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Challenges in tuberculosis drug research and development

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1016/s0140-6736(02)09742-8openalex-snapshot
Rifapentine and isoniazid once a week versus rifampicin and isoniazid twice a week for treatment of drug-susceptible pulmonary tuberculosis in HIV-negative patients: a randomised clinical trial
inferredcites →https://doi.org/10.1016/s0140-6736(06)68384-0openalex-snapshot
Global epidemiology of tuberculosis
inferredcites →https://doi.org/10.1016/s0140-6736(06)69573-1openalex-snapshot
Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa
inferredcites →https://doi.org/10.1038/35016103openalex-snapshot
A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis
inferredcites →https://doi.org/10.1054/tube.2001.0288openalex-snapshot
Foreword from the Co-Editor-in-Chief
inferredcites →https://doi.org/10.1056/nejmoa055191openalex-snapshot
Outpatient Gatifloxacin Therapy and Dysglycemia in Older Adults
inferredcites →https://doi.org/10.1073/pnas.0508392103openalex-snapshot
Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis
inferredcites →https://doi.org/10.1086/505877openalex-snapshot
Global Incidence of Multidrug‐Resistant Tuberculosis
inferredcites →https://doi.org/10.1093/jac/dki319openalex-snapshot
Identification of a new antitubercular drug candidate, SQ109, from a combinatorial library of 1,2-ethylenediamines
inferredcites →https://doi.org/10.1093/jac/dkl227openalex-snapshot
Synergistic interactions of SQ109, a new ethylene diamine, with front-line antitubercular drugs in vitro
inferredcites →https://doi.org/10.1093/jac/dkl260openalex-snapshot
Clinical development of anti-tuberculosis drugs
inferredcites →https://doi.org/10.1097/00002030-200201040-00010openalex-snapshot
Treatment of tuberculosis in HIV-infected persons in the era of highly active antiretroviral therapy
inferredcites →https://doi.org/10.1126/science.1106753openalex-snapshot
A Diarylquinoline Drug Active on the ATP Synthase of Mycobacterium tuberculosis
inferredcites →https://doi.org/10.1136/bmj.1.4769.1162openalex-snapshot
Chemotherapy of Pulmonary Tuberculosis in Young Adults
inferredcites →https://doi.org/10.1136/bmj.2.4582.769openalex-snapshot
Streptomycin Treatment of Pulmonary Tuberculosis: A Medical Research Council Investigation
inferredcites →https://doi.org/10.1164/ajrccm.156.3.9609132openalex-snapshot
The Early Bactericidal Activity of Isoniazid Related to Its Dose Size in Pulmonary Tuberculosis
inferredcites →https://doi.org/10.1164/rccm.200407-885ocopenalex-snapshot
Moxifloxacin-containing Regimens of Reduced Duration Produce a Stable Cure in Murine Tuberculosis
inferredcites →https://doi.org/10.1164/rccm.200603-360ocopenalex-snapshot
Moxifloxacin versus Ethambutol in the First 2 Months of Treatment for Pulmonary Tuberculosis

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Myths, Realities and Prejudices about Factors Associated with Loss to Follow Up, Relapse and Treatment Failure in Tuberculosis Patients A Qualitative Study
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Stable Alkynyl Glycosyl Carbonates: Catalytic Anomeric Activation and Synthesis of a Tridecasaccharide Reminiscent of Mycobacterium tuberculosis Cell Wall Lipoarabinomannan
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Stable Alkynyl Glycosyl Carbonates: Catalytic Anomeric Activation and Synthesis of a Tridecasaccharide Reminiscent of Mycobacterium tuberculosis Cell Wall Lipoarabinomannan
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Identification of small molecular inhibitors for efflux protein Rv2688c of Mycobacterium tuberculosis
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Azaaurones as Potent Antimycobacterial Agents Active against MDR‐ and XDR‐TB
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Natural products and their analogues acting against Mycobacterium tuberculosis : A recent update
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Functionalized Polydopamine Nanoparticles: A Promising Drug Delivery Platform for the Treatment of Tuberculosis
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An overview of new antitubercular drugs, drug candidates, and their targets
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Pretomanid dose selection for pulmonary tuberculosis: An application of multi‐objective optimization to dosage regimen design
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Drug Resistant and Persistent Tuberculosis: Mechanisms and Drug Development
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Mycobacterium tuberculosis in Transplantation
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Mycobacterium tuberculosis in Transplantation
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Tuberculosis: Integrated Studies for a Complex Disease 2050
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Neue Ansätze in der Therapie der Tuberkulose
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Computer-assisted combinatorial design of bicyclic thymidine analogs as inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase
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In vitro antituberculosis activity of diterpenoids from the Vietnamese medicinal plant Croton tonkinensis
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Reverse vaccinology approach to design a multi-epitope vaccine construct based on the Mycobacterium tuberculosis biomarker PE_PGRS17
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Prevention and control strategies for antibiotic resistance: from species to community level
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Nonfluoroquinolone-Based Inhibitors of Mycobacterial Type II Topoisomerase as Potential Therapeutic Agents for TB
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Drug combinations: A strategy to extend the life of antimicrobials
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Structure and Biosynthesis of the Mycobacterial Cell Wall
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Rapid screening drug susceptibility test in tuberculosis using sandwich electrochemical immunosensor
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Nickel impact on human health: An intrinsic disorder perspective
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An ArsR-like transcriptional factor recognizes a conserved sequence motif and positively regulates the expression of phoP in mycobacteria
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Inhibition of mycobacterial alanine racemase activity and growth by thiadiazolidinones
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Cell wall: A versatile fountain of drug targets in Mycobacterium tuberculosis
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Recent therapeutic approaches for the management of tuberculosis: Challenges and opportunities
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Drug targets exploited in Mycobacterium tuberculosis: Pitfalls and promises on the horizon
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Evaluation of NTF1836 as an inhibitor of the mycothiol biosynthetic enzyme MshC in growing and non-replicating Mycobacterium tuberculosis
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Inhibition of Mycobacterium tuberculosis strains H37Rv and MDR MS-115 by a new set of C5 modified pyrimidine nucleosides
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A novel synthesis of 2-arylbenzimidazoles in molecular sieves-MeOH system and their antitubercular activity
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Synthesis and antitubercular evaluation of amidoalkyl dibenzofuranols and 1H-benzo[2,3]benzofuro[4,5-e][1,3]oxazin-3(2H)-ones
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Novel inhibitors of Mycobacterium tuberculosis dTDP-6-deoxy-l-lyxo-4-hexulose reductase (RmlD) identified by virtual screening
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Synthesis and binary QSAR study of antitubercular quinolylhydrazides
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Recent advancements in the development of anti-tuberculosis drugs
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Toward an Optimized Therapy for Tuberculosis? Drugs in Clinical Trials and in Preclinical Development
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Genome-wide Analysis of the Host Intracellular Network that Regulates Survival of Mycobacterium tuberculosis
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Recent progress in the drug development of coumarin derivatives as potent antituberculosis agents
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Mycobacterium Tuberculosis (MTB) GyrB inhibitors: An attractive approach for developing novel drugs against TB
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Chitosan nanoparticles as a promising approach for pulmonary delivery of bedaquiline
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Structure based identification of novel inhibitors against ATP synthase of Mycobacterium tuberculosis: A combined in silico and in vitro study
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Factors contributing to non-adherence with treatment among TB patients in Sodo Woreda, Gurage Zone, Southern Ethiopia: A qualitative study
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Low plasma levels of cholecalciferol and 13-cis-retinoic acid in tuberculosis: Implications in host-based chemotherapy
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An update on ATP synthase inhibitors: A unique target for drug development in M. tuberculosis
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T lymphocyte surface expression of exhaustion markers as biomarkers of the efficacy of chemotherapy for tuberculosis
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Differential expression of efflux pump genes of Mycobacterium tuberculosis in response to varied subinhibitory concentrations of antituberculosis agents
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The rise of companies from emerging markets in global health governance: Opportunities and challenges
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Tuberculosis Drug Discovery: Challenges and New Horizons
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Influence of Steric Crowding on Diastereoselective Arabinofuranosylations
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First-in-Class Inhibitors of Sulfur Metabolism with Bactericidal Activity against Non-ReplicatingM. tuberculosis
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Immunotherapeutic Role of NOD-2 and TLR-4 Signaling as an Adjunct to Antituberculosis Chemotherapy
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Adsorption of Isoniazid on Aluminum Silicate Tubular Structures
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Atomic-Level Structures Reveal How a Repurposed 3-Aminopyrazine-2-carboxamide Scaffold Inhibits Mycobacterium tuberculosis Prolyl-tRNA Synthetase
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Global Bayesian Models for the Prioritization of Antitubercular Agents
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One-Pot Assembly of Mannose-Capped Lipoarabinomannan Motifs up to 101-Mer from the Mycobacterium tuberculosis Cell Wall
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Natural Products, Small Molecules, and Genetics in Tuberculosis Drug Development
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Design, Synthesis, and Structure–Activity Correlations of Novel Dibenzo[b,d]furan, Dibenzo[b,d]thiophene, and N-Methylcarbazole Clubbed 1,2,3-Triazoles as Potent Inhibitors of Mycobacterium tuberculosis
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Facile Synthesis of β- and α-Arabinofuranosides and Application to Cell Wall Motifs of M. tuberculosis
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Metabolomic Signatures in Guinea Pigs Infected with Epidemic-Associated W-Beijing Strains of Mycobacterium tuberculosis
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Inhalation of recombinant adenovirus expressing granulysin protects mice infected with Mycobacterium tuberculosis
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[Au]/[Ag]-catalysed expedient synthesis of branched heneicosafuranosyl arabinogalactan motif of Mycobacterium tuberculosis cell wall
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Drugs versus bugs: in pursuit of the persistent predator Mycobacterium tuberculosis
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Characterization of programmed cell death pathways activated in Mycobacterium tuberculosis-infected human macrophages
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Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems
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A first-in-class leucyl-tRNA synthetase inhibitor, ganfeborole, for rifampicin-susceptible tuberculosis: a phase 2a open-label, randomized trial
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PLAS-5k: Dataset of Protein-Ligand Affinities from Molecular Dynamics for Machine Learning Applications
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Designing novel possible kinase inhibitor derivatives as therapeutics against Mycobacterium tuberculosis: An in silico study
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In vitro anti-tuberculosis effect of probiotic Lacticaseibacillus rhamnosus PMC203 isolated from vaginal microbiota
inferred← citeshttps://doi.org/10.1038/s41598-024-63051-6openalex-snapshot
Discovery of potent antimycobacterial agents targeting lumazine synthase (RibH) of Mycobacterium tuberculosis
inferred← citeshttps://doi.org/10.1038/s44259-026-00238-zopenalex-snapshot
Antimicrobial peptides for tuberculosis in a post-antibiotic era: from in vitro promise to therapeutic potential
inferred← citeshttps://doi.org/10.1038/srep11910openalex-snapshot
Proteasome Accessory Factor C (pafC) Is a novel gene Involved in Mycobacterium Intrinsic Resistance to broad-spectrum antibiotics - Fluoroquinolones
inferred← citeshttps://doi.org/10.1039/b906682aopenalex-snapshot
Bacterial metal-sensing proteins exemplified by ArsR–SmtB family repressors
inferred← citeshttps://doi.org/10.1039/c0cc05635aopenalex-snapshot
Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads
inferred← citeshttps://doi.org/10.1039/c1mb05106gopenalex-snapshot
Modeling synergistic drug inhibition of Mycobacterium tuberculosis growth in murine macrophages
inferred← citeshttps://doi.org/10.1039/c3ob41896kopenalex-snapshot
Inhibition studies on Mycobacterium tuberculosis N-acetylglucosamine-1-phosphate uridyltransferase (GlmU)
inferred← citeshttps://doi.org/10.1039/c3ra43755hopenalex-snapshot
Design, synthesis, and preliminary biological evaluation of novel ketone derivatives of shikimic acid
inferred← citeshttps://doi.org/10.1039/d5ra03641kopenalex-snapshot
Isoniazid–rhodanine molecular hybrids: design, synthesis, antimycobacterial activity and computational validation
inferred← citeshttps://doi.org/10.1042/bj20080466openalex-snapshot
Characterization of coenzyme binding and selectivity determinants in Mycobacterium tuberculosis flavoprotein reductase A: analysis of Arg199 and Arg200 mutants at the NADP(H) 2′-phosphate binding site
inferred← citeshttps://doi.org/10.1073/pnas.1003219107openalex-snapshot
Mycobacterium tuberculosis persistence mutants identified by screening in isoniazid-treated mice
inferred← citeshttps://doi.org/10.1074/jbc.m112.419069openalex-snapshot
The Naphthoquinone Diospyrin Is an Inhibitor of DNA Gyrase with a Novel Mechanism of Action
inferred← citeshttps://doi.org/10.1074/jbc.m703451200openalex-snapshot
Mycobacterial Cells Have Dual Nickel-Cobalt Sensors
inferred← citeshttps://doi.org/10.1074/jbc.m707535200openalex-snapshot
Interdomain Interaction Reconstitutes the Functionality of PknA, a Eukaryotic Type Ser/Thr Kinase from Mycobacterium tuberculosis
inferred← citeshttps://doi.org/10.1074/jbc.m709672200openalex-snapshot
Three Consecutive Arginines Are Important for the Mycobacterial Peptide Deformylase Enzyme Activity
inferred← citeshttps://doi.org/10.1074/jbc.m805324200openalex-snapshot
Distinct Specificities of Mycobacterium tuberculosis and Mammalian Proteasomes for N-Acetyl Tripeptide Substrates
inferred← citeshttps://doi.org/10.1080/07391102.2023.2226728openalex-snapshot
Copper transporter protein (MctB) as a therapeutic target to elicit antimycobacterial activity against tuberculosis
inferred← citeshttps://doi.org/10.1080/07391102.2023.2245486openalex-snapshot
Computational insights into the role of structurally diverse plant secondary metabolites as inhibitors against Imidazole Glycerol Phosphate Dehydratase of Mycobacterium tuberculosis
inferred← citeshttps://doi.org/10.1080/08927020903033141openalex-snapshot
Comparative QSAR studies of nitrofuranyl amide derivatives using theoretical structural properties
inferred← citeshttps://doi.org/10.1080/1040841x.2022.2035314openalex-snapshot
Biosensors for the detection ofMycobacterium tuberculosis: a comprehensive overview
inferred← citeshttps://doi.org/10.1080/1062936x.2022.2066175openalex-snapshot
Molecular docking-based interactions in QSAR studies on Mycobacterium tuberculosis ATP synthase inhibitors
inferred← citeshttps://doi.org/10.1080/10717544.2022.2089294openalex-snapshot
Emerging strategies in nanotechnology to treat respiratory tract infections: realizing current trends for future clinical perspectives
inferred← citeshttps://doi.org/10.1080/13543776.2022.2012151openalex-snapshot
An updated patent review on drugs for the treatment of tuberculosis (2018-present)
inferred← citeshttps://doi.org/10.1093/femsml/uqae021openalex-snapshot
Pyoverdine–antibiotic combination treatment: its efficacy and effects on resistance evolution in Escherichia coli
inferred← citeshttps://doi.org/10.1093/infdis/jis034openalex-snapshot
New Drugs for the Treatment of Tuberculosis: Needs, Challenges, Promise, and Prospects for the Future
inferred← citeshttps://doi.org/10.1093/infdis/jis425openalex-snapshot
Therapeutic Immunization against Mycobacterium tuberculosis Is an Effective Adjunct to Antibiotic Treatment
inferred← citeshttps://doi.org/10.1093/jac/dkr203openalex-snapshot
Interaction of N-methyl-2-alkenyl-4-quinolones with ATP-dependent MurE ligase of Mycobacterium tuberculosis: antibacterial activity, molecular docking and inhibition kinetics
inferred← citeshttps://doi.org/10.1097/coh.0b013e3282fbaad0openalex-snapshot
Interactions between antiretroviral agents and those used to treat tuberculosis
inferred← citeshttps://doi.org/10.1097/mcp.0b013e328337580copenalex-snapshot
New drugs and new regimens for the treatment of tuberculosis: review of the drug development pipeline and implications for national programmes
inferred← citeshttps://doi.org/10.1097/qad.0b013e3282f7cb4bopenalex-snapshot
Impact of HIV on novel therapies for tuberculosis control
inferred← citeshttps://doi.org/10.1098/rsos.172416openalex-snapshot
Functionalization of 3-chloroformylcoumarin to coumarin Schiff bases using reusable catalyst: an approach to molecular docking and biological studies
inferred← citeshttps://doi.org/10.1099/mic.0.082206-0openalex-snapshot
Mycobacterium tuberculosis adhesins: potential biomarkers as anti-tuberculosis therapeutic and diagnostic targets
inferred← citeshttps://doi.org/10.1101/2023.07.18.549608openalex-snapshot
Elucidation of the essentiality of lumazine synthase (RibH) for Mycobacterium tuberculosis survival and discovery of potent inhibitors for enhanced antimycobacterial therapy
inferred← citeshttps://doi.org/10.1101/2025.11.23.690070openalex-snapshot
Targeting Metabolic Vulnerabilities: Valinomycin Augments the Potency of Bioenergetic Inhibitors in Combatting Drug-Resistant and Dormant Mycobacterium tuberculosis
inferred← citeshttps://doi.org/10.1101/861799openalex-snapshot
Combining antibiotics with antivirulence compounds can have synergistic effects and reverse selection for antibiotic resistance in Pseudomonas aeruginosa
inferred← citeshttps://doi.org/10.1111/ajt.12100openalex-snapshot
Mycobacterium tuberculosis Infections in Solid Organ Transplantation
inferred← citeshttps://doi.org/10.1111/bcp.15908openalex-snapshot
No action is without its side effects: Adverse drug reactions and missed doses of antituberculosis therapy, a scoping review
inferred← citeshttps://doi.org/10.1111/bph.15247openalex-snapshot
Anti‐tuberculosis effect of isoniazid scales accurately from zebrafish to humans
inferred← citeshttps://doi.org/10.1111/cbdd.12527openalex-snapshot
Triazole: A Promising Antitubercular Agent
inferred← citeshttps://doi.org/10.1111/ctr.13513openalex-snapshot
Mycobacterium tuberculosis infections in solid organ transplantation: Guidelines from the infectious diseases community of practice of the American Society of Transplantation
inferred← citeshttps://doi.org/10.1111/j.1399-3062.2008.00332.xopenalex-snapshot
Tuberculosis in transplant recipients: diagnostic and therapeutic dilemmas
inferred← citeshttps://doi.org/10.1111/j.1600-6143.2009.02894.xopenalex-snapshot
Mycobacterium tuberculosis in Solid Organ Transplant Recipients
inferred← citeshttps://doi.org/10.1111/j.1747-0285.2012.01436.xopenalex-snapshot
Evaluation of Structurally Diverse Benzoazepines Clubbed with Coumarins asMycobacterium tuberculosisAgents
inferred← citeshttps://doi.org/10.1126/scitranslmed.adi4000openalex-snapshot
Selection and prioritization of candidate combination regimens for the treatment of tuberculosis
inferred← citeshttps://doi.org/10.1128/aac.00186-22openalex-snapshot
Respirable Clofazimine Particles Produced by Air Jet Milling Technique Are Efficacious in Treatment of BALB/c Mice with Chronic Mycobacterium tuberculosis Infection
inferred← citeshttps://doi.org/10.1128/aac.00366-22openalex-snapshot
Quantitative Systems Pharmacology Modeling Framework of Autophagy in Tuberculosis: Application to Adjunctive Metformin Host-Directed Therapy
inferred← citeshttps://doi.org/10.1128/aac.00692-15openalex-snapshot
Disulfiram and Copper Ions Kill Mycobacterium tuberculosis in a Synergistic Manner
inferred← citeshttps://doi.org/10.1128/aac.00749-08openalex-snapshot
New Drugs against Tuberculosis: Problems, Progress, and Evaluation of Agents in Clinical Development
inferred← citeshttps://doi.org/10.1128/aac.00762-22openalex-snapshot
Novel Antibacterial Activity of Febuxostat, an FDA-Approved Antigout Drug against Mycobacterium tuberculosis Infection
inferred← citeshttps://doi.org/10.1128/aac.00898-22openalex-snapshot
Pharmacodynamics and Bactericidal Activity of Combination Regimens in Pulmonary Tuberculosis: Application to Bedaquiline-Pretomanid-Pyrazinamide
inferred← citeshttps://doi.org/10.1128/aac.01521-09openalex-snapshot
Evaluation of Standard Chemotherapy in the Guinea Pig Model of Tuberculosis
inferred← citeshttps://doi.org/10.1128/jb.00585-12openalex-snapshot
Mycobacterium tuberculosis Protein Kinase K Enables Growth Adaptation through Translation Control
inferred← citeshttps://doi.org/10.1134/s1068162023603257openalex-snapshot
Recent Developments in Structurally Diverse Anti-Tubercular Drug Molecules and Their Molecular Targets Against Mycobacterium tuberculosis
inferred← citeshttps://doi.org/10.1136/thx.2007.090936openalex-snapshot
Tuberculosis and its future management
inferred← citeshttps://doi.org/10.1136/thx.2007.090969openalex-snapshot
The future for lung disease in children
inferred← citeshttps://doi.org/10.1136/thx.2007.091116openalex-snapshot
The BTS and our 25th anniversary
inferred← citeshttps://doi.org/10.1157/13128781openalex-snapshot
Tuberculosis multirresistente
inferred← citeshttps://doi.org/10.1159/000327513openalex-snapshot
Chapter 23: Serial Sputum Colony Counting in Drug Development
inferred← citeshttps://doi.org/10.1164/rccm.202101-0117ocopenalex-snapshot
Precision-Enhancing Risk Stratification Tools for Selecting Optimal Treatment Durations in Tuberculosis Clinical Trials
inferred← citeshttps://doi.org/10.1172/jci34614openalex-snapshot
Confronting the scientific obstacles to global control of tuberculosis
inferred← citeshttps://doi.org/10.1186/1471-2091-12-35openalex-snapshot
Amino-terminal extension present in the methionine aminopeptidase type 1c of Mycobacterium tuberculosis is indispensible for its activity
inferred← citeshttps://doi.org/10.1186/s13063-023-07068-8openalex-snapshot
Implementation challenges and lessons learned from the STREAM clinical trial—a survey of trial sites
inferred← citeshttps://doi.org/10.1186/s13063-025-08887-7openalex-snapshot
The role of stakeholder mapping and engagement in Mongolia during the implementation of the STREAM clinical trial for MDR-TB
inferred← citeshttps://doi.org/10.1208/s12249-023-02510-1openalex-snapshot
Solubility Enhancement and Inhalation Delivery of Cyclodextrin-Based Inclusion Complex of Delamanid for Pulmonary Tuberculosis Treatment
inferred← citeshttps://doi.org/10.1246/cl.130839openalex-snapshot
Task-specific Ionic Liquid-mediated Facile Synthesis of 1,3,5-Triaryltriazines by Cyclotrimerization of Imines and Their Biological Evaluation
inferred← citeshttps://doi.org/10.12688/gatesopenres.13058.1openalex-snapshot
Integrating tuberculosis research with public health infrastructure: Lessons on community engagement from Orizaba, Mexico
inferred← citeshttps://doi.org/10.1371/journal.pbio.3000805openalex-snapshot
Combining antibiotics with antivirulence compounds can have synergistic effects and reverse selection for antibiotic resistance in Pseudomonas aeruginosa
inferred← citeshttps://doi.org/10.1371/journal.pmed.1002769openalex-snapshot
Advances in clinical trial design for development of new TB treatments: A call for innovation
inferred← citeshttps://doi.org/10.1371/journal.pmed.1002915openalex-snapshot
Development of new TB regimens: Harmonizing trial design, product registration requirements, and public health guidance
inferred← citeshttps://doi.org/10.1371/journal.pmed.1003059openalex-snapshot
Advances in clinical trial design: Weaving tomorrow’s TB treatments
inferred← citeshttps://doi.org/10.1371/journal.pone.0020374openalex-snapshot
New Classes of Alanine Racemase Inhibitors Identified by High-Throughput Screening Show Antimicrobial Activity against Mycobacterium tuberculosis
inferred← citeshttps://doi.org/10.1371/journal.pone.0027398openalex-snapshot
Amino Acids Involved in Polyphosphate Synthesis and Its Mobilization Are Distinct in Polyphosphate Kinase-1 from Mycobacterium tuberculosis
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