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Pharmacological repression of PPARγ promotes osteogenesis
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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HDX Workbench: Software for the Analysis of H/D Exchange MS Data
inferredcites →https://doi.org/10.1016/j.bcp.2006.03.023openalex-snapshot
Antagonism of peroxisome proliferator-activated receptor γ prevents high-fat diet-induced obesity in vivo
inferredcites →https://doi.org/10.1016/j.biochi.2005.02.002openalex-snapshot
The conserved residue Phe273(282) of PPARα(γ), beyond the ligand-binding site, functions in binding affinity through solvation effect
inferredcites →https://doi.org/10.1016/j.bmc.2012.11.058openalex-snapshot
Discovery of INT131: A selective PPARγ modulator that enhances insulin sensitivity
inferredcites →https://doi.org/10.1016/j.cellsig.2009.08.003openalex-snapshot
Lysophosphatidic acid-induced arterial wall remodeling: Requirement of PPARγ but not LPA1 or LPA2 GPCR
inferredcites →https://doi.org/10.1016/j.cmet.2014.01.021openalex-snapshot
PPARγ in Vagal Neurons Regulates High-Fat Diet Induced Thermogenesis
inferredcites →https://doi.org/10.1016/j.molcel.2010.07.022openalex-snapshot
Phospholipase D2-Dependent Inhibition of the Nuclear Hormone Receptor PPARγ by Cyclic Phosphatidic Acid
inferredcites →https://doi.org/10.1016/j.str.2007.07.014openalex-snapshot
Partial Agonists Activate PPARγ Using a Helix 12 Independent Mechanism
inferredcites →https://doi.org/10.1016/s0076-6879(97)76066-xopenalex-snapshot
[20] Processing of X-ray diffraction data collected in oscillation mode
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The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen
inferredcites →https://doi.org/10.1016/s1097-2765(01)00353-7openalex-snapshot
A Unique PPARγ Ligand with Potent Insulin-Sensitizing yet Weak Adipogenic Activity
inferredcites →https://doi.org/10.1021/ac051294fopenalex-snapshot
Probing Protein Ligand Interactions by Automated Hydrogen/Deuterium Exchange Mass Spectrometry
inferredcites →https://doi.org/10.1038/nature09291openalex-snapshot
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5
inferredcites →https://doi.org/10.1038/nature10383openalex-snapshot
Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation
inferredcites →https://doi.org/10.1038/ncomms4571openalex-snapshot
An alternate binding site for PPARγ ligands
inferredcites →https://doi.org/10.1038/nm.2349openalex-snapshot
A role for central nervous system PPAR-γ in the regulation of energy balance
inferredcites →https://doi.org/10.1038/nsmb.1474openalex-snapshot
Structural basis for the activation of PPARγ by oxidized fatty acids
inferredcites →https://doi.org/10.1038/sj.bjp.0705973openalex-snapshot
GW9662, an antagonist of PPAR-gamma, inhibits breast tumour cell growth and promotes the anticancer effects of the PPAR-gamma agonist Rosiglitazone, independently of PPAR-gamma activation.
inferredcites →https://doi.org/10.1073/pnas.0914360107openalex-snapshot
Pharmaceutical modulation of canonical Wnt signaling in multipotent stromal cells for improved osteoinductive therapy
inferredcites →https://doi.org/10.1074/jbc.c800139200openalex-snapshot
A Functional Peroxisome Proliferator-activated Receptor-γ Ligand-binding Domain Is Not Required for Adipogenesis
inferredcites →https://doi.org/10.1107/s0907444904019158openalex-snapshot
Coot : model-building tools for molecular graphics
inferredcites →https://doi.org/10.1111/j.1463-1326.2010.01225.xopenalex-snapshot
Rosiglitazone and pioglitazone increase fracture risk in women and men with type 2 diabetes
inferredcites →https://doi.org/10.1152/ajpendo.00312.2002openalex-snapshot
Effect of heterozygous PPARγ deficiency and TZD treatment on insulin resistance associated with age and high-fat feeding
inferredcites →https://doi.org/10.1155/2008/494161openalex-snapshot
Potential of Peroxisome Proliferator‐Activated Receptor Gamma Antagonist Compounds as Therapeutic Agents for a Wide Range of Cancer Types
inferredcites →https://doi.org/10.1172/jci19900openalex-snapshot
PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors
inferredcites →https://doi.org/10.1172/jci8538openalex-snapshot
Improved insulin-sensitivity in mice heterozygous for PPAR-γ deficiency
inferredcites →https://doi.org/10.1634/stemcells.19-5-408openalex-snapshot
MicroSAGE Analysis of 2,353 Expressed Genes in a Single Cell‐Derived Colony of Undifferentiated Human Mesenchymal Stem Cells Reveals mRNAs of Multiple Cell Lineages
inferredcites →https://doi.org/10.2210/pdb2vv1/pdbopenalex-snapshot
hPPARgamma Ligand binding domain in complex with 4-HDHA
inferredcites →https://doi.org/10.3945/ajcn.2009.28449eopenalex-snapshot
Selective peroxisome proliferator-activated receptor γ (PPARγ) modulation as a strategy for safer therapeutic PPARγ activation
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Telmisartan impairs the in vitro osteogenic differentiation of mesenchymal stromal cells from spontaneously hypertensive male rats
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CMHX008, a PPARγ partial agonist, enhances insulin sensitivity with minor influences on bone loss
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Single-cell transcriptomics identifies CD36 as a negative regulator of osteogenic differentiation in murine osteoporosis
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Noncanonical agonist PPARγ ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy
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Cooperative Cobinding of Synthetic and Natural Ligands to the Nuclear Receptor PPARγ
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LAMA2 regulates the fate commitment of mesenchymal stem cells via hedgehog signaling
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Core level regulatory network of osteoblast as molecular mechanism for osteoporosis and treatment
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CHARMM Force Field Parameterization of Peroxisome Proliferator-Activated Receptor γ Ligands
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Novel QSAR Models for Molecular Initiating Event Modeling in Two Intersecting Adverse Outcome Pathways Based Pulmonary Fibrosis Prediction for Biocidal Mixtures
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Inhibition of CXCR4 inhibits the proliferation and osteogenic potential of fibroblasts from ankylosing spondylitis via the Wnt/β‑catenin pathway
inferred← citeshttps://doi.org/10.55544/jrasb.1.5.1openalex-snapshot
Article Review: Biochemical Aspect of Survivin Hormone
inferred← citeshttps://doi.org/10.6026/97320630019633openalex-snapshot
Molecular docking analysis of PPARγ antagonists for obesity associated diabetes management
inferred← citeshttps://doi.org/10.6084/m9.figshare.12033009openalex-snapshot
Additional file 1 of LAMA2 regulates the fate commitment of mesenchymal stem cells via hedgehog signaling
inferred← citeshttps://doi.org/10.6084/m9.figshare.12033015openalex-snapshot
Additional file 2 of LAMA2 regulates the fate commitment of mesenchymal stem cells via hedgehog signaling
inferred← citeshttps://doi.org/10.6084/m9.figshare.12033021openalex-snapshot
Additional file 3 of LAMA2 regulates the fate commitment of mesenchymal stem cells via hedgehog signaling
inferred← citeshttps://doi.org/10.6084/m9.figshare.12033027openalex-snapshot
Additional file 4 of LAMA2 regulates the fate commitment of mesenchymal stem cells via hedgehog signaling
inferred← citeshttps://doi.org/10.64898/2026.02.04.703935openalex-snapshot
Dexamethasone-induced PPARG expression in osteogenic differentiation in vitro: impact on SOX9 and RUNX2 levels
inferred← citeshttps://doi.org/10.70675/99f394a9zdd8bz4cb8z8348z6ada0a583d32openalex-snapshot
Mécanisme moléculaires du rôle protumorigénique de PPARgamma et RXRalpha dans les cancers de vessie
inferred← citeshttps://doi.org/10.7150/ijms.16484openalex-snapshot
Cultured Human Periosteum-Derived Cells Can Differentiate into Osteoblasts in a Perioxisome Proliferator-Activated Receptor Gamma-Mediated Fashion via Bone Morphogenetic Protein signaling
inferred← citeshttps://doi.org/10.7554/elife.106697openalex-snapshot
Shifting the PPARγ conformational ensemble toward a transcriptionally repressive state improves covalent inhibitor efficacy
inferred← citeshttps://doi.org/10.7554/elife.106697.1openalex-snapshot
Shifting the PPARγ conformational ensemble towards a transcriptionally repressive state improves covalent inhibitor efficacy
inferred← citeshttps://doi.org/10.7554/elife.106697.2openalex-snapshot
Shifting the PPARγ conformational ensemble towards a transcriptionally repressive state improves covalent inhibitor efficacy
inferred← citeshttps://doi.org/10.7554/elife.43320openalex-snapshot
Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPARγ.
inferred← citeshttps://doi.org/10.7554/elife.99782openalex-snapshot
Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPARγ
inferred← citeshttps://doi.org/10.7554/elife.99782.1openalex-snapshot
Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPARγ
inferred← citeshttps://doi.org/10.7554/elife.99782.2openalex-snapshot
Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPARγ
inferred← citeshttps://doi.org/10.7554/elife.99782.3openalex-snapshot
Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPARγ
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