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Critical challenges and advances in recombinant adeno‐associated virus (rAAV) biomanufacturing

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Extended gene expression for Gag VLP production achieved at bioreactor scale

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Economized large‐scale production of high yield of rAAV for gene therapy applications exploiting baculovirus expression system

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The Human Transcriptome

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Cellular pathways of recombinant adeno-associated virus production for gene therapy

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A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism

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Reducing Recon 2 for steady-state flux analysis of HEK cell culture

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An RNA-seq based transcriptomic investigation into the productivity and growth variants with Chinese hamster ovary cells

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Separation of adeno-associated virus type 2 empty particles from genome containing vectors by anion-exchange column chromatography

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Developing an Anion Exchange Chromatography Assay for Determining Empty and Full Capsid Contents in AAV6.2

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Methods Matter: Standard Production Platforms for Recombinant AAV Produce Chemically and Functionally Distinct Vectors

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Creation of a High-Yield AAV Vector Production Platform in Suspension Cells Using a Design-of-Experiment Approach

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NaCl and KCl mediate log increase in AAV vector particles and infectious titers in a specific/timely manner with the HSV platform

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Development of a scalable and robust AEX method for enriched rAAV preparations in genome-containing VCs of serotypes 5, 6, 8, and 9

inferredcites →https://doi.org/10.1016/j.omtm.2021.04.006openalex-snapshot

Mechanistic model for production of recombinant adeno-associated virus via triple transfection of HEK293 cells

inferredcites →https://doi.org/10.1016/j.omtm.2023.01.002openalex-snapshot

Production of rAAV by plasmid transfection induces antiviral and inflammatory responses in suspension HEK293 cells

inferredcites →https://doi.org/10.1016/j.pep.2012.04.023openalex-snapshot

Human cells: New platform for recombinant therapeutic protein production

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Cellular targets for improved manufacturing of virus-based biopharmaceuticals in animal cells

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Modern trends in downstream processing of biotherapeutics through continuous chromatography: The potential of Multicolumn Countercurrent Solvent Gradient Purification

inferredcites →https://doi.org/10.1016/j.vaccine.2015.05.097openalex-snapshot

Influence of HEK293 metabolism on the production of viral vectors and vaccine

inferredcites →https://doi.org/10.1016/j.vaccine.2019.05.064openalex-snapshot

Zika virus-like particles (VLPs): Stable cell lines and continuous perfusion processes as a new potential vaccine manufacturing platform

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Manufacturing Challenges and Rational Formulation Development for AAV Viral Vectors

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Metabolic pathways recruited in the production of a recombinant enveloped virus: Mining targets for process and cell engineering

inferredcites →https://doi.org/10.1016/j.ymthe.2005.08.018openalex-snapshot

Successful Production of Pseudotyped rAAV Vectors Using a Modified Baculovirus Expression System

inferredcites →https://doi.org/10.1016/j.ymthe.2006.05.009openalex-snapshot

Adeno-associated Virus Serotypes: Vector Toolkit for Human Gene Therapy

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“D” matters in recombinant AAV DNA packaging

inferredcites →https://doi.org/10.1016/s1525-0016(02)00019-9openalex-snapshot

Quantification of adeno-associated virus particles and empty capsids by optical density measurement

inferredcites →https://doi.org/10.1016/s1525-0016(16)41455-3openalex-snapshot

1013. In Vivo Performance of AAV2 Vectors Purified by CsCl Gradient Centrifugation or Column Chromatography

inferredcites →https://doi.org/10.1021/acs.jproteome.9b00601openalex-snapshot

Multiplexed Quantitative Proteomic Analysis of HEK293 Provides Insights into Molecular Changes Associated with the Cell Density Effect, Transient Transfection, and Virus-Like Particle Production

inferredcites →https://doi.org/10.1021/acssynbio.2c00207openalex-snapshot

Construction of an rAAV Producer Cell Line through Synthetic Biology

inferredcites →https://doi.org/10.1038/gt.2009.157openalex-snapshot

High AAV vector purity results in serotype- and tissue-independent enhancement of transduction efficiency

inferredcites →https://doi.org/10.1038/gt.2010.27openalex-snapshot

Near-perfect infectivity of wild-type AAV as benchmark for infectivity of recombinant AAV vectors

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miRNA-mediated post-transcriptional silencing of transgenes leads to increased adeno-associated viral vector yield and targeting specificity

inferredcites →https://doi.org/10.1038/mt.2008.35openalex-snapshot

Intron Splicing–mediated Expression of AAV Rep and Cap Genes and Production of AAV Vectors in Insect Cells

inferredcites →https://doi.org/10.1038/mt.2009.128openalex-snapshot

A Simplified Baculovirus-AAV Expression Vector System Coupled With One-step Affinity Purification Yields High-titer rAAV Stocks From Insect Cells

inferredcites →https://doi.org/10.1038/mt.2013.268openalex-snapshot

AAV Empty Capsids: For Better or for Worse?

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Riboswitch-mediated Attenuation of Transgene Cytotoxicity Increases Adeno-associated Virus Vector Yields in HEK-293 Cells

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Production of Recombinant Adeno-associated Virus Vectors Using Suspension HEK293 Cells and Continuous Harvest of Vector From the Culture Media for GMP FIX and FLT1 Clinical Vector

inferredcites →https://doi.org/10.1038/mtm.2013.9openalex-snapshot

Empty virions in AAV8 vector preparations reduce transduction efficiency and may cause total viral particle dose-limiting side effects

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Ultracentrifugation-free chromatography-mediated large-scale purification of recombinant adeno-associated virus serotype 1 (rAAV1)

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Manufacturing of recombinant adeno-associated viral vectors for clinical trials

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The haplotype-resolved genome and epigenome of the aneuploid HeLa cancer cell line

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A draft map of the human proteome

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Biopharmaceutical benchmarks 2018

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Genome dynamics of the human embryonic kidney 293 lineage in response to cell biology manipulations

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New developments in the generation of Ad-free, high-titer rAAV gene therapy vectors

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Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

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CD8+ T-cell responses to adeno-associated virus capsid in humans

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Synthetic materials at the forefront of gene delivery

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Adeno-associated virus vector as a platform for gene therapy delivery

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Engineering adeno-associated virus vectors for gene therapy

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Coupling Multi Angle Light Scattering to Ion Exchange chromatography (IEX-MALS) for protein characterization

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Direct intramuscular injection with recombinant AAV vectors results in sustained expression in a dog model of hemophilia

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High-titer recombinant adeno-associated virus production utilizing a recombinant herpes simplex virus type I vector expressing AAV-2 Rep and Cap

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Inducible Packaging Cells for Large-scale Production of Lentiviral Vectors in Serum-free Suspension Culture

inferredcites →https://doi.org/10.1038/sj.onc.1209046openalex-snapshot

SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation

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Reconstruction of genome-scale human metabolic models using omics data

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Cytoplasmic transport and nuclear import of plasmid DNA

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How adeno-associated virus Rep78 protein arrests cells completely in S phase

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Advancements in mammalian cell transient gene expression (TGE) technology for accelerated production of biologics

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Current challenges in biotherapeutic particles manufacturing

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Downstream processing and chromatography based analytical methods for production of vaccines, gene therapy vectors, and bacteriophages

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Insect Cells as a Factory to Produce Adeno-Associated Virus Type 2 Vectors

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Efficient Production of rAAV in a Perfusion Bioreactor Using an ELEVECTA ® Stable Producer Cell Line

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Analysis of Particle Content of Recombinant Adeno-Associated Virus Serotype 8 Vectors by Ion-Exchange Chromatography

inferredcites →https://doi.org/10.1089/hgtb.2013.046openalex-snapshot

Generation and Characterization of Adeno-Associated Virus Producer Cell Lines for Research and Preclinical Vector Production

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Comparative Analysis of Cesium Chloride- and Iodixanol-Based Purification of Recombinant Adeno-Associated Viral Vectors for Preclinical Applications

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Sodium Chloride Enhances Recombinant Adeno-Associated Virus Production in a Serum-Free Suspension Manufacturing Platform Using the Herpes Simplex Virus System

inferredcites →https://doi.org/10.1089/hgtb.2016.188openalex-snapshot

Improving the Quality of Adeno-Associated Viral Vector Preparations: The Challenge of Product-Related Impurities

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Scalable Lentiviral Vector Production Using Stable HEK293SF Producer Cell Lines

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Analytical Strategies for Quantification of Adeno-Associated Virus Empty Capsids to Support Process Development

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Development of Versatile and Flexible Sf9 Packaging Cell Line-Dependent OneBac System for Large-Scale Recombinant Adeno-Associated Virus Production

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Scalable Recombinant Adeno-Associated Virus Production Using Recombinant Herpes Simplex Virus Type 1 Coinfection of Suspension-Adapted Mammalian Cells

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Manufacturing Recombinant Adeno-Associated Viral Vectors from Producer Cell Clones

inferredcites →https://doi.org/10.1089/hum.2009.094openalex-snapshot

Large-Scale Adeno-Associated Viral Vector Production Using a Herpesvirus-Based System Enables Manufacturing for Clinical Studies

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Rapid, Simple, and Versatile Manufacturing of Recombinant Adeno-Associated Viral Vectors at Scale

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A Versatile Adeno-Associated Virus Vector Producer Cell Line Method for Scalable Vector Production of Different Serotypes

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OneBac: Platform for Scalable and High-Titer Production of Adeno-Associated Virus Serotype 1–12 Vectors for Gene Therapy

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Adeno-Associated Virus at 50: A Golden Anniversary of Discovery, Research, and Gene Therapy Success—A Personal Perspective

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OneBac 2.0: Sf 9 Cell Lines for Production of AAV5 Vectors with Enhanced Infectivity and Minimal Encapsidation of Foreign DNA

inferredcites →https://doi.org/10.1089/hum.2017.29039.trfopenalex-snapshot

Empty Adeno-Associated Virus Capsids: Contaminant or Natural Decoy?

inferredcites →https://doi.org/10.1089/hum.2020.069openalex-snapshot

Adeno-Associated Virus Genome Interactions Important for Vector Production and Transduction

inferredcites →https://doi.org/10.1089/humc.2014.060openalex-snapshot

Herpes Simplex Virus Clearance During Purification of a Recombinant Adeno-Associated Virus Serotype 1 Vector

inferredcites →https://doi.org/10.1093/emboj/20.12.3282openalex-snapshot

DNA helicase‐mediated packaging of adeno‐associated virus type 2 genomes into preformed capsids

inferredcites →https://doi.org/10.1093/nar/gky955openalex-snapshot

GENCODE reference annotation for the human and mouse genomes

inferredcites →https://doi.org/10.1099/vir.0.79940-0openalex-snapshot

The adenovirus E1A and E1B19K genes provide a helper function for transfection-based adeno-associated virus vector production

inferredcites →https://doi.org/10.1101/488585openalex-snapshot

Improved yield of AAV2 and rAAV2-retro serotypes following sugar supplementation during the viral production phase

inferredcites →https://doi.org/10.1126/science.aal3321openalex-snapshot

A subcellular map of the human proteome

inferredcites →https://doi.org/10.1126/science.aan4672openalex-snapshot

Gene therapy comes of age

inferredcites →https://doi.org/10.1128/cmr.00008-08openalex-snapshot

Gene Therapy Using Adeno-Associated Virus Vectors

inferredcites →https://doi.org/10.1128/jvi.00318-09openalex-snapshot

Adeno-Associated Virus Replication Induces a DNA Damage Response Coordinated by DNA-Dependent Protein Kinase

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Adeno-associated virus P5 promoter contains an adenovirus E1A-inducible element and a binding site for the major late transcription factor

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Cell lines inducibly expressing the adeno-associated virus (AAV) rep gene: requirements for productive replication of rep-negative AAV mutants

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In vitro replication of adeno-associated virus DNA

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Characterization of cell lines that inducibly express the adeno-associated virus Rep proteins

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Development of a complementing cell line and a system for construction of adenovirus vectors with E1 and E2a deleted

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In Vitro Packaging of Adeno-Associated Virus DNA

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The Early Region 4 orf4 Protein of Human Adenovirus Type 5 Induces p53-Independent Cell Death by Apoptosis

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Adeno-Associated Virus Type 2 Rep78 Induces Apoptosis through Caspase Activation Independently of p53

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A Novel Gene Expression Control System and Its Use in Stable, High-Titer 293 Cell-Based Adeno-Associated Virus Packaging Cell Lines

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Feasibility of Generating Adeno-Associated Virus Packaging Cell Lines Containing Inducible Adenovirus Helper Genes

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Scalable Generation of High-Titer Recombinant Adeno-Associated Virus Type 5 in Insect Cells

inferredcites →https://doi.org/10.1128/mbio.03528-22openalex-snapshot

Adeno-Associated Virus Monoinfection Induces a DNA Damage Response and DNA Repair That Contributes to Viral DNA Replication

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AAV-Mediated Gene Therapy for Research and Therapeutic Purposes

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Additional file 1 of Administration of an AAV vector coding for a P2X7-blocking nanobody-based biologic ameliorates colitis in mice

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