/10.1016/j.conb.2005.12.001openalex-snapshot
Molecular mechanisms of dendritic spine morphogenesis
inferredcites →https://doi.org/10.1016/j.mcn.2005.03.013openalex-snapshot
Ontogeny of postsynaptic density proteins at glutamatergic synapses
inferredcites →https://doi.org/10.1016/j.neuint.2007.04.029openalex-snapshot
Role of actin cytoskeleton in dendritic spine morphogenesis
inferredcites →https://doi.org/10.1016/j.neuron.2008.01.013openalex-snapshot
The Subspine Organization of Actin Fibers Regulates the Structure and Plasticity of Dendritic Spines
inferredcites →https://doi.org/10.1016/j.tig.2010.05.007openalex-snapshot
Key role for gene dosage and synaptic homeostasis in autism spectrum disorders
inferredcites →https://doi.org/10.1016/s0140-6736(06)69041-7openalex-snapshot
Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP)
inferredcites →https://doi.org/10.1016/s0896-6273(00)80809-0openalex-snapshot
Shank, a Novel Family of Postsynaptic Density Proteins that Binds to the NMDA Receptor/PSD-95/GKAP Complex and Cortactin
inferredcites →https://doi.org/10.1016/s0896-6273(01)00339-7openalex-snapshot
Regulation of Dendritic Spine Morphology and Synaptic Function by Shank and Homer
inferredcites →https://doi.org/10.1038/35060051openalex-snapshot
Activation of Arp2/3 complex-mediated actin polymerization by cortactin
inferredcites →https://doi.org/10.1038/emboj.2010.336openalex-snapshot
Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation
inferredcites →https://doi.org/10.1038/nature07458openalex-snapshot
Copy-number variations associated with neuropsychiatric conditions
inferredcites →https://doi.org/10.1038/nature09146openalex-snapshot
Functional impact of global rare copy number variation in autism spectrum disorders
inferredcites →https://doi.org/10.1038/ncb1325openalex-snapshot
mPins modulates PSD-95 and SAP102 trafficking and influences NMDA receptor surface expression
inferredcites →https://doi.org/10.1038/ncb990openalex-snapshot
NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex
inferredcites →https://doi.org/10.1038/ng.589openalex-snapshot
Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation
inferredcites →https://doi.org/10.1038/ng1136openalex-snapshot
Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism
inferredcites →https://doi.org/10.1038/ng1933openalex-snapshot
Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders
inferredcites →https://doi.org/10.1038/nn811openalex-snapshot
Rapid turnover of actin in dendritic spines and its regulation by activity
inferredcites →https://doi.org/10.1038/nrn2373openalex-snapshot
Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy
inferredcites →https://doi.org/10.1038/sj.ejhg.5202006openalex-snapshot
Familial deletion within NLGN4 associated with autism and Tourette syndrome
inferredcites →https://doi.org/10.1046/j.1471-4159.2002.00931.xopenalex-snapshot
ProSAP/Shank proteins – a family of higher order organizing molecules of the postsynaptic density with an emerging role in human neurological disease
inferredcites →https://doi.org/10.1073/pnas.0906232107openalex-snapshot
De novo mutations in the gene encoding the synaptic scaffolding protein SHANK3 in patients ascertained for schizophrenia
inferredcites →https://doi.org/10.1073/pnas.80.6.1738openalex-snapshot
Immunocytochemical localization of actin and microtubule-associated protein MAP2 in dendritic spines.
inferredcites →https://doi.org/10.1074/jbc.m102454200openalex-snapshot
Synaptic Scaffolding Proteins in Rat Brain
inferredcites →https://doi.org/10.1074/jbc.m301052200openalex-snapshot
The Shank Family of Postsynaptic Density Proteins Interacts with and Promotes Synaptic Accumulation of the βPIX Guanine Nucleotide Exchange Factor for Rac1 and Cdc42
inferredcites →https://doi.org/10.1074/jbc.m504450200openalex-snapshot
Interaction of SPIN90 with the Arp2/3 Complex Mediates Lamellipodia and Actin Comet Tail Formation
inferredcites →https://doi.org/10.1074/jbc.m601101200openalex-snapshot
ProSAP-interacting Protein 1 (ProSAPiP1), a Novel Protein of the Postsynaptic Density That Links the Spine-associated Rap-Gap (SPAR) to the Scaffolding Protein ProSAP2/Shank3
inferredcites →https://doi.org/10.1074/jbc.m801555200openalex-snapshot
N-WASP and the Arp2/3 Complex Are Critical Regulators of Actin in the Development of Dendritic Spines and Synapses
inferredcites →https://doi.org/10.1086/321293openalex-snapshot
Disruption of the ProSAP2 Gene in a t(12;22)(q24.1;q13.3) Is Associated with the 22q13.3 Deletion Syndrome
inferredcites →https://doi.org/10.1086/382137openalex-snapshot
X-Linked Mental Retardation and Autism Are Associated with a Mutation in the NLGN4 Gene, a Member of the Neuroligin Family
inferredcites →https://doi.org/10.1086/522590openalex-snapshot
Contribution of SHANK3 Mutations to Autism Spectrum Disorder
inferredcites →https://doi.org/10.1091/mbc.e09-07-0596openalex-snapshot
Molecular Architecture of Synaptic Actin Cytoskeleton in Hippocampal Neurons Reveals a Mechanism of Dendritic Spine Morphogenesis
inferredcites →https://doi.org/10.1111/j.1471-4159.2004.02910.xopenalex-snapshot
C‐terminal synaptic targeting elements for postsynaptic density proteins ProSAP1/Shank2 and ProSAP2/Shank3
inferredcites →https://doi.org/10.1113/jphysiol.1996.sp021603openalex-snapshot
Calcium‐induced inactivation of NMDA receptor‐channels evolves independently of run‐down in cultured rat brain neurones.
inferredcites →https://doi.org/10.1126/science.1118995openalex-snapshot
An Architectural Framework That May Lie at the Core of the Postsynaptic Density
inferredcites →https://doi.org/10.1128/mcb.18.10.5838openalex-snapshot
Identification of a Novel Cortactin SH3 Domain-Binding Protein and Its Localization to Growth Cones of Cultured Neurons
inferredcites →https://doi.org/10.1128/mcb.24.24.10905-10922.2004openalex-snapshot
Abi2-Deficient Mice Exhibit Defective Cell Migration, Aberrant Dendritic Spine Morphogenesis, and Deficits in Learning and Memory
inferredcites →https://doi.org/10.1146/annurev.publhealth.28.021406.144007openalex-snapshot
The Epidemiology of Autism Spectrum Disorders
inferredcites →https://doi.org/10.1176/appi.ajp.162.6.1133openalex-snapshot
Pervasive Developmental Disorders in Preschool Children: Confirmation of High Prevalence
inferredcites →https://doi.org/10.1242/jcs.113.11.1851openalex-snapshot
The Shank family of scaffold proteins
inferredcites →https://doi.org/10.1371/journal.pone.0000400openalex-snapshot
Regulation of N-WASP and the Arp2/3 Complex by Abp1 Controls Neuronal Morphology
inferredcites →https://doi.org/10.1523/jneurosci.0336-08.2008openalex-snapshot
The Actin-Binding Protein Abp1 Controls Dendritic Spine Morphology and Is Important for Spine Head and Synapse Formation
inferredcites →https://doi.org/10.1523/jneurosci.0522-06.2006openalex-snapshot
Differential Control of Postsynaptic Density Scaffolds via Actin-Dependent and -Independent Mechanisms
inferredcites →https://doi.org/10.1523/jneurosci.1070-07.2007openalex-snapshot
Fast Regulation of Axonal Growth Cone Motility by Electrical Activity
inferredcites →https://doi.org/10.1523/jneurosci.20-03-01260.2000openalex-snapshot
A Developmental Change in NMDA Receptor-Associated Proteins at Hippocampal Synapses
inferredcites →https://doi.org/10.1523/jneurosci.23-15-06327.2003openalex-snapshot
Inhibition of Dendritic Spine Morphogenesis and Synaptic Transmission by Activity-Inducible Protein Homer1a
inferredcites →https://doi.org/10.1523/jneurosci.23-37-11759.2003openalex-snapshot
Activity-Dependent Redistribution and Essential Role of Cortactin in Dendritic Spine Morphogenesis
inferredcites →https://doi.org/10.1523/jneurosci.2699-04.2005openalex-snapshot
Postsynaptic Shank Antagonizes Dendrite Branching Induced by the Leucine-Rich Repeat Protein Densin-180
inferredcites →https://doi.org/10.1523/jneurosci.3032-07.2008openalex-snapshot
Smaller Dendritic Spines, Weaker Synaptic Transmission, but Enhanced Spatial Learning in Mice Lacking Shank1
inferredcites →https://doi.org/10.1523/jneurosci.3209-06.2006openalex-snapshot
A WAVE-1 and WRP Signaling Complex Regulates Spine Density, Synaptic Plasticity, and Memory
inferredcites →https://doi.org/10.1523/jneurosci.4354-04.2005openalex-snapshot
Shank Expression Is Sufficient to Induce Functional Dendritic Spine Synapses in Aspiny Neurons
inferredcites →https://doi.org/10.1523/jneurosci.5479-03.2004openalex-snapshot
Linkage of the Actin Cytoskeleton to the Postsynaptic Density via Direct Interactions of Abp1 with the ProSAP/Shank Family
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Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Anatomy and Cell Biology of Autism Spectrum Disorder: Lessons from Human Genetics
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Neurobiology of autism gene products: towards pathogenesis and drug targets
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Developmental profiling of ASD-related shank3 transcripts and their differential regulation by valproic acid in zebrafish
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Common variants in genes of the postsynaptic FMRP signalling pathway are risk factors for autism spectrum disorders
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Amphiphysin I but not dynamin I nor synaptojanin mRNA expression increased after repeated methamphetamine administration in the rat cerebrum and cerebellum
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Expression of SHANK3 in the Temporal Neocortex of Patients with Intractable Temporal Epilepsy and Epilepsy Rat Models
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A commonly carried genetic variant, rs9616915, in SHANK3 gene is associated with a reduced risk of autism spectrum disorder: replication in a Chinese population
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Dopamine and serotonin: overview of the functions and function disorders, leading to neurodegeneration
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SHANK1 Deletions in Males with Autism Spectrum Disorder
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Dysregulation of the Synaptic Cytoskeleton in the PFC Drives Neural Circuit Pathology, Leading to Social Dysfunction
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POSH regulates assembly of the NMDAR/PSD-95/Shank complex and synaptic function
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New insights on synaptic dysfunction in neuropsychiatric disorders
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SHANK3 conformation regulates direct actin binding and crosstalk with Rap1 signaling
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3p14.1 de novo microdeletion involving the FOXP1 gene in an adult patient with autism, severe speech delay and deficit of motor coordination
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Determination of genetic changes in etiology of autism spectrum disorder in twins by whole-exome sequencing
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Shank3B mutant mice display pitch discrimination enhancements and learning deficits
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Dosage-sensitive genes in autism spectrum disorders: From neurobiology to therapy
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Shank3a/b isoforms regulate the susceptibility to seizures and thalamocortical development in the early postnatal period of mice
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Genetic Removal of p70 S6 Kinase 1 Corrects Molecular, Synaptic, and Behavioral Phenotypes in Fragile X Syndrome Mice
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An epigenetic framework for neurodevelopmental disorders: From pathogenesis to potential therapy
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SHANK3 Mutations Associated with Autism and Schizophrenia Lead to Shared and Distinct Changes in Dendritic Spine Dynamics in the Developing Mouse Brain
inferred← citeshttps://doi.org/10.1016/j.niox.2023.09.003openalex-snapshot
Effects of Extended-Release 7-Nitroindazole Gel Formulation Treatment on the Behavior of Shank3 Mouse Model of Autism
inferred← citeshttps://doi.org/10.1016/j.nlm.2018.07.009openalex-snapshot
Neocortical SHANK1 regulation of forebrain dependent associative learning
inferred← citeshttps://doi.org/10.1016/j.nlm.2020.107247openalex-snapshot
Modifications to cytoskeleton-associated proteins in dendritic spines underlie the adaptive plasticity involved in long term reference memory
inferred← citeshttps://doi.org/10.1016/j.phrs.2017.08.006openalex-snapshot
Dendritic spine anomalies and PTEN alterations in a mouse model of VPA-induced autism spectrum disorder
inferred← citeshttps://doi.org/10.1016/j.pnpbp.2017.08.023openalex-snapshot
Dendritic spine actin cytoskeleton in autism spectrum disorder
inferred← citeshttps://doi.org/10.1016/j.pnpbp.2023.110876openalex-snapshot
Structural and biochemical alterations in dendritic spines as key mechanisms for severe mental illnesses
inferred← citeshttps://doi.org/10.1016/j.pnpbp.2025.111496openalex-snapshot
Disentangling the role of tau pathology in autism spectrum disorders
inferred← citeshttps://doi.org/10.1016/j.psychres.2016.07.058openalex-snapshot
Evaluating the association between the SHANK3 gene and bipolar disorder
inferred← citeshttps://doi.org/10.1016/j.ridd.2012.03.025openalex-snapshot
First-degree relatives of young children with autism spectrum disorders: Some gender aspects
inferred← citeshttps://doi.org/10.1016/j.tcb.2011.07.003openalex-snapshot
Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies
inferred← citeshttps://doi.org/10.1016/j.xhgg.2022.100145openalex-snapshot
Large 22q13.3 deletions perturb peripheral transcriptomic and metabolomic profiles in Phelan-McDermid syndrome
inferred← citeshttps://doi.org/10.1038/clpt.2011.245openalex-snapshot
Pathways to Drug Development for Autism Spectrum Disorders
inferred← citeshttps://doi.org/10.1038/ejhg.2012.175openalex-snapshot
Prevalence of SHANK3 variants in patients with different subtypes of autism spectrum disorders
inferred← citeshttps://doi.org/10.1038/mp.2011.163openalex-snapshot
Transcriptome profiling of UPF3B/NMD-deficient lymphoblastoid cells from patients with various forms of intellectual disability
inferred← citeshttps://doi.org/10.1038/mp.2012.102openalex-snapshot
Translational approaches to the biology of Autism: false dawn or a new era?
inferred← citeshttps://doi.org/10.1038/mp.2012.20openalex-snapshot
Modeling psychiatric disorders at the cellular and network levels
inferred← citeshttps://doi.org/10.1038/mp.2013.46openalex-snapshot
The adhesion-GPCR BAI3, a gene linked to psychiatric disorders, regulates dendrite morphogenesis in neurons
inferred← citeshttps://doi.org/10.1038/mp.2014.172openalex-snapshot
Identification and functional characterization of rare SHANK2 variants in schizophrenia
inferred← citeshttps://doi.org/10.1038/mp.2016.103openalex-snapshot
Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects
inferred← citeshttps://doi.org/10.1038/mp.2017.140openalex-snapshot
Targeted sequencing and functional analysis reveal brain-size-related genes and their networks in autism spectrum disorders
inferred← citeshttps://doi.org/10.1038/ncb3487openalex-snapshot
SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras
inferred← citeshttps://doi.org/10.1038/ncomms14907openalex-snapshot
Defective Gpsm2/Gαi3 signalling disrupts stereocilia development and growth cone actin dynamics in Chudley-McCullough syndrome
inferred← citeshttps://doi.org/10.1038/nm.3193openalex-snapshot
Progress toward treatments for synaptic defects in autism
inferred← citeshttps://doi.org/10.1038/nn.4015openalex-snapshot
Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine
inferred← citeshttps://doi.org/10.1038/nrn.2018.16openalex-snapshot
Dendritic structural plasticity and neuropsychiatric disease
inferred← citeshttps://doi.org/10.1038/nrn3992openalex-snapshot
From the genetic architecture to synaptic plasticity in autism spectrum disorder
inferred← citeshttps://doi.org/10.1038/nrneurol.2013.276openalex-snapshot
Neuroimaging in autism—from basic science to translational research
inferred← citeshttps://doi.org/10.1038/s41380-018-0324-xopenalex-snapshot
An autism-linked missense mutation in SHANK3 reveals the modularity of Shank3 function
inferred← citeshttps://doi.org/10.1038/s41380-019-0454-9openalex-snapshot
Foetal oestrogens and autism
inferred← citeshttps://doi.org/10.1038/s41380-021-01140-yopenalex-snapshot
Imbalanced post- and extrasynaptic SHANK2A functions during development affect social behavior in SHANK2-mediated neuropsychiatric disorders
inferred← citeshttps://doi.org/10.1038/s41380-022-01506-wopenalex-snapshot
Genetics of glutamate and its receptors in autism spectrum disorder
inferred← citeshttps://doi.org/10.1038/s41380-022-01603-wopenalex-snapshot
SH3- and actin-binding domains connect ADNP and SHANK3, revealing a fundamental shared mechanism underlying autism
inferred← citeshttps://doi.org/10.1038/s41380-022-01822-1openalex-snapshot
Cntnap2-dependent molecular networks in autism spectrum disorder revealed through an integrative multi-omics analysis
inferred← citeshttps://doi.org/10.1038/s41380-022-01904-0openalex-snapshot
An IGFBP2-derived peptide promotes neuroplasticity and rescues deficits in a mouse model of Phelan-McDermid syndrome
inferred← citeshttps://doi.org/10.1038/s41380-024-02725-zopenalex-snapshot
The multifaceted role of mitochondria in autism spectrum disorder
inferred← citeshttps://doi.org/10.1038/s41392-022-01081-0openalex-snapshot
Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications
inferred← citeshttps://doi.org/10.1038/s41398-018-0194-7openalex-snapshot
Neurofilament light interaction with GluN1 modulates neurotransmission and schizophrenia-associated behaviors
inferred← citeshttps://doi.org/10.1038/s41398-026-03890-1openalex-snapshot
Patient-derived brain organoids reveal divergent neuronal activity across subpopulations of autism spectrum disorder
inferred← citeshttps://doi.org/10.1038/s41398-026-03932-8openalex-snapshot
SHANK3 and beta-synuclein are novel blood-based biomarkers for the Phelan-McDermid Syndrome: a pilot study
inferred← citeshttps://doi.org/10.1038/s41436-021-01222-wopenalex-snapshot
Truncating variants in the SHANK1 gene are associated with a spectrum of neurodevelopmental disorders
inferred← citeshttps://doi.org/10.1038/s41467-017-00472-0openalex-snapshot
An autism spectrum disorder-related de novo mutation hotspot discovered in the GEF1 domain of Trio
inferred← citeshttps://doi.org/10.1038/s41467-025-57699-5openalex-snapshot
PTN activity in quiescent neural stem cells mediates Shank3 overexpression-induced manic behavior
inferred← citeshttps://doi.org/10.1038/s41525-021-00254-0openalex-snapshot
A recurrent SHANK3 frameshift variant in Autism Spectrum Disorder
inferred← citeshttps://doi.org/10.1038/s41582-023-00896-xopenalex-snapshot
Rare genetic brain disorders with overlapping neurological and psychiatric phenotypes
inferred← citeshttps://doi.org/10.1038/s41598-017-02348-1openalex-snapshot
Genetic variants in the transcription regulatory region of MEGF10 are associated with autism in Chinese Han population
inferred← citeshttps://doi.org/10.1038/s41598-018-36993-xopenalex-snapshot
Altered spinogenesis in iPSC-derived cortical neurons from patients with autism carrying de novo SHANK3 mutations
inferred← citeshttps://doi.org/10.1038/s41598-020-70056-4openalex-snapshot
A chimeric mouse model to study human iPSC-derived neurons: the case of a truncating SHANK3 mutation
inferred← citeshttps://doi.org/10.1038/s42003-025-08530-wopenalex-snapshot
Male caregiving experience alters hippocampal neuroplasticity and transcription independent of reproduction in a biparental species
inferred← citeshttps://doi.org/10.1038/s42003-026-10660-8openalex-snapshot
Disrupted cortex-wide dynamics impair motor planning in Shank3-mutant mice
inferred← citeshttps://doi.org/10.1038/srep28548openalex-snapshot
Autism phenotypes in ZnT3 null mice: Involvement of zinc dyshomeostasis, MMP-9 activation and BDNF upregulation
inferred← citeshttps://doi.org/10.1038/tp.2014.16openalex-snapshot
The autism and schizophrenia associated gene CYFIP1 is critical for the maintenance of dendritic complexity and the stabilization of mature spines
inferred← citeshttps://doi.org/10.1038/tp.2017.111openalex-snapshot
Mice lacking the chromodomain helicase DNA-binding 5 chromatin remodeler display autism-like characteristics
inferred← citeshttps://doi.org/10.1038/tp.2017.170openalex-snapshot
A novel rare variant R292H in RTN4R affects growth cone formation and possibly contributes to schizophrenia susceptibility
inferred← citeshttps://doi.org/10.1055/s-0037-1602823openalex-snapshot
Drug Treatments for Core Symptoms of Autism Spectrum Disorder: Unmet Needs and Future Directions
inferred← citeshttps://doi.org/10.1074/jbc.m111.258384openalex-snapshot
Importance of Shank3 Protein in Regulating Metabotropic Glutamate Receptor 5 (mGluR5) Expression and Signaling at Synapses
inferred← citeshttps://doi.org/10.1074/jbc.m111.279661openalex-snapshot
Dileucine and PDZ-binding Motifs Mediate Synaptic Adhesion-like Molecule 1 (SALM1) Trafficking in Hippocampal Neurons
inferred← citeshttps://doi.org/10.1074/jbc.m112.424747openalex-snapshot
SHANK3 Gene Mutations Associated with Autism Facilitate Ligand Binding to the Shank3 Ankyrin Repeat Region
inferred← citeshttps://doi.org/10.1074/mcp.m115.055079openalex-snapshot
Analysis of Proteins That Rapidly Change Upon Mechanistic/Mammalian Target of Rapamycin Complex 1 (mTORC1) Repression Identifies Parkinson Protein 7 (PARK7) as a Novel Protein Aberrantly Expressed in Tuberous Sclerosis Complex (TSC)
inferred← citeshttps://doi.org/10.1080/19420889.2015.1114194openalex-snapshot
Novel functions for ADF/cofilin in excitatory synapses - lessons from gene-targeted mice
inferred← citeshttps://doi.org/10.1088/0034-4885/76/7/074601openalex-snapshot
Control of flux by narrow passages and hidden targets in cellular biology
inferred← citeshttps://doi.org/10.1093/cercor/bhad268openalex-snapshot
Increased number of excitatory synapsis and decreased number of inhibitory synapsis in the prefrontal cortex in autism
inferred← citeshttps://doi.org/10.1093/cercor/bhx333openalex-snapshot
Sestd1 Encodes a Developmentally Dynamic Synapse Protein That Complexes With BCR Rac1-GAP to Regulate Forebrain Dendrite, Spine and Synapse Formation
inferred← citeshttps://doi.org/10.1093/hmg/ddab233openalex-snapshot
The autism risk gene CNTN4 modulates dendritic spine formation
inferred← citeshttps://doi.org/10.1093/hmg/ddab277openalex-snapshot
Neuroligin-3 and neuroligin-4X form nanoscopic clusters and regulate growth cone organization and size
inferred← citeshttps://doi.org/10.1093/hmg/ddv138openalex-snapshot
Two knockdown models of the autism genes SYNGAP1 and SHANK3 in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis
inferred← citeshttps://doi.org/10.1093/hmg/ddw102openalex-snapshot
Fasudil treatment in adult reverses behavioural changes and brain ventricular enlargement in Oligophrenin-1 mouse model of intellectual disability
inferred← citeshttps://doi.org/10.1093/nar/gkaf934openalex-snapshot
Disrupted transcriptional networks regulated by CHD1L during neurodevelopment underlie the mirrored neuroanatomical and growth phenotypes of the 1q21.1 copy number variant
inferred← citeshttps://doi.org/10.1093/schbul/sbu147openalex-snapshot
Identification of Rare, Single-Nucleotide Mutations in NDE1 and Their Contributions to Schizophrenia Susceptibility
inferred← citeshttps://doi.org/10.1098/rstb.2013.0143openalex-snapshot
Shank mutant mice as an animal model of autism
inferred← citeshttps://doi.org/10.1101/2020.07.31.230656openalex-snapshot
SK3-overexpression drives sex-dimorphic working and social memory impairment in mice
inferred← citeshttps://doi.org/10.1101/2020.11.12.379222openalex-snapshot
Conformational dynamics regulate SHANK3 actin and Rap1 binding
inferred← citeshttps://doi.org/10.1101/2023.12.15.571360openalex-snapshot
NMDAR Phosphoproteome Controls Synaptic Growth and Learning
inferred← citeshttps://doi.org/10.1101/2025.11.05.685843openalex-snapshot
A spatial transcriptomic atlas of autism-associated genes identifies convergence in the developing human thalamus
inferred← citeshttps://doi.org/10.1111/dmcn.15482openalex-snapshot
Neurodevelopmental profile and stages of regression in Phelan– McDermid syndrome
inferred← citeshttps://doi.org/10.1111/ejn.12510openalex-snapshot
Synaptic basis of social dysfunction: a focus on postsynaptic proteins linking group‐ I m G lu R s with AMPAR s and NMDAR s
inferred← citeshttps://doi.org/10.1111/ejn.12877openalex-snapshot
Shank1 regulates excitatory synaptic transmission in mouse hippocampal parvalbumin‐expressing inhibitory interneurons
inferred← citeshttps://doi.org/10.1111/ejn.13129openalex-snapshot
Shank–cortactin interactions control actin dynamics to maintain flexibility of neuronal spines and synapses
inferred← citeshttps://doi.org/10.1111/gbb.12405openalex-snapshot
Comprehensive analysis of two Shank3 and the Cacna1c mouse models of autism spectrum disorder
inferred← citeshttps://doi.org/10.1111/gbb.12767openalex-snapshot
An assessment of executive function in two different rat models of attention‐deficit hyperactivity disorder: Spontaneously hypertensive versus Lphn3 knockout rats
inferred← citeshttps://doi.org/10.1111/gtc.13142openalex-snapshot
An N‐terminal and ankyrin repeat domain interactome of Shank3 identifies the protein complex with the splicing regulator Nono in mice
inferred← citeshttps://doi.org/10.1111/jnc.13232openalex-snapshot
Shank synaptic scaffold proteins: keys to understanding the pathogenesis of autism and other synaptic disorders
inferred← citeshttps://doi.org/10.1111/jnc.13523openalex-snapshot
Shank3 is localized in axons and presynaptic specializations of developing hippocampal neurons and involved in the modulation of NMDA receptor levels at axon terminals
inferred← citeshttps://doi.org/10.1126/scisignal.ado9852openalex-snapshot
Signal flow in the NMDA receptor–dependent phosphoproteome regulates postsynaptic plasticity for aversive learning
inferred← citeshttps://doi.org/10.1126/scitranslmed.aaz3267openalex-snapshot
Autism-associated SHANK3 mutations impair maturation of neuromuscular junctions and striated muscles
inferred← citeshttps://doi.org/10.1136/jmedgenet-2016-104487openalex-snapshot
Genetics implicate common mechanisms in autism and schizophrenia: synaptic activity and immunity
inferred← citeshttps://doi.org/10.1146/annurev-genom-091212-153431openalex-snapshot
The Genetic Landscapes of Autism Spectrum Disorders
inferred← citeshttps://doi.org/10.1152/physrev.00012.2013openalex-snapshot
Dendritic Spines: The Locus of Structural and Functional Plasticity
inferred← citeshttps://doi.org/10.1155/2016/8051861openalex-snapshot
Actin-Dependent Alterations of Dendritic Spine Morphology in Shankopathies
inferred← citeshttps://doi.org/10.1155/2017/8081758openalex-snapshot
Emerging Synaptic Molecules as Candidates in the Etiology of Neurological Disorders
inferred← citeshttps://doi.org/10.1155/2019/2382639openalex-snapshot
Enhanced Glutamatergic Currents at Birth in Shank3 KO Mice
inferred← citeshttps://doi.org/10.1159/000336644openalex-snapshot
Modeling of Autism Genetic Variations in Mice: Focusing on Synaptic and Microcircuit Dysfunctions
inferred← citeshttps://doi.org/10.1159/000363593openalex-snapshot
Molecular Pathways in Autistic Spectrum Disorders
inferred← citeshttps://doi.org/10.1159/000368949openalex-snapshot
SHANK Mutations May Disorder Brain Development
inferred← citeshttps://doi.org/10.1172/jci.insight.92052openalex-snapshot
Deficiency of Shank2 causes mania-like behavior that responds to mood stabilizers
inferred← citeshttps://doi.org/10.1172/jci87997openalex-snapshot
Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism
inferred← citeshttps://doi.org/10.1186/s12864-016-2702-6openalex-snapshot
Genome-wide patterns of copy number variation in the Chinese yak genome
inferred← citeshttps://doi.org/10.1186/s13023-020-01592-5openalex-snapshot
A 29 Mainland Chinese cohort of patients with Phelan–McDermid syndrome: genotype–phenotype correlations and the role of SHANK3 haploinsufficiency in the important phenotypes
inferred← citeshttps://doi.org/10.1186/s13041-015-0165-3openalex-snapshot
Post-transcriptional regulation of SHANK3 expression by microRNAs related to multiple neuropsychiatric disorders
inferred← citeshttps://doi.org/10.1186/s13229-015-0020-5openalex-snapshot
Phenotypic and functional analysis of SHANK3 stop mutations identified in individuals with ASD and/or ID
inferred← citeshttps://doi.org/10.1186/s13229-018-0205-9openalex-snapshot
Delineation of the genetic and clinical spectrum of Phelan-McDermid syndrome caused by SHANK3 point mutations
inferred← citeshttps://doi.org/10.1186/s13229-020-00349-yopenalex-snapshot
Dysregulation of protein synthesis and dendritic spine morphogenesis in ASD: studies in human pluripotent stem cells
inferred← citeshttps://doi.org/10.1186/s13229-020-00355-0openalex-snapshot
Transcriptional signatures of participant-derived neural progenitor cells and neurons implicate altered Wnt signaling in Phelan-McDermid syndrome and autism
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