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Disruption of diacylglycerol metabolism impairs the induction of T cell anergy

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/(sici)1521-4141(199903)29:03<789::aid-immu789>3.0.co;2-5openalex-snapshot

CD28 induces cell cycle progression by IL-2-independent down-regulation of p27kip1 expression in human peripheral T lymphocytes

inferredcites →https://doi.org/10.1006/bbrc.1995.2427openalex-snapshot

Selective Inhibition of Phosphatidylinositol 3-Kinase by Phosphatidic Acid and Related Lipids

inferredcites →https://doi.org/10.1006/smim.1993.1040openalex-snapshot

Protein and lipid kinase activation cascades in interleukin-2 receptor signalling

inferredcites →https://doi.org/10.1016/0022-1759(95)00135-wopenalex-snapshot

Phosphatidylinositol hydrolysis in freshly isolated human T lymphocytes

inferredcites →https://doi.org/10.1016/0092-8674(94)90056-6openalex-snapshot

JNK is involved in signal integration during costimulation of T lymphocytes

inferredcites →https://doi.org/10.1016/0167-5699(92)90137-vopenalex-snapshot

The role of cell division in the induction of clonal anergy

inferredcites →https://doi.org/10.1016/0898-6568(95)00076-3openalex-snapshot

Phosphatidic acid: A lipid messenger involved in intracellular and extracellular signalling

inferredcites →https://doi.org/10.1016/j.cellsig.2004.01.010openalex-snapshot

Diacylglycerol kinase ζ regulates phosphatidylinositol 4-phosphate 5-kinase Iα by a novel mechanism

inferredcites →https://doi.org/10.1016/j.cellsig.2004.03.016openalex-snapshot

Diacylglycerol kinases

inferredcites →https://doi.org/10.1016/j.molcel.2005.06.011openalex-snapshot

Histone H3 Lysine 9 Methylation and HP1γ Are Associated with Transcription Elongation through Mammalian Chromatin

inferredcites →https://doi.org/10.1016/j.neulet.2004.09.052openalex-snapshot

Selective translocation of diacylglycerol kinase ζ in hippocampal neurons under transient forebrain ischemia

inferredcites →https://doi.org/10.1016/s0006-2952(99)00395-0openalex-snapshot

Selectivity of the diacylglycerol kinase inhibitor 3-{2-(4-[bis-(4-fluorophenyl)methylene]-1-piperidinyl)ethyl}-2,3-dihydro-2-thioxo-4(1H)quinazolinone (R59949) among diacylglycerol kinase subtypes

inferredcites →https://doi.org/10.1016/s0014-5793(98)00875-8openalex-snapshot

Interleukin‐2 stimulates a late increase in phosphatidic acid production in the absence of phospholipase D activation

inferredcites →https://doi.org/10.1016/s0021-9258(19)36862-0openalex-snapshot

The regulation of phospholipase C-gamma 1 by phosphatidic acid. Assessment of kinetic parameters.

inferredcites →https://doi.org/10.1016/s0092-8674(02)00767-5openalex-snapshot

Transcriptional Mechanisms Underlying Lymphocyte Tolerance

inferredcites →https://doi.org/10.1016/s0952-7915(03)00080-3openalex-snapshot

Recognition of microbial infection by Toll-like receptors

inferredcites →https://doi.org/10.1016/s0960-9822(99)80193-6openalex-snapshot

Nuclei contain two differentially regulated pools of diacylglycerol

inferredcites →https://doi.org/10.1016/s1074-7613(00)00080-7openalex-snapshot

Impact of Negative Selection on the T Cell Repertoire Reactive to a Self-Peptide

inferredcites →https://doi.org/10.1016/s1074-7613(04)00111-6openalex-snapshot

Back to Central Tolerance

inferredcites →https://doi.org/10.1034/j.1600-065x.2003.00034.xopenalex-snapshot

Molecular modifiers of T cell antigen receptor triggering threshold: the mechanism of CD28 costimulatory receptor

inferredcites →https://doi.org/10.1038/29337openalex-snapshot

Protein kinase C regulates the nuclear localization of diacylglycerol kinase-ζ

inferredcites →https://doi.org/10.1038/386855a0openalex-snapshot

Differential activation of transcription factors induced by Ca2+ response amplitude and duration

inferredcites →https://doi.org/10.1038/40912openalex-snapshot

Differential activation of transcription factors induced by Ca2+ response amplitude and duration

inferredcites →https://doi.org/10.1038/79766openalex-snapshot

RasGRP is essential for mouse thymocyte differentiation and TCR signaling

inferredcites →https://doi.org/10.1038/ni1047openalex-snapshot

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

inferredcites →https://doi.org/10.1038/ni1193openalex-snapshot

Egr-2 and Egr-3 are negative regulators of T cell activation

inferredcites →https://doi.org/10.1038/ni958openalex-snapshot

Enhanced T cell responses due to diacylglycerol kinase ζ deficiency

inferredcites →https://doi.org/10.1038/nrc883openalex-snapshot

The Bcl2 family: regulators of the cellular life-or-death switch

inferredcites →https://doi.org/10.1038/nri1710openalex-snapshot

Fuel feeds function: energy metabolism and the T-cell response

inferredcites →https://doi.org/10.1042/bst0320113openalex-snapshot

B-cell antigen receptor activates transcription factors NFAT (nuclear factor of activated T-cells) and NF-κB (nuclear factor κB) via a mechanism that involves diacylglycerol

inferredcites →https://doi.org/10.1073/pnas.84.15.5409openalex-snapshot

Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones.

inferredcites →https://doi.org/10.1073/pnas.91.1.38openalex-snapshot

Anergic T-lymphocyte clones have altered inositol phosphate, calcium, and tyrosine kinase signaling pathways.

inferredcites →https://doi.org/10.1074/jbc.271.17.10334openalex-snapshot

Phosphatidic Acid Generation through Interleukin 2 (IL-2)-induced α-Diacylglycerol Kinase Activation Is an Essential Step in IL-2-mediated Lymphocyte Proliferation

inferredcites →https://doi.org/10.1074/jbc.273.39.25185openalex-snapshot

IκB Kinases Serve as a Target of CD28 Signaling

inferredcites →https://doi.org/10.1074/jbc.274.17.11447openalex-snapshot

Mammalian Diacylglycerol Kinases, a Family of Lipid Kinases with Signaling Functions

inferredcites →https://doi.org/10.1074/jbc.m203818200openalex-snapshot

Regulation of T Cell Receptor-induced Activation of the Ras-ERK Pathway by Diacylglycerol Kinase ζ

inferredcites →https://doi.org/10.1074/jbc.m305635200openalex-snapshot

Regulation of Diacylglycerol Kinase α by Phosphoinositide 3-Kinase Lipid Products

inferredcites →https://doi.org/10.1074/jbc.m307153200openalex-snapshot

Protein Kinase Cα Phosphorylates and Negatively Regulates Diacylglycerol Kinase ζ

inferredcites →https://doi.org/10.1074/jbc.m412296200openalex-snapshot

Modulation of the Mammalian Target of Rapamycin Pathway by Diacylglycerol Kinase-produced Phosphatidic Acid

inferredcites →https://doi.org/10.1084/jem.172.4.1065openalex-snapshot

Selective anergy of V beta 8+,CD4+ T cells in Staphylococcus enterotoxin B-primed mice.

inferredcites →https://doi.org/10.1084/jem.172.4.1091openalex-snapshot

In vivo induction of anergy in peripheral V beta 8+ T cells by staphylococcal enterotoxin B.

inferredcites →https://doi.org/10.1084/jem.20050176openalex-snapshot

CD28 costimulatory signal induces protein arginine methylation in T cells

inferredcites →https://doi.org/10.1089/dna.1993.12.473openalex-snapshot

The Role of Diacylglycerol Kinase Activation and Phosphatidate Accumulation in Interleukin-2-Dependent Lymphocyte Proliferation

inferredcites →https://doi.org/10.1091/mbc.e03-03-0190openalex-snapshot

Diacylglycerol Kinase-ζ Localization in Skeletal Muscle Is Regulated by Phosphorylation and Interaction with Syntrophins

inferredcites →https://doi.org/10.1096/fj.01-0762fjeopenalex-snapshot

Expression of a catalytically inactive form of diacylglycerol kinase α induces sustained signaling through RasGRP

inferredcites →https://doi.org/10.1111/j.1365-2443.2005.00842.xopenalex-snapshot

Importance of chroman ring and tyrosine phosphorylation in the subtype‐specific translocation and activation of diacylglycerol kinase α by d ‐α‐tocopherol

inferredcites →https://doi.org/10.1126/science.2540528openalex-snapshot

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

inferredcites →https://doi.org/10.1126/science.257.5073.1134openalex-snapshot

Transactivation by AP-1 Is a Molecular Target of T Cell Clonal Anergy

inferredcites →https://doi.org/10.1126/science.271.5253.1272openalex-snapshot

Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4 + T Cells

inferredcites →https://doi.org/10.1126/science.271.5253.1276openalex-snapshot

Blocked Ras Activation in Anergic CD4 + T Cells

inferredcites →https://doi.org/10.1128/mcb.17.5.2475openalex-snapshot

Expression of NFAT-Family Proteins in Normal Human T Cells

inferredcites →https://doi.org/10.1128/mcb.17.7.4051openalex-snapshot

CD28 Mediates Transcriptional Upregulation of the Interleukin-2 (IL-2) Promoter through a Composite Element Containing the CD28RE and NF-IL-2B AP-1 Sites

inferredcites →https://doi.org/10.1146/annurev.immunol.21.120601.141110openalex-snapshot

T Cell Anergy

inferredcites →https://doi.org/10.4049/jimmunol.163.2.708openalex-snapshot

Diacylglycerol Kinase Inhibition Prevents IL-2-Induced G1 to S Transition Through a Phosphatidylinositol-3 Kinase-Independent Mechanism

inferredcites →https://doi.org/10.4049/jimmunol.170.6.2877openalex-snapshot

T Cell Activation In Vivo Targets Diacylglycerol Kinase α to the Membrane: A Novel Mechanism for Ras Attenuation

inferredcites →https://doi.org/10.4049/jimmunol.170.8.4127openalex-snapshot

Regulation of T Cell Activation and Tolerance by Phospholipase Cγ-1-Dependent Integrin Avidity Modulation

inferredcites →https://doi.org/10.4049/jimmunol.172.8.4661openalex-snapshot

Regulation of T Lymphocyte Metabolism

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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DNA-Demethylating Agents Enhance Cytolytic Activity of CD8 T Cells and Anti-Tumor Immunity

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Identifying Reactive Sites on Diacylglycerol Kinases for Covalent Binding in Cells

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Diacylglycerol kinase ε depletion suppresses LPS ‐stimulated NF ‐ κB activation and reduces free radical‐induced DNA damage

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Diacylglycerol kinase alpha is a proliferation marker of intrahepatic cholangiocarcinoma associated with the prognosis

inferred← citeshttps://doi.org/10.1002/eji.201142307openalex-snapshot

Silencing of the I l2 gene transcription is regulated by epigenetic changes in anergic T cells

inferred← citeshttps://doi.org/10.1002/eji.201242571openalex-snapshot

Negative control of mast cell degranulation and the anaphylactic response by the phosphatase lipin1

inferred← citeshttps://doi.org/10.1002/eji.201948289openalex-snapshot

Graded diacylglycerol kinases α and ζ activities ensure mucosal‐associated invariant T‐cell development in mice

inferred← citeshttps://doi.org/10.1002/eji.201948442openalex-snapshot

Negative control of diacylglycerol kinase ζ‐mediated inhibition of T cell receptor signaling by nuclear sequestration in mice

inferred← citeshttps://doi.org/10.1002/eji.70192openalex-snapshot

CD8 T Cell Sensing of Type I Interferon Impacts Anergy

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Diacylglycerol kinase α‐selective inhibitors induce apoptosis and reduce viability of melanoma and several other cancer cell lines

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Combined inhibition/silencing of diacylglycerol kinase α and ζ simultaneously and synergistically enhances interleukin‐2 production in T cells and induces cell death of melanoma cells

inferred← citeshttps://doi.org/10.1002/jcp.25461openalex-snapshot

DGKζ Downregulation Enhances Osteoclast Differentiation and Bone Resorption Activity Under Inflammatory Conditions

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Analytical Method for Diacylglycerol Kinase ζ Activity in Cells Using Protein Myristoylation and Liquid Chromatography–Tandem Mass Spectrometry

inferred← citeshttps://doi.org/10.1002/med.70010openalex-snapshot

Modulators of Diacylglycerol Kinase Activity: A Review of Advances and Challenges

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Crystal structure and calcium‐induced conformational changes of diacylglycerol kinase α EF‐hand domains

inferred← citeshttps://doi.org/10.1002/pro.4365openalex-snapshot

Ca2+‐induced structural changes and intramolecular interactions in N‐terminal region of diacylglycerol kinase alpha

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Diacylglycerol Kinase Malfunction in Human Disease and the Search for Specific Inhibitors

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The Role of Diacylglycerol Kinases in T Cell Anergy

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Deciphering T Cell Immunometabolism with Activity-Based Protein Profiling

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Genome Editing for Engineering the Next Generation of Advanced Immune Cell Therapies

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The Role and Regulation of mTOR in T-Lymphocyte Function

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Diacylglycerol kinase α inactivation is an integral component of the costimulatory pathway that amplifies TCR signals

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Diacylglycerol kinase α inhibition cooperates with PD-1-targeted therapies to restore the T cell activation program

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Combination therapy for hepatocellular carcinoma with diacylglycerol kinase alpha inhibition and anti-programmed cell death-1 ligand blockade

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T Cells and Stromal Fibroblasts in Human Tumor Microenvironments Represent Potential Therapeutic Targets

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Magnetic nanoparticles and their applications in image-guided drug delivery

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Membrane Conformation and the Modulation of Cell Function

inferred← citeshttps://doi.org/10.1016/bs.ircmb.2016.12.001openalex-snapshot

Cellular and Molecular Mechanisms of Autoimmunity and Lupus Nephritis

inferred← citeshttps://doi.org/10.1016/j.advenzreg.2009.01.003openalex-snapshot

Diacylglycerol kinase alpha, from negative modulation of T cell activation to control of cancer progression

inferred← citeshttps://doi.org/10.1016/j.advenzreg.2011.09.004openalex-snapshot

Regulation of diacylglycerol kinase by phosphorylation

inferred← citeshttps://doi.org/10.1016/j.apsb.2025.06.019openalex-snapshot

Macrophage DGKζ-mediated phosphatidic acid remodeling aggravates acute liver failure

inferred← citeshttps://doi.org/10.1016/j.bbagen.2009.01.010openalex-snapshot

Mammalian diacylglycerol kinases: Molecular interactions and biological functions of selected isoforms

inferred← citeshttps://doi.org/10.1016/j.bbalip.2007.04.006openalex-snapshot

Diacylglycerol kinases: Why so many of them?

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Diacylglycerol kinases as sources of phosphatidic acid

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Phosphatidic acid signaling regulation of Ras superfamily of small guanosine triphosphatases

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Downregulation of diacylglycerol kinase ζ enhances activation of cytokine-induced NF-κB signaling pathway

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Distinct 1-monoacylglycerol and 2-monoacylglycerol kinase activities of diacylglycerol kinase isozymes

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Calcium negatively regulates an intramolecular interaction between the N-terminal recoverin homology and EF-hand motif domains and the C-terminal C1 and catalytic domains of diacylglycerol kinase α

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Both the C1 domain and a basic amino acid cluster at the C-terminus are important for the neurite and branch induction ability of DGKβ

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Palmitic acid- and/or palmitoleic acid-containing phosphatidic acids are generated by diacylglycerol kinase α in starved Jurkat T cells

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Activation of conventional and novel protein kinase C isozymes by different diacylglycerol molecular species

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Saturated fatty acid- and/or monounsaturated fatty acid-containing-phosphatidic acids selectively interact with and activate phosphoglycerate mutase 1

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Dual activities of ritanserin and R59022 as DGKα inhibitors and serotonin receptor antagonists

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Identification of ritanserin analogs that display DGK isoform specificity

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MRI-visible polymeric vector bearing CD3 single chain antibody for gene delivery to T cells for immunosuppression

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Advances in chemical proteomic evaluation of lipid kinases—DAG kinases as a case study

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Signalling to transcription: Store-operated Ca2+ entry and NFAT activation in lymphocytes

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The Ubiquitin Ligase Adaptor NDFIP1 Selectively Enforces a CD8+ T Cell Tolerance Checkpoint to High-Dose Antigen

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Ocular immune privilege in action: The living eye imposes unique regulatory and anergic gene signatures on uveitogenic T cells

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Molecular profiling to identify relevant immune resistance mechanisms in the tumor microenvironment

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The role of diacylglycerol kinases in allergic airway disease

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Peripheral tolerance in CD8+ T cells

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EF‐hand motifs of diacylglycerol kinase α interact intra‐molecularly with its C1 domains

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Nanoparticle-based T cell immunoimaging and immunomodulatory for diagnosing and treating transplant rejection

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Mechanisms of polarized cell-cell communication of T lymphocytes

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Targeted Cleavage of Signaling Proteins by Caspase 3 Inhibits T Cell Receptor Signaling in Anergic T Cells

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Deltex1 Is a Target of the Transcription Factor NFAT that Promotes T Cell Anergy

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Saturated fatty acid– and/or monounsaturated fatty acid–containing phosphatidic acids selectively interact with heat shock protein 27

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Inhibition of diacylglycerol kinases as a physiological way to promote diacylglycerol signaling

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Reciprocal regulation of p53 and NF-κB by diacylglycerol kinase ζ

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Diacylglycerol kinases in cancer

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Where do substrates of diacylglycerol kinases come from? Diacylglycerol kinases utilize diacylglycerol species supplied from phosphatidylinositol turnover-independent pathways

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Biological regulation of diacylglycerol kinases in normal and neoplastic tissues: New opportunities for cancer immunotherapy

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Modified lipidomic profile of cancer-associated small extracellular vesicles facilitates tumorigenic behaviours and contributes to disease progression

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Upstream and downstream pathways of diacylglycerol kinase : Novel phosphatidylinositol turnover-independent signal transduction pathways

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Harnessing lipid metabolism through diacylglycerol kinases: implications for immune modulation and cancer therapy

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Diacylglycerol kinase alpha enhances hepatocellular carcinoma progression by activation of Ras–Raf–MEK–ERK pathway

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Pharmacological inhibition of both DGKα and DGKζ is required for optimal T cell activation

inferred← citeshttps://doi.org/10.1016/j.molimm.2008.09.029openalex-snapshot

IL-2 signaling prevents T cell anergy by inhibiting the expression of anergy-inducing genes

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Egr2-dependent gene expression profiling and ChIP-Seq reveal novel biologic targets in T cell anergy

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mTOR and its tight regulation for iNKT cell development and effector function

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CRISPR-Cas9 knockout of DGKα/ζ improves the anti-tumor activities of TAG-72 CAR-T cells in ovarian cancer

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Diacylglycerol kinase ζ: At the crossroads of lipid signaling and protein complex organization

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Diacylglycerol kinases: Molecular mechanism of cellular and physiological functions

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Regulatory factors involved in Th17/Treg cell balance of immune thrombocytopenia

inferred← citeshttps://doi.org/10.1016/j.smim.2007.02.004openalex-snapshot

Regulation of peripheral T cell tolerance by the E3 ubiquitin ligase Cbl-b

inferred← citeshttps://doi.org/10.1016/j.smim.2007.02.006openalex-snapshot

Transcriptional regulation of T cell tolerance

inferred← citeshttps://doi.org/10.1016/j.smim.2013.10.010openalex-snapshot

Induction and stability of the anergic phenotype in T cells

inferred← citeshttps://doi.org/10.1016/j.tibs.2011.06.005openalex-snapshot

Shaping up the membrane: diacylglycerol coordinates spatial orientation of signaling

inferred← citeshttps://doi.org/10.1016/j.virol.2014.08.020openalex-snapshot

Circulating rotavirus-specific T cells have a poor functional profile

inferred← citeshttps://doi.org/10.1016/s0074-7696(07)64002-9openalex-snapshot

Cell Biology and Pathophysiology of the Diacylglycerol Kinase Family: Morphological Aspects in Tissues and Organs

inferred← citeshttps://doi.org/10.1016/s0213-9626(10)70008-1openalex-snapshot

Mechanisms of self-inactivation in anergic T cells

inferred← citeshttps://doi.org/10.1016/s1937-6448(09)75006-3openalex-snapshot

Chapter 6 Cell and Molecular Biology of the Novel Protein Tyrosine‐Phosphatase‐Interacting Protein 51

inferred← citeshttps://doi.org/10.1021/acs.biochem.7b00962openalex-snapshot

Deconstructing Lipid Kinase Inhibitors by Chemical Proteomics

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c00584openalex-snapshot

Design, Synthesis, and Evaluation of 11C-Labeled 3-Acetyl-Indole Derivatives as a Novel Positron Emission Tomography Imaging Agent for Diacylglycerol Kinase Gamma (DGKγ) in Brain

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c01943openalex-snapshot

Design, Synthesis and Biological Evaluation of Novel, Potent, Selective and Orally Available DGKα Inhibitors for the Treatment of Tumors

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c01944openalex-snapshot

Discovery of Novel, Potent, Selective, and Orally Available DGKα Inhibitors for the Treatment of Tumors

inferred← citeshttps://doi.org/10.1021/acsomega.9b00079openalex-snapshot

Expression, Purification, and Characterization of Human Diacylglycerol Kinase ζ

inferred← citeshttps://doi.org/10.1021/bi800492copenalex-snapshot

Dramatic Differences in the Roles in Lipid Metabolism of Two Isoforms of Diacylglycerol Kinase

inferred← citeshttps://doi.org/10.1021/cr1004106openalex-snapshot

Regulation and Functions of Diacylglycerol Kinases

inferred← citeshttps://doi.org/10.1021/nn3037573openalex-snapshot

Simultaneous Diagnosis and Gene Therapy of Immuno-Rejection in Rat Allogeneic Heart Transplantation Model Using a T-Cell-Targeted Theranostic Nanosystem

inferred← citeshttps://doi.org/10.1038/cddis.2013.396openalex-snapshot

Diacylglycerol metabolism attenuates T-cell receptor signaling and alters thymocyte differentiation

inferred← citeshttps://doi.org/10.1038/icb.2017.7openalex-snapshot

Predominant contribution of DGKζ over DGKα in the control of PKC/PDK‐1‐regulated functions in T cells

inferred← citeshttps://doi.org/10.1038/ncb1592openalex-snapshot

The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2

inferred← citeshttps://doi.org/10.1038/ncomms10893openalex-snapshot

Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis

inferred← citeshttps://doi.org/10.1038/ncomms9698openalex-snapshot

Ndrg1 is a T-cell clonal anergy factor negatively regulated by CD28 costimulation and interleukin-2

inferred← citeshttps://doi.org/10.1038/ni.2590openalex-snapshot

The transcriptional landscape of αβ T cell differentiation

inferred← citeshttps://doi.org/10.1038/ni.2773openalex-snapshot

Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness

inferred← citeshttps://doi.org/10.1038/nri2131openalex-snapshot

Molecular mechanisms of CD4+ T-cell anergy

inferred← citeshttps://doi.org/10.1038/s12276-020-0435-8openalex-snapshot

Recent insights of T cell receptor-mediated signaling pathways for T cell activation and development

inferred← citeshttps://doi.org/10.1038/s41392-021-00823-wopenalex-snapshot

T cell receptor (TCR) signaling in health and disease

inferred← citeshttps://doi.org/10.1038/s41392-025-02357-xopenalex-snapshot

Lipid metabolism in homeostasis and disease

inferred← citeshttps://doi.org/10.1038/s41577-020-00454-2openalex-snapshot

Rethinking peripheral T cell tolerance: checkpoints across a T cell’s journey

inferred← citeshttps://doi.org/10.1038/s41589-019-0445-9openalex-snapshot

Reprogramming fatty acyl specificity of lipid kinases via C1 domain engineering

inferred← citeshttps://doi.org/10.1038/s41598-020-68716-6openalex-snapshot

The mechanisms of ameliorating effect of a green tea polyphenol on diabetic nephropathy based on diacylglycerol kinase α

inferred← citeshttps://doi.org/10.1038/s43018-023-00534-xopenalex-snapshot

Multimodal immunogenomic biomarker analysis of tumors from pediatric patients enrolled to a phase 1-2 study of single-agent atezolizumab

inferred← citeshttps://doi.org/10.1038/sj.embor.7401138openalex-snapshot

Molecular regulation of T‐cell anergy

inferred← citeshttps://doi.org/10.1038/sj.onc.1210717openalex-snapshot

Diacylglycerol kinase-α phosphorylation by Src on Y335 is required for activation, membrane recruitment and Hgf-induced cell motility

inferred← citeshttps://doi.org/10.1039/d3cb00057eopenalex-snapshot

Predicting small molecule binding pockets on diacylglycerol kinases using chemoproteomics and AlphaFold

inferred← citeshttps://doi.org/10.1042/bcj20180620openalex-snapshot

Diacylglycerol kinase control of protein kinase C

inferred← citeshttps://doi.org/10.1042/bj20071040openalex-snapshot

Diacylglycerol kinases: at the hub of cell signalling

inferred← citeshttps://doi.org/10.1042/bj20111700openalex-snapshot

Protein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells

inferred← citeshttps://doi.org/10.1042/cs20200389openalex-snapshot

Potential role of diacylglycerol kinases in immune-mediated diseases

inferred← citeshttps://doi.org/10.1073/pnas.0711856105openalex-snapshot

Synergistic control of T cell development and tumor suppression by diacylglycerol kinase α and ζ

inferred← citeshttps://doi.org/10.1073/pnas.1008437107openalex-snapshot

Role of antigen persistence and dose for CD4 + T-cell exhaustion and recovery

inferred← citeshttps://doi.org/10.1073/pnas.1119744109openalex-snapshot

Tumor suppressor TSC1 is critical for T-cell anergy

inferred← citeshttps://doi.org/10.1073/pnas.2218668120openalex-snapshot

Therapy targeting antigen-specific T cells by a peptide-based tolerizing vaccine against autoimmune arthritis

inferred← citeshttps://doi.org/10.1074/jbc.m109.055731openalex-snapshot

Diacylglycerol Kinase δ and Protein Kinase Cα Modulate Epidermal Growth Factor Receptor Abundance and Degradation through Ubiquitin-specific Protease 8

inferred← citeshttps://doi.org/10.1074/jbc.m110.171884openalex-snapshot

Decreased Diacylglycerol Metabolism Enhances ERK Activation and Augments CD8+ T Cell Functional Responses

inferred← citeshttps://doi.org/10.1074/jbc.m112.407379openalex-snapshot

Diacylglycerol Kinase δ Modulates Akt Phosphorylation through Pleckstrin Homology Domain Leucine-rich Repeat Protein Phosphatase 2 (PHLPP2)

inferred← citeshttps://doi.org/10.1074/jbc.m702085200openalex-snapshot

Role of the Diacylglycerol Kinase α-Conserved Domains in Membrane Targeting in Intact T Cells

inferred← citeshttps://doi.org/10.1074/jbc.m804084200openalex-snapshot

p21 Ras/Impedes Mitogenic Signal Propagation Regulates Cytokine Production and Migration in CD4 T Cells

inferred← citeshttps://doi.org/10.1080/08820139.2020.1748047openalex-snapshot

Exosomes Represent an Immune Suppressive T Cell Checkpoint in Human Chronic Inflammatory Microenvironments

inferred← citeshttps://doi.org/10.1080/08916930701464939openalex-snapshot

Adenosine and anergy

inferred← citeshttps://doi.org/10.1080/2162402x.2021.1941566openalex-snapshot

DGKζ exerts greater control than DGKα over CD8 + T cell activity and tumor inhibition

inferred← citeshttps://doi.org/10.1084/jem.20061856openalex-snapshot

Diacylglycerol kinase ζ regulates microbial recognition and host resistance to Toxoplasma gondii

inferred← citeshttps://doi.org/10.1084/jem.20082731openalex-snapshot

Transcriptional complexes formed by NFAT dimers regulate the induction of T cell tolerance

inferred← citeshttps://doi.org/10.1089/mab.2017.0023openalex-snapshot

DaMab-2: Anti-Human DGKα Monoclonal Antibody for Immunocytochemistry

inferred← citeshttps://doi.org/10.1089/mab.2018.0047openalex-snapshot

Epitope Mapping of Antidiacylglycerol Kinase α Monoclonal Antibody DaMab-2

inferred← citeshttps://doi.org/10.1089/mab.2019.0004openalex-snapshot

Establishment and Epitope Mapping of Anti-Diacylglycerol Kinase α Monoclonal Antibody DaMab-8 for Immunohistochemical Analyses

inferred← citeshttps://doi.org/10.1089/mab.2019.0005openalex-snapshot

Epitope Mapping of Anti-Diacylglycerol Kinase ζ Monoclonal Antibody for the Detection of T Cells by Immunohistochemical Analyses

inferred← citeshttps://doi.org/10.1089/mab.2019.0020openalex-snapshot

Epitope Mapping of Anti-Diacylglycerol Kinase Zeta Monoclonal Antibody DzMab-1 for Immunohistochemical Analyses

inferred← citeshttps://doi.org/10.1091/mbc.e07-02-0177openalex-snapshot

Diacylglycerol Kinase-α Mediates Hepatocyte Growth Factor-induced Epithelial Cell Scatter by Regulating Rac Activation and Membrane Ruffling

inferred← citeshttps://doi.org/10.1091/mbc.e11-03-0247openalex-snapshot

Diacylglycerol kinase ζ controls diacylglycerol metabolism at the immunological synapse

inferred← citeshttps://doi.org/10.1093/jb/mvz008openalex-snapshot

Screening of subtype-specific activators and inhibitors for diacylglycerol kinase

inferred← citeshttps://doi.org/10.1093/rheumatology/kead096openalex-snapshot

Identification of new candidate drugs for primary Sjögren’s syndrome using a drug repurposing transcriptomic approach

inferred← citeshttps://doi.org/10.1096/fj.201701050ropenalex-snapshot

Deletion of diacylglycerol kinase ε confers susceptibility to obesity via reduced lipolytic activity in murine adipocytes

inferred← citeshttps://doi.org/10.1096/fj.202100264ropenalex-snapshot

Membrane morphology determines diacylglycerol kinase α substrate acyl chain specificity

inferred← citeshttps://doi.org/10.1096/fj.202502281ropenalex-snapshot

Regulatory Functions of TDP‐43 and FMRP in Non‐Neuronal Diseases: Are Co‐Targeted mRNAs the Keys?

inferred← citeshttps://doi.org/10.1101/2025.08.28.672769openalex-snapshot

Diacylglycerol metabolism drives host-pathogen responses during enteric infection in Drosophila

inferred← citeshttps://doi.org/10.1101/cshperspect.a002428openalex-snapshot

Lipid Signaling in T-Cell Development and Function

inferred← citeshttps://doi.org/10.1111/1759-7714.14851openalex-snapshot

Targeting diacylglycerol kinase α impairs lung tumorigenesis by inhibiting cyclin D3

inferred← citeshttps://doi.org/10.1111/imr.12116openalex-snapshot

From lipid second messengers to molecular motors: microtubule‐organizing center reorientation in T cells

inferred← citeshttps://doi.org/10.1111/j.1600-065x.2007.00538.xopenalex-snapshot

Small GTPases and LFA‐1 reciprocally modulate adhesion and signaling

inferred← citeshttps://doi.org/10.1111/j.1600-065x.2008.00647.xopenalex-snapshot

Diacylglycerol kinases in immune cell function and self‐tolerance

inferred← citeshttps://doi.org/10.1111/j.1600-065x.2008.00759.xopenalex-snapshot

New insights into the regulation and function of serine/threonine kinases in T lymphocytes

inferred← citeshttps://doi.org/10.1111/j.1600-065x.2009.00817.xopenalex-snapshot

Regulation of T‐cell tolerance by calcium/NFAT signaling

inferred← citeshttps://doi.org/10.11144/javeriana.10554.15425openalex-snapshot

Caracterización de los linfocitos T Cd4 específicos de Rotavirus

inferred← citeshttps://doi.org/10.1126/sciadv.adk1853openalex-snapshot

DGKα/ζ inhibition lowers the TCR affinity threshold and potentiates antitumor immunity

inferred← citeshttps://doi.org/10.1126/scisignal.2000409openalex-snapshot

RIAM Regulates the Cytoskeletal Distribution and Activation of PLC-γ1 in T Cells

inferred← citeshttps://doi.org/10.1126/scisignal.2004189openalex-snapshot

Diacylglycerol Kinase ζ Limits B Cell Antigen Receptor–Dependent Activation of ERK Signaling to Inhibit Early Antibody Responses

inferred← citeshttps://doi.org/10.1126/scisignal.2004373openalex-snapshot

The ζ Isoform of Diacylglycerol Kinase Plays a Predominant Role in Regulatory T Cell Development and TCR-Mediated Ras Signaling

inferred← citeshttps://doi.org/10.1126/scisignal.2004411openalex-snapshot

Diacylglycerol Kinase ζ Limits the Generation of Natural Regulatory T Cells

inferred← citeshttps://doi.org/10.1126/scisignal.2005287openalex-snapshot

Diacylglycerol kinase α establishes T cell polarity by shaping diacylglycerol accumulation at the immunological synapse

inferred← citeshttps://doi.org/10.1126/scisignal.2005477openalex-snapshot

Protein kinase D2 is a digital amplifier of T cell receptor–stimulated diacylglycerol signaling in naïve CD8 + T cells

inferred← citeshttps://doi.org/10.1126/scisignal.aaa0974openalex-snapshot

Redundant and specialized roles for diacylglycerol kinases α and ζ in the control of T cell functions

inferred← citeshttps://doi.org/10.1126/scisignal.aaw8214openalex-snapshot

Diacylglycerol kinase ζ promotes actin cytoskeleton remodeling and mechanical forces at the B cell immune synapse

inferred← citeshttps://doi.org/10.1126/scisignal.abo0264openalex-snapshot

Overarching roles of diacylglycerol signaling in cancer development and antitumor immunity

inferred← citeshttps://doi.org/10.1126/scitranslmed.aad1565openalex-snapshot

Inhibition of diacylglycerol kinase α restores restimulation-induced cell death and reduces immunopathology in XLP-1

inferred← citeshttps://doi.org/10.1126/stke.3982007pe43openalex-snapshot

Diacylglycerol Kinases Put the Brakes on Immune Function

inferred← citeshttps://doi.org/10.1128/mcb.00355-07openalex-snapshot

Cyclic AMP-Stimulated Interaction between Steroidogenic Factor 1 and Diacylglycerol Kinase θ Facilitates Induction of CYP17

inferred← citeshttps://doi.org/10.1128/mcb.00654-12openalex-snapshot

FoxO-Dependent Regulation of Diacylglycerol Kinase α Gene Expression

inferred← citeshttps://doi.org/10.1128/mcb.00902-13openalex-snapshot

Tle4 Regulates Epigenetic Silencing of Gamma Interferon Expression during Effector T Helper Cell Tolerance

inferred← citeshttps://doi.org/10.1134/s000629791302003xopenalex-snapshot

Molecular mechanisms of T-cell anergy

inferred← citeshttps://doi.org/10.1152/ajplung.00091.2024openalex-snapshot

Diacylglycerol kinase is a keystone regulator of signaling relevant to the pathophysiology of asthma

inferred← citeshttps://doi.org/10.1155/2011/294968openalex-snapshot

Mechanisms That Regulate Peripheral Immune Responses to Control Organ-Specific Autoimmunity

inferred← citeshttps://doi.org/10.1158/0008-5472.can-11-3775openalex-snapshot

NFAT1 Supports Tumor-induced Anergy of CD4+ T Cells

inferred← citeshttps://doi.org/10.1158/0008-5472.can-12-3874openalex-snapshot

Enhanced Effector Responses in Activated CD8+ T Cells Deficient in Diacylglycerol Kinases

inferred← citeshttps://doi.org/10.1158/0008-5472.can-17-1309openalex-snapshot

T Cells Deficient in Diacylglycerol Kinase ζ Are Resistant to PD-1 Inhibition and Help Create Persistent Host Immunity to Leukemia

inferred← citeshttps://doi.org/10.1158/0008-5472.can-18-0030openalex-snapshot

CRISPR/Cas9-Mediated Knockout of DGK Improves Antitumor Activities of Human T Cells

inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-15-0413openalex-snapshot

Molecular Pathways: Targeting Diacylglycerol Kinase Alpha in Cancer

inferred← citeshttps://doi.org/10.1158/2159-8290.cd-12-0215openalex-snapshot

Diacylglycerol Kinase α Is a Critical Signaling Node and Novel Therapeutic Target in Glioblastoma and Other Cancers

inferred← citeshttps://doi.org/10.1158/2326-6066.cir-15-0086openalex-snapshot

Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade

inferred← citeshttps://doi.org/10.1158/2326-6066.cir-17-0113openalex-snapshot

Exosomes Associated with Human Ovarian Tumors Harbor a Reversible Checkpoint of T-cell Responses

inferred← citeshttps://doi.org/10.1158/2326-6066.cir-25-0156openalex-snapshot

Discovery of BMS-986408, a First-In-Class Dual DGKα and DGKζ Inhibitor that Unleashes PD-1 Checkpoint and CAR T-cell Immunotherapies

inferred← citeshttps://doi.org/10.1159/000351849openalex-snapshot

Evaluations of the Selectivities of the Diacylglycerol Kinase Inhibitors R59022 and R59949 Among Diacylglycerol Kinase Isozymes Using a New Non-Radioactive Assay Method

inferred← citeshttps://doi.org/10.1161/atvbaha.124.320728openalex-snapshot

Glycoursodeoxycholic Acid Alleviates Arterial Thrombosis via Suppressing Diacylglycerol Kinases Activity in Platelet

inferred← citeshttps://doi.org/10.1166/jbn.2015.2145openalex-snapshot

Recent Developments in Active Tumor Targeted Multifunctional Nanoparticles for Combination Chemotherapy in Cancer Treatment and Imaging

inferred← citeshttps://doi.org/10.1172/jci33071openalex-snapshot

Impact of bacteria on the phenotype, functions, and therapeutic activities of invariant NKT cells in mice

inferred← citeshttps://doi.org/10.1172/jci38902openalex-snapshot

The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice

inferred← citeshttps://doi.org/10.1172/jci99321openalex-snapshot

A transgenic mouse model for HLA-B*57:01–linked abacavir drug tolerance and reactivity

inferred← citeshttps://doi.org/10.1177/1947601911408082openalex-snapshot

Regulation and Function of the RasGRP Family of Ras Activators in Blood Cells

inferred← citeshttps://doi.org/10.1182/blood-2006-07-037754openalex-snapshot

Interleukin 2 gene transcription is regulated by Ikaros-induced changes in histone acetylation in anergic T cells

inferred← citeshttps://doi.org/10.1182/blood-2006-07-038752openalex-snapshot

A novel negative regulatory function of the phosphoprotein associated with glycosphingolipid-enriched microdomains: blocking Ras activation

inferred← citeshttps://doi.org/10.1182/blood-2008-10-185223openalex-snapshot

The molecular signature of CD8+ T cells undergoing deletional tolerance

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