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PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/dvg.20231openalex-snapshot
Development of a steroidogenic factor 1/Cre transgenic mouse line
inferredcites →https://doi.org/10.1002/dvg.20335openalex-snapshot
A global double‐fluorescent Cre reporter mouse
inferredcites →https://doi.org/10.1002/dvg.20566openalex-snapshot
Generation of an allele to inactivate Wnt4 gene function conditionally in the mouse
inferredcites →https://doi.org/10.1002/j.1460-2075.1993.tb05715.xopenalex-snapshot
Modulation of the glycogen synthase kinase‐3 family by tyrosine phosphorylation.
inferredcites →https://doi.org/10.1016/j.ccell.2016.04.002openalex-snapshot
Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma
inferredcites →https://doi.org/10.1016/j.cell.2006.01.053openalex-snapshot
Parafibromin/Hyrax Activates Wnt/Wg Target Gene Transcription by Direct Association with β-catenin/Armadillo
inferredcites →https://doi.org/10.1016/j.devcel.2006.03.015openalex-snapshot
Apc Tumor Suppressor Gene Is the “Zonation-Keeper” of Mouse Liver
inferredcites →https://doi.org/10.1016/j.devcel.2013.07.016openalex-snapshot
Adrenocortical Zonation Results from Lineage Conversion of Differentiated Zona Glomerulosa Cells
inferredcites →https://doi.org/10.1016/j.mce.2008.10.045openalex-snapshot
A transgenic mouse line with specific Cre recombinase expression in the adrenal cortex
inferredcites →https://doi.org/10.1016/j.mce.2012.04.004openalex-snapshot
Investigating the role of adrenal cortex in organization and differentiation of the adrenal medulla in mice
inferredcites →https://doi.org/10.1016/j.mce.2014.12.014openalex-snapshot
Adrenal cortex tissue homeostasis and zonation: A WNT perspective
inferredcites →https://doi.org/10.1016/j.molcel.2011.05.014openalex-snapshot
SHP2 Tyrosine Phosphatase Converts Parafibromin/Cdc73 from a Tumor Suppressor to an Oncogenic Driver
inferredcites →https://doi.org/10.1016/j.yexcr.2009.06.021openalex-snapshot
Genomic response to Wnt signalling is highly context-dependent — Evidence from DNA microarray and chromatin immunoprecipitation screens of Wnt/TCF targets
inferredcites →https://doi.org/10.1038/msb.2013.12openalex-snapshot
Construction of human activity‐based phosphorylation networks
inferredcites →https://doi.org/10.1038/nature11308openalex-snapshot
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors
inferredcites →https://doi.org/10.1038/ncb3164openalex-snapshot
Inactivation of a Gαs–PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis
inferredcites →https://doi.org/10.1038/ncomms4149openalex-snapshot
RSPO2–LGR5 signaling has tumour-suppressive activity in colorectal cancer
inferredcites →https://doi.org/10.1038/ng1330openalex-snapshot
Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer
inferredcites →https://doi.org/10.1055/s-2006-950500openalex-snapshot
Adenovirus-delivered DKK3/WNT4 and Steroidogenesis in Primary Cultures of Adrenocortical Cells
inferredcites →https://doi.org/10.1073/pnas.0706953104openalex-snapshot
Melanocortin 2 receptor is required for adrenal gland development, steroidogenesis, and neonatal gluconeogenesis
inferredcites →https://doi.org/10.1073/pnas.0909471106openalex-snapshot
Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages
inferredcites →https://doi.org/10.1073/pnas.220413597openalex-snapshot
Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A
inferredcites →https://doi.org/10.1074/jbc.m111412200openalex-snapshot
Protein Kinase A Deficiency Causes Axially Localized Neural Tube Defects in Mice
inferredcites →https://doi.org/10.1074/jbc.m508778200openalex-snapshot
Phosphorylation of β-Catenin by Cyclic AMP-dependent Protein Kinase
inferredcites →https://doi.org/10.1093/emboj/18.21.5931openalex-snapshot
Intestinal polyposis in mice with a dominant stable mutation of the β‐catenin gene
inferredcites →https://doi.org/10.1093/hmg/ddq029openalex-snapshot
Constitutive β-catenin activation induces adrenal hyperplasia and promotes adrenal cancer development
inferredcites →https://doi.org/10.1093/hmg/ddt484openalex-snapshot
WNT/β-catenin signalling is activated in aldosterone-producing adenomas and controls aldosterone production
inferredcites →https://doi.org/10.1101/gad.277756.116openalex-snapshot
The adrenal capsule is a signaling center controlling cell renewal and zonation through Rspo3
inferredcites →https://doi.org/10.1111/j.1365-2265.2008.03273.xopenalex-snapshot
Detection of somatic β‐catenin mutations in primary pigmented nodular adrenocortical disease (PPNAD)
inferredcites →https://doi.org/10.1126/scisignal.2000230openalex-snapshot
Bruton’s Tyrosine Kinase Revealed as a Negative Regulator of Wnt–β-Catenin Signaling
inferredcites →https://doi.org/10.1128/mcb.25.20.9063-9072.2005openalex-snapshot
Phosphorylation of β-Catenin by Cyclic AMP-Dependent Protein Kinase Stabilizes β-Catenin through Inhibition of Its Ubiquitination
inferredcites →https://doi.org/10.1158/0008-5472.can-05-0580openalex-snapshot
A Mouse Model for the Carney Complex Tumor Syndrome Develops Neoplasia in Cyclic AMP–Responsive Tissues
inferredcites →https://doi.org/10.1158/0008-5472.can-05-0593openalex-snapshot
Mutations of β-Catenin in Adrenocortical Tumors: Activation of the Wnt Signaling Pathway Is a Frequent Event in both Benign and Malignant Adrenocortical Tumors
inferredcites →https://doi.org/10.1210/en.2002-220275openalex-snapshot
Wnt-4 Deficiency Alters Mouse Adrenal Cortex Function, Reducing Aldosterone Production
inferredcites →https://doi.org/10.1210/en.2006-1509openalex-snapshot
Disabled-2 Is Expressed in Adrenal Zona Glomerulosa and Is Involved in Aldosterone Secretion
inferredcites →https://doi.org/10.1210/er.2008-0039openalex-snapshot
In Search of Adrenocortical Stem and Progenitor Cells
inferredcites →https://doi.org/10.1210/jc.2005-1301openalex-snapshot
Serial Analysis of Gene Expression in Adrenocortical Hyperplasia Caused by a GermlinePRKAR1AMutation
inferredcites →https://doi.org/10.1210/jc.2008-0631openalex-snapshot
Wnt/β-Catenin and 3′,5′-Cyclic Adenosine 5′-Monophosphate/Protein Kinase A Signaling Pathways Alterations and Somatic β-Catenin Gene Mutations in the Progression of Adrenocortical Tumors
inferredcites →https://doi.org/10.1210/jc.2011-3000openalex-snapshot
Activation of Cyclic AMP Signaling Leads to Different Pathway Alterations in Lesions of the Adrenal Cortex Caused by Germline PRKAR1A Defects versus Those due to Somatic GNAS Mutations
inferredcites →https://doi.org/10.1210/jcem.82.9.4211openalex-snapshot
Deletion of the Adrenocorticotropin Receptor Gene in Human Adrenocortical Tumors: Implications for Tumorigenesis1
inferredcites →https://doi.org/10.1210/me.2014-1060openalex-snapshot
Wnt Signaling Inhibits Adrenal Steroidogenesis by Cell-Autonomous and Non–Cell-Autonomous Mechanisms
inferredcites →https://doi.org/10.1210/mend.15.1.0577openalex-snapshot
SF-1 (Steroidogenic Factor-1), C/EBPβ (CCAAT/Enhancer Binding Protein), and Ubiquitous Transcription Factors NF1 (Nuclear Factor 1) and Sp1 (Selective Promoter Factor 1) Are Required for Regulation of the Mouse Aldose Reductase-Like Gene (AKR1B7) Expression in Adrenocortical Cells
inferredcites →https://doi.org/10.1210/mend.16.3.0793openalex-snapshot
Mutation of the Cα Subunit of PKA Leads to Growth Retardation and Sperm Dysfunction
inferredcites →https://doi.org/10.1242/dev.126.20.4557openalex-snapshot
Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation
inferredcites →https://doi.org/10.1242/jcs.147835openalex-snapshot
The metastasis suppressor, NDRG1, modulates β-Catenin phosphorylation and nuclear translocation by mechanisms involving FRAT1 and PAK4
inferredcites →https://doi.org/10.1371/journal.pgen.1000980openalex-snapshot
Cushing's Syndrome and Fetal Features Resurgence in Adrenal Cortex–Specific Prkar1a Knockout Mice
inferredcites →https://doi.org/10.1371/journal.pone.0044171openalex-snapshot
Analysis of the Role of Igf2 in Adrenal Tumour Development in Transgenic Mouse Models
inferredcites →https://doi.org/10.1371/journal.pone.0109523openalex-snapshot
Protein Kinase A Activation Enhances β-Catenin Transcriptional Activity through Nuclear Localization to PML Bodies
inferredcites →https://doi.org/10.1530/jme-11-0011openalex-snapshot
Localisation of the melanocortin-2-receptor and its accessory proteins in the developing and adult adrenal gland
inferredcites →https://doi.org/10.4158/ep10412.raopenalex-snapshot
The Transcriptome that Mediates Increased Cyclic Adenosine Monophosphate Signaling in Prkar1a Defects and Other Settings

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4771923openalex-extracted
Cellular Landscape of Adrenocortical Carcinoma at Single-Nuclei Resolution
inferred← citeshttps://doi.org/10.1002/ctd2.113openalex-snapshot
The secreted protein augurin is a novel modulator of canonical Wnt signalling involved in osteoblast differentiation
inferred← citeshttps://doi.org/10.1007/978-3-030-44628-4_13-1openalex-snapshot
Primary Aldosteronism
inferred← citeshttps://doi.org/10.1007/978-3-031-27119-9_13openalex-snapshot
Primary Aldosteronism
inferred← citeshttps://doi.org/10.1007/978-3-319-62470-9_1openalex-snapshot
Adrenal Zonation and Development
inferred← citeshttps://doi.org/10.1007/s00418-025-02446-6openalex-snapshot
Identification of conserved canonical marker genes in human and mouse adrenal glands using Visium spatial transcriptomics
inferred← citeshttps://doi.org/10.1007/s00441-021-03432-9openalex-snapshot
Flow-dependent differentiation of cultured adrenal cells under different stimuli
inferred← citeshttps://doi.org/10.1007/s00535-021-01846-4openalex-snapshot
Mutant GNAS limits tumor aggressiveness in established pancreatic cancer via antagonizing the KRAS-pathway
inferred← citeshttps://doi.org/10.1007/s00535-023-02024-4openalex-snapshot
Current status of molecular diagnostic approaches using liquid biopsy
inferred← citeshttps://doi.org/10.1007/s11154-022-09756-3openalex-snapshot
Development and function of the fetal adrenal
inferred← citeshttps://doi.org/10.1007/s13402-026-01258-7openalex-snapshot
PDIA6 exacerbates hepatocellular carcinoma via enhancing proteasome-dependent degradation of AKAP12
inferred← citeshttps://doi.org/10.1016/b978-0-12-801238-3.03726-0openalex-snapshot
Adrenal Cortex; Development
inferred← citeshttps://doi.org/10.1016/b978-0-443-13825-6.00262-4openalex-snapshot
Adrenal cortex; Development
inferred← citeshttps://doi.org/10.1016/j.ando.2018.03.014openalex-snapshot
Adrenocortical development: Lessons from mouse models
inferred← citeshttps://doi.org/10.1016/j.celrep.2018.01.003openalex-snapshot
Modeling Congenital Adrenal Hyperplasia and Testing Interventions for Adrenal Insufficiency Using Donor-Specific Reprogrammed Cells
inferred← citeshttps://doi.org/10.1016/j.celrep.2020.107524openalex-snapshot
Beta-Catenin Causes Adrenal Hyperplasia by Blocking Zonal Transdifferentiation
inferred← citeshttps://doi.org/10.1016/j.coemr.2019.06.011openalex-snapshot
Partial glucocorticoid resistance in the pathophysiology of adrenal cortex hyperplasia
inferred← citeshttps://doi.org/10.1016/j.coemr.2019.07.009openalex-snapshot
Regulation of stem and progenitor cells in the adrenal cortex
inferred← citeshttps://doi.org/10.1016/j.coemr.2019.08.016openalex-snapshot
WNT pathway deregulation in adrenal cortex tumorigenesis
inferred← citeshttps://doi.org/10.1016/j.cpblue.2026.100015openalex-snapshot
An organoid model of the human adrenal cortex identifies drivers of steroidogenesis and zonation
inferred← citeshttps://doi.org/10.1016/j.devcel.2020.10.004openalex-snapshot
Limiting Self-Renewal of the Basal Compartment by PKA Activation Induces Differentiation and Alters the Evolution of Mammary Tumors
inferred← citeshttps://doi.org/10.1016/j.ebiom.2024.105087openalex-snapshot
Steroids-producing nodules: a two-layered adrenocortical nodular structure as a precursor lesion of cortisol-producing adenoma
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2025.119497openalex-snapshot
Adrenal injury induced by real-ambient PM2.5: Mechanisms of disrupted Shh/Wnt signaling crosstalk
inferred← citeshttps://doi.org/10.1016/j.heliyon.2021.e05932openalex-snapshot
Transcription factors β-catenin and Hex in postnatal development of the rat adrenal cortex: implication in proliferation control
inferred← citeshttps://doi.org/10.1016/j.jid.2022.04.019openalex-snapshot
Steroidogenic Factor-1 Lineage Origin of Skin Lesions in Carney Complex Syndrome
inferred← citeshttps://doi.org/10.1016/j.jsbmb.2019.04.009openalex-snapshot
RNA-seq analysis of LPS-induced transcriptional changes and its possible implications for the adrenal gland dysregulation during sepsis
inferred← citeshttps://doi.org/10.1016/j.jsbmb.2019.105422openalex-snapshot
DLK1/PREF1 marks a novel cell population in the human adrenal cortex
inferred← citeshttps://doi.org/10.1016/j.jsbmb.2026.106939openalex-snapshot
Androgen production in adrenocortical H295R cells is regulated by thyroid hormone T3 without reciprocal thyroid axis modulation in pediatric CAH
inferred← citeshttps://doi.org/10.1016/j.lpm.2025.104300openalex-snapshot
Adrenocortical organoids: A promising tool for modelling human physiology and translational research
inferred← citeshttps://doi.org/10.1016/j.mce.2016.12.005openalex-snapshot
Cell signaling pathways in the adrenal cortex: Links to stem/progenitor biology and neoplasia
inferred← citeshttps://doi.org/10.1016/j.mce.2020.111043openalex-snapshot
Stem cell function and plasticity in the normal physiology of the adrenal cortex
inferred← citeshttps://doi.org/10.1016/j.mce.2020.111120openalex-snapshot
β-catenin in adrenal zonation and disease
inferred← citeshttps://doi.org/10.1016/j.mce.2021.111172openalex-snapshot
Developmental mechanisms of adrenal cortex formation and their links with adult progenitor populations
inferred← citeshttps://doi.org/10.1016/j.mce.2021.111206openalex-snapshot
Adrenal cortex development and related disorders leading to adrenal insufficiency
inferred← citeshttps://doi.org/10.1016/j.mce.2021.111239openalex-snapshot
Adrenal androgens, adrenarche, and zona reticularis: A human affair?
inferred← citeshttps://doi.org/10.1016/j.mce.2021.111287openalex-snapshot
Rosette morphology in zona glomerulosa formation and function
inferred← citeshttps://doi.org/10.1016/j.mce.2021.111377openalex-snapshot
Steroidogenic cell microenvironment and adrenal function in physiological and pathophysiological conditions
inferred← citeshttps://doi.org/10.1016/j.mce.2024.112272openalex-snapshot
Cellular landscape of adrenocortical carcinoma at single-nuclei resolution
inferred← citeshttps://doi.org/10.1016/j.molmet.2024.101954openalex-snapshot
Single-cell and spatial transcriptomics analysis of human adrenal aging
inferred← citeshttps://doi.org/10.1016/j.psyneuen.2021.105334openalex-snapshot
Potential associations between immune signaling genes, deactivated microglia, and oligodendrocytes and cortical gray matter loss in patients with long-term remitted Cushing’s disease
inferred← citeshttps://doi.org/10.1016/j.stem.2019.04.012openalex-snapshot
The Adult Adrenal Cortex Undergoes Rapid Tissue Renewal in a Sex-Specific Manner
inferred← citeshttps://doi.org/10.1016/j.stem.2026.02.002openalex-snapshot
Modeling human prenatal adrenocortical functional zonation dynamics from pluripotent stem cells
inferred← citeshttps://doi.org/10.1016/j.stem.2026.05.002openalex-snapshot
Human adrenal cortex organoids unlock new frontiers in development, disease, and regenerative therapy
inferred← citeshttps://doi.org/10.1016/j.stemcr.2024.07.010openalex-snapshot
In vitro differentiation of mouse pluripotent stem cells into corticosteroid-producing adrenocortical cells
inferred← citeshttps://doi.org/10.1038/s41388-020-1358-5openalex-snapshot
Wnt/β-catenin activation cooperates with loss of p53 to cause adrenocortical carcinoma in mice
inferred← citeshttps://doi.org/10.1038/s41416-018-0109-7openalex-snapshot
Cancer subtype identification using somatic mutation data
inferred← citeshttps://doi.org/10.1038/s41416-019-0538-yopenalex-snapshot
EZH2 cooperates with E2F1 to stimulate expression of genes involved in adrenocortical carcinoma aggressiveness
inferred← citeshttps://doi.org/10.1038/s41416-020-01166-zopenalex-snapshot
HOX genes promote cell proliferation and are potential therapeutic targets in adrenocortical tumours
inferred← citeshttps://doi.org/10.1038/s41436-020-00958-1openalex-snapshot
Genomic and sequence variants of protein kinase A regulatory subunit type 1β (PRKAR1B) in patients with adrenocortical disease and Cushing syndrome
inferred← citeshttps://doi.org/10.1038/s41467-022-35526-5openalex-snapshot
Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice
inferred← citeshttps://doi.org/10.1038/s41467-023-41843-0openalex-snapshot
The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6
inferred← citeshttps://doi.org/10.1038/s41467-025-68257-4openalex-snapshot
The transcription factor HHEX maintains glucocorticoid levels and protects adrenals from androgen-induced lipid depletion
inferred← citeshttps://doi.org/10.1038/s41556-018-0122-3openalex-snapshot
Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism
inferred← citeshttps://doi.org/10.1038/s41574-021-00491-4openalex-snapshot
Adrenal cortex renewal in health and disease
inferred← citeshttps://doi.org/10.1038/s41574-025-01091-2openalex-snapshot
Adrenocortical stem cells in health and disease
inferred← citeshttps://doi.org/10.1038/s41598-017-11654-7openalex-snapshot
ApoE4-associated phospholipid dysregulation contributes to development of Tau hyper-phosphorylation after traumatic brain injury
inferred← citeshttps://doi.org/10.1038/s41598-019-50988-2openalex-snapshot
Retinoic acid receptor α as a novel contributor to adrenal cortex structure and function through interactions with Wnt and Vegfa signalling
inferred← citeshttps://doi.org/10.1038/s41598-023-41016-5openalex-snapshot
RNA-Seq reveals ACTH-induced steroid hormone pathway participating in goat adrenal gland response to castration
inferred← citeshttps://doi.org/10.1073/pnas.1809185115openalex-snapshot
Steroidogenic differentiation and PKA signaling are programmed by histone methyltransferase EZH2 in the adrenal cortex
inferred← citeshttps://doi.org/10.1073/pnas.2421489122openalex-snapshot
Multiomics analysis unveils the cellular ecosystem with clinical relevance in aldosterone-producing adenomas with KCNJ5 mutations
inferred← citeshttps://doi.org/10.1080/17512433.2026.2737175openalex-snapshot
The emerging role of PDE4 inhibitors for the treatment of pulmonary fibrosis
inferred← citeshttps://doi.org/10.1093/ejendo/lvag104openalex-snapshot
Sexual dimorphism in the adrenal cortex: implications for stress responsiveness
inferred← citeshttps://doi.org/10.1096/fj.201701274rropenalex-snapshot
MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation
inferred← citeshttps://doi.org/10.1096/fj.201900557ropenalex-snapshot
Hormonal and spatial control of SUMOylation in the human and mouse adrenal cortex
inferred← citeshttps://doi.org/10.1097/js9.0000000000002814openalex-snapshot
Genomic alterations in pancreatic cystic neoplasms: from molecular characterization to precision clinical management
inferred← citeshttps://doi.org/10.1097/moh.0000000000000336openalex-snapshot
Wnt signaling in the vessel wall
inferred← citeshttps://doi.org/10.1101/2020.12.21.423735openalex-snapshot
PKA drives paracrine crisis and WNT4-dependent testis tumor in Carney complex
inferred← citeshttps://doi.org/10.1101/2022.02.08.479354openalex-snapshot
Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation
inferred← citeshttps://doi.org/10.1101/2023.02.10.527992openalex-snapshot
Aberrant activation of Wnt/β-Catenin signaling pathway drives the expression of poor prognosis-associated microRNAs in adrenocortical cancer with a major impact on miR-139-5p and its host gene PDE2A
inferred← citeshttps://doi.org/10.1101/2023.10.09.561514openalex-snapshot
Cellular landscape of adrenocortical carcinoma at single-nuclei resolution
inferred← citeshttps://doi.org/10.1101/2023.12.22.572808openalex-snapshot
In vitro differentiation of mouse pluripotent stem cells into glucocorticoid-producing adrenocortical cells
inferred← citeshttps://doi.org/10.1101/2024.08.23.609423openalex-snapshot
Non-canonical Wnt signaling triggered by WNT2B drives adrenal aldosterone production
inferred← citeshttps://doi.org/10.1101/2025.05.24.655925openalex-snapshot
Reconstitution of adrenocortical functional zonation from human pluripotent stem cells
inferred← citeshttps://doi.org/10.1101/gad.317412.118openalex-snapshot
A ZNRF3-dependent Wnt/β-catenin signaling gradient is required for adrenal homeostasis
inferred← citeshttps://doi.org/10.1111/jne.13125openalex-snapshot
Gene expression changes in the brain of a Cushing's syndrome mouse model
inferred← citeshttps://doi.org/10.1111/joa.13912openalex-snapshot
Structure of rosettes in the zona glomerulosa of human adrenal cortex
inferred← citeshttps://doi.org/10.11606/t.42.2023.tde-11082023-091004openalex-snapshot
O papel de SOCS3 na regulação da diferenciação do córtex adrenal de camundongos.
inferred← citeshttps://doi.org/10.1161/circulationaha.122.062349openalex-snapshot
Genetic Risk of Primary Aldosteronism and Its Contribution to Hypertension: A Cross-Ancestry Meta-Analysis of Genome-Wide Association Studies
inferred← citeshttps://doi.org/10.1161/hypertensionaha.119.14177openalex-snapshot
Genetic, Cellular, and Molecular Heterogeneity in Adrenals With Aldosterone-Producing Adenoma
inferred← citeshttps://doi.org/10.1161/jaha.123.034180openalex-snapshot
Primary Aldosteronism and Risk of Cardiovascular Outcomes: Genome‐Wide Association and Mendelian Randomization Study
inferred← citeshttps://doi.org/10.1161/jaha.124.036496openalex-snapshot
Unveiling the Causal Relationship of Cardiovascular Burden in Primary Aldosteronism by Genome‐Wide Association and Mendelian Randomization: A Possible Solution?
inferred← citeshttps://doi.org/10.1172/jci.insight.179071openalex-snapshot
FDXR variants cause adrenal insufficiency and atypical sexual development
inferred← citeshttps://doi.org/10.1172/jci.insight.98394openalex-snapshot
PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal
inferred← citeshttps://doi.org/10.1172/jci127429openalex-snapshot
Chemogenetic activation of adrenocortical Gq signaling causes hyperaldosteronism and disrupts functional zonation
inferred← citeshttps://doi.org/10.1172/jci146910openalex-snapshot
Protein kinase A drives paracrine crisis and WNT4-dependent testis tumor in Carney complex
inferred← citeshttps://doi.org/10.1172/jci153752openalex-snapshot
Embryonic osteocalcin signaling determines lifelong adrenal steroidogenesis and homeostasis in the mouse
inferred← citeshttps://doi.org/10.1172/jci164915openalex-snapshot
Loss of LGR4/GPR48 causes severe neonatal salt wasting due to disrupted WNT signaling altering adrenal zonation
inferred← citeshttps://doi.org/10.1183/16000617.0265-2025openalex-snapshot
Mechanistic basis for the antifibrotic actions of cAMP-based therapies
inferred← citeshttps://doi.org/10.1186/s12964-023-01090-8openalex-snapshot
Complex and pleiotropic signaling pathways regulated by the secreted protein augurin
inferred← citeshttps://doi.org/10.1210/clinem/dgab118openalex-snapshot
Cushing Syndrome in a Pediatric Patient With a KCNJ5 Variant and Successful Treatment With Low-dose Ketoconazole
inferred← citeshttps://doi.org/10.1210/en.2017-00098openalex-snapshot
Targeted Disruption of YAP and TAZ Impairs the Maintenance of the Adrenal Cortex
inferred← citeshttps://doi.org/10.1210/en.2017-03061openalex-snapshot
Sonic Hedgehog and WNT Signaling Promote Adrenal Gland Regeneration in Male Mice
inferred← citeshttps://doi.org/10.1210/endocr/bqab187openalex-snapshot
Adrenal Cortex Development and Maintenance: Knowledge Acquired From Mouse Models
inferred← citeshttps://doi.org/10.1210/endocr/bqaf077openalex-snapshot
Hippo Signaling Is Essential for the Maintenance of Zona Glomerulosa Cell Fate in the Murine Adrenal Cortex
inferred← citeshttps://doi.org/10.1210/endocr/bqag077openalex-snapshot
ROR1/ROR2 regulate aldosterone production from the zona glomerulosa
inferred← citeshttps://doi.org/10.1210/endrev/bnac012openalex-snapshot
Update on Biology and Genomics of Adrenocortical Carcinomas: Rationale for Emerging Therapies
inferred← citeshttps://doi.org/10.1210/er.2017-00189openalex-snapshot
Genetic Causes of Functional Adrenocortical Adenomas
inferred← citeshttps://doi.org/10.1210/jendso/bvac143openalex-snapshot
Effect of Inactivation of Mst1 and Mst2 in the Mouse Adrenal Cortex
inferred← citeshttps://doi.org/10.1210/jendso/bvad097openalex-snapshot
Age-related Changes in the Adrenal Cortex: Insights and Implications
inferred← citeshttps://doi.org/10.1210/jendso/bvad131openalex-snapshot
In Situ Spatial Reconstruction of Distinct Normal and Pathological Cell Populations Within the Human Adrenal Gland
inferred← citeshttps://doi.org/10.14341/probl12819openalex-snapshot
Adrenal glands stem cells: general signaling pathways
inferred← citeshttps://doi.org/10.1530/ec-19-0190openalex-snapshot
ACTH signalling and adrenal development: lessons from mouse models
inferred← citeshttps://doi.org/10.1530/ey.15.8.14openalex-snapshot
Modeling Congenital Adrenal Hyperplasia and Testing Interventions for Adrenal Insufficiency Using Donor-Specific Reprogrammed Cells
inferred← citeshttps://doi.org/10.1530/jme-18-0122openalex-snapshot
Pathobiology and genetics of adrenocortical carcinoma
inferred← citeshttps://doi.org/10.2174/1874467212666191015161334openalex-snapshot
Effects of Adipocyte-derived Factors on the Adrenal Cortex
inferred← citeshttps://doi.org/10.24272/j.issn.2095-8137.2023.280openalex-snapshot
Human-like adrenal features in Chinese tree shrews revealed by multi-omics analysis of adrenal cell populations and steroid synthesis
inferred← citeshttps://doi.org/10.3389/fendo.2017.00052openalex-snapshot
Molecular Mechanisms of Stem/Progenitor Cell Maintenance in the Adrenal Cortex
inferred← citeshttps://doi.org/10.3389/fendo.2019.00772openalex-snapshot
Stem Cells, Self-Renewal, and Lineage Commitment in the Endocrine System
inferred← citeshttps://doi.org/10.3389/fendo.2024.1423027openalex-snapshot
Evaluating the role of aldosterone synthesis on adrenal cell fate
inferred← citeshttps://doi.org/10.3389/fnins.2021.604103openalex-snapshot
Effects of Long-Term Endogenous Corticosteroid Exposure on Brain Volume and Glial Cells in the AdKO Mouse
inferred← citeshttps://doi.org/10.3389/fonc.2019.00018openalex-snapshot
Salt-Inducible Kinase 2: An Oncogenic Signal Transmitter and Potential Target for Cancer Therapy
inferred← citeshttps://doi.org/10.3390/cells15010063openalex-snapshot
Protein Kinase A Signaling in Cortisol Production and Adrenal Cushing’s Syndrome
inferred← citeshttps://doi.org/10.3390/genes16020191openalex-snapshot
Evaluation of Prenatal Transportation Stress on DNA Methylation (DNAm) and Gene Expression in the Hypothalamic–Pituitary–Adrenal (HPA) Axis Tissues of Mature Brahman Cows
inferred← citeshttps://doi.org/10.3390/ijms232214388openalex-snapshot
Transgenic Mouse Models to Study the Development and Maintenance of the Adrenal Cortex
inferred← citeshttps://doi.org/10.3390/ijms252111341openalex-snapshot
Molecular and Genetics Perspectives on Primary Adrenocortical Hyperfunction Disorders
inferred← citeshttps://doi.org/10.3410/f.736931179.793578066openalex-snapshot
Faculty Opinions recommendation of Chemogenetic activation of adrenocortical Gq signaling causes hyperaldosteronism and disrupts functional zonation.
inferred← citeshttps://doi.org/10.3803/enm.2021.1217openalex-snapshot
Clinical and Molecular Characteristics of PRKACA L206R Mutant Cortisol-Producing Adenomas in Korean Patients
inferred← citeshttps://doi.org/10.64898/2026.06.30.735632openalex-snapshot
Organoid-like Functional Adrenal Gland Cortex Derived From Human Pluripotent Stem Cells
inferred← citeshttps://doi.org/10.70675/36869127z1fb2z41bbzb082z1048e489a8e6openalex-snapshot
Génomique intégrée des tumeurs bénignes corticosurrénaliennes
inferred← citeshttps://doi.org/10.70675/5f0b4f73zaca0z4bc4z99d5z8ca373f11d25openalex-snapshot
Interactions vasculaires et hormonales dans l'hyperaldostéronisme primaire
inferred← citeshttps://doi.org/10.70675/7076b966z729fz4200z82dcz22235060a8bdopenalex-snapshot
Rôle de la signalisation PKA dans la zonation de la glande surrénale : modèles génétiques murins et mécanismes post-traductionnels
inferred← citeshttps://doi.org/10.70675/cab4c4e4z049az4c9czbbefzbf46cdba1d44openalex-snapshot
Rôle des voies de signalisation AMPc/PKA et Wnt/bêta-caténine dans la formation des systèmes de régulation aberrants au sein de la corticosurrénale
inferred← citeshttps://doi.org/10.70675/cdd60a63za0e0z4c83z8b12z5917efe238f5openalex-snapshot
Étiologies moléculaires des insuffisances surrénales primaires congénitales : développements statistiques pour la validation du séquençage parallèle massif
inferred← citeshttps://doi.org/10.70675/f21bb585zdf26z43f8zbfd6z687aea86457bopenalex-snapshot
The adrenal cortex exhibits sexually dimorphic tissue renewal and disease development
inferred← citeshttps://doi.org/10.7150/ijms.60261openalex-snapshot
The underlying molecular mechanism and drugs for treatment in adrenal cortical carcinoma
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