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Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/eji.200324048openalex-snapshot
Activated Akt promotes increased resting T cell size, CD28‐independent T cell growth, and development of autoimmunity and lymphoma
inferredcites →https://doi.org/10.1006/smim.2000.0204openalex-snapshot
The role of lipid rafts in T cell antigen receptor (TCR) signalling
inferredcites →https://doi.org/10.1016/j.cell.2008.04.052openalex-snapshot
LXR Signaling Couples Sterol Metabolism to Proliferation in the Acquired Immune Response
inferredcites →https://doi.org/10.1016/j.cell.2011.12.017openalex-snapshot
Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway
inferredcites →https://doi.org/10.1016/j.immuni.2011.09.021openalex-snapshot
The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation
inferredcites →https://doi.org/10.1016/j.immuni.2011.12.007openalex-snapshot
Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development
inferredcites →https://doi.org/10.1016/j.molcel.2010.06.022openalex-snapshot
Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
inferredcites →https://doi.org/10.1016/j.smim.2004.09.001openalex-snapshot
Lipid rafts and the initiation of T cell receptor signaling
inferredcites →https://doi.org/10.1016/s0021-9258(18)98884-8openalex-snapshot
Interrelationships between mevalonate metabolism and the mitogenic signaling pathway in T lymphocyte proliferation
inferredcites →https://doi.org/10.1021/bi100882yopenalex-snapshot
Greasing Their Way: Lipid Modifications Determine Protein Association with Membrane Rafts
inferredcites →https://doi.org/10.1038/nature08097openalex-snapshot
Enhancing CD8 T-cell memory by modulating fatty acid metabolism
inferredcites →https://doi.org/10.1038/nature08155openalex-snapshot
mTOR regulates memory CD8 T-cell differentiation
inferredcites →https://doi.org/10.1038/ni.2068openalex-snapshot
The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function
inferredcites →https://doi.org/10.1038/nprot.2008.211openalex-snapshot
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
inferredcites →https://doi.org/10.1038/nrc2274openalex-snapshot
The interplay between MYC and HIF in cancer
inferredcites →https://doi.org/10.1038/nri1710openalex-snapshot
Fuel feeds function: energy metabolism and the T-cell response
inferredcites →https://doi.org/10.1073/pnas.0506716102openalex-snapshot
Transcriptional regulation of phagocytosis-induced membrane biogenesis by sterol regulatory element binding proteins
inferredcites →https://doi.org/10.1073/pnas.1108856108openalex-snapshot
Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation
inferredcites →https://doi.org/10.1073/pnas.72.5.1950openalex-snapshot
Relationship between sterol synthesis and DNA synthesis in phytohemagglutinin-stimulated mouse lymphocytes.
inferredcites →https://doi.org/10.1074/jbc.273.52.35299openalex-snapshot
Nuclear Sterol Regulatory Element-binding Proteins Activate Genes Responsible for the Entire Program of Unsaturated Fatty Acid Biosynthesis in Transgenic Mouse Liver
inferredcites →https://doi.org/10.1074/jbc.m105796200openalex-snapshot
Gleevec (STI571) Influences Metabolic Enzyme Activities and Glucose Carbon Flow toward Nucleic Acid and Fatty Acid Synthesis in Myeloid Tumor Cells
inferredcites →https://doi.org/10.1084/jem.160.2.521openalex-snapshot
Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence.
inferredcites →https://doi.org/10.1084/jem.192.4.557openalex-snapshot
Naive T Cells Transiently Acquire a Memory-like Phenotype during Homeostasis-Driven Proliferation
inferredcites →https://doi.org/10.1084/jem.20052469openalex-snapshot
Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes
inferredcites →https://doi.org/10.1093/nar/gkn923openalex-snapshot
Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists
inferredcites →https://doi.org/10.1101/gad.891301openalex-snapshot
SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation
inferredcites →https://doi.org/10.1126/scisignal.2000446openalex-snapshot
EGFR Signaling Through an Akt-SREBP-1–Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy
inferredcites →https://doi.org/10.1128/jvi.79.16.10514-10527.2005openalex-snapshot
Intrinsic Functional Dysregulation of CD4 T Cells Occurs Rapidly following Persistent Viral Infection
inferredcites →https://doi.org/10.1152/ajpcell.00247.2006openalex-snapshot
Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells
inferredcites →https://doi.org/10.1158/0008-5472.can-06-1501openalex-snapshot
Cancer's Molecular Sweet Tooth and the Warburg Effect
inferredcites →https://doi.org/10.1172/jci0215593openalex-snapshot
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
inferredcites →https://doi.org/10.1172/jci118951openalex-snapshot
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.
inferredcites →https://doi.org/10.1172/jci119746openalex-snapshot
Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.
inferredcites →https://doi.org/10.1172/jci15593openalex-snapshot
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
inferredcites →https://doi.org/10.1189/jlb.0108024openalex-snapshot
Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival
inferredcites →https://doi.org/10.1189/jlb.1008663openalex-snapshot
Liver X receptors interfere with cytokine-induced proliferation and cell survival in normal and leukemic lymphocytes
inferredcites →https://doi.org/10.4049/jimmunol.0903586openalex-snapshot
Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation
inferredcites →https://doi.org/10.4049/jimmunol.179.3.1760openalex-snapshot
OX40 Gene Expression Is Up-Regulated by Chromatin Remodeling in Its Promoter Region Containing Sp1/Sp3, YY1, and NF-κB Binding Sites
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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inferred← citeshttps://doi.org/10.1002/cyto.a.24294openalex-snapshot
Acly promotes metabolic reprogramming and induction of IRF4 during early CD8 + T cell activation
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Cytometry at the Intersection of Metabolism and Epigenetics in Lymphocyte Dynamics
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Oleic acid enhances proliferation and calcium mobilization of CD3/CD28 activated CD4 + T cells through incorporation into membrane lipids
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A New Role for IKK-α in Hepatitis C Virus-Induced Lipogenesis
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mTOR: A double-edged sword for diabetes
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Lipid metabolism in cancer progression and therapeutic strategies
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Amino Acid and Lipid Metabolism in Cancer: Mechanisms and Therapeutic Opportunities
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Metabolism in Immune Cell Differentiation and Function
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Innate and Adaptive Immune Cell Metabolism in Tumor Microenvironment
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Metabolomics of Immunity and Its Clinical Applications
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T-Cell Activation and Differentiation: Role of Signaling and Metabolic Cross-Talk
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Lipid Metabolism in Tumor-Infiltrating T Cells
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Lipid Metabolism in Tumor-Associated Natural Killer Cells
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The obesity-related pathology and Th17 cells
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Dysregulation of cholesterol homeostasis in cancer pathogenesis
inferred← citeshttps://doi.org/10.1007/s00109-019-01784-yopenalex-snapshot
Mevalonate promotes differentiation of regulatory T cells
inferred← citeshttps://doi.org/10.1007/s00262-024-03748-9openalex-snapshot
The significance of lipid metabolism reprogramming of tumor-associated macrophages in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1007/s00281-022-00917-9openalex-snapshot
Th17 cells in the liver: balancing autoimmunity and pathogen defense
inferred← citeshttps://doi.org/10.1007/s10238-022-00939-5openalex-snapshot
CYP51-mediated cholesterol biosynthesis is required for the proliferation of CD4+ T cells in Sjogren’s syndrome
inferred← citeshttps://doi.org/10.1007/s10269-015-2535-yopenalex-snapshot
Congrès de l’association américaine de recherche contre le cancer — AACR 2015
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Congrès de l’association américaine de recherche contre le cancer — AACR 2016
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The Role of the Pentose Phosphate Pathway in Cardiovascular Diseases
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Role of T Cells in the Pathogenesis of Rheumatoid Arthritis: Focus on Immunometabolism Dysfunctions
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Cancer metabolism and tumor microenvironment: fostering each other?
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Regulation of Adaptive Immunity in Health and Disease by Cholesterol Metabolism
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The Interplay of Lipids, Lipoproteins, and Immunity in Atherosclerosis
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T-cell Cholesterol Accumulation, Aging, and Atherosclerosis
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The Interconnection Between Immuno-Metabolism, Diabetes, and CKD
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Cellular Metabolism Controls Lymphocyte Activation and Differentiation
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SCAP knockout in SM22α-Cre mice induces defective angiogenesis in the placental labyrinth
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Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity
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inferred← citeshttps://doi.org/10.1016/j.cell.2017.04.001openalex-snapshot
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Lipid metabolic reprogramming of CD8+ T cells in the tumor microenvironment
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Obesity Drives Th17 Cell Differentiation by Inducing the Lipid Metabolic Kinase, ACC1
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Activation of Mevalonate Pathway Via LKB1 is Essential for Stability of Treg Cells
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Acsbg1-dependent mitochondrial fitness is a metabolic checkpoint for tissue Treg cell homeostasis
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CD8+ T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiation
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T cell receptor sequences are the dominant factor contributing to the phenotype of CD8+ T cells with specificities against immunogenic viral antigens
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Metabolic rewiring and communication in cancer immunity
inferred← citeshttps://doi.org/10.1016/j.chembiol.2024.04.005openalex-snapshot
Transient hydroxycholesterol treatment restrains TCR signaling to promote long-term immunity
inferred← citeshttps://doi.org/10.1016/j.clim.2023.109289openalex-snapshot
Targeting immunometabolism against acute lung injury
inferred← citeshttps://doi.org/10.1016/j.cmet.2014.05.004openalex-snapshot
The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function
inferred← citeshttps://doi.org/10.1016/j.cmet.2016.05.015openalex-snapshot
Modulating Cholesterol Homeostasis to Build a Better T Cell
inferred← citeshttps://doi.org/10.1016/j.cmet.2017.06.004openalex-snapshot
Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors
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Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells
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Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells
inferred← citeshttps://doi.org/10.1016/j.cmet.2022.02.003openalex-snapshot
Metabolic programs tailor T cell immunity in viral infection, cancer, and aging
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Tracing insights into human metabolism using chemical engineering approaches
inferred← citeshttps://doi.org/10.1016/j.coi.2013.05.002openalex-snapshot
mTOR and lymphocyte metabolism
inferred← citeshttps://doi.org/10.1016/j.coi.2017.03.012openalex-snapshot
Reviewing the impact of lipid synthetic flux on Th17 function
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Retinoic acid-related orphan receptor γ (RORγ): Connecting sterol metabolism to regulation of the immune system and autoimmune disease
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Unraveling the link between cholesterol and immune system in cancer: From biological mechanistic insights to clinical evidence. A narrative review
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Tissue and circulating proprotein convertase subtilisin/Kexin type 9 (PCSK9) as promising prognostic biomarkers for curative-intent colorectal liver metastases resection: A case-control study
inferred← citeshttps://doi.org/10.1016/j.cyto.2018.06.028openalex-snapshot
Immuno-metabolic changes in herpes virus infection
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Metabolic regulation of infection and inflammation
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MYC and HIF in shaping immune response and immune metabolism
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Lipid metabolism in cancer: New perspectives and emerging mechanisms
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Fatostatin promotes anti-tumor immunity by reducing SREBP2 mediated cholesterol metabolism in tumor-infiltrating T lymphocytes
inferred← citeshttps://doi.org/10.1016/j.fsi.2023.108863openalex-snapshot
ATGL-mediated lipophagy balances cholesterol-induced inflammation in pathogen infected Apostichopus japonicus coelomocytes
inferred← citeshttps://doi.org/10.1016/j.fsi.2023.108884openalex-snapshot
Adenosine 5′-monophosphate-activated protein kinase (AMPK) negatively regulates the immunity and resistance to Vibrio alginolyticus of white shrimp, Penaeus vannamei
inferred← citeshttps://doi.org/10.1016/j.gendis.2025.101965openalex-snapshot
The multifaceted landscape of T cell exhaustion in organ transplantation: From molecular mechanisms (epigenetics, transcription, metabolism) to induction strategies
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e30807openalex-snapshot
Targeting lipid reprogramming in the tumor microenvironment by traditional Chinese medicines as a potential cancer treatment
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e39425openalex-snapshot
Cholesterol: The driving force behind the remodeling of tumor microenvironment in colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.humimm.2022.10.002openalex-snapshot
Loss of immune regulation in aged T-cells: A metabolic review to show lack of ability to control responses within the self
inferred← citeshttps://doi.org/10.1016/j.imbio.2017.03.001openalex-snapshot
T cell metabolism in metabolic disease-associated autoimmunity
inferred← citeshttps://doi.org/10.1016/j.immuni.2013.09.015openalex-snapshot
T Cell Exit from Quiescence and Differentiation into Th2 Cells Depend on Raptor-mTORC1-Mediated Metabolic Reprogramming
inferred← citeshttps://doi.org/10.1016/j.immuni.2014.06.005openalex-snapshot
Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development
inferred← citeshttps://doi.org/10.1016/j.immuni.2016.10.017openalex-snapshot
Constitutive Glycolytic Metabolism Supports CD8+ T Cell Effector Memory Differentiation during Viral Infection
inferred← citeshttps://doi.org/10.1016/j.immuni.2017.02.010openalex-snapshot
Integrative Proteomics and Phosphoproteomics Profiling Reveals Dynamic Signaling Networks and Bioenergetics Pathways Underlying T Cell Activation
inferred← citeshttps://doi.org/10.1016/j.immuni.2019.06.005openalex-snapshot
The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair
inferred← citeshttps://doi.org/10.1016/j.immuni.2021.09.004openalex-snapshot
The cholesterol metabolite 25-hydroxycholesterol restrains the transcriptional regulator SREBP2 and limits intestinal IgA plasma cell differentiation
inferred← citeshttps://doi.org/10.1016/j.immuni.2021.12.012openalex-snapshot
Metabolic adaptation of lymphocytes in immunity and disease
inferred← citeshttps://doi.org/10.1016/j.immuni.2023.01.025openalex-snapshot
Skin γδ T cell inflammatory responses are hardwired in the thymus by oxysterol sensing via GPR183 and calibrated by dietary cholesterol
inferred← citeshttps://doi.org/10.1016/j.immuni.2026.03.027openalex-snapshot
NK cell dysfunction and interferon-γ production underlie autoinflammation in mevalonate kinase deficiency
inferred← citeshttps://doi.org/10.1016/j.immuni.2026.04.009openalex-snapshot
Modulation of the mevalonate pathway by TCR engagement regulates T follicular helper cell generation in homeostasis and autoimmunity
inferred← citeshttps://doi.org/10.1016/j.immuni.2026.05.007openalex-snapshot
Cholesterol metabolism in immune cells: From mechanisms to therapeutic opportunities
inferred← citeshttps://doi.org/10.1016/j.immuno.2024.100038openalex-snapshot
In silico single-cell metabolism analysis unravels a new transition stage of CD8 T cells 4 days post-infection
inferred← citeshttps://doi.org/10.1016/j.intimp.2022.108621openalex-snapshot
Therapeutic nexus of T cell immunometabolism in improving transplantation immunotherapy
inferred← citeshttps://doi.org/10.1016/j.isci.2024.109496openalex-snapshot
Oleic acid triggers metabolic rewiring of T cells poising them for T helper 9 differentiation
inferred← citeshttps://doi.org/10.1016/j.isci.2026.114859openalex-snapshot
PCSK9-mediated degradation of cell-surface LDL receptors impairs human CD8+ T cell effector functions
inferred← citeshttps://doi.org/10.1016/j.it.2014.12.004openalex-snapshot
Targeting T cell metabolism for therapy
inferred← citeshttps://doi.org/10.1016/j.it.2014.12.005openalex-snapshot
Fatty acid metabolism in the regulation of T cell function
inferred← citeshttps://doi.org/10.1016/j.it.2015.09.004openalex-snapshot
Asymmetric Cell Division in T Lymphocyte Fate Diversification
inferred← citeshttps://doi.org/10.1016/j.it.2016.09.001openalex-snapshot
The Intracellular Cholesterol Landscape: Dynamic Integrator of the Immune Response
inferred← citeshttps://doi.org/10.1016/j.it.2021.11.007openalex-snapshot
The cholesterol pathway: impact on immunity and cancer
inferred← citeshttps://doi.org/10.1016/j.it.2024.09.013openalex-snapshot
Cholesterol sensing and metabolic adaptation in tissue immunity
inferred← citeshttps://doi.org/10.1016/j.it.2026.09.001openalex-snapshot
Coupling and uncoupling cell cycle and metabolism in CD8+ T cells
inferred← citeshttps://doi.org/10.1016/j.jaci.2015.05.004openalex-snapshot
RhoA orchestrates glycolysis for TH2 cell differentiation and allergic airway inflammation
inferred← citeshttps://doi.org/10.1016/j.jaci.2022.09.025openalex-snapshot
Sterols and immune mechanisms in asthma
inferred← citeshttps://doi.org/10.1016/j.jaci.2025.07.018openalex-snapshot
CARMIL2 deficiency disrupts activation-induced metabolic reprogramming in T cells and is partially rescued by glutamine supplementation
inferred← citeshttps://doi.org/10.1016/j.jaut.2019.102373openalex-snapshot
The immunobiology of mTOR in autoimmunity
inferred← citeshttps://doi.org/10.1016/j.jnutbio.2015.11.002openalex-snapshot
Role of lipids in the metabolism and activation of immune cells
inferred← citeshttps://doi.org/10.1016/j.jpha.2024.101150openalex-snapshot
Targeting tumor metabolism to augment CD8+ T cell anti-tumor immunity
inferred← citeshttps://doi.org/10.1016/j.mam.2020.100918openalex-snapshot
Metabolic adaptations of cells at the vascular-immune interface during atherosclerosis
inferred← citeshttps://doi.org/10.1016/j.molimm.2015.07.023openalex-snapshot
Rethinking the paradigm: How comparative studies on fatty acid oxidation inform our understanding of T cell metabolism
inferred← citeshttps://doi.org/10.1016/j.molimm.2015.07.027openalex-snapshot
Metabolic regulation of T cell differentiation and function
inferred← citeshttps://doi.org/10.1016/j.molimm.2015.07.035openalex-snapshot
T cell metabolism and susceptibility to autoimmune diseases
inferred← citeshttps://doi.org/10.1016/j.molimm.2015.07.036openalex-snapshot
T cell metabolic reprogramming and plasticity
inferred← citeshttps://doi.org/10.1016/j.molimm.2015.07.038openalex-snapshot
Transcriptional regulation of T cell metabolism
inferred← citeshttps://doi.org/10.1016/j.molimm.2015.08.004openalex-snapshot
Hypoxia-inducible factors regulate T cell metabolism and function
inferred← citeshttps://doi.org/10.1016/j.molimm.2018.05.007openalex-snapshot
Genome-wide analysis reveals TNFAIP8L2 as an immune checkpoint regulator of inflammation and metabolism
inferred← citeshttps://doi.org/10.1016/j.molimm.2019.03.005openalex-snapshot
Metabolic regulation of TH17 cells
inferred← citeshttps://doi.org/10.1016/j.molmed.2017.11.005openalex-snapshot
Metabolic Control of CD8+ T Cell Fate Decisions and Antitumor Immunity
inferred← citeshttps://doi.org/10.1016/j.msard.2022.103672openalex-snapshot
Serum metabolic profiles and metal levels of patients with multiple sclerosis and patients with neuromyelitis optica spectrum disorders - NMR spectroscopy and ICP–MS studies
inferred← citeshttps://doi.org/10.1016/j.nano.2018.08.008openalex-snapshot
Enhanced chemo-immunotherapy against melanoma by inhibition of cholesterol esterification in CD8+ T cells
inferred← citeshttps://doi.org/10.1016/j.neuron.2025.09.022openalex-snapshot
Integrated omics reveals disease-associated radial glia-like cells with epigenetically dysregulated interferon response in multiple sclerosis
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2023.108411openalex-snapshot
Lipid metabolism in Th17 cell function
inferred← citeshttps://doi.org/10.1016/j.phrs.2025.108015openalex-snapshot
Metabolic modulation of CD8⁺ T cells by metformin: A promising adjuvant strategy for CD8⁺ T Cell-Based Immunotherapies
inferred← citeshttps://doi.org/10.1016/j.plipres.2021.101099openalex-snapshot
Lipid homeostasis and mevalonate pathway in COVID-19: Basic concepts and potential therapeutic targets
inferred← citeshttps://doi.org/10.1016/j.plipres.2022.101198openalex-snapshot
Endoplasmic reticulum stress and lipids in health and diseases
inferred← citeshttps://doi.org/10.1016/j.semcancer.2022.02.010openalex-snapshot
Metabolic modulation of immune checkpoints and novel therapeutic strategies in cancer
inferred← citeshttps://doi.org/10.1016/j.semcancer.2026.05.001openalex-snapshot
Systemic lipid metabolic alterations and the tumor microenvironment: A hidden driver of immune dysfunction
inferred← citeshttps://doi.org/10.1016/j.semcdb.2017.07.011openalex-snapshot
Developmental and extrahepatic physiological functions of SREBP pathway genes in mice
inferred← citeshttps://doi.org/10.1016/j.semcdb.2024.03.002openalex-snapshot
Mitochondrial control of lymphocyte homeostasis
inferred← citeshttps://doi.org/10.1016/j.smim.2016.10.007openalex-snapshot
Metabolic reprogramming & inflammation: Fuelling the host response to pathogens
inferred← citeshttps://doi.org/10.1016/j.smim.2021.101485openalex-snapshot
Metabolic regulation of T cells in the tumor microenvironment by nutrient availability and diet
inferred← citeshttps://doi.org/10.1016/j.smrv.2024.102031openalex-snapshot
Circadian immunometabolism: A future insight for targeted therapy in cancer
inferred← citeshttps://doi.org/10.1016/j.tem.2014.04.002openalex-snapshot
mTORC2 in the center of cancer metabolic reprogramming
inferred← citeshttps://doi.org/10.1016/j.tem.2024.11.014openalex-snapshot
Lipids guide T cell antitumor immunity by shaping their metabolic and functional fitness
inferred← citeshttps://doi.org/10.1016/j.tem.2025.08.009openalex-snapshot
CD8+ T cell stressors converge on shared metabolic–epigenetic networks
inferred← citeshttps://doi.org/10.1016/j.tips.2015.04.010openalex-snapshot
Targeting SREBPs for treatment of the metabolic syndrome
inferred← citeshttps://doi.org/10.1016/j.tips.2018.12.006openalex-snapshot
Lysosomal Acid Lipase: From Cellular Lipid Handler to Immunometabolic Target
inferred← citeshttps://doi.org/10.1016/j.tranon.2020.100847openalex-snapshot
Searching for the real function of mTOR signaling in the regulation of PD-L1 expression
inferred← citeshttps://doi.org/10.1016/j.trecan.2024.03.010openalex-snapshot
Immunometabolism of CD8+ T cell differentiation in cancer
inferred← citeshttps://doi.org/10.1016/j.vetmic.2024.110034openalex-snapshot
PI3K/AKT mediated De novo fatty acid synthesis regulates RIG-1/MDA-5-dependent type I IFN responses in BVDV-infected CD8+T cells
inferred← citeshttps://doi.org/10.1016/j.vetmic.2025.110778openalex-snapshot
The miR-29a/c-3p/HMCCR pathway is a potential mechanism by which chicken bursa of Fabricius responds to stress affecting immune response
inferred← citeshttps://doi.org/10.1016/j.xcrm.2024.101733openalex-snapshot
Single-cell analysis of cerebrospinal fluid reveals common features of neuroinflammation
inferred← citeshttps://doi.org/10.1016/j.xinn.2024.100783openalex-snapshot
NPC1L1 on pancreatic adenocarcinoma cell functions as a two-pronged checkpoint against antitumor activity
inferred← citeshttps://doi.org/10.1016/j.yexcr.2018.03.032openalex-snapshot
Dysfunction of cholesterol sensor SCAP promotes inflammation activation in THP-1 macrophages
inferred← citeshttps://doi.org/10.1016/j.ymgme.2023.107582openalex-snapshot
Clinical and biochemical footprints of inherited metabolic diseases. XII. Immunological defects
inferred← citeshttps://doi.org/10.1021/acsami.5c01194openalex-snapshot
Ultrasound-Triggered NPC1L1-Targeting Nanobubbles for Remodeling the Tumor Microenvironment in Pancreatic Cancer Chemoimmunotherapy
inferred← citeshttps://doi.org/10.1021/acsnano.3c11260openalex-snapshot
Nanotechnology Reprogramming Metabolism for Enhanced Tumor Immunotherapy
inferred← citeshttps://doi.org/10.1038/icb.2016.98openalex-snapshot
Impact of T‐cell‐specific Smad4 deficiency on the development of autoimmune diabetes in NOD mice
inferred← citeshttps://doi.org/10.1038/nature17412openalex-snapshot
Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism
inferred← citeshttps://doi.org/10.1038/nchembio.1714openalex-snapshot
Sterol metabolism controls TH17 differentiation by generating endogenous RORγ agonists
inferred← citeshttps://doi.org/10.1038/ncomms13683openalex-snapshot
Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells
inferred← citeshttps://doi.org/10.1038/ni.2941openalex-snapshot
Serine-threonine kinases in TCR signaling
inferred← citeshttps://doi.org/10.1038/ni.3314openalex-snapshot
The cytotoxic T cell proteome and its shaping by the kinase mTOR
inferred← citeshttps://doi.org/10.1038/ni.3706openalex-snapshot
Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation
inferred← citeshttps://doi.org/10.1038/ni.3808openalex-snapshot
Metabolic control of the scaffold protein TKS5 in tissue-invasive, proinflammatory T cells
inferred← citeshttps://doi.org/10.1038/ni.3838openalex-snapshot
Srebp-controlled glucose metabolism is essential for NK cell functional responses
inferred← citeshttps://doi.org/10.1038/ni.3855openalex-snapshot
Cytokine-driven role of Srebps in killer cell metabolism
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