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Optimization And Biological Evaluation of L-DOPA Derivatives as Potent Influenza PA N Endonuclease Inhibitors Withmulti-Site Binding Characteristics

https://doi.org/10.2139/ssrn.4655402
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Synthesis and SARs of dopamine derivatives as potential inhibitors of influenza virus PAN endonuclease
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Two Distinctive Binding Modes of Endonuclease Inhibitors to the N-Terminal Region of Influenza Virus Polymerase Acidic Subunit
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Identification of N- and C-3-Modified Laudanosoline Derivatives as Novel Influenza PAN Endonuclease Inhibitors
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Fragment-Based Identification of Influenza Endonuclease Inhibitors
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SAR Exploration of Tight-Binding Inhibitors of Influenza Virus PA Endonuclease
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Synthesis and SAR Study of Carbamoyl Pyridone Bicycle Derivatives as Potent Inhibitors of Influenza Cap-dependent Endonuclease
inferredcites →https://doi.org/10.1021/acsmedchemlett.2c00434openalex-extracted
Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors
inferredcites →https://doi.org/10.1021/acsmedchemlett.5b00109openalex-extracted
Virtual Screening and Biological Validation of Novel Influenza Virus PA Endonuclease Inhibitors
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Optimization of Small-Molecule Inhibitors of Influenza Virus Polymerase: From Thiophene-3-Carboxamide to Polyamido Scaffolds
inferredcites →https://doi.org/10.1038/nature06956openalex-extracted
Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants
inferredcites →https://doi.org/10.1038/nature07745openalex-extracted
The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit
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Structural insight into cap-snatching and RNA synthesis by influenza polymerase
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Scientific barriers to developing vaccines against avian influenza viruses
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Cap snatch prevention: a novel approach to tackle influenza viruses
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Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets
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Structures of influenza A virus RNA polymerase offer insight into viral genome replication
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Emerging antiviral therapies and drugs for the treatment of influenza
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Mapping the Antigenic and Genetic Evolution of Influenza Virus
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Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication
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Large-Scale Sequence Analysis of M Gene of Influenza A Viruses from Different Species: Mechanisms for Emergence and Spread of Amantadine Resistance
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Antiviral Approaches against Influenza Virus
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Identification of tanshinone I as cap-dependent endonuclease inhibitor with broad-spectrum antiviral effect
inferredcites →https://doi.org/10.1128/jvi.00832-13openalex-extracted
Mutational Analysis of the Binding Pockets of the Diketo Acid Inhibitor L-742,001 in the Influenza Virus PA Endonuclease
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High-throughput super-resolution analysis of influenza virus pleomorphism reveals insights into viral spatial organization
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