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Temporal dissection of p53 function in vitro and in vivo
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/j.1460-2075.1984.tb02110.xopenalex-snapshot
Analysis of the gene coding for the murine cellular tumour antigen p53.
inferredcites →https://doi.org/10.1006/meth.2001.1262openalex-snapshot
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
inferredcites →https://doi.org/10.1016/j.exger.2003.09.003openalex-snapshot
Living forever and dying in the attempt
inferredcites →https://doi.org/10.1016/j.mrrev.2003.06.002openalex-snapshot
Functional characterization of global genomic DNA repair and its implications for cancer
inferredcites →https://doi.org/10.1016/s0002-9440(10)65215-7openalex-snapshot
Different Responses of Epidermal and Hair Follicular Cells to Radiation Correlate with Distinct Patterns of p53 and p21 Induction
inferredcites →https://doi.org/10.1016/s0092-8674(03)01075-4openalex-snapshot
Principles of Tumor Suppression
inferredcites →https://doi.org/10.1016/s0301-472x(02)00806-8openalex-snapshot
Gene quantification using real-time quantitative PCR
inferredcites →https://doi.org/10.1016/s1568-7864(03)00087-9openalex-snapshot
p53 and regulation of DNA damage recognition during nucleotide excision repair
inferredcites →https://doi.org/10.1038/25870openalex-snapshot
p19ARF links the tumour suppressor p53 to Ras
inferredcites →https://doi.org/10.1038/356215a0openalex-snapshot
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
inferredcites →https://doi.org/10.1038/362847a0openalex-snapshot
p53 is required for radiation-induced apoptosis in mouse thymocytes
inferredcites →https://doi.org/10.1038/ng1193-225openalex-snapshot
Spontaneous and carcinogen–induced tumorigenesis in p53–deficient mice
inferredcites →https://doi.org/10.1038/sj.onc.1201482openalex-snapshot
Genomic instability and apoptosis are frequent in p53 deficient young mice
inferredcites →https://doi.org/10.1038/sj.onc.1203717openalex-snapshot
Different impact of p53 and p21 on the radiation response of mouse tissues
inferredcites →https://doi.org/10.1038/sj.onc.1205707openalex-snapshot
Loss of p53 and centrosome hyperamplification
inferredcites →https://doi.org/10.1038/sj.onc.1207026openalex-snapshot
Activation of the p53-dependent G1 checkpoint response in mouse embryo fibroblasts depends on the specific DNA damage inducer
inferredcites →https://doi.org/10.1073/pnas.92.20.9363openalex-snapshot
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
inferredcites →https://doi.org/10.1080/09553009414550101openalex-snapshot
Characterization of Radiation-induced Apoptosis in the Small Intestine and Its Biological Implications
inferredcites →https://doi.org/10.1093/nar/23.10.1686openalex-snapshot
A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins
inferredcites →https://doi.org/10.1096/fasebj.7.10.8344491openalex-snapshot
Genetic background alters the spectrum of tumors that develop in p53‐deficient mice
inferredcites →https://doi.org/10.1128/mcb.22.10.3497-3508.2002openalex-snapshot
Oncogenic ras and p53 Cooperate To Induce Cellular Senescence
inferredcites →https://doi.org/10.1242/jcs.108.5.1843openalex-snapshot
Coupling between gamma irradiation, p53 induction and the apoptotic response depends upon cell type in vivo
inferredcites →https://doi.org/10.2174/1389200033489451openalex-snapshot
Tamoxifen: Is it Safe? Comparison of Activation and Detoxication Mechanisms in Rodents and in Humans
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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The Abl1 Tyrosine Kinase and p53 are Key Players in Doxorubicin-Induced Cardiomyopathy and Their Cell Death Signaling Differs in Atrial and Ventricular Cardiomyocytes
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The kinetics of p53‐binding and histone acetylation at target promoters do not strictly correlate with gene expression after UV damage
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Expression Profiling of Mouse Models of Human Cancer: Model Categorization and Guidance for Preclinical Testing
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Roles of p53 and pRB Tumor Suppressor Networks in Human Cancer: Insight from Studies in the Engineered Mouse
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Senescence, Apoptosis, and Cancer
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The p53 Master Regulator and Rules of Engagement with Target Sequences
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Mutant p53 Located in the Cytoplasm Inhibits Autophagy
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Cellular mechanisms of aging
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Combined MYC and P53 Defects Emerge at Medulloblastoma Relapse and Define Rapidly Progressive, Therapeutically Targetable Disease
inferred← citeshttps://doi.org/10.1016/j.ccr.2006.10.010openalex-snapshot
Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo
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Targeted Inactivation of Mdm2 RING Finger E3 Ubiquitin Ligase Activity in the Mouse Reveals Mechanistic Insights into p53 Regulation
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Tumor Stroma-Derived TGF-β Limits Myc-Driven Lymphomagenesis via Suv39h1-Dependent Senescence
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Regulation of p53 by Mdm2 E3 Ligase Function Is Dispensable in Embryogenesis and Development, but Essential in Response to DNA Damage
inferred← citeshttps://doi.org/10.1016/j.cell.2006.12.007openalex-snapshot
Modeling the Therapeutic Efficacy of p53 Restoration in Tumors
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Wild-Type p53: Tumors Can't Stand It
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SnapShot: Genetic Mouse Models of Cancer
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Myc Cooperates with Ras by Programming Inflammation and Immune Suppression
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Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models
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IRE1α silences dsRNA to prevent taxane-induced pyroptosis in triple-negative breast cancer
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A selective p53 activator and anticancer agent to improve colorectal cancer therapy
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Virtual screening of p53 mutants reveals Y220S as an additional rescue drug target for PhiKan083 with higher binding characteristics
inferred← citeshttps://doi.org/10.1016/j.drup.2012.10.001openalex-snapshot
From tumor prevention to therapy: Empowering p53 to fight back
inferred← citeshttps://doi.org/10.1016/j.drup.2024.101196openalex-snapshot
Wip1 phosphatase activator QGC-8–52 specifically sensitizes p53-negative cancer cells to chemotherapy while protecting normal cells
inferred← citeshttps://doi.org/10.1016/j.febslet.2014.03.049openalex-snapshot
Wild type p53 reactivation: From lab bench to clinic
inferred← citeshttps://doi.org/10.1016/j.ijrobp.2015.04.003openalex-snapshot
p53-Based Strategy for Protection of Bone Marrow From Y-90 Ibritumomab Tiuxetan
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Downmodulation of Tumor Suppressor p53 by T Cell Receptor Signaling Is Critical for Antigen-Specific CD4+ T Cell Responses
inferred← citeshttps://doi.org/10.1016/j.jbc.2026.113199openalex-snapshot
Reciprocal compensation of caspase-2 and p53 regulates the DNA damage response in HCT116 colon cancer cells
inferred← citeshttps://doi.org/10.1016/j.molcel.2020.10.022openalex-snapshot
Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program
inferred← citeshttps://doi.org/10.1016/j.molonc.2015.09.004openalex-snapshot
p53‐Based strategy to reduce hematological toxicity of chemotherapy: A proof of principle study
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Indolo‐pyrido‐isoquinolin based alkaloid inhibits growth, invasion and migration of breast cancer cells via activation of p53‐miR34a axis
inferred← citeshttps://doi.org/10.1016/j.semcancer.2010.02.006openalex-snapshot
Therapeutic targeting of p53 by small molecules
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Genetically engineered murine models – Contribution to our understanding of the genetics, molecular pathology and therapeutic targeting of neuroblastoma
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The Myc/macrophage tango: Oncogene-induced senescence, Myc style
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Illuminating p53 function in cancer with genetically engineered mouse models
inferred← citeshttps://doi.org/10.1016/j.stem.2010.03.002openalex-snapshot
p53-Mediated Hematopoietic Stem and Progenitor Cell Competition
inferred← citeshttps://doi.org/10.1016/j.stem.2015.08.004openalex-snapshot
HDAC8 Inhibition Specifically Targets Inv(16) Acute Myeloid Leukemic Stem Cells by Restoring p53 Acetylation
inferred← citeshttps://doi.org/10.1016/j.taap.2013.08.007openalex-snapshot
Teroxirone inhibited growth of human non-small cell lung cancer cells by activating p53
inferred← citeshttps://doi.org/10.1016/j.tig.2022.02.010openalex-snapshot
The p53 network: cellular and systemic DNA damage responses in cancer and aging
inferred← citeshttps://doi.org/10.1016/j.yexcr.2010.06.006openalex-snapshot
Regulation of p53 in embryonic stem cells
inferred← citeshttps://doi.org/10.1016/s0076-6879(08)01609-1openalex-snapshot
Chapter 9 Studying p53‐Dependent Cell Death In Vitro and In Vivo
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.8b00194openalex-snapshot
N–O Reduction and ROS-Mediated AKT/FOXO1 and AKT/P53 Pathways Are Involved in Growth Promotion and Cytotoxicity of Cyadox
inferred← citeshttps://doi.org/10.1038/cdd.2017.171openalex-snapshot
Deconstructing networks of p53-mediated tumor suppression in vivo
inferred← citeshttps://doi.org/10.1038/cddis.2015.165openalex-snapshot
Sall2 is required for proapoptotic Noxa expression and genotoxic stress-induced apoptosis by doxorubicin
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A miR‐34a‐SIRT6 axis in the squamous cell differentiation network
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The pathological response to DNA damage does not contribute to p53-mediated tumour suppression
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Restoration of p53 function leads to tumour regression in vivo
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Selective activation of p53-mediated tumour suppression in high-grade tumours
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Mutant Kras copy number defines metabolic reprogramming and therapeutic susceptibilities
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Recombinase-based conditional and reversible gene regulation via XTR alleles
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20 years studying p53 functions in genetically engineered mice
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Unravelling mechanisms of p53-mediated tumour suppression
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The mutant p53 mouse as a pre-clinical model
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The uric acid transporter SLC2A9 is a direct target gene of the tumor suppressor p53 contributing to antioxidant defense
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The kinetics of ER fusion protein activation in vivo
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Genome-wide analysis of p53-regulated transcription in Myc-driven lymphomas
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Transient stabilization, rather than inhibition, of MYC amplifies extrinsic apoptosis and therapeutic responses in refractory B-cell lymphoma
inferred← citeshttps://doi.org/10.1038/s41375-019-0650-2openalex-snapshot
Correction: Transient stabilization, rather than inhibition, of MYC amplifies extrinsic apoptosis and therapeutic responses in refractory B-cell lymphoma
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Off and back-on again: a tumor suppressor’s tale
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p53 prophylactic therapy for cancer prevention
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Atm reactivation reverses ataxia telangiectasia phenotypes in vivo
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Cancer-associated fibroblasts induce antigen-specific deletion of CD8 + T Cells to protect tumour cells
inferred← citeshttps://doi.org/10.1038/s41568-023-00658-3openalex-snapshot
Translating p53-based therapies for cancer into the clinic
inferred← citeshttps://doi.org/10.1038/s41576-020-0262-8openalex-snapshot
Emerging mechanisms of cell competition
inferred← citeshttps://doi.org/10.1038/s41586-026-10738-7openalex-snapshot
Targeting cancer-specific mutations with RNA-triggered chromatin shredding
inferred← citeshttps://doi.org/10.1038/s41598-023-39678-2openalex-snapshot
Characterizing the role of Phlda3 in the development of acute toxicity and malignant transformation of hematopoietic cells induced by total-body irradiation in mice
inferred← citeshttps://doi.org/10.1038/sj.bjc.6605642openalex-snapshot
Guidelines for the welfare and use of animals in cancer research
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Regulation of translation factors eIF4GI and 4E-BP1 during recovery of protein synthesis from inhibition by p53
inferred← citeshttps://doi.org/10.1038/sj.onc.1210295openalex-snapshot
Reactivation of mutant p53: molecular mechanisms and therapeutic potential
inferred← citeshttps://doi.org/10.1073/pnas.0813177106openalex-snapshot
Trim24 targets endogenous p53 for degradation
inferred← citeshttps://doi.org/10.1073/pnas.0902880106openalex-snapshot
Inhibition of Hsp90 via 17-DMAG induces apoptosis in a p53-dependent manner to prevent medulloblastoma
inferred← citeshttps://doi.org/10.1073/pnas.1107017108openalex-snapshot
Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents
inferred← citeshttps://doi.org/10.1073/pnas.1219142110openalex-snapshot
Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy
inferred← citeshttps://doi.org/10.1073/pnas.1302184110openalex-snapshot
Arf tumor suppressor and miR-205 regulate cell adhesion and formation of extraembryonic endoderm from pluripotent stem cells
inferred← citeshttps://doi.org/10.1073/pnas.1910255116openalex-snapshot
Loss of p53 function at late stages of tumorigenesis confers ARF-dependent vulnerability to p53 reactivation therapy
inferred← citeshttps://doi.org/10.1074/jbc.m110.163063openalex-snapshot
Mitochondrial Dysfunction Impairs Tumor Suppressor p53 Expression/Function
inferred← citeshttps://doi.org/10.1074/jbc.m111.254227openalex-snapshot
p53-inducible DHRS3 Is an Endoplasmic Reticulum Protein Associated with Lipid Droplet Accumulation
inferred← citeshttps://doi.org/10.1074/jbc.ra117.000122openalex-snapshot
Inactivation of the MDM2 RING domain enhances p53 transcriptional activity in mice
inferred← citeshttps://doi.org/10.1089/ars.2010.3652openalex-snapshot
Interaction of p53 with Tumor Suppressive and Oncogenic Signaling Pathways to Control Cellular Reactive Oxygen Species Production
inferred← citeshttps://doi.org/10.1093/carcin/bgp331openalex-snapshot
In vivo analysis of p53 tumor suppressor function using genetically engineered mouse models
inferred← citeshttps://doi.org/10.1093/jmcb/mjx006openalex-snapshot
Mouse modelling of the MDM2/MDMX−p53 signalling axis
inferred← citeshttps://doi.org/10.1093/jmcb/mjz075openalex-snapshot
Inhibition of p53 inhibitors: progress, challenges and perspectives
inferred← citeshttps://doi.org/10.1093/mutage/gem021openalex-snapshot
Wild-type p53 reduces radiation hypermutability in p53-mutated human lymphoblast cells
inferred← citeshttps://doi.org/10.1093/nar/gkm744openalex-snapshot
Two faces of p53: aging and tumor suppression
inferred← citeshttps://doi.org/10.1093/oxfordhb/9780198703174.013.7openalex-snapshot
Linking systems biology models to data: A stochastic kinetic model of p53 oscillations
inferred← citeshttps://doi.org/10.1101/413732openalex-snapshot
The NuA4 acetyltransferase and non-canonical chromatin-associated MRN/ATM activity temporally define senescence-associated secretory programs
inferred← citeshttps://doi.org/10.1101/cshperspect.a001081openalex-snapshot
Using Mice to Examine p53 Functions in Cancer, Aging, and Longevity
inferred← citeshttps://doi.org/10.1101/cshperspect.a001115openalex-snapshot
Mouse Models of p53 Functions
inferred← citeshttps://doi.org/10.1101/cshperspect.a001883openalex-snapshot
Tumor Suppressive Functions of p53
inferred← citeshttps://doi.org/10.1101/cshperspect.a026161openalex-snapshot
p53 and the Carcinogenicity of Chronic Inflammation
inferred← citeshttps://doi.org/10.1101/gad.16722111openalex-snapshot
Validation of MdmX as a therapeutic target for reactivating p53 in tumors
inferred← citeshttps://doi.org/10.1101/gad.189001.112openalex-snapshot
STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA
inferred← citeshttps://doi.org/10.1101/gad.190678.112openalex-snapshot
Mutant p53: one name, many proteins
inferred← citeshttps://doi.org/10.1101/gad.205542.112openalex-snapshot
Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice
inferred← citeshttps://doi.org/10.1101/gad.298463.117openalex-snapshot
Lung tumors with distinct p53 mutations respond similarly to p53 targeted therapy but exhibit genotype-specific statin sensitivity
inferred← citeshttps://doi.org/10.1101/gr.277037.122openalex-snapshot
A temporal in vivo catalog of chromatin accessibility and expression profiles in pineoblastoma reveals a prevalent role for repressor elements
inferred← citeshttps://doi.org/10.1101/pdb.top069815openalex-snapshot
The Estrogen Receptor Fusion System in Mouse Models: A Reversible Switch
inferred← citeshttps://doi.org/10.1101/sqb.2005.70.054openalex-snapshot
Oncogene-dependent Tumor Suppression: Using the Dark Side of the Force for Cancer Therapy
inferred← citeshttps://doi.org/10.1111/j.1582-4934.2008.00616.xopenalex-snapshot
Isolation and characterization of DUSP11, a novel p53 target gene
inferred← citeshttps://doi.org/10.1111/joim.12336openalex-snapshot
Pharmacological reactivation of p53 as a strategy to treat cancer
inferred← citeshttps://doi.org/10.1128/mcb.00747-15openalex-snapshot
p53 Restoration in Induction and Maintenance of Senescence: Differential Effects in Premalignant and Malignant Tumor Cells
inferred← citeshttps://doi.org/10.1146/annurev-physiol-030212-183653openalex-snapshot
Aging, Cellular Senescence, and Cancer
inferred← citeshttps://doi.org/10.1152/ajprenal.00562.2007openalex-snapshot
Transcriptional control of terminal nephron differentiation
inferred← citeshttps://doi.org/10.1158/0008-5472.can-14-2852openalex-snapshot
Ibrutinib Exerts Potent Antifibrotic and Antitumor Activities in Mouse Models of Pancreatic Adenocarcinoma
inferred← citeshttps://doi.org/10.1158/0008-5472.can-14-3701openalex-snapshot
TP53 Silencing Bypasses Growth Arrest of BRAFV600E-Induced Lung Tumor Cells in a Two-Switch Model of Lung Tumorigenesis
inferred← citeshttps://doi.org/10.1158/0008-5472.can-15-1939openalex-snapshot
p53 Loss in MYC-Driven Neuroblastoma Leads to Metabolic Adaptations Supporting Radioresistance
inferred← citeshttps://doi.org/10.1158/0008-5472.can-20-0790openalex-snapshot
MDMX Recruits UbcH5c to Facilitate MDM2 E3 Ligase Activity and Subsequent p53 Degradation In Vivo
inferred← citeshttps://doi.org/10.1158/1541-7786.mcr-13-0539openalex-snapshot
Smoking, p53 Mutation, and Lung Cancer
inferred← citeshttps://doi.org/10.1158/1541-7786.mcr-14-0163openalex-snapshot
CDK2 Transcriptional Repression Is an Essential Effector in p53-Dependent Cellular Senescence—Implications for Therapeutic Intervention
inferred← citeshttps://doi.org/10.1158/2159-8290.cd-12-0536openalex-snapshot
ZNF365 Promotes Stability of Fragile Sites and Telomeres
inferred← citeshttps://doi.org/10.1158/2159-8290.cd-19-0435openalex-snapshot
MYC Instructs and Maintains Pancreatic Adenocarcinoma Phenotype
inferred← citeshttps://doi.org/10.1172/jci28833openalex-snapshot
Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma
inferred← citeshttps://doi.org/10.1172/jci63103openalex-snapshot
Differentiation-induced skin cancer suppression by FOS, p53, and TACE/ADAM17
inferred← citeshttps://doi.org/10.1177/1947601911409747openalex-snapshot
Inflammation and p53: A Tale of Two Stresses
inferred← citeshttps://doi.org/10.1177/1947601912455198openalex-snapshot
It Takes 15 to Tango: Making Sense of the Many Ubiquitin Ligases of p53
inferred← citeshttps://doi.org/10.1182/blood-2006-10-050294openalex-snapshot
p53 status dictates responses of B lymphomas to monotherapy with proteasome inhibitors
inferred← citeshttps://doi.org/10.1182/blood-2017-03-771386openalex-snapshot
HDAC8 regulates long-term hematopoietic stem-cell maintenance under stress by modulating p53 activity
inferred← citeshttps://doi.org/10.1186/1747-1028-1-24openalex-snapshot
Building a better model of cancer.
inferred← citeshttps://doi.org/10.1186/1752-0509-2-75openalex-snapshot
Explaining oscillations and variability in the p53-Mdm2 system
inferred← citeshttps://doi.org/10.1186/s12967-024-05623-8openalex-snapshot
The Abl1 tyrosine kinase is a key player in doxorubicin-induced cardiomyopathy and its p53/p73 cell death mediated signaling differs in atrial and ventricular cardiomyocytes
inferred← citeshttps://doi.org/10.1186/s13046-018-0705-7openalex-snapshot
New therapeutic strategies to treat human cancers expressing mutant p53 proteins
inferred← citeshttps://doi.org/10.1242/dmm.049673openalex-snapshot
Reducing the aneuploid cell burden – cell competition and the ribosome connection
inferred← citeshttps://doi.org/10.1371/journal.pgen.1012309openalex-snapshot
Dual contributions of Xrp1 to genome integrity through the DNA damage response and cell competition
inferred← citeshttps://doi.org/10.1371/journal.pone.0003230openalex-snapshot
Characterization of the p53 Response to Oncogene-Induced Senescence
inferred← citeshttps://doi.org/10.1371/journal.pone.0020643openalex-snapshot
p53 Transactivation and the Impact of Mutations, Cofactors and Small Molecules Using a Simplified Yeast-Based Screening System
inferred← citeshttps://doi.org/10.1371/journal.pone.0028356openalex-snapshot
miRNA Expression Profiling of the Murine TH-MYCN Neuroblastoma Model Reveals Similarities with Human Tumors and Identifies Novel Candidate MiRNAs
inferred← citeshttps://doi.org/10.1371/journal.pone.0037308openalex-snapshot
Temporal Dissection of K-rasG12D Mutant In Vitro and In Vivo Using a Regulatable K-rasG12D Mouse Allele
inferred← citeshttps://doi.org/10.1371/journal.pone.0038212openalex-snapshot
Mdm2 RING Mutation Enhances p53 Transcriptional Activity and p53-p300 Interaction
inferred← citeshttps://doi.org/10.1371/journal.pone.0052172openalex-snapshot
Global Effect of Inauhzin on Human p53-Responsive Transcriptome
inferred← citeshttps://doi.org/10.1371/journal.pone.0073817openalex-snapshot
Wild Type p53 Transcriptionally Represses the SALL2 Transcription Factor under Genotoxic Stress
inferred← citeshttps://doi.org/10.1371/journal.pone.0202263openalex-snapshot
Trans-chalcone increases p53 activity via DNAJB1/HSP40 induction and CRM1 inhibition
inferred← citeshttps://doi.org/10.14201/gredos.110634openalex-snapshot
La restauración de la función de p53 retrasa el progreso de la Leucemia Mieloide Crónica causa por p210BCR-ABL en un modelo murino
inferred← citeshttps://doi.org/10.14201/gredos.76287openalex-snapshot
Función del gen Snai3 (Smuc) en la transición epitelio mesenquimal y en cáncer
inferred← citeshttps://doi.org/10.14712/fb2013059010001openalex-snapshot
Availability of Haematopoietic Niches for Transplanted Stem Cells
inferred← citeshttps://doi.org/10.1517/17530059.2.9.1013openalex-snapshot
p53: a molecular marker for the detection of cancer
inferred← citeshttps://doi.org/10.15252/embr.202050718openalex-snapshot
Non‐canonical ATM/MRN activities temporally define the senescence secretory program
inferred← citeshttps://doi.org/10.17863/cam.18854openalex-snapshot
Gain-of-function and dominant-negative effects of distinct p53 mutations in lung tumours
inferred← citeshttps://doi.org/10.18632/oncoscience.542openalex-snapshot
New insight into the role of MDMX in MDM2-mediated p53 degradation and anti-cancer drug development
inferred← citeshttps://doi.org/10.18632/oncotarget.18112openalex-snapshot
p53 upregulates PLCε-IP3-Ca2+ pathway and inhibits autophagy through its target gene Rap2B
inferred← citeshttps://doi.org/10.18632/oncotarget.7857openalex-snapshot
Cancer therapeutic approach based on conformational stabilization of mutant p53 protein by small peptides
inferred← citeshttps://doi.org/10.18632/oncotarget.9390openalex-snapshot
Loss of T-cell quiescence by targeting Slfn2 prevents the development and progression of T-ALL
inferred← citeshttps://doi.org/10.2174/092986707781058869openalex-snapshot
Therapeutic Targets in the ARF Tumor Suppressor Pathway
inferred← citeshttps://doi.org/10.2217/nnm.10.105openalex-snapshot
Nonviral Vectors for The Delivery of Small Interfering RNAs to The CNS
inferred← citeshttps://doi.org/10.25560/4253openalex-snapshot
Regulation of FoxO Transcription Factors in Breast Cancer
inferred← citeshttps://doi.org/10.3233/bd-2007-28105openalex-snapshot
Comparing Genetically Engineered Mouse Mammary Cancer Models with Human Breast Cancer by Expression Profiling1
inferred← citeshttps://doi.org/10.3233/jad-2012-120661openalex-snapshot
The Use of Nanoparticles for Gene Therapy in the Nervous System
inferred← citeshttps://doi.org/10.3324/haematol.2017.177394openalex-snapshot
miR-144/451 represses the LKB1/AMPK/mTOR pathway to promote red cell precursor survival during recovery from acute anemia
inferred← citeshttps://doi.org/10.3389/fimmu.2021.670280openalex-snapshot
Forward and Reverse Genetics of B Cell Malignancies: From Insertional Mutagenesis to CRISPR-Cas
inferred← citeshttps://doi.org/10.3389/fonc.2022.860446openalex-snapshot
Tumor Suppressor Par-4 Regulates Complement Factor C3 and Obesity
inferred← citeshttps://doi.org/10.3390/biom12040548openalex-snapshot
Advanced Strategies for Therapeutic Targeting of Wild-Type and Mutant p53 in Cancer
inferred← citeshttps://doi.org/10.3390/cancers10060188openalex-snapshot
Gain-of-Function (GOF) Mutant p53 as Actionable Therapeutic Target
inferred← citeshttps://doi.org/10.3390/cancers13133344openalex-snapshot
Structural and Drug Targeting Insights on Mutant p53
inferred← citeshttps://doi.org/10.3390/ijms20246241openalex-snapshot
Do Mutations Turn p53 into an Oncogene?
inferred← citeshttps://doi.org/10.3390/ph9020025openalex-snapshot
Chemical Variations on the p53 Reactivation Theme
inferred← citeshttps://doi.org/10.3858/emm.2008.40.1.118openalex-snapshot
Low energy proton beam induces tumor cell apoptosis through reactive oxygen species and activation of caspases
inferred← citeshttps://doi.org/10.3892/ijo_00000115openalex-snapshot
Proton induces apoptosis of hypoxic tumor cells by the p53-dependent and p38/JNK MAPK signaling pathways
inferred← citeshttps://doi.org/10.4161/cc.23031openalex-snapshot
p53 restoration kills primitive leukemia cells in vivo and increases survival of leukemic mice
inferred← citeshttps://doi.org/10.64898/2026.02.24.707647openalex-snapshot
Myc inhibition triggers GM-CSF-driven regression of pancreatic tumours
inferred← citeshttps://doi.org/10.70675/42ed1cefz7195z4db8z9d27zc481ff5a90e7openalex-snapshot
Involvement of tumor suppressors, TET2 and TP53, in the evolution and treatment of Chronic Myelomonocytic Leukemia
inferred← citeshttps://doi.org/10.7750/biodiscovery.2013.8.3openalex-snapshot
Distinct target genes and effector processes appear to be critical for p53-activated responses to acute DNA damage versus p53-mediated tumour suppression
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