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Amino Acid Residues in the N-Terminal Region of the PA Subunit of Influenza A Virus RNA Polymerase Play a Critical Role in Protein Stability, Endonuclease Activity, Cap Binding, and Virion RNA Promoter Binding
3’‐Dehydroxypurpurogallin‐4‐Carboxamides as Influenza A Endonuclease Inhibitors: Synthesis, Structure‐Activity Relationship Analysis, and Structural Characterization of Protein Complex
B‐cell lymphoma‐2 family proteins‐activated proteases as potential therapeutic targets for influenza A virus and severe acute respiratory syndrome coronavirus‐2: Killing two birds with one stone?
A DFT-based theoretical approach on the strength of non-covalent interactions of 2,4-dioxo-4-phenylbutanoic acid complex: structural analysis and electronic properties
Computational analysis of the effect of polymerase acidic (PA) gene mutation F35L in the 2009 pandemic influenza A (H1N1) virus on binding aspects of mononucleotides in the endonuclease domain
Synthesis and antinociceptive activity of potassium 1-alkoxy-6-aryl-2-cyano-4-[(3-cyano-4,5,6,7-tetrahydrobenzo[b]-thiophen-2-yl)amino]-1,6-dioxohexa-2,4-dien-3-olates
Effect of E23G/K, F36V, N37T, E119D, and E199G polymerase acidic protein substitutions on the replication and baloxavir susceptibility of influenza B viruses
High throughput profiling identified PA-L106R amino acid substitution in A(H1N1)pdm09 influenza virus that confers reduced susceptibility to baloxavir in vitro
Linking target-based screening to in vivo efficacy in aquaculture: identification of anti-WSSV compounds via a non-specific endonuclease (NSN) platform
Identification of novel inhibitor against endonuclease subunit of Influenza pH1N1 polymerase: A combined molecular docking, molecular dynamics, MMPBSA, QMMM and ADME studies to combat influenza A viruses
Bioinformatics and immunoinformatic approaches for structural modeling and vaccine design of the CCHFV whole genome to develop a novel broad-spectrum multiepitope vaccine candidate
Design and synthesis of 7-membered lactam fused hydroxypyridinones as potent metal binding pharmacophores (MBPs) for inhibiting influenza virus PAN endonuclease
The N-terminal fragment of PA subunit of the influenza A virus effectively inhibits ribonucleoprotein (RNP) activity via suppression of its RNP expression
Establishment of an at-line nanofractionation-based screening platform for rapid identification of influenza PAN/PAN I38T inhibitors from Artemisiae Argyi Folium
Diels-Alder adducts of 3-N-substituted derivatives of (−)-Cytisine as influenza A/H1N1 virus inhibitors; stereodifferentiation of antiviral properties and preliminary assessment of action mechanism
The N-terminal region of pdm09/H1N1 PA synergizes with its cognate NP to enhance mammalian adaptation of avian-origin H9N2 canine influenza virus
showing the first 200 of 741
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