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Biopharmaceutical benchmarks 2018

https://doi.org/10.1038/nbt.4305
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/jgm.2698openalex-snapshot
Gene therapy clinical trials worldwide to 2012 – an update
inferredcites →https://doi.org/10.1002/jgm.3015openalex-snapshot
Gene therapy clinical trials worldwide to 2017: An update
inferredcites →https://doi.org/10.1007/s11248-016-9933-9openalex-snapshot
The transgenic animal platform for biopharmaceutical production
inferredcites →https://doi.org/10.1016/j.drudis.2018.02.012openalex-snapshot
Approved CAR T cell therapies: ice bucket challenges on glaring safety risks and long-term impacts
inferredcites →https://doi.org/10.1038/nbt.3040openalex-snapshot
Biopharmaceutical benchmarks 2014
inferredcites →https://doi.org/10.1038/nbt0706-769openalex-snapshot
Biopharmaceutical benchmarks 2006
inferredcites →https://doi.org/10.1038/nbt0910-917openalex-snapshot
Biopharmaceutical benchmarks 2010
inferredcites →https://doi.org/10.1038/s41551-018-0235-9openalex-snapshot
Programming CAR-T cells to kill cancer
inferredcites →https://doi.org/10.1080/19420862.2018.1415671openalex-snapshot
Antibodies to watch in 2018
inferredcites →https://doi.org/10.1089/hum.2017.254openalex-snapshot
CAR T Cells in Trials: Recent Achievements and Challenges that Remain in the Production of Modified T Cells for Clinical Applications
inferredcites →https://doi.org/10.1096/fj.14-264739openalex-snapshot
Deposition of bioactive human epidermal growth factor in the egg white of transgenic hens using an oviduct‐specific minisynthetic promoter
inferredcites →https://doi.org/10.1111/cts.12459openalex-snapshot
Clinical Pharmacology and Translational Aspects of Bispecific Antibodies
inferredcites →https://doi.org/10.1111/imr.12393openalex-snapshot
Harnessing T cells to fight cancer with BiTE® antibody constructs – past developments and future directions
inferredcites →https://doi.org/10.1126/science.aar6711openalex-snapshot
CAR T cell immunotherapy for human cancer
inferredcites →https://doi.org/10.2174/1389201019666180418095526openalex-snapshot
CAR T-cell Therapy: A New Era in Cancer Immunotherapy

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4661347openalex-extracted
Boric Affinity/Hydrophobic Charge Induction Synergistic Adsorption for Improving Purification of Antibody
inferred← citeshttps://doi.org/10.2139/ssrn.4781045openalex-extracted
Mechanistic Modeling of Multimodal Chromatography for Separation of a Monoclonal Antibody from Product-Related Impurities: Fab Fragment and Aggregates
inferred← citeshttps://doi.org/10.1002/0471266949.bmc160openalex-snapshot
Process Development of Protein Therapeutics
inferred← citeshttps://doi.org/10.1002/0471266949.bmc160.pub2openalex-snapshot
Process Development of Protein Therapeutics
inferred← citeshttps://doi.org/10.1002/14651858.cd013539openalex-snapshot
Biosimilar monoclonal antibodies for cancer treatment
inferred← citeshttps://doi.org/10.1002/14651858.cd013539.pub2openalex-snapshot
Biosimilar monoclonal antibodies for cancer treatment in adults
inferred← citeshttps://doi.org/10.1002/2211-5463.13019openalex-snapshot
Methylthioadenosine (MTA) boosts cell‐specific productivities of Chinese hamster ovary cultures: dosage effects on proliferation, cell cycle and gene expression
inferred← citeshttps://doi.org/10.1002/9780470027318.a1618.pub4openalex-snapshot
High‐Performance Liquid Chromatography–Mass Spectrometry in Peptide and Protein Analysis
inferred← citeshttps://doi.org/10.1002/9781119564690.ch4openalex-snapshot
Major Classes of Biotherapeutics
inferred← citeshttps://doi.org/10.1002/9781394278572.ch11openalex-snapshot
DEVELOPMENT OF A PLATFORM PROCESS FOR THE PURIFICATION OF THERAPEUTIC ANTIBODIES*
inferred← citeshttps://doi.org/10.1002/9783527815128.ch13openalex-snapshot
Engineering Antibody‐Based Therapeutics: Progress and Opportunities
inferred← citeshttps://doi.org/10.1002/9783527823468.ch10openalex-snapshot
Genome Editing of Eukarya
inferred← citeshttps://doi.org/10.1002/9783527824045.ch1openalex-snapshot
Downstream Processing of Biotechnology Products
inferred← citeshttps://doi.org/10.1002/9783527827343.ch1openalex-snapshot
Strategies for Continuous Processing in Microbial Systems
inferred← citeshttps://doi.org/10.1002/9783527827343.ch2openalex-snapshot
Control of Continuous Manufacturing Processes for Production of Monoclonal Antibodies
inferred← citeshttps://doi.org/10.1002/9783527827343.ch4openalex-snapshot
Bioprocess Intensification: Technologies and Goals
inferred← citeshttps://doi.org/10.1002/9783527827343.ch8openalex-snapshot
Consistent Value Creation from Bioprocess Data with Customized Algorithms: Opportunities Beyond Multivariate Analysis
inferred← citeshttps://doi.org/10.1002/9783527836895.ch9openalex-snapshot
Perspectives for Future Work
inferred← citeshttps://doi.org/10.1002/adfm.202101633openalex-snapshot
Protein Engineering Strategies for Improved Pharmacokinetics
inferred← citeshttps://doi.org/10.1002/adfm.202407787openalex-snapshot
Engineered Nanobodies Elicit Durable and Robust Bi‐Therapeutic Efficacy Toward Virus and Tumors
inferred← citeshttps://doi.org/10.1002/adhm.202400466openalex-snapshot
Probing the Topological Effects on Stability Enhancement and Therapeutic Performance of Protein Bioconjugates: Tadpole, Macrocycle versus Figure‐of‐Eight
inferred← citeshttps://doi.org/10.1002/adma.202209765openalex-snapshot
Thermo‐pH‐Sensitive Polymer Conjugated Glucose Oxidase for Tumor‐Selective Starvation‐Oxidation‐Immune Therapy
inferred← citeshttps://doi.org/10.1002/adma.73544openalex-snapshot
Molecular Engineering of the Nano‐Bio Interface for Programmable and Precision Protein Delivery
inferred← citeshttps://doi.org/10.1002/adtp.202400098openalex-snapshot
Synergic Chemoimmunotherapy of Cervical Cancer by Combining Cisplatin with Thermosensitive Polypeptide Fused Interferon Alpha
inferred← citeshttps://doi.org/10.1002/advs.202405593openalex-snapshot
SiMPl‐GS: Advancing Cell Line Development via Synthetic Selection Marker for Next‐Generation Biopharmaceutical Production
inferred← citeshttps://doi.org/10.1002/advs.75892openalex-snapshot
AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint
inferred← citeshttps://doi.org/10.1002/ange.202003708openalex-snapshot
Precision Conjugation: An Emerging Tool for Generating Protein–Polymer Conjugates
inferred← citeshttps://doi.org/10.1002/anie.202003708openalex-snapshot
Precision Conjugation: An Emerging Tool for Generating Protein–Polymer Conjugates
inferred← citeshttps://doi.org/10.1002/biot.202000057openalex-snapshot
A Site‐Specific Integration Reporter System That Enables Rapid Evaluation of CRISPR/Cas9‐Mediated Genome Editing Strategies in CHO Cells
inferred← citeshttps://doi.org/10.1002/biot.202000081openalex-snapshot
Temperature Down‐Shift Modifies Expression of UPR‐/ERAD‐Related Genes and Enhances Production of a Chimeric Fusion Protein in CHO Cells
inferred← citeshttps://doi.org/10.1002/biot.202000264openalex-snapshot
Forskolin Increases cAMP Levels and Enhances Recombinant Antibody Production in CHO Cell Cultures
inferred← citeshttps://doi.org/10.1002/biot.202000320openalex-snapshot
Error propagation in constraint‐based modeling of Chinese hamster ovary cells
inferred← citeshttps://doi.org/10.1002/biot.202000350openalex-snapshot
Subcloning induces changes in the DNA‐methylation pattern of outgrowing Chinese hamster ovary cell colonies
inferred← citeshttps://doi.org/10.1002/biot.202000464openalex-snapshot
Effect of vitamins and metal ions on productivity and charge heterogeneity of IgG1 expressed in CHO cells
inferred← citeshttps://doi.org/10.1002/biot.202100088openalex-snapshot
Continuous optical in‐line glucose monitoring and control in CHO cultures contributes to enhanced metabolic efficiency while maintaining darbepoetin alfa product quality
inferred← citeshttps://doi.org/10.1002/biot.202100395openalex-snapshot
Real‐time amino acid and glucose monitoring system for the automatic control of nutrient feeding in CHO cell culture using Raman spectroscopy
inferred← citeshttps://doi.org/10.1002/biot.202100499openalex-snapshot
Coupling CRISPR interference with FACS enrichment: New approach in glycoengineering of CHO cell lines for therapeutic glycoprotein production
inferred← citeshttps://doi.org/10.1002/biot.202200147openalex-snapshot
Apilimod enhances specific productivity in recombinant CHO cells through cell cycle arrest and mediation of autophagy
inferred← citeshttps://doi.org/10.1002/biot.202200604openalex-snapshot
Strategies for controlling afucosylation in monoclonal antibodies during upstream manufacturing
inferred← citeshttps://doi.org/10.1002/biot.202200638openalex-snapshot
Cystine and tyrosine feed reduces oxidative and ER stress in CHO cells
inferred← citeshttps://doi.org/10.1002/biot.202300033openalex-snapshot
Customizing amino acid metabolism of Pichia pastoris for recombinant protein production
inferred← citeshttps://doi.org/10.1002/biot.202300126openalex-snapshot
Debottlenecking and reformulating feed media for improved CHO cell growth and titer by data‐driven and model‐guided analyses
inferred← citeshttps://doi.org/10.1002/biot.202400072openalex-snapshot
Genome‐Scale Modeling of CHO Cells Unravel the Critical Role of Asparagine in Cell Culture Feed Media
inferred← citeshttps://doi.org/10.1002/biot.202400474openalex-snapshot
Selective Recruitment of a Synthetic Histone Acetyltransferase Can Boost CHO Cell Productivity
inferred← citeshttps://doi.org/10.1002/biot.70129openalex-snapshot
Intracellular Antibody Levels Predict Secretion Efficiency in HEK293T Cells Expressing a Chimeric Anti‐CD99 Antibody from a Single‐Expression Plasmid
inferred← citeshttps://doi.org/10.1002/biot.70171openalex-snapshot
Pioneer Factor FOXA1 Boosts CHO Cell Productivity
inferred← citeshttps://doi.org/10.1002/bit.27014openalex-snapshot
Multi‐omics profiling of CHO parental hosts reveals cell line‐specific variations in bioprocessing traits
inferred← citeshttps://doi.org/10.1002/bit.27196openalex-snapshot
Unraveling what makes a monoclonal antibody difficult‐to‐express: From intracellular accumulation to incomplete folding and degradation via ERAD
inferred← citeshttps://doi.org/10.1002/bit.27269openalex-snapshot
Attenuating apoptosis in Chinese hamster ovary cells for improved biopharmaceutical production
inferred← citeshttps://doi.org/10.1002/bit.27292openalex-snapshot
Truly continuous low pH viral inactivation for biopharmaceutical process integration
inferred← citeshttps://doi.org/10.1002/bit.27315openalex-snapshot
Optimized CRISPR/Cas9 strategy for homology‐directed multiple targeted integration of transgenes in CHO cells
inferred← citeshttps://doi.org/10.1002/bit.27347openalex-snapshot
Tailoring translational strength using Kozak sequence variants improves bispecific antibody assembly and reduces product‐related impurities in CHO cells
inferred← citeshttps://doi.org/10.1002/bit.27365openalex-snapshot
Subphysiological temperature induces pervasive alternative splicing in Chinese hamster ovary cells
inferred← citeshttps://doi.org/10.1002/bit.27374openalex-snapshot
Engineered human FcγRIIa fusion: A novel strategy to extend serum half‐life of therapeutic proteins
inferred← citeshttps://doi.org/10.1002/bit.27432openalex-snapshot
Chromosome‐scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome
inferred← citeshttps://doi.org/10.1002/bit.27439openalex-snapshot
Overexpression of the mitochondrial pyruvate carrier reduces lactate production and increases recombinant protein productivity in CHO cells
inferred← citeshttps://doi.org/10.1002/bit.27461openalex-snapshot
Technology outlook for real‐time quality attribute and process parameter monitoring in biopharmaceutical development—A review
inferred← citeshttps://doi.org/10.1002/bit.27484openalex-snapshot
S‐adenosylmethionine and methylthioadenosine boost cellular productivities of antibody forming Chinese hamster ovary cells
inferred← citeshttps://doi.org/10.1002/bit.27493openalex-snapshot
Random epigenetic modulation of CHO cells by repeated knockdown of DNA methyltransferases increases population diversity and enables sorting of cells with higher production capacities
inferred← citeshttps://doi.org/10.1002/bit.27532openalex-snapshot
Real‐time monitoring of quality attributes by in‐line Fourier transform infrared spectroscopic sensors at ultrafiltration and diafiltration of bioprocess
inferred← citeshttps://doi.org/10.1002/bit.27548openalex-snapshot
‘Omics driven discoveries of gene targets for apoptosis attenuation in CHO cells
inferred← citeshttps://doi.org/10.1002/bit.27599openalex-snapshot
Systematic identification of safe harbor regions in the CHO genome through a comprehensive epigenome analysis
inferred← citeshttps://doi.org/10.1002/bit.27627openalex-snapshot
Development and application of a cultivation platform for mammalian suspension cell lines with single‐cell resolution
inferred← citeshttps://doi.org/10.1002/bit.27635openalex-snapshot
Questioning coverage values determined by 2D western blots: A critical study on the characterization of anti‐HCP ELISA reagents
inferred← citeshttps://doi.org/10.1002/bit.27693openalex-snapshot
Application of metabolic modeling for targeted optimization of high seeding density processes
inferred← citeshttps://doi.org/10.1002/bit.27715openalex-snapshot
Tracing production instability in a clonally derived CHO cell line using single‐cell transcriptomics
inferred← citeshttps://doi.org/10.1002/bit.27747openalex-snapshot
Hyperosmolality in CHO culture: Effects on cellular behavior and morphology
inferred← citeshttps://doi.org/10.1002/bit.27769openalex-snapshot
Probabilistic model by Bayesian network for the prediction of antibody glycosylation in perfusion and fed‐batch cell cultures
inferred← citeshttps://doi.org/10.1002/bit.27806openalex-snapshot
Process intensification to produce a difficult‐to‐express therapeutic enzyme by high cell density perfusion or enhanced fed‐batch
inferred← citeshttps://doi.org/10.1002/bit.27942openalex-snapshot
Production of butyrate and branched‐chain amino acid catabolic byproducts by CHO cells in fed‐batch culture enhances their specific productivity
inferred← citeshttps://doi.org/10.1002/bit.27944openalex-snapshot
A comparative analysis of recombinant Fab and full‐length antibody production in Chinese hamster ovary cells
inferred← citeshttps://doi.org/10.1002/bit.27990openalex-snapshot
Systematic assessment of process analytical technologies for biologics
inferred← citeshttps://doi.org/10.1002/bit.28011openalex-snapshot
Rapid at‐line early cell death quantification using capacitance spectroscopy
inferred← citeshttps://doi.org/10.1002/bit.28012openalex-snapshot
Structural analysis of random transgene integration in CHO manufacturing cell lines by targeted sequencing
inferred← citeshttps://doi.org/10.1002/bit.28013openalex-snapshot
Small molecule epigenetic modulators for enhancing recombinant antibody production in CHO cell cultures
inferred← citeshttps://doi.org/10.1002/bit.28079openalex-snapshot
High‐density adherent culture of CHO cells using rolled scaffold bioreactor
inferred← citeshttps://doi.org/10.1002/bit.28104openalex-snapshot
Combined multivariate statistical and flux balance analyses uncover media bottlenecks to the growth and productivity of Chinese hamster ovary cell cultures
inferred← citeshttps://doi.org/10.1002/bit.28128openalex-snapshot
Comprehensive assessment of host cell protein expression after extended culture and bioreactor production of CHO cell lines
inferred← citeshttps://doi.org/10.1002/bit.28289openalex-snapshot
Artificial induction of chromosome aneuploidy in CHO cells alters their function as host cells
inferred← citeshttps://doi.org/10.1002/bit.28322openalex-snapshot
Production cell analysis and compound‐based boosting of small extracellular vesicle secretion using a generic and scalable production platform
inferred← citeshttps://doi.org/10.1002/bit.28329openalex-snapshot
CRISPR‐interceded CHO cell line development approaches
inferred← citeshttps://doi.org/10.1002/bit.28366openalex-snapshot
How reliable are Chinese hamster ovary (CHO) cell genome‐scale metabolic models?
inferred← citeshttps://doi.org/10.1002/bit.28393openalex-snapshot
High‐efficiency and multilocus targeted integration in CHO cells using CRISPR‐mediated donor nicking and DNA repair inhibitors
inferred← citeshttps://doi.org/10.1002/bit.28399openalex-snapshot
Long term culture promotes changes to growth, gene expression, and metabolism in CHO cells that are independent of production stability
inferred← citeshttps://doi.org/10.1002/bit.28412openalex-snapshot
Critical challenges and advances in recombinant adeno‐associated virus (rAAV) biomanufacturing
inferred← citeshttps://doi.org/10.1002/bit.28576openalex-snapshot
Modeling of bioprocess pre‐stages for optimization of perfusion profiles and increased process understanding
inferred← citeshttps://doi.org/10.1002/bit.28611openalex-snapshot
Genome‐wide CRISPR/Cas9 knockout screening to mitigate cell growth inhibition induced by histone deacetylase inhibitors in recombinant CHO cells
inferred← citeshttps://doi.org/10.1002/bit.28616openalex-snapshot
Developing microRNAs as engineering tools to modulate monoclonal antibody galactosylation
inferred← citeshttps://doi.org/10.1002/bit.28678openalex-snapshot
Host cell protein networks as a novel co‐elution mechanism during protein A chromatography
inferred← citeshttps://doi.org/10.1002/bit.28717openalex-snapshot
Development of generic metabolic Raman calibration models using solution titration in aqueous phase and data augmentation for in‐line cell culture analysis
inferred← citeshttps://doi.org/10.1002/bit.28757openalex-snapshot
Multi‐cell‐line learning for the data‐driven construction of mechanistic metabolic models
inferred← citeshttps://doi.org/10.1002/bit.28879openalex-snapshot
Sequence and Configuration of a Novel Bispecific Antibody Format Impacts Its Production Using Chinese Hamster Ovary (CHO) Cells
inferred← citeshttps://doi.org/10.1002/bit.28884openalex-snapshot
Streamlined Clarification and Capture Process for Monoclonal Antibodies Using Fluidized Bed Centrifugation and Multi‐Column Chromatography With Membrane Adsorbers
inferred← citeshttps://doi.org/10.1002/bit.70147openalex-snapshot
Do We Really Need End‐To‐End Continuous Processing for Biomanufacturing of Monoclonal Antibodies?
inferred← citeshttps://doi.org/10.1002/bmc.5348openalex-snapshot
LC‐HRMS‐based targeted metabolomics for high‐throughput and quantitative analysis of 21 growth inhibition‐related metabolites in Chinese hamster ovary cell fed‐batch cultures
inferred← citeshttps://doi.org/10.1002/btpr.2805openalex-snapshot
Identification of upstream culture conditions and harvest time parameters that affect host cell protein clearance
inferred← citeshttps://doi.org/10.1002/btpr.3016openalex-snapshot
Highly sensitive HPLC analysis and biophysical characterization of N‐glycans of IgG‐Fc domain in comparison between CHO and 293 cells using FcγRIIIa ligand
inferred← citeshttps://doi.org/10.1002/btpr.3047openalex-snapshot
Development of a high cell density transient CHO platform yielding mAb titers greater than 2 g/L in only 7 days
inferred← citeshttps://doi.org/10.1002/btpr.3079openalex-snapshot
Hydrofoam and oxygen headspace bioreactors improve cell‐free therapeutic protein production yields through enhanced oxygen transport
inferred← citeshttps://doi.org/10.1002/btpr.3099openalex-snapshot
Metabolic profiling of Chinese hamster ovary cell cultures at different working volumes and agitation speeds using spin tube reactors
inferred← citeshttps://doi.org/10.1002/btpr.3137openalex-snapshot
CHOK1SV GS‐KO SSI expression system: A combination of the Fer1L4 locus and glutamine synthetase selection
inferred← citeshttps://doi.org/10.1002/btpr.3154openalex-snapshot
Rapid serum‐free /suspension adaptation: Medium development using a definitive screening design for Chinese hamster ovary cells
inferred← citeshttps://doi.org/10.1002/btpr.3176openalex-snapshot
Modulation of high mannose levels in N ‐linked glycosylation through cell culture process conditions to increase antibody‐dependent cell‐mediated cytotoxicity activity for an antibody biosimilar
inferred← citeshttps://doi.org/10.1002/btpr.3177openalex-snapshot
Process analytics 4.0: A paradigm shift in rapid analytics for biologics development
inferred← citeshttps://doi.org/10.1002/btpr.3220openalex-snapshot
Metabolic trends of Chinese hamster ovary cells in biopharmaceutical production under batch and fed‐batch conditions
inferred← citeshttps://doi.org/10.1002/btpr.3254openalex-snapshot
Generation of a host cell line containing a MAR ‐rich landing pad for site‐specific integration and expression of transgenes
inferred← citeshttps://doi.org/10.1002/btpr.3327openalex-snapshot
Tuning metabolic efficiency for increased product yield in high titer fed‐batch Chinese hamster ovary cell culture
inferred← citeshttps://doi.org/10.1002/btpr.3343openalex-snapshot
Analytical characterization of host‐cell‐protein‐rich aggregates in monoclonal antibody solutions
inferred← citeshttps://doi.org/10.1002/btpr.3378openalex-snapshot
Current challenges and recent advances on the path towards continuous biomanufacturing
inferred← citeshttps://doi.org/10.1002/btpr.3399openalex-snapshot
Utilizing targeted integration CHO pools to potentially accelerate the GMP manufacturing of monoclonal and bispecific antibodies
inferred← citeshttps://doi.org/10.1002/btpr.3410openalex-snapshot
An automated high inoculation density fed‐batch bioreactor, enabled through N‐1 perfusion, accommodates clonal diversity and doubles titers
inferred← citeshttps://doi.org/10.1002/btpr.3423openalex-snapshot
Development of bioreactor scale‐down model using orthogonal projections to latent structures method and CO 2 supplementation
inferred← citeshttps://doi.org/10.1002/btpr.3424openalex-snapshot
Adaptive modeling optimized by the data fusion strategy: Real‐time dying cell percentage prediction using capacitance spectroscopy
inferred← citeshttps://doi.org/10.1002/btpr.3449openalex-snapshot
When will we have a clone? An industry perspective on the typical CLD timeline
inferred← citeshttps://doi.org/10.1002/btpr.3471openalex-snapshot
Strategies to improve CHO cell culture performance: Targeted deletion of amino acid catabolism and apoptosis genes paired with growth inhibitor supplementation
inferred← citeshttps://doi.org/10.1002/btpr.3479openalex-snapshot
SPEED‐MODE cell line development ( CLD ): Reducing Chinese hamster ovary ( CHO ) CLD timelines via earlier suspension adaptation and maximizing time spent in the exponential growth phase
inferred← citeshttps://doi.org/10.1002/btpr.3519openalex-snapshot
Sensitivity of bulk electrical impedance spectroscopy (bio‐capacitance) probes to cell and culture properties: Study on CHO cell cultures
inferred← citeshttps://doi.org/10.1002/btpr.3532openalex-snapshot
Pre‐folding purification procedures for inclusion body‐derived non‐tagged cationic recombinant proteins with multiple disulfide bonds for efficient refolding
inferred← citeshttps://doi.org/10.1002/btpr.70022openalex-snapshot
Predictive mechanistic model for separation of monoclonal antibody, fab fragment, and aggregate species on multimodal chromatography
inferred← citeshttps://doi.org/10.1002/btpr.70089openalex-snapshot
Artificial intelligence and machine learning‐assisted digital applications for biopharmaceutical manufacturing
inferred← citeshttps://doi.org/10.1002/btpr.88512openalex-snapshot
Addressing challenging impurities in fusion proteins: A comprehensive review and cost‐effective strategy for HCP and low molecular weight species control
inferred← citeshttps://doi.org/10.1002/elps.202000252openalex-snapshot
Harnessing the power of electrophoresis and chromatography: Offline coupling of reverse phase liquid chromatography‐capillary zone electrophoresis‐tandem mass spectrometry for analysis of host cell proteins in monoclonal antibody producing CHO cell line
inferred← citeshttps://doi.org/10.1002/elps.202000375openalex-snapshot
Fast in‐line bottom‐up analysis of monoclonal antibodies: Toward an electrophoretic fingerprinting approach
inferred← citeshttps://doi.org/10.1002/elps.202100182openalex-snapshot
Applications of capillary electrophoresis for biopharmaceutical product characterization
inferred← citeshttps://doi.org/10.1002/elps.202200208openalex-snapshot
High‐throughput capillary electrophoresis analysis of biopharmaceuticals utilizing sequential injections
inferred← citeshttps://doi.org/10.1002/elps.202300221openalex-snapshot
Isolation and characterization of rabies monoclonal antibody charge variants
inferred← citeshttps://doi.org/10.1002/elsc.202000037openalex-snapshot
Regulation of pyruvate dehydrogenase complex related to lactate switch in CHO cells
inferred← citeshttps://doi.org/10.1002/elsc.202100057openalex-snapshot
Compartment‐specific 13C metabolic flux analysis reveals boosted NADPH availability coinciding with increased cell‐specific productivity for IgG1 producing CHO cells after MTA treatment
inferred← citeshttps://doi.org/10.1002/elsc.202100123openalex-snapshot
Applying intensified design of experiments to mammalian cell culture processes
inferred← citeshttps://doi.org/10.1002/elsc.202100124openalex-snapshot
Exploitation of the ribosomal protein L10 R98S mutation to enhance recombinant protein production in mammalian cells
inferred← citeshttps://doi.org/10.1002/elsc.70075openalex-snapshot
Molecular Pharming: Advances, Applications, and Future Prospects in Biotechnology and Medicine
inferred← citeshttps://doi.org/10.1002/eng2.12147openalex-snapshot
The uniqueness of flow in probing the aggregation behavior of clinically relevant antibodies
inferred← citeshttps://doi.org/10.1002/eng2.12172openalex-snapshot
Serum‐free suspension cultured human cells can produce a high‐level of recombinant human erythropoietin
inferred← citeshttps://doi.org/10.1002/jctb.6883openalex-snapshot
A novel strategy for efficient expression of an antibody fragment in Escherichia coli : ranibizumab as a case study
inferred← citeshttps://doi.org/10.1002/jctb.6933openalex-snapshot
Engineered asparaginase from Erwinia chrysanthemi enhances asparagine hydrolase activity and diminishes enzyme immunoreactivity ‐ a new promise to treat acute lymphoblastic leukemia
inferred← citeshttps://doi.org/10.1002/jctb.7363openalex-snapshot
Scale‐related process heterogeneities change properties of high‐cell‐density fermentation broths demonstrated with Escherichia coli B and K‐12 strains
inferred← citeshttps://doi.org/10.1002/jimd.70052openalex-snapshot
A Minor Haplotype Variant Determines the Pathogenicity of the p.Ile279Thr Substitution in the Primary Hyperoxaluria Type 1 Gene, AGXT
inferred← citeshttps://doi.org/10.1002/jms.4909openalex-snapshot
A multiparameter optimization in middle‐down analysis of monoclonal antibodies by LC–MS/MS
inferred← citeshttps://doi.org/10.1002/jssc.202100986openalex-snapshot
Rapid antibody conformational screening by matrix‐assisted laser desorption/ionization hydrogen‐deuterium exchange mass spectrometry
inferred← citeshttps://doi.org/10.1002/jssc.202200342openalex-snapshot
Study on antibody adsorption and elution performance of carboxyl and hydrophobic groups on mixed‐mode ligands
inferred← citeshttps://doi.org/10.1002/mame.201900311openalex-snapshot
Synthesis of Strong Cation Exchange Macroporous Polymer Cluster for Convective Protein Chromatography
inferred← citeshttps://doi.org/10.1002/mame.202100197openalex-snapshot
Effect of Poly(trehalose methacrylate) Molecular Weight and Concentration on the Stability and Viscosity of Insulin
inferred← citeshttps://doi.org/10.1002/pmic.202300069openalex-snapshot
Monitoring mAb proteoforms in mouse plasma using an automated immunocapture combined with top‐down and middle‐down mass spectrometry
inferred← citeshttps://doi.org/10.1002/pro.70200openalex-snapshot
A large language model for predicting neurotoxic peptides and neurotoxins
inferred← citeshttps://doi.org/10.1002/prot.26177openalex-snapshot
A trivalent TNF‐R2 as a new tumor necrosis factor alpha‐blocking molecule
inferred← citeshttps://doi.org/10.1002/smll.202005523openalex-snapshot
High‐Throughput Optimization of Recombinant Protein Production in Microfluidic Gel Beads
inferred← citeshttps://doi.org/10.1002/smtd.202100402openalex-snapshot
Nanotechnology‐Assisted RNA Delivery: From Nucleic Acid Therapeutics to COVID‐19 Vaccines
inferred← citeshttps://doi.org/10.1002/tbio.201900031openalex-snapshot
Photosensitizing proteins for antibacterial photodynamic inactivation
inferred← citeshttps://doi.org/10.1002/wnan.1684openalex-snapshot
Nanotechnology‐based approaches for treating lysosomal storage disorders, a focus on Fabry disease
inferred← citeshttps://doi.org/10.1002/wnan.1712openalex-snapshot
Hot melt extrusion: An emerging manufacturing method for slow and sustained protein delivery
inferred← citeshttps://doi.org/10.1007/10_2019_109openalex-snapshot
Gene Therapy
inferred← citeshttps://doi.org/10.1007/10_2019_119openalex-snapshot
Insights on the Formulation of Recombinant Proteins
inferred← citeshttps://doi.org/10.1007/10_2020_136openalex-snapshot
Digital Twins and Their Role in Model-Assisted Design of Experiments
inferred← citeshttps://doi.org/10.1007/978-1-0716-0928-6_3openalex-snapshot
Peptide Nanoparticles for Gene Packaging and Intracellular Delivery
inferred← citeshttps://doi.org/10.1007/978-1-0716-1241-5_22openalex-snapshot
Glycosylation Profiling of Glycoproteins Secreted from Cultured Cells Using Glycan Node Analysis and GC-MS
inferred← citeshttps://doi.org/10.1007/978-1-0716-1685-7_7openalex-snapshot
Rapid Antibody Glycoengineering in CHO Cells Via RNA Interference and CGE-LIF N-Glycomics
inferred← citeshttps://doi.org/10.1007/978-1-0716-1859-2_1openalex-snapshot
Recombinant Protein Production and Purification of Insoluble Proteins
inferred← citeshttps://doi.org/10.1007/978-1-0716-1859-2_25openalex-snapshot
Eukaryotic Aggresomes: Protocols and Tips for Their Production, Purification, and Handling
inferred← citeshttps://doi.org/10.1007/978-1-0716-1859-2_7openalex-snapshot
Cleavable Self-Aggregating Tags (cSAT) for Therapeutic Peptide Expression and Purification
inferred← citeshttps://doi.org/10.1007/978-1-0716-2493-7_2openalex-snapshot
Capillary Electrophoresis–Mass Spectrometry (CE-MS) by Sheath–Flow Nanospray Interface and Its Use in Biopharmaceutical Applications
inferred← citeshttps://doi.org/10.1007/978-1-0716-2930-7_1openalex-snapshot
Inclusion Bodies: Status Quo and Perspectives
inferred← citeshttps://doi.org/10.1007/978-1-0716-2930-7_2openalex-snapshot
Thermoinducible E. coli for Recombinant Protein Production in Inclusion Bodies
inferred← citeshttps://doi.org/10.1007/978-1-0716-3279-6_19openalex-snapshot
Cell Line Development Using Targeted Gene Integration into MAR-Rich Landing Pads for Stable Expression of Transgenes
inferred← citeshttps://doi.org/10.1007/978-1-0716-3279-6_20openalex-snapshot
Generation of Human 293-F Suspension NGFR Knockout Cells Using CRISPR/Cas9 Coupled to Fluorescent Protein Expression
inferred← citeshttps://doi.org/10.1007/978-1-0716-3362-5_5openalex-snapshot
Scale-Up of Protein Purification: Downstream Processing Issues
inferred← citeshttps://doi.org/10.1007/978-1-0716-4104-0_9openalex-snapshot
The ‘Omics Revolution in CHO Biology: Roadmap to Improved CHO Productivity
inferred← citeshttps://doi.org/10.1007/978-1-0716-5041-7_10openalex-snapshot
Transient Expression and Characterization of Antibodies and Antibody Fragments
inferred← citeshttps://doi.org/10.1007/978-3-030-11751-1_7openalex-snapshot
NMR in the Characterization of Complex Mixture Drugs
inferred← citeshttps://doi.org/10.1007/978-3-030-49924-2_13openalex-snapshot
Yeast Cell Factories
inferred← citeshttps://doi.org/10.1007/978-3-030-54630-4_13openalex-snapshot
Eukaryotic Expression Systems for Upstream Processing of Monoclonal Antibodies
inferred← citeshttps://doi.org/10.1007/978-3-030-58271-5_5openalex-snapshot
Duckweeds for the Production of Therapeutic Proteins
inferred← citeshttps://doi.org/10.1007/978-3-030-79871-0_1openalex-snapshot
Biopharmaceuticals Produced from Cultivated Mammalian Cells
inferred← citeshttps://doi.org/10.1007/978-3-030-79871-0_13openalex-snapshot
Intensified and Continuous mAb Production with Single-Use Systems
inferred← citeshttps://doi.org/10.1007/978-3-030-79871-0_16openalex-snapshot
Monitoring Tools for the Development of High Cell Density Culture Strategies
inferred← citeshttps://doi.org/10.1007/978-3-030-79871-0_3openalex-snapshot
Next Generation Cell Engineering Using microRNAs
inferred← citeshttps://doi.org/10.1007/978-3-030-79871-0_5openalex-snapshot
Redesigning Spent Media from Cell Culture Bioprocess to Feed New Bacterial Fermentations
inferred← citeshttps://doi.org/10.1007/978-3-030-79871-0_6openalex-snapshot
Monoclonal Antibody Glycoengineering for Biopharmaceutical Quality Assurance
inferred← citeshttps://doi.org/10.1007/978-3-030-79871-0_7openalex-snapshot
Next-Generation Cell Engineering Platform for Improving Recombinant Protein Production in Mammalian Cells
inferred← citeshttps://doi.org/10.1007/978-3-030-83395-4_3openalex-snapshot
Models Used for Biopharmaceutical Evaluation of Nanoparticulate Drug Delivery System (NPDDS)
inferred← citeshttps://doi.org/10.1007/978-3-031-06600-9_1openalex-snapshot
Advancements in Inducer Systems for Recombinant Protein Production in E. coli
inferred← citeshttps://doi.org/10.1007/978-3-031-06600-9_4openalex-snapshot
Strategies for Improving Biotherapeutic Protein Production in Microbial Cell Factories
inferred← citeshttps://doi.org/10.1007/978-3-031-12794-6_1openalex-snapshot
Molecular Farming in Plants: Introduction and Applications
inferred← citeshttps://doi.org/10.1007/978-3-031-17929-7_3openalex-snapshot
Role of Machine Learning in Bioprocess Engineering: Current Perspectives and Future Directions
inferred← citeshttps://doi.org/10.1007/978-3-031-45669-5_6openalex-snapshot
Towards Digital Twin for Biopharmaceutical Processes: Concept and Progress
inferred← citeshttps://doi.org/10.1007/978-3-031-62007-2_17openalex-snapshot
CMC Considerations for Continuous Bioprocess Design, Development, and Manufacturing
inferred← citeshttps://doi.org/10.1007/978-3-031-62007-2_4openalex-snapshot
Advancements in the Manufacture of Monoclonal Antibodies and Other Large Molecule Protein Therapeutics: Recent Innovations in Cell Culture Technology Enabling Process Intensification
inferred← citeshttps://doi.org/10.1007/978-3-031-75700-6_2openalex-snapshot
Digitale Zwillinge und ihre Rolle im modellgestützten Design von Experimenten
inferred← citeshttps://doi.org/10.1007/978-3-032-17514-4_10openalex-snapshot
Standardized Process Engineering Characterization and Biological Evaluation of Stirred Bioreactors for Microbial Processes
inferred← citeshttps://doi.org/10.1007/978-3-032-18003-2_4openalex-snapshot
Chimeric Enzymes
inferred← citeshttps://doi.org/10.1007/978-3-032-28873-8_5openalex-snapshot
Media and Growth Conditions
inferred← citeshttps://doi.org/10.1007/978-981-13-9077-7_3openalex-snapshot
Membrane Proteins as Targets for Biological Drugs
inferred← citeshttps://doi.org/10.1007/978-981-15-7590-7_1openalex-snapshot
Large Biomolecules: An Overview
inferred← citeshttps://doi.org/10.1007/978-981-16-3307-2_21openalex-snapshot
Heterologous Protein Expression in Yeast and Molds
inferred← citeshttps://doi.org/10.1007/978-981-16-5485-5_10openalex-snapshot
Biopharmaceutical Applications
inferred← citeshttps://doi.org/10.1007/978-981-16-7262-0_10openalex-snapshot
Molecular Farming: Sustainable Manufacturing of Vaccines, Antibodies, and Other Therapeutic Substances
inferred← citeshttps://doi.org/10.1007/978-981-16-7897-4_10openalex-snapshot
Therapeutic Peptides in Skin and Hair Disorders
inferred← citeshttps://doi.org/10.1007/978-981-19-7911-8_1openalex-snapshot
Strain Design and Optimization Methods for Sustainable Production
inferred← citeshttps://doi.org/10.1007/978-981-19-8853-0_18openalex-snapshot
Heterologous Gene Expression in Pichia pastoris: Success Stories and Commercial Ventures
inferred← citeshttps://doi.org/10.1007/978-981-95-5378-5_12openalex-snapshot
Biotechnological Advances in Therapeutics: Therapeutic Proteins, Antibodies, Vaccines, and Regulatory Standards
inferred← citeshttps://doi.org/10.1007/978-981-95-5378-5_2openalex-snapshot
Genetically Engineered Microorganisms and Their Role in Industrial and Therapeutic Product Development
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