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Structure and mechanism of human DNA polymerase η

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/em.1046openalex-snapshot

A single (6‐4) photoproduct inhibits plasmid DNA replication in xeroderma pigmentosum variant cell extracts

inferredcites →https://doi.org/10.1002/j.1460-2075.1990.tb08287.xopenalex-snapshot

Selenomethionyl proteins produced for analysis by multiwavelength anomalous diffraction (MAD): a vehicle for direct determination of three‐dimensional structure.

inferredcites →https://doi.org/10.1002/prot.340110407openalex-snapshot

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

inferredcites →https://doi.org/10.1007/978-0-387-09599-8_6openalex-snapshot

XPC: Its Product and Biological Roles

inferredcites →https://doi.org/10.1007/978-94-011-7589-0_2openalex-snapshot

The active site

inferredcites →https://doi.org/10.1016/0076-6879(95)62021-4openalex-snapshot

[19] Gel fidelity assay measuring nucleotide misinsertion, exonucleolytic proofreading, and lesion bypass efficiencies

inferredcites →https://doi.org/10.1016/0092-8674(95)90190-6openalex-snapshot

Atomic model of a pyrimidine dimer excision repair enzyme complexed with a dna substrate: Structural basis for damaged DNA recognition

inferredcites →https://doi.org/10.1016/j.cell.2006.05.013openalex-snapshot

An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor

inferredcites →https://doi.org/10.1016/j.cell.2008.10.045openalex-snapshot

Structural Basis of UV DNA-Damage Recognition by the DDB1–DDB2 Complex

inferredcites →https://doi.org/10.1016/j.cell.2009.11.043openalex-snapshot

Structural Insight into Translesion Synthesis by DNA Pol II

inferredcites →https://doi.org/10.1016/j.critrevonc.2004.08.008openalex-snapshot

Recognition and processing of cisplatin- and oxaliplatin-DNA adducts

inferredcites →https://doi.org/10.1016/j.dnarep.2006.02.004openalex-snapshot

Poor base stacking at DNA lesions may initiate recognition by many repair proteins

inferredcites →https://doi.org/10.1016/j.dnarep.2007.02.003openalex-snapshot

Translesion synthesis: Y-family polymerases and the polymerase switch

inferredcites →https://doi.org/10.1016/j.ejca.2009.04.034openalex-snapshot

Variants of the xeroderma pigmentosum variant gene (POLH) are associated with melanoma risk

inferredcites →https://doi.org/10.1016/j.jmb.2009.04.029openalex-snapshot

Polymerase-Tailored Variations in the Water-Mediated and Substrate-Assisted Mechanism for Nucleotidyl Transfer: Insights from a Study of T7 DNA Polymerase

inferredcites →https://doi.org/10.1016/j.molcel.2005.10.001openalex-snapshot

Human DNA Polymerase η Promotes DNA Synthesis from Strand Invasion Intermediates of Homologous Recombination

inferredcites →https://doi.org/10.1016/j.molcel.2005.10.016openalex-snapshot

Dual Roles for DNA Polymerase η in Homologous DNA Recombination and Translesion DNA Synthesis

inferredcites →https://doi.org/10.1016/j.molcel.2007.01.018openalex-snapshot

Human DNA Polymerase κ Encircles DNA: Implications for Mismatch Extension and Lesion Bypass

inferredcites →https://doi.org/10.1016/j.molcel.2008.01.014openalex-snapshot

Structural Insights into the Generation of Single-Base Deletions by the Y Family DNA Polymerase Dbh

inferredcites →https://doi.org/10.1016/j.tibs.2008.02.004openalex-snapshot

Lesion processing: high-fidelity versus lesion-bypass DNA polymerases

inferredcites →https://doi.org/10.1016/s0076-6879(97)76066-xopenalex-snapshot

[20] Processing of X-ray diffraction data collected in oscillation mode

inferredcites →https://doi.org/10.1016/s0092-8674(01)00515-3openalex-snapshot

Crystal Structure of a Y-Family DNA Polymerase in Action

inferredcites →https://doi.org/10.1016/s0168-9525(97)01246-8openalex-snapshot

Sunlight and the onset of skin cancer

inferredcites →https://doi.org/10.1016/s1097-2765(01)00306-9openalex-snapshot

Structure of the Catalytic Core of S. cerevisiae DNA Polymerase η

inferredcites →https://doi.org/10.1016/s1097-2765(04)00101-7openalex-snapshot

Snapshots of Replication through an Abasic Lesion

inferredcites →https://doi.org/10.1021/bi025549kopenalex-snapshot

Translesion Synthesis by Human DNA Polymerase η across Thymine Glycol Lesions

inferredcites →https://doi.org/10.1021/bi035359popenalex-snapshot

Efficiency of Extension of Mismatched Primer Termini across from Cisplatin and Oxaliplatin Adducts by Human DNA Polymerases β and η in Vitro

inferredcites →https://doi.org/10.1038/21447openalex-snapshot

The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η

inferredcites →https://doi.org/10.1038/jid.2008.48openalex-snapshot

Xeroderma Pigmentosum-Variant Patients from America, Europe, and Asia

inferredcites →https://doi.org/10.1038/nature01919openalex-snapshot

Replication of a cis–syn thymine dimer at atomic resolution

inferredcites →https://doi.org/10.1038/nature02352openalex-snapshot

Preferential cis–syn thymine dimer bypass by DNA polymerase η occurs with biased fidelity

inferredcites →https://doi.org/10.1038/nature04318openalex-snapshot

A single amino acid governs enhanced activity of DinB DNA polymerases on damaged templates

inferredcites →https://doi.org/10.1038/nature06155openalex-snapshot

Recognition of DNA damage by the Rad4 nucleotide excision repair protein

inferredcites →https://doi.org/10.1038/nature07580openalex-snapshot

RAD6–RAD18–RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light

inferredcites →https://doi.org/10.1038/nsmb1268openalex-snapshot

Rad54 dissociates homologous recombination intermediates by branch migration

inferredcites →https://doi.org/10.1038/nsmb792openalex-snapshot

Nucleotide insertion opposite a cis-syn thymine dimer by a replicative DNA polymerase from bacteriophage T7

inferredcites →https://doi.org/10.1038/sj.jid.5700759openalex-snapshot

Molecular Analysis of DNA Polymerase Eta Gene in Japanese Patients Diagnosed as Xeroderma Pigmentosum Variant Type

inferredcites →https://doi.org/10.1073/pnas.022473899openalex-snapshot

Molecular analysis of mutations in DNA polymerase η in xeroderma pigmentosum-variant patients

inferredcites →https://doi.org/10.1073/pnas.0700717104openalex-snapshot

A structural gap in Dpo4 supports mutagenic bypass of a major benzo[ a ]pyrene dG adduct in DNA through template misalignment

inferredcites →https://doi.org/10.1073/pnas.0704219104openalex-snapshot

What a difference a decade makes: Insights into translesion DNA synthesis

inferredcites →https://doi.org/10.1073/pnas.242422699openalex-snapshot

Crystal structure of a DNA decamer containing a cis-syn thymine dimer

inferredcites →https://doi.org/10.1074/jbc.m308515200openalex-snapshot

The Efficiency and Specificity of Apurinic/Apyrimidinic Site Bypass by Human DNA Polymerase η and Sulfolobus solfataricus Dpo4

inferredcites →https://doi.org/10.1093/emboj/19.12.3100openalex-snapshot

Mechanisms of accurate translesion synthesis by human DNA polymerase η

inferredcites →https://doi.org/10.1093/emboj/20.24.7303openalex-snapshot

Mutations in human DNA polymerase η motif II alter bypass of DNA lesions

inferredcites →https://doi.org/10.1093/nar/gkm216openalex-snapshot

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

inferredcites →https://doi.org/10.1093/nar/gkn719openalex-snapshot

The N-clasp of human DNA polymerase κ promotes blockage or error-free bypass of adenine- or guanine-benzo[a]pyrenyl lesions

inferredcites →https://doi.org/10.1098/rstb.2008.0188openalex-snapshot

Hijacked DNA repair proteins and unchained DNA polymerases

inferredcites →https://doi.org/10.1107/s0021889807021206openalex-snapshot

Phaser crystallographic software

inferredcites →https://doi.org/10.1107/s0907444906045975openalex-snapshot

Solving structures of protein complexes by molecular replacement with Phaser

inferredcites →https://doi.org/10.1107/s0907444909047337openalex-snapshot

XDS

inferredcites →https://doi.org/10.1107/s0907444910007493openalex-snapshot

Features and development of Coot

inferredcites →https://doi.org/10.1107/s0907444994003112openalex-snapshot

The CCP4 suite: programs for protein crystallography

inferredcites →https://doi.org/10.1107/s0907444998003254openalex-snapshot

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

inferredcites →https://doi.org/10.1107/s0907444999000839openalex-snapshot

Automated MAD and MIR structure solution

inferredcites →https://doi.org/10.1111/j.1365-2443.2004.00797.xopenalex-snapshot

DNA binding properties of human DNA polymerase η: implications for fidelity and polymerase switching of translesion synthesis

inferredcites →https://doi.org/10.1126/science.1101598openalex-snapshot

Crystal Structure of a Photolyase Bound to a CPD-Like DNA Lesion After in Situ Repair

inferredcites →https://doi.org/10.1126/science.1148242openalex-snapshot

Bypass of DNA Lesions Generated During Anticancer Treatment with Cisplatin by DNA Polymerase η

inferredcites →https://doi.org/10.1126/science.285.5425.263openalex-snapshot

hRAD30 Mutations in the Variant Form of Xeroderma Pigmentosum

inferredcites →https://doi.org/10.1128/mcb.00115-09openalex-snapshot

Human DNA Polymerase η Is Required for Common Fragile Site Stability during Unperturbed DNA Replication

inferredcites →https://doi.org/10.1146/annurev.genet.41.042007.165900openalex-snapshot

Chromosome Fragile Sites

inferredcites →https://doi.org/10.1385/1-59745-266-1:215openalex-snapshot

Automated Structure Solution With autoSHARP

inferredcites →https://doi.org/10.2210/pdb1sm5/pdbopenalex-snapshot

Crystal Structure of a DNA Decamer Containing a Thymine-dimer

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4200126openalex-extracted

inferred← citeshttps://doi.org/10.1002/0471142700.nc0721s59openalex-snapshot

Steady‐State Kinetic Analysis of DNA Polymerase Single‐Nucleotide Incorporation Products

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Effect of Soy Isoflavones on DNA Metabolic Enzyme Inhibitory Activity and Anticancer Activity

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Plant Response to Genotoxic Stress: A Crucial Role in the Context of Global Climate Change

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Selective Modulation of DNA Polymerase Activity by Fixed‐Conformation Nucleoside Analogues

inferred← citeshttps://doi.org/10.1002/ange.202109418openalex-snapshot

Site‐Specific 5‐Formyl Cytosine Mediated DNA‐Histone Cross‐Links: Synthesis and Polymerase Bypass by Human DNA Polymerase η

inferred← citeshttps://doi.org/10.1002/anie.201003168openalex-snapshot

Selective Modulation of DNA Polymerase Activity by Fixed‐Conformation Nucleoside Analogues

inferred← citeshttps://doi.org/10.1002/anie.202109418openalex-snapshot

Site‐Specific 5‐Formyl Cytosine Mediated DNA‐Histone Cross‐Links: Synthesis and Polymerase Bypass by Human DNA Polymerase η

inferred← citeshttps://doi.org/10.1002/cbic.201000783openalex-snapshot

Learning from Directed Evolution: Thermus aquaticus DNA Polymerase Mutants with Translesion Synthesis Activity

inferred← citeshttps://doi.org/10.1002/cbic.201600420openalex-snapshot

Mechanism of Error‐Free Bypass of the Environmental Carcinogen N‐(2′‐Deoxyguanosin‐8‐yl)‐3‐aminobenzanthrone Adduct by Human DNA Polymerase η

inferred← citeshttps://doi.org/10.1002/chem.201100177openalex-snapshot

Crystal Structures and Repair Studies Reveal the Identity and the Base‐Pairing Properties of the UV‐Induced Spore Photoproduct DNA Lesion

inferred← citeshttps://doi.org/10.1002/chem.201604289openalex-snapshot

Minor Groove 3‐Deaza‐Adenosine Analogues: Synthesis and Bypass in Translesion DNA Synthesis

inferred← citeshttps://doi.org/10.1002/cpnc.2openalex-snapshot

Pre‐Steady‐State Kinetic Analysis of Single‐Nucleotide Incorporation by DNA Polymerases

inferred← citeshttps://doi.org/10.1002/em.21730openalex-snapshot

Effects of non‐catalytic, distal amino acid residues on activity of E. coli DinB (DNA polymerase IV)

inferred← citeshttps://doi.org/10.1002/em.21731openalex-snapshot

Mouse models of DNA polymerases

inferred← citeshttps://doi.org/10.1002/em.21735openalex-snapshot

Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools

inferred← citeshttps://doi.org/10.1002/em.21807openalex-snapshot

Mutation of the little finger domain in human DNA polymerase η alters fidelity when copying undamaged DNA

inferred← citeshttps://doi.org/10.1002/humu.22462openalex-snapshot

Correlation of Phenotype/Genotype in a Cohort of 23 Xeroderma Pigmentosum-Variant Patients Reveals 12 New Disease-CausingPOLHMutations

inferred← citeshttps://doi.org/10.1002/iub.1403openalex-snapshot

A rescue act: Translesion DNA synthesis past N 2‐deoxyguanosine adducts

inferred← citeshttps://doi.org/10.1002/jcp.30155openalex-snapshot

DNA polymerase eta: A potential pharmacological target for cancer therapy

inferred← citeshttps://doi.org/10.1002/pro.723openalex-snapshot

Surviving the Sun: Repair and bypass of DNA UV lesions

inferred← citeshttps://doi.org/10.1002/psc.3491openalex-snapshot

Why to target G‐quadruplexes using peptides: Next‐generation G4‐interacting ligands

inferred← citeshttps://doi.org/10.1007/978-1-4614-1531-2_442openalex-snapshot

Ultraviolet Light DNA Damage

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Ultraviolet Light DNA Damage

inferred← citeshttps://doi.org/10.1007/978-3-642-39796-7_4openalex-snapshot

Eukaryotic Y-Family Polymerases: A Biochemical and Structural Perspective

inferred← citeshttps://doi.org/10.1007/978-4-431-55873-6_11openalex-snapshot

Translesion DNA Synthesis and Damage Tolerance Pathways

inferred← citeshttps://doi.org/10.1007/978-981-10-6722-8_12openalex-snapshot

Translesion DNA Synthesis

inferred← citeshttps://doi.org/10.1007/s00018-019-03368-yopenalex-snapshot

Structure and function relationships in mammalian DNA polymerases

inferred← citeshttps://doi.org/10.1007/s10822-013-9642-xopenalex-snapshot

Managing missing measurements in small-molecule screens

inferred← citeshttps://doi.org/10.1007/s11010-025-05291-2openalex-snapshot

Human TLS DNA polymerase: saviors or threats under replication stress?

inferred← citeshttps://doi.org/10.1007/s13131-021-1823-1openalex-snapshot

Characterization of DNA polymerase δ from deep-sea hydrothermal vent shrimp Rimicaris exoculata

inferred← citeshttps://doi.org/10.1007/s13238-012-2102-xopenalex-snapshot

Structural insights into the assembly of human translesion polymerase complexes

inferred← citeshttps://doi.org/10.1016/b978-0-12-801238-3.95611-3openalex-snapshot

Cellular Responses to DNA Damage

inferred← citeshttps://doi.org/10.1016/b978-0-12-819460-7.00130-4openalex-snapshot

DNA repair | XPV Polymerase and the Bypass of Ultraviolet DNA Damage

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Repair Mechanisms and Initiation in Carcinogenesis

inferred← citeshttps://doi.org/10.1016/bs.apcsb.2014.10.001openalex-snapshot

Applications of Quantum Mechanical/Molecular Mechanical Methods to the Chemical Insertion Step of DNA and RNA Polymerization

inferred← citeshttps://doi.org/10.1016/bs.enz.2019.07.001openalex-snapshot

The Rev1-Polζ translesion synthesis mutasome: Structure, interactions and inhibition

inferred← citeshttps://doi.org/10.1016/bs.mie.2017.03.022openalex-snapshot

Detection of Reaction Intermediates in Mg 2+ -Dependent DNA Synthesis and RNA Degradation by Time-Resolved X-Ray Crystallography

inferred← citeshttps://doi.org/10.1016/j.ab.2012.07.016openalex-snapshot

A strategy for the expression of recombinant proteins traditionally hard to purify

inferred← citeshttps://doi.org/10.1016/j.ab.2015.03.002openalex-snapshot

Quantification of pyrophosphate as a universal approach to determine polymerase activity and assay polymerase inhibitors

inferred← citeshttps://doi.org/10.1016/j.abb.2015.02.032openalex-snapshot

5-O-Acyl plumbagins inhibit DNA polymerase activity and suppress the inflammatory response

inferred← citeshttps://doi.org/10.1016/j.biotechadv.2026.109018openalex-snapshot

Interplay Between Base Editing and DNA repair: From Molecular Mechanisms to Clinical Translation

inferred← citeshttps://doi.org/10.1016/j.cbi.2025.111551openalex-snapshot

Four germline POLH variants, including two found in skin tumors, impair DNA polymerase η function and cellular tolerance to UV radiation and cisplatin

inferred← citeshttps://doi.org/10.1016/j.cell.2019.01.023openalex-snapshot

Error-Prone Replication through UV Lesions by DNA Polymerase θ Protects against Skin Cancers

inferred← citeshttps://doi.org/10.1016/j.celrep.2023.112887openalex-snapshot

Spontaneous mutagenesis in human cells is controlled by REV1-Polymerase ζ and PRIMPOL

inferred← citeshttps://doi.org/10.1016/j.chembiol.2024.09.007openalex-snapshot

Quinoline-based compounds can inhibit diverse enzymes that act on DNA

inferred← citeshttps://doi.org/10.1016/j.dnarep.2011.05.009openalex-snapshot

Replication of ribonucleotide-containing DNA templates by yeast replicative polymerases

inferred← citeshttps://doi.org/10.1016/j.dnarep.2012.06.005openalex-snapshot

Escherichia coli UmuC active site mutants: Effects on translesion DNA synthesis, mutagenesis and cell survival

inferred← citeshttps://doi.org/10.1016/j.dnarep.2013.02.007openalex-snapshot

PCNA trimer instability inhibits translesion synthesis by DNA polymerase η and by DNA polymerase δ

inferred← citeshttps://doi.org/10.1016/j.dnarep.2015.02.016openalex-snapshot

Genetic evidence that both dNTP-stabilized and strand slippage mechanisms may dictate DNA polymerase errors within mononucleotide microsatellites

inferred← citeshttps://doi.org/10.1016/j.dnarep.2015.09.020openalex-snapshot

How Y-Family DNA polymerase IV is more accurate than Dpo4 at dCTP insertion opposite an N2-dG adduct of benzo[a]pyrene

inferred← citeshttps://doi.org/10.1016/j.dnarep.2016.05.004openalex-snapshot

Involvement of translesion synthesis DNA polymerases in DNA interstrand crosslink repair

inferred← citeshttps://doi.org/10.1016/j.dnarep.2016.07.003openalex-snapshot

Y-family DNA polymerase-independent gap-filling translesion synthesis across aristolochic acid-derived adenine adducts in mouse cells

inferred← citeshttps://doi.org/10.1016/j.dnarep.2016.11.001openalex-snapshot

Structural basis of accurate replication beyond a bulky major benzo[a]pyrene adduct by human DNA polymerase kappa

inferred← citeshttps://doi.org/10.1016/j.dnarep.2017.04.002openalex-snapshot

Combined loss of three DNA damage response pathways renders C. elegans intolerant to light

inferred← citeshttps://doi.org/10.1016/j.dnarep.2017.05.006openalex-snapshot

DNA polymerases eta and kappa exchange with the polymerase delta holoenzyme to complete common fragile site synthesis

inferred← citeshttps://doi.org/10.1016/j.dnarep.2018.08.016openalex-snapshot

Eukaryotic translesion synthesis: Choosing the right tool for the job

inferred← citeshttps://doi.org/10.1016/j.dnarep.2019.03.015openalex-snapshot

Epigenetically modified N6-methyladenine inhibits DNA replication by human DNA polymerase η

inferred← citeshttps://doi.org/10.1016/j.dnarep.2020.102947openalex-snapshot

Mechanisms of direct replication restart at stressed replisomes

inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.115044openalex-snapshot

Computer-aided identification, synthesis, and biological evaluation of DNA polymerase η inhibitors for the treatment of cancer

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2023.126770openalex-snapshot

Structure and function of extreme TLS DNA polymerase TTEDbh from Thermoanaerobacter tengcongensis

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.130351openalex-snapshot

Review: Protein O-GlcNAcylation regulates DNA damage response: A novel target for cancer therapy

inferred← citeshttps://doi.org/10.1016/j.jbc.2021.100642openalex-snapshot

Enzymatic bypass and the structural basis of miscoding opposite the DNA adduct 1,N2-ethenodeoxyguanosine by human DNA translesion polymerase η

inferred← citeshttps://doi.org/10.1016/j.jbc.2021.100868openalex-snapshot

DNA polymerase λ promotes error-free replication through Watson–Crick impairing N1-methyl-deoxyadenosine adduct in conjunction with DNA polymerase ζ

inferred← citeshttps://doi.org/10.1016/j.jbc.2023.102938openalex-snapshot

Primer terminal ribonucleotide alters the active site dynamics of DNA polymerase η and reduces DNA synthesis fidelity

inferred← citeshttps://doi.org/10.1016/j.jbc.2024.107361openalex-snapshot

Sugar ring alignment and dynamics underline cytarabine and gemcitabine inhibition on Pol η catalyzed DNA synthesis

inferred← citeshttps://doi.org/10.1016/j.jbc.2024.107461openalex-snapshot

Dynamic stem–loop extension by Pol θ and templated insertion during DNA repair

inferred← citeshttps://doi.org/10.1016/j.jbc.2026.113555openalex-snapshot

Overlapping RAD18-and DNA-binding interfaces in DNA polymerase η contribute to UV-induced DNA damage tolerance

inferred← citeshttps://doi.org/10.1016/j.jmb.2011.01.037openalex-snapshot

Structural Mechanism of Ribonucleotide Discrimination by a Y-Family DNA Polymerase

inferred← citeshttps://doi.org/10.1016/j.jmb.2011.02.042openalex-snapshot

Role of Human DNA Polymerase κ in Extension Opposite from a cis–syn Thymine Dimer

inferred← citeshttps://doi.org/10.1016/j.jmb.2011.11.038openalex-snapshot

Human DNA Polymerase η Is Pre-Aligned for dNTP Binding and Catalysis

inferred← citeshttps://doi.org/10.1016/j.jmb.2013.07.020openalex-snapshot

Structural Mechanism of Replication Stalling on a Bulky Amino-Polycyclic Aromatic Hydrocarbon DNA Adduct by a Y Family DNA Polymerase

inferred← citeshttps://doi.org/10.1016/j.jmb.2013.09.022openalex-snapshot

The Human Specialized DNA Polymerases and Non-B DNA: Vital Relationships to Preserve Genome Integrity

inferred← citeshttps://doi.org/10.1016/j.jmb.2026.170029openalex-snapshot

DNA Polymerase α has Cyclobutane Pyrimidine Dimer Translesion Activity that is Suppressed During Normal Replication

inferred← citeshttps://doi.org/10.1016/j.jmgm.2012.09.005openalex-snapshot

Structural model of the Y-Family DNA polymerase V/RecA mutasome

inferred← citeshttps://doi.org/10.1016/j.lfs.2017.12.035openalex-snapshot

Actual state of knowledge in the field of diseases related with defective nucleotide excision repair

inferred← citeshttps://doi.org/10.1016/j.molcel.2026.04.007openalex-snapshot

Sub-2 Å cryo-EM structures of transcribing RNA polymerase II reveal critical roles of water molecules in catalysis

inferred← citeshttps://doi.org/10.1016/j.mrfmmm.2012.11.002openalex-snapshot

The roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability

inferred← citeshttps://doi.org/10.1016/j.mrfmmm.2013.03.001openalex-snapshot

Biochemical analysis of active site mutations of human polymerase η

inferred← citeshttps://doi.org/10.1016/j.mrfmmm.2017.08.002openalex-snapshot

Role of specialized DNA polymerases in the limitation of replicative stress and DNA damage transmission

inferred← citeshttps://doi.org/10.1016/j.mrfmmm.2021.111762openalex-snapshot

Biochemical and photochemical mechanisms that produce different UV-induced mutation spectra

inferred← citeshttps://doi.org/10.1016/j.mrfmmm.2023.111840openalex-snapshot

The accurate bypass of pyrimidine dimers by DNA polymerase eta contributes to ultraviolet-induced mutagenesis

inferred← citeshttps://doi.org/10.1016/j.mrrev.2022.108436openalex-snapshot

Current state of knowledge of human DNA polymerase eta protein structure and disease-causing mutations

inferred← citeshttps://doi.org/10.1016/j.mrrev.2026.108608openalex-snapshot

Structural insight into human Y-family polymerases and mechanistic basis of translesion synthesis of key DNA damages

inferred← citeshttps://doi.org/10.1016/j.plaphy.2026.111678openalex-snapshot

Nitric oxide delays tomato fruit carotenoid accumulation by inhibiting the transcriptional activation of the SlbZIP16-SlPol η module

inferred← citeshttps://doi.org/10.1016/j.sbi.2011.03.008openalex-snapshot

DNA polymerases provide a canon of strategies for translesion synthesis past oxidatively generated lesions

inferred← citeshttps://doi.org/10.1016/j.sbi.2018.06.003openalex-snapshot

Eukaryotic DNA polymerases

inferred← citeshttps://doi.org/10.1016/j.sbi.2023.102529openalex-snapshot

Deep learning for protein complex structure prediction

inferred← citeshttps://doi.org/10.1016/j.sbi.2023.102618openalex-snapshot

Repair and tolerance of DNA damage at the replication fork: A structural perspective

inferred← citeshttps://doi.org/10.1016/j.semcancer.2010.10.003openalex-snapshot

Mutator phenotypes due to DNA replication infidelity

inferred← citeshttps://doi.org/10.1016/j.semcdb.2020.10.001openalex-snapshot

Making choices: DNA replication fork recovery mechanisms

inferred← citeshttps://doi.org/10.1016/j.str.2010.08.019openalex-snapshot

Structural Basis for Error-free Replication of Oxidatively Damaged DNA by Yeast DNA Polymerase η

inferred← citeshttps://doi.org/10.1016/j.str.2011.03.020openalex-snapshot

Implications for Damage Recognition during Dpo4-Mediated Mutagenic Bypass of m1G and m3C Lesions

inferred← citeshttps://doi.org/10.1016/j.str.2014.10.019openalex-snapshot

Unique Structural Features in DNA Polymerase IV Enable Efficient Bypass of the N 2 Adduct Induced by the Nitrofurazone Antibiotic

inferred← citeshttps://doi.org/10.1016/j.tibs.2025.07.004openalex-snapshot

Just bypass it: mechanisms of DNA damage tolerance

inferred← citeshttps://doi.org/10.1016/j.tig.2021.10.005openalex-snapshot

RNA-directed DNA repair and antibody somatic hypermutation

inferred← citeshttps://doi.org/10.1017/s0033583514000018openalex-snapshot

Anomalous diffraction in crystallographic phase evaluation

inferred← citeshttps://doi.org/10.1017/s0033583515000268openalex-snapshot

Molecular mechanisms of xeroderma pigmentosum (XP) proteins

inferred← citeshttps://doi.org/10.1021/acs.biochem.1c00130openalex-snapshot

Translesion Synthesis Past 5-Formylcytosine-Mediated DNA–Peptide Cross-Links by hPolη Is Dependent on the Local DNA Sequence

inferred← citeshttps://doi.org/10.1021/acs.biochem.2c00663openalex-snapshot

Human Translesion Synthesis Polymerases polκ and polη Perform Error-Free Replication across N2-dG Methyleugenol and Estragole DNA Adducts

inferred← citeshttps://doi.org/10.1021/acs.biochem.3c00569openalex-snapshot

Replication Bypass of the N-(2-Deoxy- d -erythro-pentofuranosyl)-urea DNA Lesion by Human DNA Polymerase η

inferred← citeshttps://doi.org/10.1021/acs.biochem.4c00387openalex-snapshot

DNA Replication across α- l -(3′-2′)-Threofuranosyl Nucleotides Mediated by Human DNA Polymerase η

inferred← citeshttps://doi.org/10.1021/acs.biochem.5b00060openalex-snapshot

Evidence for the Kinetic Partitioning of Polymerase Activity on G-Quadruplex DNA

inferred← citeshttps://doi.org/10.1021/acs.biochem.5c00781openalex-snapshot

A Thymine Dimer Stalls a High-Fidelity DNA Polymerase by Providing No Template Information in the Same Manner as an Abasic Site

inferred← citeshttps://doi.org/10.1021/acs.biochem.6b00374openalex-snapshot

Human Translesion Polymerase κ Exhibits Enhanced Activity and Reduced Fidelity Two Nucleotides from G-Quadruplex DNA

inferred← citeshttps://doi.org/10.1021/acs.biochem.8b00417openalex-snapshot

Probing DNA Base-Dependent Leaving Group Kinetic Effects on the DNA Polymerase Transition State

inferred← citeshttps://doi.org/10.1021/acs.biochem.9b00087openalex-snapshot

A Transition-State Perspective on Y-Family DNA Polymerase η Fidelity in Comparison with X-Family DNA Polymerases λ and β

inferred← citeshttps://doi.org/10.1021/acs.biochem.9b00938openalex-snapshot

Rad6/Rad18 Competes with DNA Polymerases η and δ for PCNA Encircling DNA

inferred← citeshttps://doi.org/10.1021/acs.chemrestox.1c00416openalex-snapshot

Effects of N7-Alkylguanine Conformation and Metal Cofactors on the Translesion Synthesis by Human DNA Polymerase η

inferred← citeshttps://doi.org/10.1021/acs.chemrestox.5b00509openalex-snapshot

In Vitro Lesion Bypass Studies of O4-Alkylthymidines with Human DNA Polymerase η

inferred← citeshttps://doi.org/10.1021/acs.chemrestox.5c00215openalex-snapshot

Peptide Sequence and Cross-Link Structure Influence Translesion Synthesis Polymerase Bypass of 5-Formylcytosine-Mediated DNA–Peptide Cross-Links

inferred← citeshttps://doi.org/10.1021/acs.chemrestox.6b00252openalex-snapshot

Replicative Bypass of O2-Alkylthymidine Lesions in Vitro

inferred← citeshttps://doi.org/10.1021/acs.chemrestox.6b00342openalex-snapshot

Advances in Structural and Single-Molecule Methods for Investigating DNA Lesion Bypass and Repair Polymerases

inferred← citeshttps://doi.org/10.1021/acs.chemrestox.6b00439openalex-snapshot

Replicative Bypass Studies of α-Anomeric Lesions of 2′-Deoxyribonucleosides in Vitro

inferred← citeshttps://doi.org/10.1021/acs.chemrestox.9b00291openalex-snapshot

Computational Insight into the Differential Mutagenic Patterns of O-Methylthymine Lesions

inferred← citeshttps://doi.org/10.1021/acs.chemrev.7b00685openalex-snapshot

Kinetic Mechanism of DNA Polymerases: Contributions of Conformational Dynamics and a Third Divalent Metal Ion

inferred← citeshttps://doi.org/10.1021/acs.jcim.5b00606openalex-snapshot

Comparative Molecular Dynamics Studies of Human DNA Polymerase η

inferred← citeshttps://doi.org/10.1021/acs.jctc.6c00345openalex-snapshot

Decoding Cancer-Associated Mutations in DNA Polymerase η through Atomistic Simulations

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.2c00185openalex-snapshot

Discovery and Structural Basis of the Selectivity of Potent Cyclic Peptide Inhibitors of MAGE-A4

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b00596openalex-snapshot

Targeting the Translesion Synthesis Pathway for the Development of Anti-Cancer Chemotherapeutics

inferred← citeshttps://doi.org/10.1021/acs.jpcb.6b09973openalex-snapshot

Effects of Active Site Mutations on Specificity of Nucleobase Binding in Human DNA Polymerase η

inferred← citeshttps://doi.org/10.1021/acs.langmuir.4c01762openalex-snapshot

Enzyme-Responsive Supramolecular Self-Assembly in Small Amphiphiles

inferred← citeshttps://doi.org/10.1021/acscatal.1c03840openalex-snapshot

Local Structural Dynamics at the Metal-Centered Catalytic Site of Polymerases is Critical for Fidelity

inferred← citeshttps://doi.org/10.1021/acscatal.8b03363openalex-snapshot

The Catalytic Mechanism of DNA and RNA Polymerases

inferred← citeshttps://doi.org/10.1021/acscatal.8b04889openalex-snapshot

Exploring the Identity of the General Base for a DNA Polymerase Catalyzed Reaction Using QM/MM: The Case Study of Human Translesion Synthesis Polymerase η

inferred← citeshttps://doi.org/10.1021/acschembio.9b00304openalex-snapshot

Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms

inferred← citeshttps://doi.org/10.1021/ar500314jopenalex-snapshot

Catalytic Metal Ions and Enzymatic Processing of DNA and RNA

inferred← citeshttps://doi.org/10.1021/bi101465nopenalex-snapshot

Kinetic Basis of Sugar Selection by a Y-Family DNA Polymerase from Sulfolobus solfataricus P2

inferred← citeshttps://doi.org/10.1021/bi400194ropenalex-snapshot

Regulatory Role of Ubiquitin in Eukaryotic DNA Translesion Synthesis

inferred← citeshttps://doi.org/10.1021/bi500019sopenalex-snapshot

An Overview of Y-Family DNA Polymerases and a Case Study of Human DNA Polymerase η

inferred← citeshttps://doi.org/10.1021/bi5003713openalex-snapshot

Quantum Mechanical Analysis of Nonenzymatic Nucleotidyl Transfer Reactions: Kinetic and Thermodynamic Effects of β–γ Bridging Groups of dNTP Substrates

inferred← citeshttps://doi.org/10.1021/cr3005179openalex-snapshot

Structural Comparison of DNA Polymerase Architecture Suggests a Nucleotide Gateway to the Polymerase Active Site

inferred← citeshttps://doi.org/10.1021/ja4102375openalex-snapshot

How a Low-Fidelity DNA Polymerase Chooses Non-Watson–Crick from Watson–Crick Incorporation

inferred← citeshttps://doi.org/10.1021/ja512547gopenalex-snapshot

Nucleotides with Altered Hydrogen Bonding Capacities Impede Human DNA Polymerase η by Reducing Synthesis in the Presence of the Major Cisplatin DNA Adduct

inferred← citeshttps://doi.org/10.1021/jacs.5b08451openalex-snapshot

Relative Binding Free Energies of Adenine and Guanine to Damaged and Undamaged DNA in Human DNA Polymerase η: Clues for Fidelity and Overall Efficiency

inferred← citeshttps://doi.org/10.1021/jacs.5c05888openalex-snapshot

Coordinated Residue Motions at the Enzyme–Substrate Interface Promote DNA Translocation in Polymerases

inferred← citeshttps://doi.org/10.1021/jacs.6b05475openalex-snapshot

A Self-Activated Mechanism for Nucleic Acid Polymerization Catalyzed by DNA/RNA Polymerases

inferred← citeshttps://doi.org/10.1021/jacs.7b12446openalex-snapshot

A Strategically Located Arg/Lys Residue Promotes Correct Base Paring During Nucleic Acid Biosynthesis in Polymerases

inferred← citeshttps://doi.org/10.1021/jacs.8b05177openalex-snapshot

Exploring the Role of the Third Active Site Metal Ion in DNA Polymerase η with QM/MM Free Energy Simulations

inferred← citeshttps://doi.org/10.1021/jacs.8b11474openalex-snapshot

Predicting Site-Binding Modes of Ions and Water to Nucleic Acids Using Molecular Solvation Theory

inferred← citeshttps://doi.org/10.1021/jacsau.1c00368openalex-snapshot

Investigating the Conformational Dynamics of a Y-Family DNA Polymerase during Its Folding and Binding to DNA and a Nucleotide

inferred← citeshttps://doi.org/10.1021/la404534ropenalex-snapshot

Stochastic Adhesion of Hydroxylated Atomic Force Microscopy Tips to Supported Lipid Bilayers

inferred← citeshttps://doi.org/10.1021/tx3001576openalex-snapshot

Accurate and Efficient Bypass of 8,5′-Cyclopurine-2′-Deoxynucleosides by Human and Yeast DNA Polymerase η

inferred← citeshttps://doi.org/10.1021/tx300168popenalex-snapshot

Effects of N2-Alkylguanine, O6-Alkylguanine, and Abasic Lesions on DNA Binding and Bypass Synthesis by the Euryarchaeal B-Family DNA Polymerase Vent (exo–)

inferred← citeshttps://doi.org/10.1021/tx3002115openalex-snapshot

Identification of an Unfolding Intermediate for a DNA Lesion Bypass Polymerase

inferred← citeshttps://doi.org/10.1021/tx300392mopenalex-snapshot

Leukotriene Biosynthesis Inhibitor MK886 Impedes DNA Polymerase Activity

inferred← citeshttps://doi.org/10.1021/tx400116nopenalex-snapshot

Structure and Thermodynamic Insights on Acetylaminofluorene-Modified Deletion DNA Duplexes as Models for Frameshift Mutagenesis

inferred← citeshttps://doi.org/10.1021/tx4002786openalex-snapshot

Mutagenicity and Genotoxicity of (5′S)-8,5′-Cyclo-2′-deoxyadenosine in Escherichia coli and Replication of (5′S)-8,5′-Cyclopurine-2′-deoxynucleosides in Vitro by DNA Polymerase IV, Exo-Free Klenow Fragment, and Dpo4

inferred← citeshttps://doi.org/10.1021/tx4002995openalex-snapshot

Replication across Regioisomeric Ethylated Thymidine Lesions by Purified DNA Polymerases

inferred← citeshttps://doi.org/10.1038/4651023aopenalex-snapshot

How to accurately bypass damage

inferred← citeshttps://doi.org/10.1038/487177aopenalex-snapshot

DNA replication caught in the act

inferred← citeshttps://doi.org/10.1038/emboj.2011.313openalex-snapshot

Crystal structures of an archaeal class II DNA photolyase and its complex with UV‐damaged duplex DNA

inferred← citeshttps://doi.org/10.1038/emboj.2011.457openalex-snapshot

Dysregulation of DNA polymerase κ recruitment to replication forks results in genomic instability

inferred← citeshttps://doi.org/10.1038/nature10338openalex-snapshot

Erratum: Structure and mechanism of human DNA polymerase η

inferred← citeshttps://doi.org/10.1038/nature11181openalex-snapshot

Watching DNA polymerase η make a phosphodiester bond

inferred← citeshttps://doi.org/10.1038/ncomms13326openalex-snapshot

Rad18-dependent SUMOylation of human specialized DNA polymerase eta is required to prevent under-replicated DNA

inferred← citeshttps://doi.org/10.1038/news.2010.313openalex-snapshot

The genome's shield from sunlight

inferred← citeshttps://doi.org/10.1038/nrc2998openalex-snapshot

DNA polymerases and cancer

inferred← citeshttps://doi.org/10.1038/nrm2948openalex-snapshot

Structure watch

inferred← citeshttps://doi.org/10.1038/nrm3289openalex-snapshot

Y-family DNA polymerases and their role in tolerance of cellular DNA damage

inferred← citeshttps://doi.org/10.1038/nsmb.2295openalex-snapshot

Structural basis for cisplatin DNA damage tolerance by human polymerase η during cancer chemotherapy

inferred← citeshttps://doi.org/10.1038/nsmb.2719openalex-snapshot

Repriming of DNA synthesis at stalled replication forks by human PrimPol

inferred← citeshttps://doi.org/10.1038/nsmb.2766openalex-snapshot

Sustained active site rigidity during synthesis by human DNA polymerase μ

inferred← citeshttps://doi.org/10.1038/s41467-017-02164-1openalex-snapshot

Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis

inferred← citeshttps://doi.org/10.1038/s41467-021-24096-7openalex-snapshot

Mechanism of genome instability mediated by human DNA polymerase mu misincorporation

inferred← citeshttps://doi.org/10.1038/s41467-025-57269-9openalex-snapshot

Structural basis of error-prone DNA synthesis by DNA polymerase θ

inferred← citeshttps://doi.org/10.1038/s41467-025-61768-0openalex-snapshot

USP1/UAF1 targets polyubiquitinated PCNA with an exo-cleavage mechanism that can temporarily enrich for monoubiquitinated PCNA

inferred← citeshttps://doi.org/10.1038/s41467-026-76668-0openalex-snapshot

Structural basis of transcription of the hachimoji eight-letter alphabet by E. coli RNA polymerase

inferred← citeshttps://doi.org/10.1038/s41570-017-0068openalex-snapshot

How DNA polymerases catalyse replication and repair with contrasting fidelity

inferred← citeshttps://doi.org/10.1038/s41589-026-02238-6openalex-snapshot

Structures of human telomerase with BIBR1532 reveal novel mechanism of inhibition

inferred← citeshttps://doi.org/10.1038/s41598-018-28664-8openalex-snapshot

The active site residues Gln55 and Arg73 play a key role in DNA damage bypass by S. cerevisiae Pol η

inferred← citeshttps://doi.org/10.1038/s41598-018-30796-wopenalex-snapshot

Structural basis for polymerase η–promoted resistance to the anticancer nucleoside analog cytarabine

inferred← citeshttps://doi.org/10.1038/s41598-019-52703-7openalex-snapshot

Structural insights into mutagenicity of anticancer nucleoside analog cytarabine during replication by DNA polymerase η

inferred← citeshttps://doi.org/10.1038/s41598-020-58180-7openalex-snapshot

Large deletions in immunoglobulin genes are associated with a sustained absence of DNA Polymerase η

inferred← citeshttps://doi.org/10.1038/s41598-021-00878-3openalex-snapshot

Genetic and physical interactions between Polη and Rev1 in response to UV-induced DNA damage in mammalian cells

inferred← citeshttps://doi.org/10.1038/s41598-023-51120-1openalex-snapshot

Homozygous substitution of threonine 191 by proline in polymerase η causes Xeroderma pigmentosum variant

inferred← citeshttps://doi.org/10.1038/srep15759openalex-snapshot

Molecular architecture of the Ub-PCNA/Pol η complex bound to DNA

inferred← citeshttps://doi.org/10.1038/srep41087openalex-snapshot

Comparative molecular dynamics studies of heterozygous open reading frames of DNA polymerase eta (η) in pathogenic yeast Candida albicans

inferred← citeshttps://doi.org/10.1039/9781849734875-00169openalex-snapshot

Nucleotides and nucleic acids; oligo- and polynucleotides

inferred← citeshttps://doi.org/10.1039/c0cs00061bopenalex-snapshot

Purine 5′,8-cyclonucleoside lesions: chemistry and biology

inferred← citeshttps://doi.org/10.1039/c3fo60650copenalex-snapshot

Inhibition of DNA polymerase λ and associated inflammatory activities of extracts from steamed germinated soybeans

inferred← citeshttps://doi.org/10.1039/c8cc00700dopenalex-snapshot

How Mg 2+ ions lower the S N 2@P barrier in enzymatic triphosphate hydrolysis

inferred← citeshttps://doi.org/10.1039/d2cp00481jopenalex-snapshot

Multiscale computational investigations of the translesion synthesis bypass of tobacco-derived DNA adducts: critical insights that complement experimental biochemical studies

inferred← citeshttps://doi.org/10.1042/bcj20180848openalex-snapshot

Structural basis for the bypass of the major oxaliplatin–DNA adducts by human DNA polymerase η

inferred← citeshttps://doi.org/10.1042/bcj20200767openalex-snapshot

Translesion synthesis of the major nitrogen mustard-induced DNA lesion by human DNA polymerase η

inferred← citeshttps://doi.org/10.1042/bcj20200800openalex-snapshot

Structural insights into the bypass of the major deaminated purines by translesion synthesis DNA polymerase

inferred← citeshttps://doi.org/10.1042/bcj20210162openalex-snapshot

Insights into the mismatch discrimination mechanism of Y-family DNA polymerase Dpo4

inferred← citeshttps://doi.org/10.1042/bcj20230029openalex-snapshot

Mutagenic incorporation of inosine into DNA via T:I mismatch formation by human DNA polymerase eta (polη)

inferred← citeshttps://doi.org/10.1042/bsr20231382openalex-snapshot

Connecting dots between nucleotide biosynthesis and DNA lesion repair/bypass in cancer

inferred← citeshttps://doi.org/10.1073/pnas.1008894107openalex-snapshot

Mechanism of replication blocking and bypass of Y-family polymerase η by bulky acetylaminofluorene DNA adducts

inferred← citeshttps://doi.org/10.1073/pnas.1012825108openalex-snapshot

Replication infidelity via a mismatch with Watson–Crick geometry

inferred← citeshttps://doi.org/10.1073/pnas.1120964109openalex-snapshot

A short adaptive path from DNA to RNA polymerases

inferred← citeshttps://doi.org/10.1073/pnas.1202681109openalex-snapshot

Structural basis of human DNA polymerase η-mediated chemoresistance to cisplatin

inferred← citeshttps://doi.org/10.1073/pnas.1303126110openalex-snapshot

Mechanism of somatic hypermutation at the WA motif by human DNA polymerase η

inferred← citeshttps://doi.org/10.1073/pnas.1324168111openalex-snapshot

Variants of mouse DNA polymerase κ reveal a mechanism of efficient and accurate translesion synthesis past a benzo[ a ]pyrene dG adduct

inferred← citeshttps://doi.org/10.1073/pnas.1405739111openalex-snapshot

Structural and mechanistic studies of polymerase η bypass of phenanthriplatin DNA damage

inferred← citeshttps://doi.org/10.1073/pnas.1704006114openalex-snapshot

Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex

inferred← citeshttps://doi.org/10.1073/pnas.1812856115openalex-snapshot

Bypassing a 8,5′-cyclo-2′-deoxyadenosine lesion by human DNA polymerase η at atomic resolution

inferred← citeshttps://doi.org/10.1073/pnas.2103990118openalex-snapshot

Multiple deprotonation paths of the nucleophile 3′-OH in the DNA synthesis reaction

inferred← citeshttps://doi.org/10.1074/jbc.m110.176826openalex-snapshot

Human DNA Polymerase β Mutations Allowing Efficient Abasic Site Bypass

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