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Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/0471142735.im1501s77openalex-snapshot
Experimental Autoimmune Encephalomyelitis in the Mouse
inferredcites →https://doi.org/10.1002/ana.21117openalex-snapshot
Environmental risk factors for multiple sclerosis. Part I: The role of infection
inferredcites →https://doi.org/10.1002/jnr.20488openalex-snapshot
Microglial cell activation and proliferation precedes the onset of CNS autoimmunity
inferredcites →https://doi.org/10.1016/j.bbadis.2010.07.008openalex-snapshot
The role of antigen presenting cells in multiple sclerosis
inferredcites →https://doi.org/10.1016/j.bbi.2007.08.011openalex-snapshot
Glial toll-like receptor signaling in central nervous system infection and autoimmunity
inferredcites →https://doi.org/10.1016/j.cell.2006.02.015openalex-snapshot
Pathogen Recognition and Innate Immunity
inferredcites →https://doi.org/10.1016/j.cell.2007.10.030openalex-snapshot
IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis
inferredcites →https://doi.org/10.1016/j.cell.2007.10.037openalex-snapshot
IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis
inferredcites →https://doi.org/10.1016/j.cell.2011.03.050openalex-snapshot
An ADIOL-ERβ-CtBP Transrepression Pathway Negatively Regulates Microglia-Mediated Inflammation
inferredcites →https://doi.org/10.1016/j.immuni.2008.01.009openalex-snapshot
TRAF2 and TRAF3 Signal Adapters Act Cooperatively to Control the Maturation and Survival Signals Delivered to B Cells by the BAFF Receptor
inferredcites →https://doi.org/10.1016/j.it.2008.10.001openalex-snapshot
The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling
inferredcites →https://doi.org/10.1016/j.jneuroim.2011.08.010openalex-snapshot
Targeting Toll-like receptors: Emerging therapeutics for multiple sclerosis management
inferredcites →https://doi.org/10.1016/j.vaccine.2010.08.103openalex-snapshot
Experimental autoimmune encephalomyelitis as a testing paradigm for adjuvants and vaccines
inferredcites →https://doi.org/10.1016/s0014-5793(97)00313-xopenalex-snapshot
‘Green mice’ as a source of ubiquitous green cells
inferredcites →https://doi.org/10.1038/cmi.2011.60openalex-snapshot
Peli: a family of signal-responsive E3 ubiquitin ligases mediating TLR signaling and T-cell tolerance
inferredcites →https://doi.org/10.1038/nature10554openalex-snapshot
Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination
inferredcites →https://doi.org/10.1038/ni.1777openalex-snapshot
Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production
inferredcites →https://doi.org/10.1038/ni.1819openalex-snapshot
Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines
inferredcites →https://doi.org/10.1038/ni.2090openalex-snapshot
The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity
inferredcites →https://doi.org/10.1038/ni1315openalex-snapshot
Regulation of T cell development by the deubiquitinating enzyme CYLD
inferredcites →https://doi.org/10.1038/nm1177openalex-snapshot
Experimental autoimmune encephalomyelitis repressed by microglial paralysis
inferredcites →https://doi.org/10.1038/nn.2887openalex-snapshot
Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool
inferredcites →https://doi.org/10.1038/nprot.2006.285openalex-snapshot
Active induction of experimental allergic encephalomyelitis
inferredcites →https://doi.org/10.1038/nri2550openalex-snapshot
Autoimmune T cell responses in the central nervous system
inferredcites →https://doi.org/10.1038/nri2998openalex-snapshot
Expanding TRAF function: TRAF3 as a tri-faced immune regulator
inferredcites →https://doi.org/10.1038/nri3086openalex-snapshot
Microglial cell origin and phenotypes in health and disease
inferredcites →https://doi.org/10.1042/bj20101421openalex-snapshot
The role of TBK1 and IKKϵ in the expression and activation of Pellino 1
inferredcites →https://doi.org/10.1042/bj20111415openalex-snapshot
Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system
inferredcites →https://doi.org/10.1074/jbc.m403286200openalex-snapshot
Regulation of the NF-κB-inducing Kinase by Tumor Necrosis Factor Receptor-associated Factor 3-induced Degradation
inferredcites →https://doi.org/10.1084/jem.20100703openalex-snapshot
Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling
inferredcites →https://doi.org/10.1093/bioinformatics/17.4.369openalex-snapshot
J-Express: exploring gene expression data using Java
inferredcites →https://doi.org/10.1093/brain/awm246openalex-snapshot
T cells and microglia as drivers of multiple sclerosis pathology
inferredcites →https://doi.org/10.1111/j.1582-4934.2007.00040.xopenalex-snapshot
Pellino Proteins: Novel Players in TLR and IL‐1R Signalling
inferredcites →https://doi.org/10.1111/j.1750-3639.2009.00343.xopenalex-snapshot
Upregulation of Immunoglobulin‐related Genes in Cortical Sections from Multiple Sclerosis Patients
inferredcites →https://doi.org/10.1111/j.1750-3639.2012.00564.xopenalex-snapshot
Prospects of Transcript Profiling for mRNAs and MicroRNAs Using Formalin‐Fixed and Paraffin‐Embedded Dissected Autoptic Multiple Sclerosis Lesions
inferredcites →https://doi.org/10.1126/science.1098231openalex-snapshot
A Small Molecule Smac Mimic Potentiates TRAIL- and TNFα-Mediated Cell Death
inferredcites →https://doi.org/10.1126/science.1194637openalex-snapshot
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
inferredcites →https://doi.org/10.1155/2011/383087openalex-snapshot
Animal Models of MS Reveal Multiple Roles of Microglia in Disease Pathogenesis
inferredcites →https://doi.org/10.1172/jci26078openalex-snapshot
Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis
inferredcites →https://doi.org/10.1182/blood-2008-12-192914openalex-snapshot
Regulation of Th17 cell differentiation and EAE induction by MAP3K NIK
inferredcites →https://doi.org/10.2741/3781openalex-snapshot
Antigen presentation in EAE: role of microglia, macrophages and dendritic cells
inferredcites →https://doi.org/10.4049/jimmunol.173.6.3916openalex-snapshot
Microglia Initiate Central Nervous System Innate and Adaptive Immune Responses through Multiple TLRs
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4948512openalex-extracted
Multi-Omics Integration Prioritizes Potential Drug Targets for Multiple Sclerosis
inferred← citeshttps://doi.org/10.1002/1878-0261.13134openalex-snapshot
PELI1 promotes radiotherapy sensitivity by inhibiting noncanonical NF‐κB in esophageal squamous cancer
inferred← citeshttps://doi.org/10.1002/advs.202503972openalex-snapshot
Regulation of Neuroinflammation by Microglial DUBA‐IRAK1‐IKKβ Signaling Loop
inferred← citeshttps://doi.org/10.1002/ctm2.1719openalex-snapshot
Ubiquitous regulation of cerebrovascular diseases by ubiquitin‐modifying enzymes
inferred← citeshttps://doi.org/10.1002/glia.22803openalex-snapshot
Tyrphostin AG126 exerts neuroprotection in CNS inflammation by a dual mechanism
inferred← citeshttps://doi.org/10.1002/glia.24626openalex-snapshot
Uptake of alpha‐synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microglia
inferred← citeshttps://doi.org/10.1002/hep.30937openalex-snapshot
Vitamin D Receptor Activation in Liver Macrophages Ameliorates Hepatic Inflammation, Steatosis, and Insulin Resistance in Mice
inferred← citeshttps://doi.org/10.1002/iid3.925openalex-snapshot
Triad3A involved in the regulation of endotoxin tolerance and mycobactericidal activity through the NFκB‐nitric oxide pathway
inferred← citeshttps://doi.org/10.1002/mco2.261openalex-snapshot
Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications
inferred← citeshttps://doi.org/10.1002/mef2.70049openalex-snapshot
MicroRNAs in Methamphetamine: Addiction, Neurotoxicity, and Therapeutic Potential
inferred← citeshttps://doi.org/10.1007/978-981-97-7288-9_8openalex-snapshot
Ubiquitin Signaling in the Immune System
inferred← citeshttps://doi.org/10.1007/s00401-021-02384-2openalex-snapshot
Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function
inferred← citeshttps://doi.org/10.1007/s10571-020-00797-3openalex-snapshot
Pellino1 Contributes to Morphine Tolerance by Microglia Activation via MAPK Signaling in the Spinal Cord of Mice
inferred← citeshttps://doi.org/10.1007/s10571-021-01153-9openalex-snapshot
Blood–Brain Barrier Dysfunction in the Pathogenesis of Major Depressive Disorder
inferred← citeshttps://doi.org/10.1007/s11626-025-01064-9openalex-snapshot
MiR-21-5p promotes RPE cell necroptosis by targeting Peli1 in a rat model of AMD
inferred← citeshttps://doi.org/10.1007/s12035-022-03134-5openalex-snapshot
Chronic Microcystin-LR-Induced α-Synuclein Promotes Neuroinflammation Through Activation of the NLRP3 Inflammasome in Microglia
inferred← citeshttps://doi.org/10.1007/s12264-015-0010-9openalex-snapshot
Programmed Death Ligand-1 on Microglia Regulates Th1 Differentiation via Nitric Oxide in Experimental Autoimmune Encephalomyelitis
inferred← citeshttps://doi.org/10.1007/s40495-017-0117-yopenalex-snapshot
TRAF Molecules in Inflammation and Inflammatory Diseases
inferred← citeshttps://doi.org/10.1016/j.ajpath.2016.01.004openalex-snapshot
Deficiency of IκB Kinase β in Myeloid Cells Reduces Severity of Experimental Autoimmune Encephalomyelitis
inferred← citeshttps://doi.org/10.1016/j.antiviral.2024.106059openalex-snapshot
Pellino-1, a therapeutic target for control of SARS-CoV-2 infection and disease severity
inferred← citeshttps://doi.org/10.1016/j.apsb.2024.01.011openalex-snapshot
Engagement of N6-methyladenisine methylation of Gng4 mRNA in astrocyte dysfunction regulated by CircHECW2
inferred← citeshttps://doi.org/10.1016/j.bbadis.2019.06.017openalex-snapshot
Peli1 induction impairs cardiac microvascular endothelium through Hsp90 dissociation from IRE1α
inferred← citeshttps://doi.org/10.1016/j.bbagrm.2020.194639openalex-snapshot
Japanese Encephalitis Virus exploits microRNA-155 to suppress the non-canonical NF-κB pathway in human microglial cells
inferred← citeshttps://doi.org/10.1016/j.bbi.2016.03.015openalex-snapshot
3H-1,2-dithiole-3-thione as a novel therapeutic agent for the treatment of experimental autoimmune encephalomyelitis
inferred← citeshttps://doi.org/10.1016/j.bbr.2019.112038openalex-snapshot
Haplotypes of coping behavior associated QTL regions reveal distinct transcript profiles in amygdala and hippocampus
inferred← citeshttps://doi.org/10.1016/j.bbrc.2018.08.121openalex-snapshot
MiR-590-5p alleviates intracerebral hemorrhage-induced brain injury through targeting Peli1 gene expression
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2017.07.029openalex-snapshot
An antigen-specific semi-therapeutic treatment with local delivery of tolerogenic factors through a dual-sized microparticle system blocks experimental autoimmune encephalomyelitis
inferred← citeshttps://doi.org/10.1016/j.biopha.2023.114593openalex-snapshot
Mesenchymal stem cell-derived exosomal microRNA-367–3p alleviates experimental autoimmune encephalomyelitis via inhibition of microglial ferroptosis by targeting EZH2
inferred← citeshttps://doi.org/10.1016/j.canlet.2017.08.021openalex-snapshot
Up-regulation of OLR1 expression by TBC1D3 through activation of TNFα/NF-κB pathway promotes the migration of human breast cancer cells
inferred← citeshttps://doi.org/10.1016/j.cellin.2025.100294openalex-snapshot
HTATSF1 regulates innate antiviral immune response by orchestrating TRAF3-IRF3 and TRAF6-NF-κB pathways
inferred← citeshttps://doi.org/10.1016/j.celrep.2017.06.088openalex-snapshot
Cytosolic Pellino-1-Mediated K63-Linked Ubiquitination of IRF5 in M1 Macrophages Regulates Glucose Intolerance in Obesity
inferred← citeshttps://doi.org/10.1016/j.expneurol.2026.115804openalex-snapshot
STING-GDF15-STAT3 signaling contributes to neuroinflammation after intracerebral hemorrhage
inferred← citeshttps://doi.org/10.1016/j.immuni.2014.11.013openalex-snapshot
The E3 Ubiquitin Ligase Pellino3 Protects against Obesity-Induced Inflammation and Insulin Resistance
inferred← citeshttps://doi.org/10.1016/j.intimp.2016.11.013openalex-snapshot
Regulation of T helper cell differentiation by E3 ubiquitin ligases and deubiquitinating enzymes
inferred← citeshttps://doi.org/10.1016/j.intimp.2023.109717openalex-snapshot
Neuroprotective effect of Vesatolimod in an experimental autoimmune encephalomyelitis mice model
inferred← citeshttps://doi.org/10.1016/j.jaci.2022.12.823openalex-snapshot
Pellino-1 promotes intrinsic activation of skin-resident IL-17A–producing T cells in psoriasis
inferred← citeshttps://doi.org/10.1016/j.jneuroim.2019.03.012openalex-snapshot
Toll-like receptors in the pathogenesis of neuroinflammation
inferred← citeshttps://doi.org/10.1016/j.jprot.2018.07.018openalex-snapshot
Label-free quantitative proteomics of rat hypothalamus under fever induced by LPS and PGE2
inferred← citeshttps://doi.org/10.1016/j.jri.2018.04.003openalex-snapshot
Pellino 1 is a novel regulator of TNF and TLR signalling in human myometrial and amnion cells
inferred← citeshttps://doi.org/10.1016/j.jsbmb.2026.106948openalex-snapshot
E3 ubiquitin ligase PELI1 promotes ferroptosis in granulosa cells in PCOS by degrading Fth1
inferred← citeshttps://doi.org/10.1016/j.metabol.2015.10.009openalex-snapshot
Differential effects of GLP-1 receptor agonist on foam cell formation in monocytes between non-obese and obese subjects
inferred← citeshttps://doi.org/10.1016/j.molcel.2018.05.016openalex-snapshot
PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation
inferred← citeshttps://doi.org/10.1016/j.molimm.2018.08.026openalex-snapshot
Interleukin-33 deficiency exacerbated experimental autoimmune encephalomyelitis with an influence on immune cells and glia cells
inferred← citeshttps://doi.org/10.1016/j.molmed.2019.02.002openalex-snapshot
Ubiquitin Ligases in Cancer Immunotherapy – Balancing Antitumor and Autoimmunity
inferred← citeshttps://doi.org/10.1016/j.mvr.2022.104311openalex-snapshot
Gene therapy with Pellino-1 improves perfusion and decreases tissue loss in Flk-1 heterozygous mice but fails in MAPKAP Kinase-2 knockout murine hind limb ischemia model
inferred← citeshttps://doi.org/10.1016/j.nano.2026.102963openalex-snapshot
Yeast-derived vacuoles as potential therapeutic agents for modulating neuroinflammation in Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.neurol.2023.07.007openalex-snapshot
Emerging autophagic endo-lysosomal targets in the management of Parkinson's disease
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2017.03.034openalex-snapshot
FTY720 (fingolimod) regulates key target genes essential for inflammation in microglial cells as defined by high-resolution mRNA sequencing
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2016.12.002openalex-snapshot
Novel genes in brain tissues of EAE-induced normal and obese mice: Upregulation of metal ion-binding protein genes in obese-EAE mice
inferred← citeshttps://doi.org/10.1016/j.omtn.2018.11.014openalex-snapshot
circARF3 Alleviates Mitophagy-Mediated Inflammation by Targeting miR-103/TRAF3 in Mouse Adipose Tissue
inferred← citeshttps://doi.org/10.1016/j.phrs.2025.107908openalex-snapshot
Exosome-mediated microglia-astrocyte interactions drive neuroinflammation in Parkinson's disease with Peli1 as a potential therapeutic target
inferred← citeshttps://doi.org/10.1016/j.pneurobio.2013.09.002openalex-snapshot
Controversies and evolving new mechanisms in subarachnoid hemorrhage
inferred← citeshttps://doi.org/10.1016/j.taap.2019.03.019openalex-snapshot
MiR-142a-3p and miR-155-5p reduce methamphetamine-induced inflammation: Role of the target protein Peli1
inferred← citeshttps://doi.org/10.1016/j.toxlet.2020.07.028openalex-snapshot
Methamphetamine induced neuroinflammation in mouse brain and microglial cell line BV2: Roles of the TLR4/TRIF/Peli1 signaling axis
inferred← citeshttps://doi.org/10.1016/j.yjmcc.2014.11.006openalex-snapshot
Pellino1-mediated TGF-β1 synthesis contributes to mechanical stress induced cardiac fibroblast activation
inferred← citeshttps://doi.org/10.1021/acschemneuro.2c00623openalex-snapshot
Role of the Peli1–RIPK1 Signaling Axis in Methamphetamine-Induced Neuroinflammation
inferred← citeshttps://doi.org/10.1021/acschemneuro.5b00317openalex-snapshot
Microglia: A Unique Versatile Cell in the Central Nervous System
inferred← citeshttps://doi.org/10.1021/bi5005156openalex-snapshot
The Pellino E3 Ubiquitin Ligases Recognize Specific Phosphothreonine Motifs and Have Distinct Substrate Specificities
inferred← citeshttps://doi.org/10.1038/cr.2016.40openalex-snapshot
Ubiquitin signaling in immune responses
inferred← citeshttps://doi.org/10.1038/ncomms11120openalex-snapshot
Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination
inferred← citeshttps://doi.org/10.1038/ni.3258openalex-snapshot
K33-linked polyubiquitination of Zap70 by Nrdp1 controls CD8+ T cell activation
inferred← citeshttps://doi.org/10.1038/nri3599openalex-snapshot
The roles of Pellino E3 ubiquitin ligases in immunity
inferred← citeshttps://doi.org/10.1038/s41392-020-00312-6openalex-snapshot
Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study
inferred← citeshttps://doi.org/10.1038/s41392-020-00421-2openalex-snapshot
Targeting ubiquitin signaling for cancer immunotherapy
inferred← citeshttps://doi.org/10.1038/s41423-020-00620-5openalex-snapshot
The roles of microglia in viral encephalitis: from sensome to therapeutic targeting
inferred← citeshttps://doi.org/10.1038/s41423-021-00660-5openalex-snapshot
The ubiquitin ligase Peli1 inhibits ICOS and thereby Tfh-mediated immunity
inferred← citeshttps://doi.org/10.1038/s41423-022-00883-0openalex-snapshot
Ferroptosis promotes T-cell activation-induced neurodegeneration in multiple sclerosis
inferred← citeshttps://doi.org/10.1038/s41423-024-01204-3openalex-snapshot
GPR34 senses demyelination to promote neuroinflammation and pathologies
inferred← citeshttps://doi.org/10.1038/s41467-018-03530-3openalex-snapshot
Peli1 negatively regulates noncanonical NF-κB signaling to restrain systemic lupus erythematosus
inferred← citeshttps://doi.org/10.1038/s41467-018-03669-zopenalex-snapshot
The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome
inferred← citeshttps://doi.org/10.1038/s41467-019-12384-2openalex-snapshot
Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24
inferred← citeshttps://doi.org/10.1038/s41467-019-12573-zopenalex-snapshot
BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration
inferred← citeshttps://doi.org/10.1038/s41467-021-21456-1openalex-snapshot
E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3
inferred← citeshttps://doi.org/10.1038/s41598-017-06914-5openalex-snapshot
RNA sequencing reveals resistance of TLR4 ligand-activated microglial cells to inflammation mediated by the selective jumonji H3K27 demethylase inhibitor
inferred← citeshttps://doi.org/10.1038/s41598-019-44573-wopenalex-snapshot
Peli1 controls the survival of dopaminergic neurons through modulating microglia-mediated neuroinflammation
inferred← citeshttps://doi.org/10.1038/s44321-026-00473-xopenalex-snapshot
OTUB1 non-canonically inhibits TAB2 ubiquitination to govern microglia-mediated neuroinflammation
inferred← citeshttps://doi.org/10.1073/pnas.2425537122openalex-snapshot
Multiomics integration prioritizes potential drug targets for multiple sclerosis
inferred← citeshttps://doi.org/10.1074/jbc.m115.640128openalex-snapshot
Pellino-1 Positively Regulates Toll-like Receptor (TLR) 2 and TLR4 Signaling and Is Suppressed upon Induction of Endotoxin Tolerance
inferred← citeshttps://doi.org/10.1074/jbc.m116.771816openalex-snapshot
RANKL cytokine enhances TNF-induced osteoclastogenesis independently of TNF receptor associated factor (TRAF) 6 by degrading TRAF3 in osteoclast precursors
inferred← citeshttps://doi.org/10.1074/jbc.ra118.007150openalex-snapshot
β-Arrestin-1 inhibits glucocorticoid receptor turnover and alters glucocorticoid signaling
inferred← citeshttps://doi.org/10.1080/08820139.2024.2343889openalex-snapshot
Sarm1 Controls the MYD88-Mediated Inflammatory Responses in Inflammatory Bowel Disease via the Regulation of TRAF3 Recruitment
inferred← citeshttps://doi.org/10.1080/14737175.2017.1287564openalex-snapshot
Endogenous repair and development inspired therapy of neurodegeneration in progressive multiple sclerosis
inferred← citeshttps://doi.org/10.1084/jem.20132640openalex-snapshot
TPL2 mediates autoimmune inflammation through activation of the TAK1 axis of IL-17 signaling
inferred← citeshttps://doi.org/10.1084/jem.20171417openalex-snapshot
Macrophage/microglial Ezh2 facilitates autoimmune inflammation through inhibition of Socs3
inferred← citeshttps://doi.org/10.1084/jem.20190377openalex-snapshot
Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis
inferred← citeshttps://doi.org/10.1089/scd.2019.0276openalex-snapshot
TRAF3, a Target of MicroRNA-363-3p, Suppresses Senescence and Regulates the Balance Between Osteoblastic and Adipocytic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells
inferred← citeshttps://doi.org/10.1093/brain/awaa090openalex-snapshot
Microglial exosomes facilitate α-synuclein transmission in Parkinson’s disease
inferred← citeshttps://doi.org/10.1093/infdis/jiw279openalex-snapshot
Endotoxin Tolerance Inhibits Degradation of Tumor Necrosis Factor Receptor–Associated Factor 3 by Suppressing Pellino 1 Expression and the K48 Ubiquitin Ligase Activity of Cellular Inhibitor of Apoptosis Protein 2
inferred← citeshttps://doi.org/10.1093/jleuko/qiac012openalex-snapshot
Peli1 deletion in macrophages attenuates myocardial ischemia/reperfusion injury by suppressing M1 polarization
inferred← citeshttps://doi.org/10.1101/2024.09.26.24314450openalex-snapshot
Multi-omics integration prioritizes potential drug targets for multiple sclerosis
inferred← citeshttps://doi.org/10.1101/334433openalex-snapshot
Pellino 1 Communicates Intercellular Signaling in Chronic Skin Inflammatory Microenvironment
inferred← citeshttps://doi.org/10.1111/bph.70175openalex-snapshot
E3 ubiquitin ligase Pellino1 suppresses acinar cell necroptosis and alleviates severe acute pancreatitis by promoting ubiquitin‐dependent receptor‐interacting protein kinase 3 (RIP3) degradation
inferred← citeshttps://doi.org/10.1111/cns.12557openalex-snapshot
The E3 Ubiquitin Ligase c‐Cbl Inhibits Microglia‐Mediated CNS Inflammation by Regulating PI 3K/Akt/ NF ‐ κ B Pathway
inferred← citeshttps://doi.org/10.1111/imm.12177openalex-snapshot
Can we switch microglia's phenotype to foster neuroprotection? Focus on multiple sclerosis
inferred← citeshttps://doi.org/10.1111/imr.12298openalex-snapshot
E3 ubiquitin ligases Pellinos as regulators of pattern recognition receptor signaling and immune responses
inferred← citeshttps://doi.org/10.1111/imr.12299openalex-snapshot
TRAF 3, ubiquitination, and B‐lymphocyte regulation
inferred← citeshttps://doi.org/10.1111/imr.12306openalex-snapshot
Molecular and physiological roles of Pellino E3 ubiquitin ligases in immunity
inferred← citeshttps://doi.org/10.1111/imr.12311openalex-snapshot
Targeting signaling factors for degradation, an emerging mechanism for TRAF functions
inferred← citeshttps://doi.org/10.1111/jcmm.14053openalex-snapshot
Leonurine suppresses neuroinflammation through promoting oligodendrocyte maturation
inferred← citeshttps://doi.org/10.1111/jnc.13714openalex-snapshot
Atf6α deficiency suppresses microglial activation and ameliorates pathology of experimental autoimmune encephalomyelitis
inferred← citeshttps://doi.org/10.1111/jnc.14294openalex-snapshot
Ndrg2 deficiency ameliorates neurodegeneration in experimental autoimmune encephalomyelitis
inferred← citeshttps://doi.org/10.1111/nyas.12841openalex-snapshot
Pathological differences between white and grey matter multiple sclerosis lesions
inferred← citeshttps://doi.org/10.1113/ep088708openalex-snapshot
MiR‐92b‐3p regulates oxygen and glucose deprivation–reperfusion‐mediated apoptosis and inflammation by targeting TRAF3 in PC12 cells
inferred← citeshttps://doi.org/10.1126/sciadv.abh0609openalex-snapshot
Microglia promote autoimmune inflammation via the noncanonical NF-κB pathway
inferred← citeshttps://doi.org/10.1155/2020/3582648openalex-snapshot
miR‐21 and Pellino‐1 Expression Profiling in Autoimmune Premature Ovarian Insufficiency
inferred← citeshttps://doi.org/10.1155/2022/7657995openalex-snapshot
miR-590-5p Overexpression Alleviates β-Amyloid-Induced Neuron Damage via Targeting Pellino-1
inferred← citeshttps://doi.org/10.1161/circulationaha.120.045765openalex-snapshot
Extracellular Vesicle–Mediated Delivery of Circular RNA SCMH1 Promotes Functional Recovery in Rodent and Nonhuman Primate Ischemic Stroke Models
inferred← citeshttps://doi.org/10.1161/hypertensionaha.124.23542openalex-snapshot
Peli1 Deficiency in Macrophages Attenuates Pulmonary Hypertension by Enhancing Foxp1-Mediated Transcriptional Inhibition of IL-6
inferred← citeshttps://doi.org/10.1161/jaha.117.007601openalex-snapshot
Disruption of VEGF Mediated Flk‐1 Signaling Leads to a Gradual Loss of Vessel Health and Cardiac Function During Myocardial Infarction: Potential Therapy With Pellino‐1
inferred← citeshttps://doi.org/10.1172/jci121901openalex-snapshot
TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation
inferred← citeshttps://doi.org/10.1172/jci66947openalex-snapshot
Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation
inferred← citeshttps://doi.org/10.1172/jci99902openalex-snapshot
Peli1 facilitates virus replication and promotes neuroinflammation during West Nile virus infection
inferred← citeshttps://doi.org/10.1177/0300060520921671openalex-snapshot
Inflammation as a risk factor for stroke in atrial fibrillation: data from a microarray data analysis
inferred← citeshttps://doi.org/10.1177/0961203315571463openalex-snapshot
Association of PELI1 polymorphisms in systemic lupus erythematosus susceptibility in a Chinese population
inferred← citeshttps://doi.org/10.1177/21925682251406197openalex-snapshot
miR-369-3p Regulates Microglia Polarization and Neuroinflammation in Traumatic Spinal Cord Injury by Targeting PELI1
inferred← citeshttps://doi.org/10.1182/blood-2014-11-610717openalex-snapshot
EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice
inferred← citeshttps://doi.org/10.1186/s12974-016-0644-1openalex-snapshot
Transcriptome sequencing reveals that LPS-triggered transcriptional responses in established microglia BV2 cell lines are poorly representative of primary microglia
inferred← citeshttps://doi.org/10.1186/s12974-018-1143-3openalex-snapshot
Increased A20-E3 ubiquitin ligase interactions in bid-deficient glia attenuate TLR3- and TLR4-induced inflammation
inferred← citeshttps://doi.org/10.1186/s12974-019-1443-2openalex-snapshot
The role of microglia in viral encephalitis: a review
inferred← citeshttps://doi.org/10.1186/s12974-020-01754-zopenalex-snapshot
Pellino1 regulates neuropathic pain as well as microglial activation through the regulation of MAPK/NF-κB signaling in the spinal cord
inferred← citeshttps://doi.org/10.1186/s13148-019-0787-xopenalex-snapshot
Methylomic profiling in trisomy 21 identifies cognition- and Alzheimer’s disease-related dysregulation
inferred← citeshttps://doi.org/10.1186/s13578-015-0024-zopenalex-snapshot
Peli1 negatively regulates type I interferon induction and antiviral immunity in the CNS
inferred← citeshttps://doi.org/10.1189/jlb.2mr0316-117rropenalex-snapshot
Molecular mechanisms of regulation of Toll-like receptor signaling
inferred← citeshttps://doi.org/10.12688/f1000research.16439.1openalex-snapshot
Recent advances in understanding inhibitor of apoptosis proteins
inferred← citeshttps://doi.org/10.1302/2046-3758.122.bjr-2022-0214.r1openalex-snapshot
Decreased Peli1 expression attenuates osteoarthritis by protecting chondrocytes and inhibiting M1-polarization of macrophages
inferred← citeshttps://doi.org/10.1371/journal.pbio.3000837openalex-snapshot
Peli1 impairs microglial Aβ phagocytosis through promoting C/EBPβ degradation
inferred← citeshttps://doi.org/10.1371/journal.ppat.1008538openalex-snapshot
Peli1 signaling blockade attenuates congenital zika syndrome
inferred← citeshttps://doi.org/10.1515/bmc-2017-0008openalex-snapshot
Role of TRAF3 in neurological and cardiovascular diseases: an overview of recent studies
inferred← citeshttps://doi.org/10.1523/jneurosci.2510-14.2015openalex-snapshot
Inflammasome-Induced IL-1β Secretion in Microglia Is Characterized by Delayed Kinetics and Is Only Partially Dependent on Inflammatory Caspases
inferred← citeshttps://doi.org/10.15252/emmm.201404653openalex-snapshot
Inhibition of lethal inflammatory responses through the targeting of membrane‐associated Toll‐like receptor 4 signaling complexes with a Smad6‐derived peptide
inferred← citeshttps://doi.org/10.15252/emmm.201708743openalex-snapshot
P2X4 receptor controls microglia activation and favors remyelination in autoimmune encephalitis
inferred← citeshttps://doi.org/10.18130/v3h31copenalex-snapshot
Microglial LRP1 modulates neuroinflammation via control of the NF-κB pathway in autoimmunity
inferred← citeshttps://doi.org/10.18632/oncotarget.9619openalex-snapshot
Pellino-1 confers chemoresistance in lung cancer cells by upregulating cIAP2 through Lys63-mediated polyubiquitination
inferred← citeshttps://doi.org/10.21203/rs.3.rs-10057610/v1openalex-snapshot
Single-Cell RNA-Sequencing Data Analysis and Identification of Potential Genes Associated with Pathogenesis and Prognosis of IgA Nephropathy
inferred← citeshttps://doi.org/10.21203/rs.3.rs-4021601/v2openalex-snapshot
Uptake of alpha-synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microglia
inferred← citeshttps://doi.org/10.2147/jir.s399021openalex-snapshot
Circulating Leukocyte as an Inflammatory Biomarker: Association with Fibrinogen and Neuronal Damage in Acute Ischemic Stroke
inferred← citeshttps://doi.org/10.2147/jir.s76707openalex-snapshot
Translational utility of experimental autoimmune encephalomyelitis: recent developments
inferred← citeshttps://doi.org/10.2174/157339551501190307091314openalex-snapshot
Meet Our Editorial Board Member
inferred← citeshttps://doi.org/10.3389/fcimb.2022.839625openalex-snapshot
TRAF3 Positively Regulates Host Innate Immune Resistance to Influenza A Virus Infection
inferred← citeshttps://doi.org/10.3389/fimmu.2018.01849openalex-snapshot
Tumor Necrosis Factor Receptor-Associated Factor Regulation of Nuclear Factor κB and Mitogen-Activated Protein Kinase Pathways
inferred← citeshttps://doi.org/10.3389/fimmu.2019.01107openalex-snapshot
Immune Control by TRAF6-Mediated Pathways of Epithelial Cells in the EIME (Epithelial Immune Microenvironment)
inferred← citeshttps://doi.org/10.3389/fimmu.2022.1065211openalex-snapshot
Viruses utilize ubiquitination systems to escape TLR/RLR-mediated innate immunity
inferred← citeshttps://doi.org/10.3389/fimmu.2022.728794openalex-snapshot
The Emerging Roles of Pellino Family in Pattern Recognition Receptor Signaling
inferred← citeshttps://doi.org/10.3389/fimmu.2023.1120710openalex-snapshot
E3-ubiquitin ligases and recent progress in osteoimmunology
inferred← citeshttps://doi.org/10.3389/fimmu.2023.1292022openalex-snapshot
Biology of Pellino1: a potential therapeutic target for inflammation in diseases and cancers
inferred← citeshttps://doi.org/10.3389/fncel.2018.00225openalex-snapshot
Rosuvastatin Reduces Neuroinflammation in the Hemorrhagic Transformation After rt-PA Treatment in a Mouse Model of Experimental Stroke
inferred← citeshttps://doi.org/10.3389/fncel.2020.00269openalex-snapshot
Dynamic Responses of Microglia in Animal Models of Multiple Sclerosis
inferred← citeshttps://doi.org/10.3389/fnmol.2017.00398openalex-snapshot
Peli1 Contributions in Microglial Activation, Neuroinflammatory Responses and Neurological Deficits Following Experimental Subarachnoid Hemorrhage
inferred← citeshttps://doi.org/10.3390/app13095553openalex-snapshot
Exploring Promising Biomarkers for Alzheimer’s Disease through the Computational Analysis of Peripheral Blood Single-Cell RNA Sequencing Data
inferred← citeshttps://doi.org/10.3390/biom12020322openalex-snapshot
Cytoplasmic and Nuclear Functions of cIAP1
inferred← citeshttps://doi.org/10.3390/biom13060922openalex-snapshot
Microglia NLRP3 Inflammasome and Neuroimmune Signaling in Substance Use Disorders
inferred← citeshttps://doi.org/10.3390/biomedicines10040840openalex-snapshot
The Role of Osteopontin in Microglia Biology: Current Concepts and Future Perspectives
inferred← citeshttps://doi.org/10.3390/brainsci3031109openalex-snapshot
Astrocyte Regulation of CNS Inflammation and Remyelination
inferred← citeshttps://doi.org/10.3390/cells11132014openalex-snapshot
The E3 Ubiquitin Ligase Peli1 Deficiency Promotes Atherosclerosis Progression
inferred← citeshttps://doi.org/10.3390/cells11233938openalex-snapshot
Mushroom Natural Products in Neurodegenerative Disease Drug Discovery
inferred← citeshttps://doi.org/10.3390/cells8020094openalex-snapshot
Expression of Translocator Protein and [18F]-GE180 Ligand Uptake in Multiple Sclerosis Animal Models
inferred← citeshttps://doi.org/10.3390/cells8070739openalex-snapshot
Anti-Neuroinflammatory Effect of Alantolactone through the Suppression of the NF-κB and MAPK Signaling Pathways
inferred← citeshttps://doi.org/10.3390/cells9051118openalex-snapshot
IAP-Mediated Protein Ubiquitination in Regulating Cell Signaling
inferred← citeshttps://doi.org/10.3390/cells9071717openalex-snapshot
Microglia: Agents of the CNS Pro-Inflammatory Response
inferred← citeshttps://doi.org/10.3390/ijms23074018openalex-snapshot
Neurotropic RNA Virus Modulation of Immune Responses within the Central Nervous System
inferred← citeshttps://doi.org/10.3390/ijms25031438openalex-snapshot
TonEBP: A Key Transcription Factor in Microglia Following Intracerebral Hemorrhage Induced-Neuroinflammation
inferred← citeshttps://doi.org/10.3390/pathogens8040215openalex-snapshot
West Nile Virus Induced Cell Death in the Central Nervous System
inferred← citeshttps://doi.org/10.3390/v13102065openalex-snapshot
Toll-like Receptors in Viral Encephalitis
inferred← citeshttps://doi.org/10.3390/v15071422openalex-snapshot
Pellino Proteins in Viral Immunity and Pathogenesis
inferred← citeshttps://doi.org/10.3410/f.736510279.793564690openalex-snapshot
Faculty Opinions recommendation of Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis.
inferred← citeshttps://doi.org/10.3724/abbs.2023089openalex-snapshot
Obesity-induced inflammatory miR-133a mediates apoptosis of granulosa cells and causes abnormal folliculogenesis
inferred← citeshttps://doi.org/10.3803/enm.2015.30.1.35openalex-snapshot
NF-κB-Mediated Regulation of Osteoclastogenesis
inferred← citeshttps://doi.org/10.3803/enm.2023.501openalex-snapshot
Nuclear Factor-Kappa B Regulation of Osteoclastogenesis and Osteoblastogenesis
inferred← citeshttps://doi.org/10.3892/mmr.2019.10488openalex-snapshot
MicroRNA‑671‑3p regulates the development of knee osteoarthritis by targeting TRAF3 in chondrocytes
inferred← citeshttps://doi.org/10.3892/ol.2016.4653openalex-snapshot
Long noncoding RNA are aberrantly expressed in human papillary thyroid carcinoma
inferred← citeshttps://doi.org/10.4045/tidsskr.13.0560openalex-snapshot
Inflammasjonsprosessen ved multippel sklerose kartlegges
inferred← citeshttps://doi.org/10.4049/jimmunol.1502146openalex-snapshot
LincRNA-Cox2 Promotes Late Inflammatory Gene Transcription in Macrophages through Modulating SWI/SNF-Mediated Chromatin Remodeling
inferred← citeshttps://doi.org/10.4049/jimmunol.2100236openalex-snapshot
Dendritic Cell–Specific Role for Pellino2 as a Mediator of TLR9 Signaling Pathway
inferred← citeshttps://doi.org/10.4103/nrr.nrr-d-24-01262openalex-snapshot
Brain-derived extracellular vesicles: A promising avenue for Parkinson’s disease pathogenesis, diagnosis, and treatment
inferred← citeshttps://doi.org/10.4110/in.2019.19.e32openalex-snapshot
Ubiquitin E3 Ligase Pellino-1 Inhibits IL-10-mediated M2c Polarization of Macrophages, Thereby Suppressing Tumor Growth
inferred← citeshttps://doi.org/10.4172/jpb.1000408openalex-snapshot
The Brain Proteome of the Ubiquitin Ligase Peli1 Knock-Out Mouse during Experimental Autoimmune Encephalomyelitis
inferred← citeshttps://doi.org/10.5772/intechopen.100203openalex-snapshot
Microglia, TREM2, and Therapeutic Methods of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.6084/m9.figshare.11986095openalex-snapshot
Additional file 1 of Pellino1 regulates neuropathic pain as well as microglial activation through the regulation of MAPK/NF-κB signaling in the spinal cord
inferred← citeshttps://doi.org/10.6084/m9.figshare.11986101openalex-snapshot
Additional file 2 of Pellino1 regulates neuropathic pain as well as microglial activation through the regulation of MAPK/NF-κB signaling in the spinal cord
inferred← citeshttps://doi.org/10.6084/m9.figshare.11986110openalex-snapshot
Additional file 3 of Pellino1 regulates neuropathic pain as well as microglial activation through the regulation of MAPK/NF-κB signaling in the spinal cord
inferred← citeshttps://doi.org/10.7717/peerj.14871openalex-snapshot
The imbalance of liver resident macrophages polarization promotes chronic autoimmune hepatitis development in mice
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