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Small-molecule Bax agonists for cancer therapy

https://doi.org/10.1038/ncomms5935
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1 of the 54 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-21): 10.1038/ncb950 (notice 2007-04-01).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/cncr.26011openalex-snapshot
Limitations in small intestinal neuroendocrine tumor therapy by mTor kinase inhibition reflect growth factor–mediated PI3K feedback loop activation via ERK1/2 and AKT
inferredcites →https://doi.org/10.1002/jcc.20084openalex-snapshot
UCSF Chimera—A visualization system for exploratory research and analysis
inferredcites →https://doi.org/10.1002/jcc.540130311openalex-snapshot
Molecular docking using shape descriptors
inferredcites →https://doi.org/10.1002/jcc.540130412openalex-snapshot
Automated docking with grid‐based energy evaluation
inferredcites →https://doi.org/10.1007/s12274-010-1009-1openalex-snapshot
Comparison and optimization of multiplexed quantum dot-based immunohistofluorescence
inferredcites →https://doi.org/10.1016/0014-5793(94)01444-6openalex-snapshot
Prohibitin, an antiproliferative protein, is localized to mitochondria
inferredcites →https://doi.org/10.1016/0022-2836(82)90153-xopenalex-snapshot
A geometric approach to macromolecule-ligand interactions
inferredcites →https://doi.org/10.1016/j.ejca.2011.12.029openalex-snapshot
Comparison of quantum dot technology with conventional immunohistochemistry in examining aldehyde dehydrogenase 1A1 as a potential biomarker for lymph node metastasis of head and neck cancer
inferredcites →https://doi.org/10.1016/j.molcel.2008.04.005openalex-snapshot
To Trigger Apoptosis, Bak Exposes Its BH3 Domain and Homodimerizes via BH3:Groove Interactions
inferredcites →https://doi.org/10.1016/s0003-2697(02)00028-3openalex-snapshot
Development of a high-throughput fluorescence polarization assay for Bcl-xL
inferredcites →https://doi.org/10.1016/s0092-8674(00)00167-7openalex-snapshot
Structure of Bax
inferredcites →https://doi.org/10.1016/s0169-409x(00)00129-0openalex-snapshot
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1
inferredcites →https://doi.org/10.1016/s0959-440x(02)00344-5openalex-snapshot
Rotamer Libraries in the 21st Century
inferredcites →https://doi.org/10.1021/jm061152topenalex-snapshot
Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL
inferredcites →https://doi.org/10.1021/jm900277zopenalex-snapshot
Identification of Enoxacin as an Inhibitor of Osteoclast Formation and Bone Resorption by Structure-Based Virtual Screening
inferredcites →https://doi.org/10.1023/a:1011115820450openalex-snapshot
DOCK 4.0: Search strategies for automated molecular docking of flexible molecule databases
inferredcites →https://doi.org/10.1038/35019596openalex-snapshot
BAX-dependent transport of cytochrome c reconstituted in pure liposomes
inferredcites →https://doi.org/10.1038/cdd.2011.138openalex-snapshot
Bax dimerizes via a symmetric BH3:groove interface during apoptosis
inferredcites →https://doi.org/10.1038/nature03579openalex-snapshot
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
inferredcites →https://doi.org/10.1038/ncb950openalex-snapshot
Ku70 suppresses the apoptotic translocation of Bax to mitochondria
inferredcites →https://doi.org/10.1038/nchembio.995openalex-snapshot
Direct and selective small-molecule activation of proapoptotic BAX
inferredcites →https://doi.org/10.1038/nprot.2007.107openalex-snapshot
Bioconjugated quantum dots for multiplexed and quantitative immunohistochemistry
inferredcites →https://doi.org/10.1042/bj3450271openalex-snapshot
Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria
inferredcites →https://doi.org/10.1073/pnas.94.8.3668openalex-snapshot
Cytosol-to-membrane redistribution of Bax and Bcl-X L during apoptosis
inferredcites →https://doi.org/10.1073/pnas.97.13.7124openalex-snapshot
Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells
inferredcites →https://doi.org/10.1074/jbc.273.17.10777openalex-snapshot
Bax in Murine Thymus Is a Soluble Monomeric Protein That Displays Differential Detergent-induced Conformations
inferredcites →https://doi.org/10.1074/jbc.m100279200openalex-snapshot
Novel Role for JNK as a Stress-activated Bcl2 Kinase
inferredcites →https://doi.org/10.1074/jbc.m100655200openalex-snapshot
Bcl-2 Prevents Bax Oligomerization in the Mitochondrial Outer Membrane
inferredcites →https://doi.org/10.1074/jbc.m400063200openalex-snapshot
×Phosphorylation of Bax Ser184 by Akt Regulates Its Activity and Apoptosis in Neutrophils
inferredcites →https://doi.org/10.1074/jbc.m500084200openalex-snapshot
Nicotine Inactivation of the Proapoptotic Function of Bax through Phosphorylation
inferredcites →https://doi.org/10.1074/jbc.m510644200openalex-snapshot
JNK- and p38 Kinase-mediated Phosphorylation of Bax Leads to Its Activation and Mitochondrial Translocation and to Apoptosis of Human Hepatoma HepG2 Cells
inferredcites →https://doi.org/10.1074/jbc.m512543200openalex-snapshot
Protein Phosphatase 2A Enhances the Proapoptotic Function of Bax through Dephosphorylation
inferredcites →https://doi.org/10.1074/jbc.m701613200openalex-snapshot
Protein Kinase Cζ Abrogates the Proapoptotic Function of Bax through Phosphorylation
inferredcites →https://doi.org/10.1083/jcb.139.5.1281openalex-snapshot
Movement of Bax from the Cytosol to Mitochondria during Apoptosis
inferredcites →https://doi.org/10.1083/jcb.143.1.207openalex-snapshot
Regulated Targeting of BAX to Mitochondria
inferredcites →https://doi.org/10.1083/jcb.153.6.1265openalex-snapshot
Bax and Bak Coalesce into Novel Mitochondria-Associated Clusters during Apoptosis
inferredcites →https://doi.org/10.1088/0957-4484/20/22/225102openalex-snapshot
Quantum dot-based quantification revealed differences in subcellular localization of EGFR and E-cadherin between EGFR-TKI sensitive and insensitive cancer cells
inferredcites →https://doi.org/10.1093/emboj/18.9.2330openalex-snapshot
Conformation of the Bax C‐terminus regulates subcellular location and cell death
inferredcites →https://doi.org/10.1093/emboj/20.23.6627openalex-snapshot
Apoptosis‐associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl‐2
inferredcites →https://doi.org/10.1097/jto.0b013e31822e2941openalex-snapshot
A Phase II Study of AT-101 (Gossypol) in Chemotherapy-Sensitive Recurrent Extensive-Stage Small Cell Lung Cancer
inferredcites →https://doi.org/10.1126/science.1059108openalex-snapshot
Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
inferredcites →https://doi.org/10.1128/mcb.01647-05openalex-snapshot
Bcl2's Flexible Loop Domain Regulates p53 Binding and Survival
inferredcites →https://doi.org/10.1128/mcb.20.3.929-935.2000openalex-snapshot
Bid Induces the Oligomerization and Insertion of Bax into the Outer Mitochondrial Membrane
inferredcites →https://doi.org/10.1158/0008-5472.can-06-4416openalex-snapshot
A Selective Small Molecule Inhibitor of c-Met, PHA665752, Inhibits Tumorigenicity and Angiogenesis in Mouse Lung Cancer Xenografts
inferredcites →https://doi.org/10.1158/1078-0432.ccr-10-0331openalex-snapshot
ShRNA-Targeted MAP4K4 Inhibits Hepatocellular Carcinoma Growth
inferredcites →https://doi.org/10.1158/1535-7163.mct-11-0578openalex-snapshot
Rapamycin Induces Bad Phosphorylation in Association with Its Resistance to Human Lung Cancer Cells
inferredcites →https://doi.org/10.1158/1535-7163.mct-13-0095openalex-snapshot
Niclosamide Overcomes Acquired Resistance to Erlotinib through Suppression of STAT3 in Non–Small Cell Lung Cancer
inferredcites →https://doi.org/10.1200/jco.2010.31.6208openalex-snapshot
Phase I Study of Navitoclax (ABT-263), a Novel Bcl-2 Family Inhibitor, in Patients With Small-Cell Lung Cancer and Other Solid Tumors
inferredcites →https://doi.org/10.1242/jcs.038166openalex-snapshot
Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis
inferredcites →https://doi.org/10.1371/journal.pone.0013393openalex-snapshot
Mono- or Double-Site Phosphorylation Distinctly Regulates the Proapoptotic Function of Bax
inferredcites →https://doi.org/10.1523/jneurosci.2057-04.2004openalex-snapshot
Glycogen Synthase Kinase-3β Phosphorylates Bax and Promotes Its Mitochondrial Localization during Neuronal Apoptosis
inferredcites →https://doi.org/10.1590/s0100-879x2003000200004openalex-snapshot
Mitochondria, calcium and pro-apoptotic proteins as mediators in cell death signaling
inferredcites →https://doi.org/10.3322/canjclin.57.1.43openalex-snapshot
Cancer Statistics, 2007
inferredcites →https://doi.org/10.4161/cbt.7.12.6944openalex-snapshot
Overcoming mTOR inhibition-induced paradoxical activation of survival signaling pathways enhances mTOR inhibitors’ anticancer efficacy

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.3921286openalex-extracted
A Kinetic Fluorescence Polarization Ligand Assay for Monitoring BAX Early-Activation
inferred← citeshttps://doi.org/10.2139/ssrn.4143267openalex-extracted
inferred← citeshttps://doi.org/10.1002/biof.1472openalex-snapshot
Vicenin‐2 acts as a radiosensitizer of the non‐small cell lung cancer by lowering Akt expression
inferred← citeshttps://doi.org/10.1002/jcb.30173openalex-snapshot
Review of cancer cell resistance mechanisms to apoptosis and actual targeted therapies
inferred← citeshttps://doi.org/10.1002/med.21379openalex-snapshot
Direct Activation of Bax Protein for Cancer Therapy
inferred← citeshttps://doi.org/10.1002/med.21398openalex-snapshot
Targeting Programmed Cell Death Using Small‐Molecule Compounds to Improve Potential Cancer Therapy
inferred← citeshttps://doi.org/10.1002/med.21999openalex-snapshot
B‐cell lymphoma‐2 family proteins in the crosshairs: Small molecule inhibitors and activators for cancer therapy
inferred← citeshttps://doi.org/10.1002/med.70108openalex-snapshot
The Executioners of Mitochondrial Apoptosis: Structures, Mechanisms, and Therapeutic Advances of BAX, BAK, and BOK
inferred← citeshttps://doi.org/10.1002/pro.4053openalex-snapshot
Membrane‐dependent amyloid aggregation of human BAX α9 (173–192)
inferred← citeshttps://doi.org/10.1007/978-1-4614-6438-9_101518-1openalex-snapshot
Apoptosis Regulator BAX
inferred← citeshttps://doi.org/10.1007/978-3-319-67199-4_101518openalex-snapshot
Apoptosis Regulator BAX
inferred← citeshttps://doi.org/10.1007/s10495-016-1273-yopenalex-snapshot
Clitocine potentiates TRAIL-mediated apoptosis in human colon cancer cells by promoting Mcl-1 degradation
inferred← citeshttps://doi.org/10.1007/s10495-016-1290-xopenalex-snapshot
2-aryl benzimidazole conjugate induced apoptosis in human breast cancer MCF-7 cells through caspase independent pathway
inferred← citeshttps://doi.org/10.1007/s10989-019-09830-6openalex-snapshot
A Comparative Analysis of the Molecular Interaction Techniques for In Silico Drug Design
inferred← citeshttps://doi.org/10.1007/s10989-021-10297-7openalex-snapshot
Peptides: A Supercilious Candidate for Activating Intrinsic Apoptosis by Targeting Mitochondrial Membrane Permeability for Cancer Therapy
inferred← citeshttps://doi.org/10.1007/s11154-022-09777-yopenalex-snapshot
The hallmarks of cancer… in pituitary tumors?
inferred← citeshttps://doi.org/10.1007/s12282-016-0738-8openalex-snapshot
NFκBP65 transcription factor modulates resistance to doxorubicin through ABC transporters in breast cancer
inferred← citeshttps://doi.org/10.1007/s13277-015-3213-9openalex-snapshot
MicroRNA-21 promotes cell proliferation in human hepatocellular carcinoma partly by targeting HEPN1
inferred← citeshttps://doi.org/10.1007/s13277-015-3644-3openalex-snapshot
MiR-570 inhibited the cell proliferation and invasion through directly targeting B7-H1 in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1007/s13277-015-3720-8openalex-snapshot
Temozolomide sensitizes stem-like cells of glioma spheres to TRAIL-induced apoptosis via upregulation of casitas B-lineage lymphoma (c-Cbl) protein
inferred← citeshttps://doi.org/10.1007/s13277-015-3774-7openalex-snapshot
Hesperidin from Citrus seed induces human hepatocellular carcinoma HepG2 cell apoptosis via both mitochondrial and death receptor pathways
inferred← citeshttps://doi.org/10.1016/b978-0-12-394447-4.30051-7openalex-snapshot
The Bcl-2 Family Proteins: Insights into Their Mechanism of Action and Therapeutic Potential
inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.12326-1openalex-snapshot
Small-Molecule Inhibitors of Protein–Protein Interactions
inferred← citeshttps://doi.org/10.1016/b978-0-12-811752-1.00002-xopenalex-snapshot
Mitochondria as Signaling Platforms
inferred← citeshttps://doi.org/10.1016/b978-0-12-821618-7.00141-3openalex-snapshot
The BCL-2 Family Proteins: Insights Into Their Mechanism of Action and Therapeutic Potential
inferred← citeshttps://doi.org/10.1016/b978-0-444-63929-5.00005-xopenalex-snapshot
Chemistry and Bioactivity of ent -Kaurene Diterpenoids
inferred← citeshttps://doi.org/10.1016/j.actbio.2018.07.009openalex-snapshot
Development of an apoptosis-assisted decellularization method for maximal preservation of nerve tissue structure
inferred← citeshttps://doi.org/10.1016/j.ailsci.2026.100181openalex-snapshot
Single-cell morphological profiling reveals insights into programmed cell death
inferred← citeshttps://doi.org/10.1016/j.apsb.2024.02.010openalex-snapshot
Directly targeting BAX for drug discovery: Therapeutic opportunities and challenges
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2022.119317openalex-snapshot
Pro-apoptotic complexes of BAX and BAK on the outer mitochondrial membrane
inferred← citeshttps://doi.org/10.1016/j.bbamem.2022.184075openalex-snapshot
Cell-Free Synthesis and Reconstitution of Bax in Nanodiscs: Comparison between Wild-Type Bax and a Constitutively Active Mutant
inferred← citeshttps://doi.org/10.1016/j.bbcan.2021.188569openalex-snapshot
Targeting Bcl-2 for cancer therapy
inferred← citeshttps://doi.org/10.1016/j.bbrc.2016.10.100openalex-snapshot
BCL-2: Long and winding path from discovery to therapeutic target
inferred← citeshttps://doi.org/10.1016/j.bioorg.2025.108388openalex-snapshot
Targeting anti-apoptotic mechanisms in tumour cells: Strategies for enhancing Cancer therapy
inferred← citeshttps://doi.org/10.1016/j.ccell.2017.09.009openalex-snapshot
Apoptosis, Up the Ante
inferred← citeshttps://doi.org/10.1016/j.cej.2023.141771openalex-snapshot
Near-infrared-inducible Bcl-2-associated X protein system for apoptosis regulation in vivo
inferred← citeshttps://doi.org/10.1016/j.compbiolchem.2018.03.003openalex-snapshot
Design and screening of syringic acid analogues as BAX activators-An in silico approach to discover “BH3 mimetics”
inferred← citeshttps://doi.org/10.1016/j.crmeth.2022.100174openalex-snapshot
A kinetic fluorescence polarization ligand assay for monitoring BAX early activation
inferred← citeshttps://doi.org/10.1016/j.drudis.2015.11.008openalex-snapshot
BH4 domain of Bcl-2 as a novel target for cancer therapy
inferred← citeshttps://doi.org/10.1016/j.ejmech.2016.06.015openalex-snapshot
Discovery and development of natural product oridonin-inspired anticancer agents
inferred← citeshttps://doi.org/10.1016/j.ejmech.2017.03.035openalex-snapshot
Anticancer copper(II) phosphorus dendrimers are potent proapoptotic Bax activators
inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.06.004openalex-snapshot
Structure-activity relationship studies on Bax activator SMBA1 for the treatment of ER-positive and triple-negative breast cancer
inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.112812openalex-snapshot
Recent progress in small molecule agents for the targeted therapy of triple-negative breast cancer
inferred← citeshttps://doi.org/10.1016/j.ejmech.2021.113427openalex-snapshot
Further lead optimization on Bax activators: Design, synthesis and pharmacological evaluation of 2-fluoro-fluorene derivatives for the treatment of breast cancer
inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.115076openalex-snapshot
Optimization of BAX trigger site activator BTSA1 with improved antitumor potency and in vitro ADMET properties
inferred← citeshttps://doi.org/10.1016/j.ejmech.2026.119204openalex-snapshot
Some novel benzimidazole and benzoxazole methyl ester derivatives as BCL2 inhibitors and BAX activators: Synthesis, anticancer activity and in silico evaluation
inferred← citeshttps://doi.org/10.1016/j.ejphar.2018.07.034openalex-snapshot
Molecular targeted therapy: Treating cancer with specificity
inferred← citeshttps://doi.org/10.1016/j.ejphar.2023.175588openalex-snapshot
Therapeutic advancements in targeting BCL-2 family proteins by epigenetic regulators, natural, and synthetic agents in cancer
inferred← citeshttps://doi.org/10.1016/j.gene.2023.147355openalex-snapshot
Evaluation of the effect of nano-encapsulated lactoferrin on the expression of Bak and Bax genes in gastric cancer cell line AGS and study of the molecular docking of lactoferrin with these proteins
inferred← citeshttps://doi.org/10.1016/j.heares.2026.109811openalex-snapshot
Structure-guided mapping of ototoxicity-related proteins: drug entry, damage amplification, cell death execution, and endogenous otoprotection
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2024.123889openalex-snapshot
Recent trends and advances in novel formulations as an armament in Bcl-2/Bax targeted breast cancer
inferred← citeshttps://doi.org/10.1016/j.jddst.2026.107991openalex-snapshot
Lactoferrin-functionalized bioinspired grapefruit-extracellular vesicles for targeted delivery of pterostilbene in lung cancer therapy
inferred← citeshttps://doi.org/10.1016/j.neo.2022.100798openalex-snapshot
Mcl-1 levels critically impact the sensitivities of human colorectal cancer cells to APG-1252-M1, a novel Bcl-2/Bcl-XL dual inhibitor that induces Bax-dependent apoptosis
inferred← citeshttps://doi.org/10.1016/j.str.2015.07.013openalex-snapshot
Solution Structure of Apoptotic BAX Oligomer: Oligomerization Likely Precedes Membrane Insertion
inferred← citeshttps://doi.org/10.1016/j.tips.2021.11.001openalex-snapshot
Physiological and pharmacological modulation of BAX
inferred← citeshttps://doi.org/10.1021/acs.jcim.0c01420openalex-snapshot
Analysis of the Binding Sites on BAX and the Mechanism of BAX Activators through Extensive Molecular Dynamics Simulations
inferred← citeshttps://doi.org/10.1021/acs.jcim.8b00258openalex-snapshot
An Analysis of Different Components of a High-Throughput Screening Library
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.0c02200openalex-snapshot
Pharmacological Targeting of Executioner Proteins: Controlling Life and Death
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c02670openalex-snapshot
Design, Synthesis, and Evaluation of Phenylpyrrole Derivatives as Small-Molecule Activators of BAX
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.7b01575openalex-snapshot
Small-Molecule Activator of UNC-51-Like Kinase 1 (ULK1) That Induces Cytoprotective Autophagy for Parkinson’s Disease Treatment
inferred← citeshttps://doi.org/10.1021/acschemneuro.7b00023openalex-snapshot
Bax Activation Blocks Self-Renewal and Induces Apoptosis of Human Glioblastoma Stem Cells
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.5b00032openalex-snapshot
Screening-Based Translation of Public Research Encounters Painful Problems
inferred← citeshttps://doi.org/10.1021/jacs.8b10098openalex-snapshot
Analysis of Protein–Protein Interaction in a Single Live Cell by Using a FRET System Based on Genetic Code Expansion Technology
inferred← citeshttps://doi.org/10.1021/jacsau.5c01620openalex-snapshot
Combined Nudged Elastic Band and Markov State Models Uncover Distinct BAX Activation Pathways by Bim Peptide and a Small Molecule
inferred← citeshttps://doi.org/10.1038/nchembio.2433openalex-snapshot
Allosteric sensitization of proapoptotic BAX
inferred← citeshttps://doi.org/10.1038/ncomms11734openalex-snapshot
Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies
inferred← citeshttps://doi.org/10.1038/s41388-022-02200-5openalex-snapshot
Overcoming acquired resistance to third-generation EGFR inhibitors by targeting activation of intrinsic apoptotic pathway through Mcl-1 inhibition, Bax activation, or both
inferred← citeshttps://doi.org/10.1038/s41392-024-01823-2openalex-snapshot
Tumor biomarkers for diagnosis, prognosis and targeted therapy
inferred← citeshttps://doi.org/10.1038/s41416-019-0465-yopenalex-snapshot
Coffee consumption by type and risk of digestive cancer: a large prospective cohort study
inferred← citeshttps://doi.org/10.1038/s41419-024-06841-0openalex-snapshot
MicroRNA miR-20a-5p targets CYCS to inhibit apoptosis in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1038/s41435-018-0048-6openalex-snapshot
Cell death in cancer in the era of precision medicine
inferred← citeshttps://doi.org/10.1038/s41467-021-25466-xopenalex-snapshot
Wdr1 and cofilin are necessary mediators of immune-cell-specific apoptosis triggered by Tecfidera
inferred← citeshttps://doi.org/10.1038/s41467-022-28741-7openalex-snapshot
Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer
inferred← citeshttps://doi.org/10.1038/s41571-020-0341-yopenalex-snapshot
Targeting apoptosis in cancer therapy
inferred← citeshttps://doi.org/10.1038/s41580-023-00629-4openalex-snapshot
Mechanisms of BCL-2 family proteins in mitochondrial apoptosis
inferred← citeshttps://doi.org/10.1038/s41589-019-0306-6openalex-snapshot
Targeting BAX to drug death directly
inferred← citeshttps://doi.org/10.1038/s41590-023-01451-yopenalex-snapshot
Mitochondrial damage activates the NLRP10 inflammasome
inferred← citeshttps://doi.org/10.1038/s41598-017-02825-7openalex-snapshot
Release of Cytochrome C from Bax Pores at the Mitochondrial Membrane
inferred← citeshttps://doi.org/10.1038/srep29502openalex-snapshot
Conformational Heterogeneity of Bax Helix 9 Dimer for Apoptotic Pore Formation
inferred← citeshttps://doi.org/10.1039/9781788016544-00087openalex-snapshot
Computational Structural Modeling to Discover PPI Modulators
inferred← citeshttps://doi.org/10.1039/c7an01026eopenalex-snapshot
An Aptamer Bio-barCode (ABC) assay using SPR, RNase H, and probes with RNA and gold-nanorods for anti-cancer drug screening
inferred← citeshttps://doi.org/10.1042/bcj20160118openalex-snapshot
Small molecules reveal an alternative mechanism of Bax activation
inferred← citeshttps://doi.org/10.1074/jbc.ra119.011297openalex-snapshot
Humanin induces conformational changes in the apoptosis regulator BAX and sequesters it into fibers, preventing mitochondrial outer-membrane permeabilization
inferred← citeshttps://doi.org/10.1080/07391102.2023.2187214openalex-snapshot
A comparative analysis of daunorubicin and its metabolite daunorubicinol interaction with apoptotic and drug resistance proteins using in silico approach
inferred← citeshttps://doi.org/10.1080/10799893.2020.1715431openalex-snapshot
Identification of potential anticancer phytochemicals against colorectal cancer by structure-based docking studies
inferred← citeshttps://doi.org/10.1080/14786419.2023.2269592openalex-snapshot
Synthesis, molecular docking studies of formononetin derivatives as potent Bax agonists for anticancer activity
inferred← citeshttps://doi.org/10.1080/15384101.2020.1843816openalex-snapshot
SEC61G plays an oncogenic role in hepatocellular carcinoma cells
inferred← citeshttps://doi.org/10.1088/1758-5090/ab5158openalex-snapshot
The bioprinting roadmap
inferred← citeshttps://doi.org/10.1093/neuonc/nox134openalex-snapshot
Selective BCL-XL inhibition promotes apoptosis in combination with MLN8237 in medulloblastoma and pediatric glioblastoma cells
inferred← citeshttps://doi.org/10.1097/cad.0000000000000303openalex-snapshot
The salicylanilide derivatives inhibit signal transducer and activator of transcription 3 pathways in A549 lung cancer cells
inferred← citeshttps://doi.org/10.1097/cad.0000000000000415openalex-snapshot
PTD4-apoptin induces Bcl-2-insensitive apoptosis in human cervical carcinoma in vitro and in vivo
inferred← citeshttps://doi.org/10.1097/md.0000000000001294openalex-snapshot
The Evolution of and Risk Factors for Neck Muscle Atrophy and Weakness in Nasopharyngeal Carcinoma Treated With Intensity-Modulated Radiotherapy
inferred← citeshttps://doi.org/10.1097/md.0000000000011591openalex-snapshot
Prognostic value and susceptibility of BAX rs4645878 polymorphism in cancer
inferred← citeshttps://doi.org/10.1101/cshperspect.a036319openalex-snapshot
BAX, BAK, and BOK: A Coming of Age for the BCL-2 Family Effector Proteins
inferred← citeshttps://doi.org/10.1111/cbdd.12920openalex-snapshot
Mannich bases of 1,2,4‐triazole‐3‐thione containing adamantane moiety: Synthesis, preliminary anticancer evaluation, and molecular modeling studies
inferred← citeshttps://doi.org/10.1111/febs.13472openalex-snapshot
Attacking cancer's Achilles heel: antagonism of anti‐apoptotic BCL ‐2 family members
inferred← citeshttps://doi.org/10.1142/s0219633620500066openalex-snapshot
A theoretical study on cyclometalated iridium (III) complexes by using a density functional theory
inferred← citeshttps://doi.org/10.1158/0008-5472.22414932openalex-snapshot
Supplementary Data and Methods from Modulation of Bax and mTOR for Cancer Therapeutics
inferred← citeshttps://doi.org/10.1158/0008-5472.22414932.v1openalex-snapshot
Supplementary Data and Methods from Modulation of Bax and mTOR for Cancer Therapeutics
inferred← citeshttps://doi.org/10.1158/0008-5472.can-16-2356openalex-snapshot
Modulation of Bax and mTOR for Cancer Therapeutics
inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-14-0959openalex-snapshot
Molecular Pathways: Leveraging the BCL-2 Interactome to Kill Cancer Cells—Mitochondrial Outer Membrane Permeabilization and Beyond
inferred← citeshttps://doi.org/10.1159/000488410openalex-snapshot
Mitofusin-2 Triggers Cervical Carcinoma Cell Hela Apoptosis via Mitochondrial Pathway in Mouse Model
inferred← citeshttps://doi.org/10.1177/0963689720931435openalex-snapshot
Ganoderma lucidum Polysaccharide Enzymatic Hydrolysate Suppresses the Growth of Human Colon Cancer Cells via Inducing Apoptosis
inferred← citeshttps://doi.org/10.1186/s12943-019-1012-4openalex-snapshot
Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy
inferred← citeshttps://doi.org/10.1186/s12957-018-1441-3openalex-snapshot
Safflower polysaccharide inhibits the development of tongue squamous cell carcinoma
inferred← citeshttps://doi.org/10.1586/17474086.2015.1026321openalex-snapshot
Therapeutic targeting of Bcl-2 family for treatment of B-cell malignancies
inferred← citeshttps://doi.org/10.18502/ijph.v52i7.13233openalex-snapshot
Advances in the Application of Apoptotic Proteins and Alternative Splicing in Tumor Therapy: A Narrative Review
inferred← citeshttps://doi.org/10.18632/oncotarget.15448openalex-snapshot
miR-363-3p inhibits tumor growth by targeting PCNA in lung adenocarcinoma
inferred← citeshttps://doi.org/10.18632/oncotarget.7971openalex-snapshot
Noninvasive bioluminescence imaging of the dynamics of sanguinarine induced apoptosis via activation of reactive oxygen species
inferred← citeshttps://doi.org/10.21203/rs.3.rs-1295136/v1openalex-snapshot
Mitochondrial damage activates the NLRP10 inflammasome
inferred← citeshttps://doi.org/10.2147/ott.s146228openalex-snapshot
MCL-1 inhibition in cancer treatment
inferred← citeshttps://doi.org/10.2147/ott.s94513openalex-snapshot
Echinacoside induces apoptotic cancer cell death by inhibiting the nucleotide pool sanitizing enzyme MTH1
inferred← citeshttps://doi.org/10.2174/0115701808275830231221192129openalex-snapshot
In silico Investigation of the Pro-apoptotic Potential of Syringic Acid Analog
inferred← citeshttps://doi.org/10.22159/ajpcr.2017.v10i7.19063openalex-snapshot
THE BIOPHYSICAL CHARACTERISTICS AND STRUCTURAL EXPLORATION OF PROGRAMMED CELL DEATH REGULATOR B-CELL LYMPHOMA 2-ASSOCIATED X PROTEIN OF CHINESE LIVER FLUKE (CLONORCHIS SINENSIS)
inferred← citeshttps://doi.org/10.31557/apjcp.2019.20.6.1849openalex-snapshot
Role of TMPRSS4 Modulation in Breast Cancer Cell Proliferation
inferred← citeshttps://doi.org/10.32598/rmm.8.3.726.3openalex-snapshot
Anticancer Effect of Bovine Lactoferrin on Breast Cancer Cell Line MCF7 and the Evaluation of Bax and Bak Genes Expression Involved in Apoptosis
inferred← citeshttps://doi.org/10.3389/fonc.2022.1068994openalex-snapshot
Non-phosphorylatable mutants of Ser184 lead to incomplete activation of Bax
inferred← citeshttps://doi.org/10.3389/fonc.2022.835290openalex-snapshot
Glycerophosphoinositol Promotes Apoptosis of Chronic Lymphocytic Leukemia Cells by Enhancing Bax Expression and Activation
inferred← citeshttps://doi.org/10.3390/ijms18061157openalex-snapshot
Loss of BAX by miR-365 Promotes Cutaneous Squamous Cell Carcinoma Progression by Suppressing Apoptosis
inferred← citeshttps://doi.org/10.3390/ijms22084086openalex-snapshot
Contribution of Yeast Studies to the Understanding of BCL-2 Family Intracellular Trafficking
inferred← citeshttps://doi.org/10.37349/etat.2023.00154openalex-snapshot
B-cell lymphoma 2 family members and sarcomas: a promising target in a heterogeneous disease
inferred← citeshttps://doi.org/10.3892/mmr.2016.5271openalex-snapshot
miR-410 regulates apoptosis by targeting Bak1 in human colorectal cancer cells
inferred← citeshttps://doi.org/10.4103/pm.pm_535_19openalex-snapshot
Naringenin sensitizes lung cancer NCI-H23 cells to radiation by downregulation of akt expression and metastasis while promoting apoptosis
inferred← citeshttps://doi.org/10.4137/cmo.s29462openalex-snapshot
Galectin-3 as a Potential Target to Prevent Cancer Metastasis
inferred← citeshttps://doi.org/10.4149/neo_2015_107openalex-snapshot
Suppression of peripheral myelin protein 22 (PMP22) expression by miR29 inhibits the progression of lung cancer
inferred← citeshttps://doi.org/10.4149/neo_2016_008openalex-snapshot
IARS2 silencing induces non-small cell lung cancer cells proliferation inhibition, cell cycle arrest and promotes cell apoptosis
inferred← citeshttps://doi.org/10.52756/ijerr.2024.v37spl.004openalex-snapshot
Apoptosis and Autophagy: Therapeutic Implications in Cancer
inferred← citeshttps://doi.org/10.5772/intechopen.97844openalex-snapshot
The Role of Apoptosis as a Double-Edge Sword in Cancer
inferred← citeshttps://doi.org/10.70675/5ffd7262za032z4230zbbaaz9d8a596af7fcopenalex-snapshot
L'insertion membranaire de la protéine pro-apoptotique Bax est un processus muti-étapes dépendant de TOM22
inferred← citeshttps://doi.org/10.70675/86dd7fafzcb40z4cedz8eb7zbb41268cd809openalex-snapshot
Bcl2L10 : polymorphisme, résistance oncogénique et conséquences thérapeutique dans le cancer du sein
inferred← citeshttps://doi.org/10.7150/thno.60349openalex-snapshot
Discovery of Small Molecule Bak Activator for Lung Cancer Therapy
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