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DNA-Demethylating Agents Enhance Cytolytic Activity of CD8 T Cells and Anti-Tumor Immunity

https://doi.org/10.2139/ssrn.3155506
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Structural Design of Engineered Costimulation Determines Tumor Rejection Kinetics and Persistence of CAR T Cells
inferredcites →https://doi.org/10.1016/j.ccr.2012.08.013openalex-extracted
Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation
inferredcites →https://doi.org/10.1016/j.cell.2011.06.041openalex-extracted
MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response
inferredcites →https://doi.org/10.1016/j.cell.2014.12.033openalex-extracted
Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity
inferredcites →https://doi.org/10.1016/j.cell.2015.07.011openalex-extracted
Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses
inferredcites →https://doi.org/10.1016/j.cell.2015.07.056openalex-extracted
DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts
inferredcites →https://doi.org/10.1016/j.cell.2015.08.005openalex-extracted
DNA Methylation Inhibitors in Cancer Therapy: The Immunity Dimension
inferredcites →https://doi.org/10.1016/j.cell.2017.06.007openalex-extracted
De Novo Epigenetic Programs Inhibit PD-1 Blockade-Mediated T Cell Rejuvenation
inferredcites →https://doi.org/10.1016/j.ymeth.2013.02.007openalex-extracted
In vivo assessment of specific cytotoxic T lymphocyte killing
inferredcites →https://doi.org/10.1038/nature08460openalex-extracted
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
inferredcites →https://doi.org/10.1038/nature13954openalex-extracted
PD-1 blockade induces responses by inhibiting adaptive immune resistance
inferredcites →https://doi.org/10.1038/nbt.3519openalex-extracted
Near-optimal probabilistic RNA-seq quantification
inferredcites →https://doi.org/10.1038/ncomms15138openalex-extracted
Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity
inferredcites →https://doi.org/10.1038/ng.3889openalex-extracted
DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats
inferredcites →https://doi.org/10.1038/ni1400openalex-extracted
Disruption of diacylglycerol metabolism impairs the induction of T cell anergy
inferredcites →https://doi.org/10.1038/nprot.2010.190openalex-extracted
Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling
inferredcites →https://doi.org/10.1038/srep15179openalex-extracted
Prognostic value of tumor-infiltrating FoxP3+ regulatory T cells in cancers: a systematic review and meta-analysis
inferredcites →https://doi.org/10.1056/nejmcibr1514673openalex-extracted
Epigenetic Modulators and the New Immunotherapies
inferredcites →https://doi.org/10.1073/pnas.0509182102openalex-extracted
Intraepithelial CD8 + tumor-infiltrating lymphocytes and a high CD8 + /regulatory T cell ratio are associated with favorable prognosis in ovarian cancer
inferredcites →https://doi.org/10.1073/pnas.1609376113openalex-extracted
Density of immunogenic antigens does not explain the presence or absence of the T-cell–inflamed tumor microenvironment in melanoma
inferredcites →https://doi.org/10.1073/pnas.1612262113openalex-extracted
Vitamin C increases viral mimicry induced by 5-aza-2′-deoxycytidine
inferredcites →https://doi.org/10.1101/gr.165985.113openalex-extracted
Neo-antigens predicted by tumor genome meta-analysis correlate with increased patient survival
inferredcites →https://doi.org/10.1126/science.1129139openalex-extracted
Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
inferredcites →https://doi.org/10.1126/science.aad0095openalex-extracted
Genomic correlates of response to CTLA-4 blockade in metastatic melanoma
inferredcites →https://doi.org/10.1126/science.aad0501openalex-extracted
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
inferredcites →https://doi.org/10.1128/jvi.01648-12openalex-extracted
A Novel Function of RNAs Arising From the Long Terminal Repeat of Human Endogenous Retrovirus 9 in Cell Cycle Arrest
inferredcites →https://doi.org/10.1186/1471-2105-14-7openalex-extracted
GSVA: gene set variation analysis for microarray and RNA-Seq data
inferredcites →https://doi.org/10.1186/1471-2164-15-190openalex-extracted
Immunomic, genomic and transcriptomic characterization of CT26 colorectal carcinoma
inferredcites →https://doi.org/10.1186/s13059-016-0947-7openalex-extracted
Pooling across cells to normalize single-cell RNA sequencing data with many zero counts
inferredcites →https://doi.org/10.4049/jimmunol.176.3.1571openalex-extracted
Tec Kinases Itk and Rlk Are Required for CD8+ T Cell Responses to Virus Infection Independent of Their Role in CD4+ T Cell Help
inferredcites →https://doi.org/10.1038/nm0116-8openalex-snapshot
Take two: Combining immunotherapy with epigenetic drugs to tackle cancer
inferredcites →https://doi.org/10.1158/0008-5472.can-11-0096openalex-snapshot
Anti-TIM3 Antibody Promotes T Cell IFN-γ–Mediated Antitumor Immunity and Suppresses Established Tumors
inferredcites →https://doi.org/10.1186/gb-2014-15-2-r29openalex-snapshot
voom: precision weights unlock linear model analysis tools for RNA-seq read counts

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1177/2515135520904238openalex-snapshot
Checkpoint inhibitor blockade and epigenetic reprogrammability in CD8+ T-cell activation and exhaustion
inferred← citeshttps://doi.org/10.1590/1678-9199-jvatitd-2019-0061openalex-snapshot
São Paulo School of Advanced Sciences on Vaccines: an overview
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