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Inactivation of a Gαs–PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis

https://doi.org/10.1038/ncb3164
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/978-1-62703-330-5_5openalex-snapshot
Lineage Tracing of Hair Follicle Stem Cells in Epidermal Whole Mounts
inferredcites →https://doi.org/10.1016/j.bbcan.2007.10.001openalex-snapshot
The merlin interacting proteins reveal multiple targets for NF2 therapy
inferredcites →https://doi.org/10.1016/j.ccr.2010.11.007openalex-snapshot
Basal Cell Carcinomas Arise from Hair Follicle Stem Cells in Ptch1+/− Mice
inferredcites →https://doi.org/10.1016/j.ccr.2014.02.004openalex-snapshot
Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition
inferredcites →https://doi.org/10.1016/j.cell.2011.02.031openalex-snapshot
Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation
inferredcites →https://doi.org/10.1016/j.cell.2012.06.037openalex-snapshot
Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling
inferredcites →https://doi.org/10.1016/j.cell.2013.08.025openalex-snapshot
Spatial Organization of Hippo Signaling at the Plasma Membrane Mediated by the Tumor Suppressor Merlin/NF2
inferredcites →https://doi.org/10.1016/j.cell.2014.02.057openalex-snapshot
Transit-Amplifying Cells Orchestrate Stem Cell Activity and Tissue Regeneration
inferredcites →https://doi.org/10.1016/j.celrep.2013.12.003openalex-snapshot
Gli Protein Activity Is Controlled by Multisite Phosphorylation in Vertebrate Hedgehog Signaling
inferredcites →https://doi.org/10.1016/j.devcel.2010.09.011openalex-snapshot
The Hippo Signaling Pathway in Development and Cancer
inferredcites →https://doi.org/10.1016/j.devcel.2010.10.008openalex-snapshot
The NF2 Tumor Suppressor, Merlin, Regulates Epidermal Development through the Establishment of a Junctional Polarity Complex
inferredcites →https://doi.org/10.1016/j.molcel.2012.10.018openalex-snapshot
A Genome-wide RNAi Screen Reveals a Trio-Regulated Rho GTPase Circuitry Transducing Mitogenic Signals Initiated by G Protein-Coupled Receptors
inferredcites →https://doi.org/10.1016/j.semcdb.2012.10.001openalex-snapshot
Epithelial stem cells and implications for wound repair
inferredcites →https://doi.org/10.1016/j.stem.2010.11.016openalex-snapshot
Tissue-Resident Adult Stem Cell Populations of Rapidly Self-Renewing Organs
inferredcites →https://doi.org/10.1016/j.stem.2011.02.021openalex-snapshot
Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells
inferredcites →https://doi.org/10.1016/j.stem.2012.06.007openalex-snapshot
mTOR Inhibition Prevents Epithelial Stem Cell Senescence and Protects from Radiation-Induced Mucositis
inferredcites →https://doi.org/10.1016/s0092-8674(00)00164-1openalex-snapshot
Genetic Ablation and Restoration of the Olfactory Topographic Map
inferredcites →https://doi.org/10.1016/s0092-8674(01)00336-1openalex-snapshot
β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin
inferredcites →https://doi.org/10.1038/340692a0openalex-snapshot
GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours
inferredcites →https://doi.org/10.1038/emboj.2008.63openalex-snapshot
A crucial role of WW45 in developing epithelial tissues in the mouse
inferredcites →https://doi.org/10.1038/emboj.2013.102openalex-snapshot
cAMP/PKA signalling reinforces the LATS–YAP pathway to fully suppress YAP in response to actin cytoskeletal changes
inferredcites →https://doi.org/10.1038/embor.2012.197openalex-snapshot
A matter of life and death: self‐renewal in stem cells
inferredcites →https://doi.org/10.1038/modpathol.3800512openalex-snapshot
Basal cell carcinoma: biology, morphology and clinical implications
inferredcites →https://doi.org/10.1038/ncb2031openalex-snapshot
Identification of the cell lineage at the origin of basal cell carcinoma
inferredcites →https://doi.org/10.1038/ncb2884openalex-snapshot
A genetic screen identifies an LKB1–MARK signalling axis controlling the Hippo–YAP pathway
inferredcites →https://doi.org/10.1038/nm.3314openalex-snapshot
Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification
inferredcites →https://doi.org/10.1038/nm.3666openalex-snapshot
The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog−driven medulloblastoma
inferredcites →https://doi.org/10.1038/nprot.2006.339openalex-snapshot
Clonogenic assay of cells in vitro
inferredcites →https://doi.org/10.1038/nprot.2010.39openalex-snapshot
Assaying proliferation and differentiation capacity of stem cells using disaggregated adult mouse epidermis
inferredcites →https://doi.org/10.1038/nrc1229openalex-snapshot
Hedgehog signalling in cancer formation and maintenance
inferredcites →https://doi.org/10.1038/nrc2069openalex-snapshot
G-protein-coupled receptors and cancer
inferredcites →https://doi.org/10.1038/nrc2503openalex-snapshot
Basal cell carcinomas: attack of the hedgehog
inferredcites →https://doi.org/10.1038/nrc3217openalex-snapshot
Epithelial stem cells, wound healing and cancer
inferredcites →https://doi.org/10.1038/nrc3521openalex-snapshot
The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer
inferredcites →https://doi.org/10.1038/nrm2636openalex-snapshot
Epidermal homeostasis: a balancing act of stem cells in the skin
inferredcites →https://doi.org/10.1038/nrm3432openalex-snapshot
Assembly of allosteric macromolecular switches: lessons from PKA
inferredcites →https://doi.org/10.1038/nrm908openalex-snapshot
Seven-transmembrane receptors
inferredcites →https://doi.org/10.1038/sj.onc.1210817openalex-snapshot
An NF-κB gene expression signature contributes to Kaposi's sarcoma virus vGPCR-induced direct and paracrine neoplasia
inferredcites →https://doi.org/10.1038/sj.onc.1210988openalex-snapshot
Protein kinase A-mediated phosphorylation of the NF2 tumor suppressor protein merlin at serine 10 affects the actin cytoskeleton
inferredcites →https://doi.org/10.1038/srep02937openalex-snapshot
Direct confocal acquisition of fluorescence from X-gal staining on thick tissue sections
inferredcites →https://doi.org/10.1046/j.1523-1747.2000.00951.xopenalex-snapshot
Conditional Disruption of Hedgehog Signaling Pathway Defines its Critical Role in Hair Development and Regeneration
inferredcites →https://doi.org/10.1056/nejm199112123252403openalex-snapshot
Activating Mutations of the Stimulatory G Protein in the McCune–Albright Syndrome
inferredcites →https://doi.org/10.1073/pnas.1019603108openalex-snapshot
Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin
inferredcites →https://doi.org/10.1073/pnas.182542899openalex-snapshot
Small molecule modulation of Smoothened activity
inferredcites →https://doi.org/10.1073/pnas.96.15.8551openalex-snapshot
The magical touch: Genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin
inferredcites →https://doi.org/10.1074/jbc.m313916200openalex-snapshot
Cyclic AMP-dependent Protein Kinase Phosphorylates Merlin at Serine 518 Independently of p21-activated Kinase and Promotes Merlin-Ezrin Heterodimerization
inferredcites →https://doi.org/10.1083/jcb.201309141openalex-snapshot
Coupling of Hedgehog and Hippo pathways promotes stem cell maintenance by stimulating proliferation
inferredcites →https://doi.org/10.1101/gad.1051603openalex-snapshot
Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis
inferredcites →https://doi.org/10.1101/gad.1664408openalex-snapshot
TEAD mediates YAP-dependent gene induction and growth control
inferredcites →https://doi.org/10.1101/gad.1824509openalex-snapshot
YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation
inferredcites →https://doi.org/10.1101/gad.219402.113openalex-snapshot
Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation
inferredcites →https://doi.org/10.1126/science.1071550openalex-snapshot
G Protein Pathways
inferredcites →https://doi.org/10.1126/science.1116221openalex-snapshot
Prostaglandin E 2 Promotes Colon Cancer Cell Growth Through a G s -Axin-ß-Catenin Signaling Axis
inferredcites →https://doi.org/10.1126/science.1862343openalex-snapshot
Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase
inferredcites →https://doi.org/10.1126/scisignal.2002906openalex-snapshot
The Hedgehog Signal Transduction Network
inferredcites →https://doi.org/10.1126/scisignal.3117pe14openalex-snapshot
Not Lost in Space: Trafficking in the Hedgehog Signaling Pathway
inferredcites →https://doi.org/10.1152/ajprenal.00193.2006openalex-snapshot
Regulation of renin in mice with Cre recombinase-mediated deletion of G protein Gsα in juxtaglomerular cells
inferredcites →https://doi.org/10.1158/0008-5472.can-04-2623openalex-snapshot
Conditional Expression of K- ras in an Epithelial Compartment that Includes the Stem Cells Is Sufficient to Promote Squamous Cell Carcinogenesis
inferredcites →https://doi.org/10.1158/1078-0432.ccr-11-2824openalex-snapshot
mTOR as a Molecular Target in HPV-Associated Oral and Cervical Squamous Carcinomas
inferredcites →https://doi.org/10.1172/jci24196openalex-snapshot
Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gsα deficiency
inferredcites →https://doi.org/10.1172/jci63735openalex-snapshot
Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice
inferredcites →https://doi.org/10.1242/dev.00115openalex-snapshot
Eyes Absent, a key repressor of polar cell fate duringDrosophilaoogenesis
inferredcites →https://doi.org/10.1242/dev.129.1.95openalex-snapshot
Expression of ΔNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours
inferredcites →https://doi.org/10.1242/dev.129.20.4753openalex-snapshot
Gli2, but notGli1, is required for initial Shh signaling and ectopic activation of the Shh pathway
inferredcites →https://doi.org/10.15252/embr.201438638openalex-snapshot
The Hippo signaling pathway in stem cell biology and cancer

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.5242140openalex-extracted
Mutant GNAS Drives a Pyloric Metaplasia with Tumor Suppressive Glycans in Intraductal Papillary Mucinous Neoplasia
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G Protein‐Coupled receptors and heterotrimeric G proteins as cancer drivers
inferred← citeshttps://doi.org/10.1002/advs.202513571openalex-snapshot
Integrated ERK‐PKA‐YAP/TAZ‐SHH Signaling Orchestrates Cortical Radial Glia Identity and Lineage Diversification
inferred← citeshttps://doi.org/10.1002/bies.201700116openalex-snapshot
Integrin‐FAK‐CDC42‐PP1A signaling gnaws at YAP/TAZ activity to control incisor stem cells
inferred← citeshttps://doi.org/10.1002/hep.32487openalex-snapshot
Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS
inferred← citeshttps://doi.org/10.1002/iub.2714openalex-snapshot
Edmond Fischer's kinase legacy: History of the protein kinase inhibitor and protein kinase A
inferred← citeshttps://doi.org/10.1002/jbio.201600025openalex-snapshot
Cell lineage responses to photobiomodulation therapy
inferred← citeshttps://doi.org/10.1002/mco2.375openalex-snapshot
Targeting Hippo signaling in cancer: novel perspectives and therapeutic potential
inferred← citeshttps://doi.org/10.1002/mco2.70375openalex-snapshot
G Protein‐Coupled Receptor Signaling: Implications and Therapeutic Development Advances in Cancers
inferred← citeshttps://doi.org/10.1002/stem.3273openalex-snapshot
The landscape of GPCR signaling in the regulation of epidermal stem cell fate and skin homeostasis
inferred← citeshttps://doi.org/10.1007/978-1-4939-8910-2_11openalex-snapshot
Luciferase Reporter Assays to Determine YAP/TAZ Activity in Mammalian Cells
inferred← citeshttps://doi.org/10.1007/978-4-431-56847-6_2openalex-snapshot
Basic Characteristics of Muse Cells
inferred← citeshttps://doi.org/10.1007/s00535-021-01846-4openalex-snapshot
Mutant GNAS limits tumor aggressiveness in established pancreatic cancer via antagonizing the KRAS-pathway
inferred← citeshttps://doi.org/10.1007/s00535-023-02024-4openalex-snapshot
Current status of molecular diagnostic approaches using liquid biopsy
inferred← citeshttps://doi.org/10.1007/s11914-022-00719-wopenalex-snapshot
Aberrant Bone Regulation in Albright Hereditary Osteodystrophy dueto Gnas Inactivation: Mechanisms and Translational Implications
inferred← citeshttps://doi.org/10.1007/s12094-021-02704-8openalex-snapshot
Lysophosphatidic acid receptor 6 regulated by miR-27a-3p attenuates tumor proliferation in breast cancer
inferred← citeshttps://doi.org/10.1007/s13238-017-0371-0openalex-snapshot
The Hippo pathway in tissue homeostasis and regeneration
inferred← citeshttps://doi.org/10.1016/b978-0-12-814537-1.00009-9openalex-snapshot
GNAS, McCune–Albright syndrome, and GH-producing tumors
inferred← citeshttps://doi.org/10.1016/b978-0-12-817868-3.00015-9openalex-snapshot
GPCRs in head and neck squamous cell carcinoma
inferred← citeshttps://doi.org/10.1016/bs.apcsb.2017.07.001openalex-snapshot
Targeting the Architecture of Deregulated Protein Complexes in Cancer
inferred← citeshttps://doi.org/10.1016/bs.ctdb.2018.11.019openalex-snapshot
Gαs signaling in skeletal development, homeostasis and diseases
inferred← citeshttps://doi.org/10.1016/j.ajhg.2017.07.002openalex-snapshot
Heterozygous De Novo UBTF Gain-of-Function Variant Is Associated with Neurodegeneration in Childhood
inferred← citeshttps://doi.org/10.1016/j.bbcan.2016.09.006openalex-snapshot
Functional characterization of AMP-activated protein kinase signaling in tumorigenesis
inferred← citeshttps://doi.org/10.1016/j.bone.2021.116270openalex-snapshot
Fibrous dysplasia animal models: A systematic review
inferred← citeshttps://doi.org/10.1016/j.bone.2021.116301openalex-snapshot
RANKL inhibition halts lesion progression and promotes bone remineralization in mice with fibrous dysplasia
inferred← citeshttps://doi.org/10.1016/j.bpj.2022.05.009openalex-snapshot
Biophysical insights into OR2T7: Investigation of a potential prognostic marker for glioblastoma
inferred← citeshttps://doi.org/10.1016/j.ccell.2020.05.003openalex-snapshot
Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells
inferred← citeshttps://doi.org/10.1016/j.cell.2015.10.044openalex-snapshot
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer
inferred← citeshttps://doi.org/10.1016/j.cellsig.2017.05.012openalex-snapshot
The many faces of compartmentalized PKA signalosomes
inferred← citeshttps://doi.org/10.1016/j.celrep.2019.10.057openalex-snapshot
The CalcR-PKA-Yap1 Axis Is Critical for Maintaining Quiescence in Muscle Stem Cells
inferred← citeshttps://doi.org/10.1016/j.celrep.2025.116684openalex-snapshot
Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia
inferred← citeshttps://doi.org/10.1016/j.cmet.2018.07.010openalex-snapshot
Interplay between YAP/TAZ and Metabolism
inferred← citeshttps://doi.org/10.1016/j.devcel.2015.10.015openalex-snapshot
Proteomics of Primary Cilia by Proximity Labeling
inferred← citeshttps://doi.org/10.1016/j.devcel.2016.07.026openalex-snapshot
Hedgehog Signal Transduction: Key Players, Oncogenic Drivers, and Cancer Therapy
inferred← citeshttps://doi.org/10.1016/j.devcel.2018.12.021openalex-snapshot
FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis
inferred← citeshttps://doi.org/10.1016/j.devcel.2019.04.014openalex-snapshot
YAP/TAZ Inhibition Induces Metabolic and Signaling Rewiring Resulting in Targetable Vulnerabilities in NF2-Deficient Tumor Cells
inferred← citeshttps://doi.org/10.1016/j.devcel.2020.06.025openalex-snapshot
Integration of Hippo-YAP Signaling with Metabolism
inferred← citeshttps://doi.org/10.1016/j.devcel.2020.10.004openalex-snapshot
Limiting Self-Renewal of the Basal Compartment by PKA Activation Induces Differentiation and Alters the Evolution of Mammary Tumors
inferred← citeshttps://doi.org/10.1016/j.imbio.2023.152705openalex-snapshot
High expression of NF-κB inducing kinase in the bulge region of hair follicle induces tumor
inferred← citeshttps://doi.org/10.1016/j.jid.2019.10.012openalex-snapshot
Activation of G-Protein Coupled Receptor–Gαi Signaling Increases Keratinocyte Proliferation and Reduces Differentiation, Leading to Epidermal Hyperplasia
inferred← citeshttps://doi.org/10.1016/j.jid.2021.05.031openalex-snapshot
Defining a Role for G-Protein Coupled Receptor/cAMP/CRE-Binding Protein Signaling in Hair Follicle Stem Cell Activation
inferred← citeshttps://doi.org/10.1016/j.jid.2021.06.020openalex-snapshot
Oncogenic Hedgehog-Smoothened Signaling Depends on YAP1‒TAZ/TEAD Transcription to Restrain Differentiation in Basal Cell Carcinoma
inferred← citeshttps://doi.org/10.1016/j.jid.2024.06.1288openalex-snapshot
G Protein–Coupled Receptors in Skin Aging
inferred← citeshttps://doi.org/10.1016/j.jid.2025.08.040openalex-snapshot
The G-Protein-Coupled Receptor Kinase 2 Orchestrates Hair Follicle Homeostasis
inferred← citeshttps://doi.org/10.1016/j.jid.2025.09.381openalex-snapshot
Does Basal Cell Carcinoma Arise from a Precursor Lesion?
inferred← citeshttps://doi.org/10.1016/j.molcel.2024.03.002openalex-snapshot
Molecular determinants and signaling effects of PKA RIα phase separation
inferred← citeshttps://doi.org/10.1016/j.neo.2017.12.004openalex-snapshot
COX-2 Forms Regulatory Loop with YAP to Promote Proliferation and Tumorigenesis of Hepatocellular Carcinoma Cells
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2017.12.011openalex-snapshot
The Hippo pathway in normal development and cancer
inferred← citeshttps://doi.org/10.1016/j.semcancer.2017.04.010openalex-snapshot
The NDR/LATS protein kinases in immunology and cancer biology
inferred← citeshttps://doi.org/10.1016/j.trecan.2018.04.007openalex-snapshot
Epigenetic Priming in Cancer Initiation
inferred← citeshttps://doi.org/10.1016/j.xcrm.2023.101244openalex-snapshot
High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma
inferred← citeshttps://doi.org/10.1016/j.ydbio.2020.12.018openalex-snapshot
YAP1 and its fusion proteins in cancer initiation, progression and therapeutic resistance
inferred← citeshttps://doi.org/10.1038/ctg.2017.3openalex-snapshot
Diversity of Precursor Lesions For Pancreatic Cancer: The Genetics and Biology of Intraductal Papillary Mucinous Neoplasm
inferred← citeshttps://doi.org/10.1038/ncomms12751openalex-snapshot
PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development
inferred← citeshttps://doi.org/10.1038/ncomms12963openalex-snapshot
Bimodal antagonism of PKA signalling by ARHGAP36
inferred← citeshttps://doi.org/10.1038/ncomms15161openalex-snapshot
A reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelination
inferred← citeshttps://doi.org/10.1038/nrgastro.2016.59openalex-snapshot
The Hippo pathway in intestinal regeneration and disease
inferred← citeshttps://doi.org/10.1038/s41418-025-01453-3openalex-snapshot
Protein kinase A regulates ferroptosis by controlling GPX4 m6A modification through phosphorylation of ALKBH5
inferred← citeshttps://doi.org/10.1038/s41420-025-02605-7openalex-snapshot
Hedgehog pathway, cell cycle, and primary cilium
inferred← citeshttps://doi.org/10.1038/s41467-019-13471-0openalex-snapshot
Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4
inferred← citeshttps://doi.org/10.1038/s41467-020-15301-0openalex-snapshot
YAP1/TAZ-TEAD transcriptional networks maintain skin homeostasis by regulating cell proliferation and limiting KLF4 activity
inferred← citeshttps://doi.org/10.1038/s41467-021-21513-9openalex-snapshot
Mechanochemical control of epidermal stem cell divisions by B-plexins
inferred← citeshttps://doi.org/10.1038/s41467-025-61402-zopenalex-snapshot
Protein kinase A is a dependent factor and therapeutic target in mouse models of fibrous dysplasia
inferred← citeshttps://doi.org/10.1038/s41556-018-0120-5openalex-snapshot
GNAS shifts metabolism in pancreatic cancer
inferred← citeshttps://doi.org/10.1038/s41556-018-0122-3openalex-snapshot
Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism
inferred← citeshttps://doi.org/10.1038/s41556-018-0142-zopenalex-snapshot
YAP/TAZ upstream signals and downstream responses
inferred← citeshttps://doi.org/10.1038/s41590-019-0400-7openalex-snapshot
Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression
inferred← citeshttps://doi.org/10.1038/s41590-023-01529-7openalex-snapshot
The GPCR–Gαs–PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure
inferred← citeshttps://doi.org/10.1038/s42003-026-10366-xopenalex-snapshot
Molecular signatures and lineage diversification of neurogenic and gliogenic radial glia in the gyrencephalic ferret cortex
inferred← citeshttps://doi.org/10.1038/s43018-022-00508-5openalex-snapshot
A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAFV600E colorectal tumors
inferred← citeshttps://doi.org/10.1042/bcj20160648openalex-snapshot
cAMP-dependent protein kinase (PKA) complexes probed by complementary differential scanning fluorimetry and ion mobility–mass spectrometry
inferred← citeshttps://doi.org/10.1042/bcj20230352openalex-snapshot
Protein kinase A and local signaling in cancer
inferred← citeshttps://doi.org/10.1053/j.gastro.2016.11.005openalex-snapshot
Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice
inferred← citeshttps://doi.org/10.1053/j.gastro.2018.08.006openalex-snapshot
GNASR201C Induces Pancreatic Cystic Neoplasms in Mice That Express Activated KRAS by Inhibiting YAP1 Signaling
inferred← citeshttps://doi.org/10.1073/pnas.1713710115openalex-snapshot
Expression of an active Gα s mutant in skeletal stem cells is sufficient and necessary for fibrous dysplasia initiation and maintenance
inferred← citeshttps://doi.org/10.1074/jbc.rev119.005601openalex-snapshot
Illuminating the Onco-GPCRome: Novel G protein–coupled receptor-driven oncocrine networks and targets for cancer immunotherapy
inferred← citeshttps://doi.org/10.1080/15384101.2016.1164371openalex-snapshot
The G protein Gα s acts as a tumor suppressor in sonic hedgehog signaling-driven tumorigenesis
inferred← citeshttps://doi.org/10.1080/15384101.2016.1211215openalex-snapshot
The secretome of MUSE cells contains factors that may play a role in regulation of stemness, apoptosis and immunomodulation
inferred← citeshttps://doi.org/10.1083/jcb.202007207openalex-snapshot
Time-resolved proteomics profiling of the ciliary Hedgehog response
inferred← citeshttps://doi.org/10.1089/dna.2016.3535openalex-snapshot
G Protein Alpha S Subunit Promotes Cell Proliferation of Renal Cell Carcinoma with Involvement of Protein Kinase A Signaling
inferred← citeshttps://doi.org/10.1093/carcin/bgw086openalex-snapshot
mTOR inhibition prevents rapid-onset of carcinogen-induced malignancies in a novel inducible HPV-16 E6/E7 mouse model
inferred← citeshttps://doi.org/10.1093/jbmr/zjaf039openalex-snapshot
Pain in fibrous dysplasia: identifying nociceptive mechanisms in a preclinical model
inferred← citeshttps://doi.org/10.1096/fj.201901278ropenalex-snapshot
Gα 13 ‐mediated LATS1 down‐regulation contributes to epithelial‐mesenchymal transition in ovarian cancer
inferred← citeshttps://doi.org/10.1096/fj.202001515ropenalex-snapshot
Protein kinase A inhibitor proteins (PKIs) divert GPCR‐Gαs‐cAMP signaling toward EPAC and ERK activation and are involved in tumor growth
inferred← citeshttps://doi.org/10.1096/fj.202002159ropenalex-snapshot
G protein‐coupled receptors can control the Hippo/YAP pathway through Gq signaling
inferred← citeshttps://doi.org/10.1101/2020.06.04.134031openalex-snapshot
In silico analysis of imprinted gene expression in the mouse skin
inferred← citeshttps://doi.org/10.1101/2022.10.20.512885openalex-snapshot
A reversible SRC-relayed COX2-inflammatory program drives therapeutic resistance in BRAF V600E colorectal tumors
inferred← citeshttps://doi.org/10.1101/2023.08.14.553002openalex-snapshot
Integrated spatial transcriptomics and lipidomics of precursor lesions of pancreatic cancer identifies enrichment of long chain sulfatide biosynthesis as an early metabolic alteration
inferred← citeshttps://doi.org/10.1101/2024.02.25.581948openalex-snapshot
Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia
inferred← citeshttps://doi.org/10.1101/310292openalex-snapshot
Gnas R201C Induces Murine Pancreatic Cystic Neoplasms through Suppression of YAP1 Signaling and Transcriptional Reprogramming
inferred← citeshttps://doi.org/10.1101/672527openalex-snapshot
Novel syngeneic animal model of tobacco-associated oral cancer reveals the activity of in situ anti-CTLA-4
inferred← citeshttps://doi.org/10.1101/747030openalex-snapshot
Biphasic Response of Protein Kinase A to Cyclic Adenosine Monophosphate Triggers Distinct Epithelial Phenotypes
inferred← citeshttps://doi.org/10.1111/exd.13355openalex-snapshot
The major miR‐31 target genes STK 40 and LATS 2 and their implications in the regulation of keratinocyte growth and hair differentiation
inferred← citeshttps://doi.org/10.1111/exd.14655openalex-snapshot
Targeting the Hippo/ YAP / TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers
inferred← citeshttps://doi.org/10.1111/exd.14811openalex-snapshot
Soluble adenylyl cyclase contributes to imiquimod‐mediated inflammation and is a potential therapeutic target in psoriasis
inferred← citeshttps://doi.org/10.1111/gtc.12461openalex-snapshot
Hippo vs. Crab: tissue‐specific functions of the mammalian Hippo pathway
inferred← citeshttps://doi.org/10.1111/jnc.15816openalex-snapshot
The activation of gastric inhibitory peptide/gastric inhibitory peptide receptor axis via sonic hedgehog signaling promotes the bridging of gapped nerves in sciatic nerve injury
inferred← citeshttps://doi.org/10.1111/srt.13285openalex-snapshot
Recent advances in the role of Yes‐associated protein in dermatosis
inferred← citeshttps://doi.org/10.1124/mol.118.115444openalex-snapshot
Identification of MRP4/ABCC4 as a Target for Reducing the Proliferation of Pancreatic Ductal Adenocarcinoma Cells by Modulating the cAMP Efflux
inferred← citeshttps://doi.org/10.1124/pharmrev.120.000269openalex-snapshot
Gαs–Protein Kinase A (PKA) Pathway Signalopathies: The Emerging Genetic Landscape and Therapeutic Potential of Human Diseases Driven by Aberrant Gαs-PKA Signaling
inferred← citeshttps://doi.org/10.1126/science.aad3680openalex-snapshot
Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability
inferred← citeshttps://doi.org/10.1126/scisignal.aac6160openalex-snapshot
AKAP95-mediated nuclear anchoring of PKA mediates cortisol-induced PTGS2 expression in human amnion fibroblasts
inferred← citeshttps://doi.org/10.1126/scisignal.aal3395openalex-snapshot
Genetic evidence that β-arrestins are dispensable for the initiation of β 2 -adrenergic receptor signaling to ERK
inferred← citeshttps://doi.org/10.1126/scisignal.aao5749openalex-snapshot
G protein–coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog
inferred← citeshttps://doi.org/10.1126/scitranslmed.abb2233openalex-snapshot
A self-amplifying loop of YAP and SHH drives formation and expansion of heterotopic ossification
inferred← citeshttps://doi.org/10.1136/gutjnl-2025-335220openalex-snapshot
Long-chain sulfatide enrichment is an actionable metabolic vulnerability in intraductal papillary mucinous neoplasm (IPMN)-associated pancreatic cancers
inferred← citeshttps://doi.org/10.1152/ajprenal.00367.2019openalex-snapshot
Ablation of Gsa impairs renal tubule proliferation after injury via CDK2/cyclin E
inferred← citeshttps://doi.org/10.1155/2022/2208176openalex-snapshot
Chemokine/GPCR Signaling-Mediated EMT in Cancer Metastasis
inferred← citeshttps://doi.org/10.1158/0008-5472.can-25-1109openalex-snapshot
Dissection of Gαs and Hedgehog Signaling Cross-talk Reveals Therapeutic Opportunities to Target Hedgehog-Dependent Tumors
inferred← citeshttps://doi.org/10.1158/0008-5472.can-25-4574openalex-snapshot
Stress-Induced ADGRL4 Orchestrates Tumor Progression and Metastasis by Inhibiting YAP1 Signaling and Activating Angiogenesis
inferred← citeshttps://doi.org/10.1172/jci.insight.158098openalex-snapshot
Inhibition of phosphodiesterase 4D suppresses mTORC1 signaling and pancreatic cancer growth
inferred← citeshttps://doi.org/10.1186/s12885-018-4133-zopenalex-snapshot
The curious case of Gαs gain-of-function in neoplasia
inferred← citeshttps://doi.org/10.1186/s12885-019-5369-yopenalex-snapshot
Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas
inferred← citeshttps://doi.org/10.1186/s13045-024-01524-xopenalex-snapshot
cAMP-PKA/EPAC signaling and cancer: the interplay in tumor microenvironment
inferred← citeshttps://doi.org/10.1186/s13287-021-02527-yopenalex-snapshot
A systematic summary of survival and death signalling during the life of hair follicle stem cells
inferred← citeshttps://doi.org/10.1210/en.2017-03061openalex-snapshot
Sonic Hedgehog and WNT Signaling Promote Adrenal Gland Regeneration in Male Mice
inferred← citeshttps://doi.org/10.1210/jendso/bvac143openalex-snapshot
Effect of Inactivation of Mst1 and Mst2 in the Mouse Adrenal Cortex
inferred← citeshttps://doi.org/10.1242/dev.143354openalex-snapshot
Osteocrin, a peptide secreted from the heart and other tissues, contributes to cranial osteogenesis and chondrogenesis in zebrafish
inferred← citeshttps://doi.org/10.1242/dev.166892openalex-snapshot
Biochemical mechanisms of vertebrate hedgehog signaling
inferred← citeshttps://doi.org/10.1242/dev.189258openalex-snapshot
Extensive crosstalk of G protein-coupled receptors with the Hedgehog signalling pathway
inferred← citeshttps://doi.org/10.1242/jcs.230425openalex-snapshot
YAP/TAZ functions and their regulation at a glance
inferred← citeshttps://doi.org/10.1371/journal.pone.0173692openalex-snapshot
Epidermal loss of Gαq confers a migratory and differentiation defect in keratinocytes
inferred← citeshttps://doi.org/10.1371/journal.pone.0182463openalex-snapshot
Cutaneous transcriptome analysis in NIH hairless mice
inferred← citeshttps://doi.org/10.1371/journal.pone.0203170openalex-snapshot
Activation of the Gi protein-RHOA axis by non-canonical Hedgehog signaling is independent of primary cilia
inferred← citeshttps://doi.org/10.1371/journal.pone.0211980openalex-snapshot
Abnormal activity of transcription factors gli in high-grade gliomas
inferred← citeshttps://doi.org/10.17305/bjbms.2018.2756openalex-snapshot
The role of the Hedgehog signaling pathway in cancer: A comprehensive review
inferred← citeshttps://doi.org/10.18632/oncotarget.19527openalex-snapshot
The Hedgehog-GLI pathway in embryonic development and cancer: implications for pulmonary oncology therapy
inferred← citeshttps://doi.org/10.3389/fcell.2022.699144openalex-snapshot
Molecular Characterization of Differentiated-Resistance MSC Subclones by Single-Cell Transcriptomes
inferred← citeshttps://doi.org/10.3389/fgene.2021.633206openalex-snapshot
Gnas Inactivation Alters Subcutaneous Tissues in Progression to Heterotopic Ossification
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1604179openalex-snapshot
Comprehensive analysis of phosducin-like 3 as a diagnostic, prognostic and immunological marker in pan-cancer
inferred← citeshttps://doi.org/10.3389/fonc.2019.00018openalex-snapshot
Salt-Inducible Kinase 2: An Oncogenic Signal Transmitter and Potential Target for Cancer Therapy
inferred← citeshttps://doi.org/10.3390/cancers11040449openalex-snapshot
Role of Protein Kinases in Hedgehog Pathway Control and Implications for Cancer Therapy
inferred← citeshttps://doi.org/10.3390/cancers14123013openalex-snapshot
O-GlcNAcylation: An Emerging Protein Modification Regulating the Hippo Pathway
inferred← citeshttps://doi.org/10.3390/cells10123288openalex-snapshot
An Insight into GPCR and G-Proteins as Cancer Drivers
inferred← citeshttps://doi.org/10.3390/cells11081370openalex-snapshot
Genomic Hippo Pathway Alterations and Persistent YAP/TAZ Activation: New Hallmarks in Head and Neck Cancer
inferred← citeshttps://doi.org/10.3390/cells8050411openalex-snapshot
The Roles of YAP/TAZ and the Hippo Pathway in Healthy and Diseased Skin
inferred← citeshttps://doi.org/10.3390/cells8050426openalex-snapshot
GPCR-Hippo Signaling in Cancer
inferred← citeshttps://doi.org/10.3390/genes10050323openalex-snapshot
Hair of the Dog: Identification of a Cis-Regulatory Module Predicted to Influence Canine Coat Composition
inferred← citeshttps://doi.org/10.3390/ijms19051494openalex-snapshot
The Making of Leukemia
inferred← citeshttps://doi.org/10.3390/ijms20061336openalex-snapshot
Primary Cilium in Cancer Hallmarks
inferred← citeshttps://doi.org/10.3390/ijms21176386openalex-snapshot
Intraductal Pancreatic Mucinous Neoplasms: A Tumor-Biology Based Approach for Risk Stratification
inferred← citeshttps://doi.org/10.3390/ijms252312903openalex-snapshot
YAP/TAZ Signalling Controls Epidermal Keratinocyte Fate
inferred← citeshttps://doi.org/10.3390/jpm12101544openalex-snapshot
Integrating Genetic Alterations and the Hippo Pathway in Head and Neck Squamous Cell Carcinoma for Future Precision Medicine
inferred← citeshttps://doi.org/10.64898/2026.04.20.718494openalex-snapshot
Pancreatic Gα s ablation disrupts tissue architecture and YAP signaling and unveils a compensatory regenerative response
inferred← citeshttps://doi.org/10.64898/2026.08.23.746553openalex-snapshot
The diverse functions of viral microproteins
inferred← citeshttps://doi.org/10.70675/7076b966z729fz4200z82dcz22235060a8bdopenalex-snapshot
Rôle de la signalisation PKA dans la zonation de la glande surrénale : modèles génétiques murins et mécanismes post-traductionnels
inferred← citeshttps://doi.org/10.70675/7a53239dzc652z4ea4z8b95z4a71961c83b4openalex-snapshot
Role of VDAC1 hypoxic form, VDAC1-∆C, in the expression of primary cilia and tumor progression
inferred← citeshttps://doi.org/10.70675/fbf71a50z8b1ez410azaf20z23eda138692aopenalex-snapshot
Optimisation et mécanisme d'action d'une matrice biomimétique innovante pour la réparation de la peau
inferred← citeshttps://doi.org/10.7554/elife.69521openalex-snapshot
Oncogenic PKA signaling increases c-MYC protein expression through multiple targetable mechanisms
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