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The transcriptional landscape of age in human peripheral blood
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Genetic dissection of gene expression observed in whole blood samples of elderly Danish twins
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Genetic determinants of mortality. Can findings from genome-wide association studies explain variation in human mortality?
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Liver mitochondrial respiratory functions decline with age
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Capillary electrophoresis of heparin and other glycosaminoglycans using a polyamine running electrolyte
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ATM-deficient human fibroblast cells are resistant to low levels of DNA double-strand break induced apoptosis and subsequently undergo drug-induced premature senescence
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The signaling hubs at the crossroad of longevity and age-related disease networks
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Actin Dynamics Affect Mitochondrial Quality Control and Aging in Budding Yeast
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A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals
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Advancing age is associated with gene expression changes resembling mTOR inhibition: Evidence from two human populations
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Genotype×age interaction in human transcriptional ageing
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Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates
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Age-related effects on hippocampal precursor cell subpopulations and neurogenesis
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A genome-wide association study of aging
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ArhGAP15, a novel human RacGAP protein with GTPase binding property 1
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Mitochondrial respiratory chain activity in the human brain as a function of age
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Genome-Wide Transcript Profiles in Aging and Calorically Restricted Drosophila melanogaster
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Altered rate of DNA replication in ageing human fibroblast cultures
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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
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Human DNA methylomes at base resolution show widespread epigenomic differences
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Mapping and analysis of chromatin state dynamics in nine human cell types
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Mitonuclear protein imbalance as a conserved longevity mechanism
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Integrative analysis of 111 reference human epigenomes
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Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants
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Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits
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Genetic associations with human longevity at the APOE and ACE loci
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Comparing genomic expression patterns across species identifies shared transcriptional profile in aging
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A role for actin in aging and apoptosis
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Similar gene expression patterns characterize aging and oxidative stress in Drosophila melanogaster
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Decline in skeletal muscle mitochondrial function with aging in humans
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FOXO3A genotype is strongly associated with human longevity
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Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila
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Oxidative damage and mitochondrial decay in aging.
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Lysosomal Function and Dysfunction: Mechanism and Disease
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Association of the FOXO3A Locus with Extreme Longevity in a Southern Italian Centenarian Study
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Meta-analysis of age-related gene expression profiles identifies common signatures of aging
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METAL: fast and efficient meta-analysis of genomewide association scans
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The Epidemiology of Longevity and Exceptional Survival
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High-Frequency Generation of Conditional Mutations Affecting Drosophila melanogaster Development and Life Span
inferredcites →https://doi.org/10.1093/gerona/glu166openalex-snapshot
GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy
inferredcites →https://doi.org/10.1093/jn/131.3.918sopenalex-snapshot
Microarray Profiling of Gene Expression in Aging and Its Alteration by Caloric Restriction in Mice
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The role of DNA damage repair in aging of adult stem cells
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The NHGRI GWAS Catalog, a curated resource of SNP-trait associations
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GRASP v2.0: an update on the Genome-Wide Repository of Associations between SNPs and phenotypes
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Effect of Aging on Wound Healing
inferredcites →https://doi.org/10.1098/rstb.2010.0276openalex-snapshot
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inferredcites →https://doi.org/10.1101/gr.184401openalex-snapshot
Changes in Gene Expression Associated with Developmental Arrest and Longevity in Caenorhabditis elegans
inferredcites →https://doi.org/10.1101/sqb.1995.060.01.008openalex-snapshot
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inferredcites →https://doi.org/10.1111/j.1474-9726.2009.00471.xopenalex-snapshot
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inferredcites →https://doi.org/10.1111/j.1474-9726.2010.00627.xopenalex-snapshot
Replication of an association of variation in the FOXO3A gene with human longevity using both case–control and longitudinal data
inferredcites →https://doi.org/10.1111/j.1474-9726.2011.00726.xopenalex-snapshot
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Major aging-associated RNA expressions change at two distinct age-positions
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Genetic and epigenetic regulation of gene expression in fetal and adult human livers
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Rotavirus NSP4 is secreted from infected cells as an oligomeric lipoprotein and binds to glycosaminoglycans on the surface of non-infected cells
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Additional annotation enhances potential for biologically-relevant analysis of the Illumina Infinium HumanMethylation450 BeadChip array
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inferredcites →https://doi.org/10.1186/gb-2013-14-10-r115openalex-snapshot
DNA methylation age of human tissues and cell types
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Gene expression changes with age in skin, adipose tissue, blood and brain
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Optimal Full Matching and Related Designs via Network Flows
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Incoming claims: where this work appears in other papers’ reference lists and arguments.
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inferred← citeshttps://doi.org/10.1016/b978-0-12-819475-1.00086-9openalex-snapshot
Systems Glycobiology: Immunoglobulin G Glycans as Biomarkers and Functional Effectors in Aging and Diseases
inferred← citeshttps://doi.org/10.1016/b978-0-12-822569-1.00016-0openalex-snapshot
Nutritional biomarkers in aging research
inferred← citeshttps://doi.org/10.1016/b978-0-12-823318-4.00032-9openalex-snapshot
Injury and regeneration in renal aging
inferred← citeshttps://doi.org/10.1016/b978-0-12-823761-8.00013-6openalex-snapshot
Personalized medicine: will it work for decreasing age-related morbidities?
inferred← citeshttps://doi.org/10.1016/b978-0-323-99144-5.00024-xopenalex-snapshot
Detection of human body fluid through mRNA analysis using NGS
inferred← citeshttps://doi.org/10.1016/b978-0-443-23802-4.00010-7openalex-snapshot
Forensic epigenetics in the massively parallel sequencing era
inferred← citeshttps://doi.org/10.1016/bs.ai.2017.05.005openalex-snapshot
Adhesion GPCRs in Regulating Immune Responses and Inflammation
inferred← citeshttps://doi.org/10.1016/j.addr.2018.09.006openalex-snapshot
Novel targets for delaying aging: The importance of the liver and advances in drug delivery
inferred← citeshttps://doi.org/10.1016/j.annonc.2022.03.058openalex-snapshot
43P Dynamic alterations of immunosenescence-related genes in older women with breast cancer receiving chemotherapy
inferred← citeshttps://doi.org/10.1016/j.archger.2024.105476openalex-snapshot
Inflammatory age and its impact on age-related health in older Chinese adults
inferred← citeshttps://doi.org/10.1016/j.arr.2020.101050openalex-snapshot
Biohorology and biomarkers of aging: Current state-of-the-art, challenges and opportunities
inferred← citeshttps://doi.org/10.1016/j.arr.2020.101070openalex-snapshot
Systematic review and analysis of human proteomics aging studies unveils a novel proteomic aging clock and identifies key processes that change with age
inferred← citeshttps://doi.org/10.1016/j.arr.2020.101164openalex-snapshot
Promising biomarkers of human aging: In search of a multi-omics panel to understand the aging process from a multidimensional perspective
inferred← citeshttps://doi.org/10.1016/j.arr.2021.101350openalex-snapshot
Assessing the rate of aging to monitor aging itself
inferred← citeshttps://doi.org/10.1016/j.arr.2024.102253openalex-snapshot
Organ-specific biological clocks: Ageotyping for personalized anti-aging medicine
inferred← citeshttps://doi.org/10.1016/j.arr.2024.102653openalex-snapshot
The immunosenescence clock: A new method for evaluating biological age and predicting mortality risk
inferred← citeshttps://doi.org/10.1016/j.arr.2025.102871openalex-snapshot
From clock to clock: Therapeutic target discovery for aging and age-related diseases
inferred← citeshttps://doi.org/10.1016/j.arr.2025.102889openalex-snapshot
Deep aging clocks: AI-powered strategies for biological age estimation
inferred← citeshttps://doi.org/10.1016/j.arr.2026.103040openalex-snapshot
Single-cell aging clocks: A precision tool for dissecting and targeting the aging process
inferred← citeshttps://doi.org/10.1016/j.arr.2026.103213openalex-snapshot
Why we age – Integrating error, program, and selective pressure
inferred← citeshttps://doi.org/10.1016/j.arr.2026.103297openalex-snapshot
Aging in the air we breathe: Mechanisms and consequences of air pollution exposure for biological aging
inferred← citeshttps://doi.org/10.1016/j.bbadis.2017.09.017openalex-snapshot
Phenome and genome based studies into human ageing and longevity: An overview
inferred← citeshttps://doi.org/10.1016/j.bbadis.2018.08.039openalex-snapshot
Genetic and epigenetic regulation of human aging and longevity
inferred← citeshttps://doi.org/10.1016/j.bbagen.2016.07.017openalex-snapshot
Deciphering hallmark processes of aging from interaction networks
inferred← citeshttps://doi.org/10.1016/j.bbagrm.2020.194491openalex-snapshot
Transcriptomic landscape, gene signatures and regulatory profile of aging in the human brain
inferred← citeshttps://doi.org/10.1016/j.brainresbull.2023.110704openalex-snapshot
Aging affects the phase coherence between spontaneous oscillations in brain oxygenation and neural activity
inferred← citeshttps://doi.org/10.1016/j.cell.2016.07.031openalex-snapshot
Metabolic Control of Longevity
inferred← citeshttps://doi.org/10.1016/j.cell.2023.08.003openalex-snapshot
Biomarkers of aging for the identification and evaluation of longevity interventions
inferred← citeshttps://doi.org/10.1016/j.cell.2026.04.032openalex-snapshot
A comparison of deep multiomics profiles across ethnicity, geography, and age
inferred← citeshttps://doi.org/10.1016/j.celrep.2016.07.085openalex-snapshot
Identification of Modifier Genes in a Mouse Model of Gaucher Disease
inferred← citeshttps://doi.org/10.1016/j.celrep.2019.03.044openalex-snapshot
Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging
inferred← citeshttps://doi.org/10.1016/j.celrep.2019.10.019openalex-snapshot
Sex Differences in the Blood Transcriptome Identify Robust Changes in Immune Cell Proportions with Aging and Influenza Infection
inferred← citeshttps://doi.org/10.1016/j.celrep.2023.113500openalex-snapshot
CellBiAge: Improved single-cell age classification using data binarization
inferred← citeshttps://doi.org/10.1016/j.cels.2021.05.005openalex-snapshot
A time-resolved proteomic and prognostic map of COVID-19
inferred← citeshttps://doi.org/10.1016/j.cirep.2025.200255openalex-snapshot
Comparative blood transcriptome analysis reveals changes in immunity, and transcripts related to metabolism and development in the critically endangered Yangtze finless porpoise (Neophocaena asiaeorientalis asiaeorientalis) with age
inferred← citeshttps://doi.org/10.1016/j.cjca.2016.02.062openalex-snapshot
Accelerated Vascular Aging as a Paradigm for Hypertensive Vascular Disease: Prevention and Therapy
inferred← citeshttps://doi.org/10.1016/j.clinms.2019.08.001openalex-snapshot
Determining histone H4 acetylation patterns in human peripheral blood mononuclear cells using mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.cmet.2024.05.012openalex-snapshot
Thermal facial image analyses reveal quantitative hallmarks of aging and metabolic diseases
inferred← citeshttps://doi.org/10.1016/j.cmet.2024.10.005openalex-snapshot
Plasma protein-based organ-specific aging and mortality models unveil diseases as accelerated aging of organismal systems
inferred← citeshttps://doi.org/10.1016/j.cmet.2024.11.007openalex-snapshot
Decoding aging clocks: New insights from metabolomics
inferred← citeshttps://doi.org/10.1016/j.cofs.2016.08.006openalex-snapshot
Translating novel insights from age-related loss of skeletal muscle mass and phenotypic flexibility into diet and lifestyle recommendations for the elderly
inferred← citeshttps://doi.org/10.1016/j.compbiomed.2025.110534openalex-snapshot
Tissue-origin transcriptomic interactions as indicators of inflammatory aging and aging gene discovery
inferred← citeshttps://doi.org/10.1016/j.conb.2020.05.001openalex-snapshot
The aging transcriptome: read between the lines
inferred← citeshttps://doi.org/10.1016/j.csbj.2022.10.021openalex-snapshot
Scale bar of aging trajectories for screening personal rejuvenation treatments
inferred← citeshttps://doi.org/10.1016/j.dadm.2018.05.006openalex-snapshot
Investigating the relationship between DNA methylation age acceleration and risk factors for Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.ddmod.2019.03.003openalex-snapshot
Computational approaches for the systematic analysis of aging-associated molecular alterations
inferred← citeshttps://doi.org/10.1016/j.drudis.2020.06.016openalex-snapshot
Treating age-related multimorbidity: the drug discovery challenge
inferred← citeshttps://doi.org/10.1016/j.ebiom.2017.03.046openalex-snapshot
Biological Age Predictors
inferred← citeshttps://doi.org/10.1016/j.ebiom.2020.102647openalex-snapshot
Comprehensive analysis of tumor necrosis factor receptor TNFRSF9 (4-1BB) DNA methylation with regard to molecular and clinicopathological features, immune infiltrates, and response prediction to immunotherapy in melanoma
inferred← citeshttps://doi.org/10.1016/j.ebiom.2023.104514openalex-snapshot
Multi-modal profiling of peripheral blood cells across the human lifespan reveals distinct immune cell signatures of aging and longevity
inferred← citeshttps://doi.org/10.1016/j.ebiom.2024.105279openalex-snapshot
NMR metabolomics-guided DNA methylation mortality predictors
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2026.119764openalex-snapshot
Ambient long-term air pollution exposure and epigenetic aging clocks: A systematic review and meta-analysis
inferred← citeshttps://doi.org/10.1016/j.eng.2025.08.016openalex-snapshot
Deep Reinforcement Learning-Driven Multi-Omics Integration for Constructing gtAge: A Novel Aging Clock from the IgG N-Glycome and Blood Transcriptome
inferred← citeshttps://doi.org/10.1016/j.envint.2019.105071openalex-snapshot
Air pollution, particulate matter composition and methylation-based biologic age
inferred← citeshttps://doi.org/10.1016/j.envint.2025.109344openalex-snapshot
Transcriptome alterations in long-term mining region residents: Insights into immune response and molecular pathways
inferred← citeshttps://doi.org/10.1016/j.exger.2016.03.020openalex-snapshot
Assessment of health status by molecular measures in adults ranging from middle-aged to old: Ready for clinical use?
inferred← citeshttps://doi.org/10.1016/j.exger.2017.08.019openalex-snapshot
Reduced dynamic range of antiviral innate immune responses in aging
inferred← citeshttps://doi.org/10.1016/j.exger.2017.12.015openalex-snapshot
Aging, inflammation and the environment
inferred← citeshttps://doi.org/10.1016/j.exger.2024.112421openalex-snapshot
Higher blood biochemistry-based biological age developed by advanced deep learning techniques is associated with frailty in geriatric rehabilitation inpatients: RESORT
inferred← citeshttps://doi.org/10.1016/j.forsciint.2021.110996openalex-snapshot
Evaluating the performance of five up-to-date DNA/RNA co-extraction methods for forensic application
inferred← citeshttps://doi.org/10.1016/j.fsigen.2021.102486openalex-snapshot
Forensic transcriptome analysis using massively parallel sequencing
inferred← citeshttps://doi.org/10.1016/j.fsigen.2021.102637openalex-snapshot
Combining current knowledge on DNA methylation-based age estimation towards the development of a superior forensic DNA intelligence tool
inferred← citeshttps://doi.org/10.1016/j.fsigen.2023.102976openalex-snapshot
Selecting mRNA markers in blood for age estimation of the donor of a biological stain
inferred← citeshttps://doi.org/10.1016/j.fsigen.2025.103282openalex-snapshot
Assessing transcriptomic signatures of aging: Testing an mRNA marker panel for forensic age estimation of blood samples
inferred← citeshttps://doi.org/10.1016/j.fsigen.2025.103373openalex-snapshot
Development and validation of an age prediction model using mRNA markers
inferred← citeshttps://doi.org/10.1016/j.fsigen.2025.103419openalex-snapshot
Long non-coding RNAs in human peripheral blood as biomarkers for age prediction
inferred← citeshttps://doi.org/10.1016/j.gecco.2026.e04284openalex-snapshot
Characteristics of fecal DNA methylation and usability in tiger age estimation
inferred← citeshttps://doi.org/10.1016/j.gene.2019.05.053openalex-snapshot
Male reproductive tract antimicrobial expression in the extremes of ages of rats
inferred← citeshttps://doi.org/10.1016/j.gene.2022.146501openalex-snapshot
Two different aging paths in human blood revealed by integrated analysis of gene Expression, mutation and alternative splicing
inferred← citeshttps://doi.org/10.1016/j.heliyon.2022.e10576openalex-snapshot
Toxoplasma gondii infection and peripheral-blood gene expression profiling of older people reveals dysregulation of cytokines and identifies hub genes as potential therapeutic targets
inferred← citeshttps://doi.org/10.1016/j.ijcard.2017.09.188openalex-snapshot
Epigenetics and cardiovascular regenerative medicine in the elderly
inferred← citeshttps://doi.org/10.1016/j.imlet.2018.10.005openalex-snapshot
Genome-wide analysis of gene expression after one year of venom immunotherapy
inferred← citeshttps://doi.org/10.1016/j.isci.2023.106368openalex-snapshot
Age or lifestyle-induced accumulation of genotoxicity is associated with a length-dependent decrease in gene expression
inferred← citeshttps://doi.org/10.1016/j.isci.2023.108558openalex-snapshot
Epitranscriptome analysis of NAD-capped RNA by spike-in-based normalization and prediction of chronological age
inferred← citeshttps://doi.org/10.1016/j.isci.2026.116439openalex-snapshot
Decoding the role of transcriptomic clocks in the human prefrontal cortex
inferred← citeshttps://doi.org/10.1016/j.it.2023.05.005openalex-snapshot
Transcriptome-based measurement of CD8+ T cell age and its applications
inferred← citeshttps://doi.org/10.1016/j.it.2025.09.001openalex-snapshot
Decoding immune aging at single-cell resolution
inferred← citeshttps://doi.org/10.1016/j.jagp.2022.02.003openalex-snapshot
Blood mRNA Expression in Alzheimer's Disease and Dementia With Lewy Bodies
inferred← citeshttps://doi.org/10.1016/j.jare.2024.11.018openalex-snapshot
Transformative applications of oculomics-based AI approaches in the management of systemic diseases: A systematic review
inferred← citeshttps://doi.org/10.1016/j.jbi.2017.11.003openalex-snapshot
Predicting age by mining electronic medical records with deep learning characterizes differences between chronological and physiological age
inferred← citeshttps://doi.org/10.1016/j.jbi.2021.103855openalex-snapshot
Predictive models of aging of the human eye based on ocular anterior segment morphology
inferred← citeshttps://doi.org/10.1016/j.jmb.2017.06.019openalex-snapshot
Transcriptional Signatures of Aging
inferred← citeshttps://doi.org/10.1016/j.joca.2016.11.011openalex-snapshot
Osteoarthritis year in review 2016: genetics, genomics and epigenetics
inferred← citeshttps://doi.org/10.1016/j.legalmed.2026.102926openalex-snapshot
Differential thermal stability of mRNA, miRNA and lncRNA in purified human tissue-derived RNA extracts: a proof-of-principle study with forensic implications
inferred← citeshttps://doi.org/10.1016/j.mad.2017.12.002openalex-snapshot
DNA methylation dynamics in aging: how far are we from understanding the mechanisms?
inferred← citeshttps://doi.org/10.1016/j.mad.2018.01.002openalex-snapshot
Back to the future: Epigenetic clock plasticity towards healthy aging
inferred← citeshttps://doi.org/10.1016/j.mad.2019.111192openalex-snapshot
Multi-omics approaches to human biological age estimation
inferred← citeshttps://doi.org/10.1016/j.maturitas.2016.07.006openalex-snapshot
Menopause: Genome stability as new paradigm
inferred← citeshttps://doi.org/10.1016/j.maturitas.2025.108601openalex-snapshot
Exploring geriatricians' perspectives on aging biomarkers: A reflexive thematic analysis
inferred← citeshttps://doi.org/10.1016/j.mayocp.2018.10.005openalex-snapshot
Exceptional Human Longevity
inferred← citeshttps://doi.org/10.1016/j.medj.2023.06.010openalex-snapshot
Determining a multimodal aging clock in a cohort of Chinese women
inferred← citeshttps://doi.org/10.1016/j.molcel.2023.02.025openalex-snapshot
Mitochondria: A “pacemaker” for species-specific development
inferred← citeshttps://doi.org/10.1016/j.nbd.2018.03.002openalex-snapshot
Antisense-mediated reduction of EphA4 in the adult CNS does not improve the function of mice with amyotrophic lateral sclerosis
inferred← citeshttps://doi.org/10.1016/j.ncrna.2025.03.003openalex-snapshot
Development of a microRNA-Based age estimation model using whole-blood microRNA expression profiling
inferred← citeshttps://doi.org/10.1016/j.neubiorev.2020.01.035openalex-snapshot
Accelerated aging in bipolar disorder: A comprehensive review of molecular findings and their clinical implications
inferred← citeshttps://doi.org/10.1016/j.neurobiolaging.2019.08.019openalex-snapshot
Global expression profiling of cognitive level and decline in middle-aged monozygotic twins
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2021.107845openalex-snapshot
Kynurenine emerges from the shadows – Current knowledge on its fate and function
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2025.108850openalex-snapshot
Resetting the aging clock through epigenetic reprogramming: Insights from natural products
inferred← citeshttps://doi.org/10.1016/j.physrep.2024.10.006openalex-snapshot
Network modeling and topology of aging
inferred← citeshttps://doi.org/10.1016/j.psyneuen.2019.04.004openalex-snapshot
Accelerating research on biological aging and mental health: Current challenges and future directions
inferred← citeshttps://doi.org/10.1016/j.sbi.2024.102777openalex-snapshot
Application of AI in biological age prediction
inferred← citeshttps://doi.org/10.1016/j.schres.2017.09.025openalex-snapshot
DNA methylation age is not accelerated in brain or blood of subjects with schizophrenia
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2025.180293openalex-snapshot
Accelerated transcriptomic age and susceptibility to traffic-related air pollution among cardiac catheterization patients
inferred← citeshttps://doi.org/10.1016/j.semcdb.2025.01.001openalex-snapshot
Towards deciphering the bone marrow microenvironment with spatial multi-omics
inferred← citeshttps://doi.org/10.1016/j.taap.2019.05.014openalex-snapshot
Tanshinone prevents alveolar bone loss in ovariectomized osteoporosis rats by up-regulating phosphoglycerate dehydrogenase
inferred← citeshttps://doi.org/10.1016/j.tem.2023.09.007openalex-snapshot
The ticking of aging clocks
inferred← citeshttps://doi.org/10.1016/j.tig.2024.09.006openalex-snapshot
Unraveling aging from transcriptomics
inferred← citeshttps://doi.org/10.1016/j.tips.2016.11.005openalex-snapshot
Molecular Diagnostics of Ageing and Tackling Age-related Disease
inferred← citeshttps://doi.org/10.1016/j.trac.2026.118803openalex-snapshot
Molecular clues from RNA: the current landscape and future potential in forensic investigation
inferred← citeshttps://doi.org/10.1016/j.tranon.2022.101527openalex-snapshot
Dynamic alterations of immunosenescence-related genes in older women with breast cancer receiving chemotherapy: A prospective study
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