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Multi-Omics Integration Prioritizes Potential Drug Targets for Multiple Sclerosis

https://doi.org/10.2139/ssrn.4948512
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Disease-Modifying Treatment in Progressive Multiple Sclerosis
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The Genetic Architecture of Gene Expression in Peripheral Blood
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Metabolomic analysis identifies altered metabolic pathways in Multiple Sclerosis
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The microglial innate immune protein PGLYRP1 mediates neuroinflammation and consequent behavioral changes
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Identification of novel drug targets for multiple sclerosis by integrating plasma genetics and proteomes
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Natural killer cells in multiple sclerosis: A review
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Integrating genetic and proteomic data to elucidate the association between immune system and blood-brain barrier dysfunction with multiple sclerosis risk and severity
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Meta-analysis of the relationship between homocysteine, vitamin B12, folate, and multiple sclerosis
inferredcites →https://doi.org/10.1016/j.lpm.2021.104068openalex-extracted
Update on treatment in multiple sclerosis
inferredcites →https://doi.org/10.1016/j.msard.2022.103515openalex-extracted
Role of interleukin-17 signaling pathway in the interaction between multiple sclerosis and acute myocardial infarction
inferredcites →https://doi.org/10.1038/nature06559openalex-extracted
Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets
inferredcites →https://doi.org/10.1038/nchembio.2576openalex-extracted
How many human proteoforms are there?
inferredcites →https://doi.org/10.1038/ng.3395openalex-extracted
Class II HLA interactions modulate genetic risk for multiple sclerosis
inferredcites →https://doi.org/10.1038/ng.3538openalex-extracted
Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets
inferredcites →https://doi.org/10.1038/ni.1678openalex-extracted
Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling
inferredcites →https://doi.org/10.1038/nm.3111openalex-extracted
Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation
inferredcites →https://doi.org/10.1038/nrd4309openalex-extracted
Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework
inferredcites →https://doi.org/10.1038/nrg.2016.12openalex-extracted
The genetics of drug efficacy: opportunities and challenges
inferredcites →https://doi.org/10.1038/s41573-019-0036-1openalex-extracted
Lysosomes as a therapeutic target
inferredcites →https://doi.org/10.1038/s41579-022-00770-5openalex-extracted
Epstein–Barr virus and multiple sclerosis
inferredcites →https://doi.org/10.1038/s41588-020-00773-zopenalex-extracted
Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer’s disease pathogenesis
inferredcites →https://doi.org/10.1038/s41588-022-01051-wopenalex-extracted
Plasma proteome analyses in individuals of European and African ancestry identify cis-pQTLs and models for proteome-wide association studies
inferredcites →https://doi.org/10.1038/s41588-022-01154-4openalex-extracted
Genetic control of RNA splicing and its distinct role in complex trait variation
inferredcites →https://doi.org/10.1038/s41590-023-01645-4openalex-extracted
Targeting PGLYRP1 promotes antitumor immunity while inhibiting autoimmune neuroinflammation
inferredcites →https://doi.org/10.1093/bioinformatics/btu416openalex-extracted
Fast and accurate imputation of summary statistics enhances evidence of functional enrichment
inferredcites →https://doi.org/10.1093/brain/awac420openalex-extracted
Novel plasma and brain proteins that are implicated in multiple sclerosis
inferredcites →https://doi.org/10.1093/brain/awad070openalex-extracted
Potential drug targets for multiple sclerosis identified through Mendelian randomization analysis
inferredcites →https://doi.org/10.1093/brain/awad363openalex-extracted
Impact of multiple sclerosis risk alleles on the plasma proteome
inferredcites →https://doi.org/10.1093/braincomms/fcaa119openalex-extracted
Summary-data-based Mendelian randomization prioritizes potential druggable targets for multiple sclerosis
inferredcites →https://doi.org/10.1093/nutrit/nuad091openalex-extracted
A comprehensive review and meta-regression analysis of randomized controlled trials examining the impact of vitamin B12 supplementation on homocysteine levels
inferredcites →https://doi.org/10.1126/science.aav7188openalex-extracted
Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility
inferredcites →https://doi.org/10.1126/sciimmunol.abn3800openalex-extracted
Immunodeficiency, autoimmunity, and increased risk of B cell malignancy in humans with TRAF3 mutations
inferredcites →https://doi.org/10.1128/mcb.19.3.1720openalex-extracted
Correlation between Protein and mRNA Abundance in Yeast
inferredcites →https://doi.org/10.1134/s0006297924030143openalex-extracted
Association of Increased Homocysteine Levels with Impaired Folate Metabolism and Vitamin B Deficiency in Early-Onset Multiple Sclerosis
inferredcites →https://doi.org/10.1186/s12967-015-0537-6openalex-extracted
Capillary nano-immunoassays: advancing quantitative proteomics analysis, biomarker assessment, and molecular diagnostics
inferredcites →https://doi.org/10.1186/s12974-020-01840-2openalex-extracted
Impact of cytomegalovirus infection on B cell differentiation and cytokine production in multiple sclerosis
inferredcites →https://doi.org/10.1186/s13104-019-4343-8openalex-extracted
Human protein-coding genes and gene feature statistics in 2019
inferredcites →https://doi.org/10.1186/s13578-022-00810-wopenalex-extracted
Application and prospect of targeting innate immune sensors in the treatment of autoimmune diseases
inferredcites →https://doi.org/10.1201/9780849360237openalex-extracted
Preclinical Drug Development
inferredcites →https://doi.org/10.2174/1573406413666170906123857openalex-extracted
Is there a Link between Vitamin B and Multiple Sclerosis?
inferredcites →https://doi.org/10.3389/fgene.2020.00019openalex-extracted
High-Throughput Transcriptome Profiling in Drug and Biomarker Discovery
inferredcites →https://doi.org/10.3389/fimmu.2018.01254openalex-extracted
Detection of Glycan Shedding in the Blood: New Class of Multiple Sclerosis Biomarkers?
inferredcites →https://doi.org/10.3389/fimmu.2020.00391openalex-extracted
Nuclear Factor κB (NF-κB)–Mediated Inflammation in Multiple Sclerosis
inferredcites →https://doi.org/10.3390/cells9102290openalex-extracted
Re-Examining the Role of TNF in MS Pathogenesis and Therapy
inferredcites →https://doi.org/10.3390/ijms23095162openalex-extracted
Proteomics in Multiple Sclerosis: The Perspective of the Clinician
inferredcites →https://doi.org/10.3390/ijms25010590openalex-extracted
Vitamin B12 Deficiency and the Nervous System: Beyond Metabolic Decompensation—Comparing Biological Models and Gaining New Insights into Molecular and Cellular Mechanisms
inferredcites →https://doi.org/10.7150/ijms.42058openalex-extracted
Serum levels of Homocysteine, Vitamin B12 and Folate in Patients with Multiple Sclerosis: an Updated Meta-Analysis
inferredcites →https://doi.org/10.7762/cnr.2019.8.1.36openalex-extracted
The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis
inferredcites →https://doi.org/10.17863/cam.93768openalex-snapshot
Immunodeficiency, autoimmunity, and increased risk of B cell malignancy in humans with TRAF3 mutations.
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