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Anti‐tuberculosis effect of isoniazid scales accurately from zebrafish to humans
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/cpt.1102openalex-snapshot
Forecasting Clinical Dose–Response From Preclinical Studies in Tuberculosis Research: Translational Predictions With Rifampicin
inferredcites →https://doi.org/10.1002/psp4.12079openalex-snapshot
Application of the Multistate Tuberculosis Pharmacometric Model in Patients With Rifampicin‐Treated Pulmonary Tuberculosis
inferredcites →https://doi.org/10.1002/psp4.12161openalex-snapshot
Model Evaluation of Continuous Data Pharmacometric Models: Metrics and Graphics
inferredcites →https://doi.org/10.1002/psp4.12297openalex-snapshot
Outside‐In Systems Pharmacology Combines Innovative Computational Methods With High‐Throughput Whole Vertebrate Studies
inferredcites →https://doi.org/10.1007/978-3-642-16001-1_26openalex-snapshot
Pattern Recognition for High Throughput Zebrafish Imaging Using Genetic Algorithm Optimization
inferredcites →https://doi.org/10.1007/s00281-015-0522-4openalex-snapshot
Protection and pathology in TB: learning from the zebrafish model
inferredcites →https://doi.org/10.1007/s10928-017-9508-2openalex-snapshot
The multistate tuberculosis pharmacometric model: a semi-mechanistic pharmacokinetic-pharmacodynamic model for studying drug effects in an acute tuberculosis mouse model
inferredcites →https://doi.org/10.1016/j.cbpa.2014.10.025openalex-snapshot
15 years of zebrafish chemical screening
inferredcites →https://doi.org/10.1016/j.cmpb.2005.04.005openalex-snapshot
PsN-Toolkit—A collection of computer intensive statistical methods for non-linear mixed effect modeling using NONMEM
inferredcites →https://doi.org/10.1016/j.cmpb.2010.04.018openalex-snapshot
Piraña and PCluster: A modeling environment and cluster infrastructure for NONMEM
inferredcites →https://doi.org/10.1016/j.ddmod.2017.04.003openalex-snapshot
Systems pharmacology of hepatic metabolism in zebrafish larvae
inferredcites →https://doi.org/10.1016/j.drudis.2011.12.020openalex-snapshot
Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival
inferredcites →https://doi.org/10.1016/j.jhealeco.2016.01.012openalex-snapshot
Innovation in the pharmaceutical industry: New estimates of R&D costs
inferredcites →https://doi.org/10.1016/j.molimm.2009.03.024openalex-snapshot
Specificity of the zebrafish host transcriptome response to acute and chronic mycobacterial infection and the role of innate and adaptive immune components
inferredcites →https://doi.org/10.1016/j.reprotox.2011.06.121openalex-snapshot
Zebrafish embryos as an alternative to animal experiments—A commentary on the definition of the onset of protected life stages in animal welfare regulations
inferredcites →https://doi.org/10.1016/j.tube.2009.08.002openalex-snapshot
A simple in vitro PK/PD model system to determine time–kill curves of drugs against Mycobacteria
inferredcites →https://doi.org/10.1016/j.tube.2014.02.004openalex-snapshot
Pharmacokinetics and dose response of anti-TB drugs in rat infection model of tuberculosis
inferredcites →https://doi.org/10.1016/j.ymeth.2013.06.002openalex-snapshot
Robotic injection of zebrafish embryos for high-throughput screening in disease models
inferredcites →https://doi.org/10.1023/a:1012299115260openalex-snapshot
Ways to Fit a PK Model with Some Data Below the Quantification Limit
inferredcites →https://doi.org/10.1038/nm0307-290openalex-snapshot
Challenges in tuberculosis drug research and development
inferredcites →https://doi.org/10.1038/s41598-017-10944-4openalex-snapshot
A fluorescence-based reporter for monitoring expression of mycobacterial cytochrome bd in response to antibacterials and during infection
inferredcites →https://doi.org/10.1038/s41598-019-38530-wopenalex-snapshot
Impact of post-hatching maturation on the pharmacokinetics of paracetamol in zebrafish larvae
inferredcites →https://doi.org/10.1074/jbc.m116.724088openalex-snapshot
iniBAC induction Is Vitamin B12- and MutAB-dependent in Mycobacterium marinum
inferredcites →https://doi.org/10.1089/zeb.2016.1313openalex-snapshot
Pharmacokinetic Modeling of Paracetamol Uptake and Clearance in Zebrafish Larvae: Expanding the Allometric Scale in Vertebrates with Five Orders of Magnitude
inferredcites →https://doi.org/10.1093/jac/dkp262openalex-snapshot
Evaluation of wild-type MIC distributions as a tool for determination of clinical breakpoints for Mycobacterium tuberculosis
inferredcites →https://doi.org/10.1093/jac/dkv416openalex-snapshot
A multistate tuberculosis pharmacometric model: a framework for studying anti-tubercular drug effectsin vitro
inferredcites →https://doi.org/10.1093/jac/dkx380openalex-snapshot
A model-informed preclinical approach for prediction of clinical pharmacodynamic interactions of anti-TB drug combinations
inferredcites →https://doi.org/10.1111/cts.12472openalex-snapshot
New Paradigm for Translational Modeling to Predict Long‐term Tuberculosis Treatment Response
inferredcites →https://doi.org/10.1111/cts.12793openalex-snapshot
Quantification of Natural Growth of Two Strains of Mycobacterium Marinum for Translational Antituberculosis Drug Development
inferredcites →https://doi.org/10.1111/j.1365-2125.2011.03940.xopenalex-snapshot
Variability in the population pharmacokinetics of isoniazid in South African tuberculosis patients
inferredcites →https://doi.org/10.1111/j.1462-5822.2008.01133.xopenalex-snapshot
Comparative pathogenesis of Mycobacterium marinum and Mycobacterium tuberculosis
inferredcites →https://doi.org/10.1124/jpet.119.260299openalex-snapshot
Mechanistic and Quantitative Understanding of Pharmacokinetics in Zebrafish Larvae through Nanoscale Blood Sampling and Metabolite Modeling of Paracetamol
inferredcites →https://doi.org/10.1126/science.aat9689openalex-snapshot
Subcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages
inferredcites →https://doi.org/10.1128/aac.00185-07openalex-snapshot
Isoniazid Bactericidal Activity and Resistance Emergence: Integrating Pharmacodynamics and Pharmacogenomics To Predict Efficacy in Different Ethnic Populations
inferredcites →https://doi.org/10.1128/aac.00595-10openalex-snapshot
Comparative Studies Evaluating Mouse Models Used for Efficacy Testing of Experimental Drugs against Mycobacterium tuberculosis
inferredcites →https://doi.org/10.1128/aac.03588-14openalex-snapshot
Testing Tuberculosis Drug Efficacy in a Zebrafish High-Throughput Translational Medicine Screen
inferredcites →https://doi.org/10.1128/aac.44.11.3133-3136.2000openalex-snapshot
Antibiotic Susceptibility Pattern of Mycobacterium marinum
inferredcites →https://doi.org/10.1128/aac.48.8.2951-2957.2004openalex-snapshot
Isoniazid Pharmacokinetics-Pharmacodynamics in an Aerosol Infection Model of Tuberculosis
inferredcites →https://doi.org/10.1128/cvi.00742-13openalex-snapshot
Time to Detection of Mycobacterium tuberculosis Using the MGIT 320 System Correlates with Colony Counting in Preclinical Testing of New Vaccines
inferredcites →https://doi.org/10.1128/jcm.01526-09openalex-snapshot
Sputum Mycobacterium tuberculosis mRNA as a Marker of Bacteriologic Clearance in Response to Antituberculosis Therapy
inferredcites →https://doi.org/10.1164/ajrccm.156.3.9612016openalex-snapshot
Early Bactericidal Activity of Isoniazid in Pulmonary Tuberculosis
inferredcites →https://doi.org/10.1164/arrd.1980.121.6.939openalex-snapshot
The early bactericidal activity of drugs in patients with pulmonary tuberculosis.
inferredcites →https://doi.org/10.1164/rccm.200210-1125ocopenalex-snapshot
Bactericidal and Sterilizing Activities of Antituberculosis Drugs during the First 14 Days
inferredcites →https://doi.org/10.1164/rccm.2112077openalex-snapshot
A Reiterative Method for Calculating the Early Bactericidal Activity of Antituberculosis Drugs
inferredcites →https://doi.org/10.1242/dmm.006676openalex-snapshot
Zebrafish embryo screen for mycobacterial genes involved in the initiation of granuloma formation reveals a newly identified ESX-1 component
inferredcites →https://doi.org/10.1364/boe.8.002611openalex-snapshot
Three-dimensional reconstruction and measurements of zebrafish larvae from high-throughput axial-view in vivo imaging
inferredcites →https://doi.org/10.1371/journal.pone.0016779openalex-snapshot
A High-Throughput Screen for Tuberculosis Progression
inferredcites →https://doi.org/10.18356/55eb9109-enopenalex-snapshot
The Sustainable Development Goals Report 2019
inferredcites →https://doi.org/10.2174/138945011795677809openalex-snapshot
Host-Pathogen Interactions Made Transparent with the Zebrafish Model
inferredcites →https://doi.org/10.3147/jsfp.43.106openalex-snapshot
In Vitro and In Vivo Activities of Drugs against Mycobacterium marinum in Yellowtail Seriola quinqueradiata
inferredcites →https://doi.org/10.3390/app10072376openalex-snapshot
Model-Informed Drug Discovery and Development Strategy for the Rapid Development of Anti-Tuberculosis Drug Combinations
inferredcites →https://doi.org/10.3791/3781openalex-snapshot
Infection of Zebrafish Embryos with Intracellular Bacterial Pathogens
inferredcites →https://doi.org/10.5588/ijtld.16.0048openalex-snapshot
Pharmacokinetics of thrice-weekly rifampicin, isoniazid and pyrazinamide in adult tuberculosis patients in India
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/adtp.202400174openalex-snapshot
Nanoparticles Combining Host‐Directed Therapeutics and Antibiotics to Boost Bacterial Killing and Overall Survival of Zebrafish Embryos Infected with Mycobacterium Marinum
inferred← citeshttps://doi.org/10.1002/cpt.70430openalex-snapshot
Successful Translational Prediction of Bedaquiline's Phase 2a Clinical Trial Results against Tuberculosis: The Zebrafish as a New Approach Methodology
inferred← citeshttps://doi.org/10.1007/978-981-99-2302-1_28openalex-snapshot
Tuberculosis: Experimental Models, Innovations, and Challenges
inferred← citeshttps://doi.org/10.1016/j.cbpc.2023.109560openalex-snapshot
Cyclosporine A induces hepatotoxicity in zebrafish larvae via upregulating oxidative stress
inferred← citeshttps://doi.org/10.1016/j.drudis.2024.104163openalex-snapshot
Embryonic and larval zebrafish models for the discovery of new bioactive compounds against tuberculosis
inferred← citeshttps://doi.org/10.1016/j.ejmech.2026.118622openalex-snapshot
New antitubercular pretomanid analogues as potent payloads in polymeric micelles: Leveraging zebrafish assays to accelerate lead optimisation
inferred← citeshttps://doi.org/10.1016/j.isci.2023.106411openalex-snapshot
Implementing best practices on data generation and reporting of Mycobacterium tuberculosis in vitro assays within the ERA4TB consortium
inferred← citeshttps://doi.org/10.1016/j.lfs.2022.120366openalex-snapshot
Impact of microplastics on the intestinal microbiota: A systematic review of preclinical evidence
inferred← citeshttps://doi.org/10.1016/j.tips.2021.11.016openalex-snapshot
Host-directed therapies for tuberculosis: quantitative systems pharmacology approaches
inferred← citeshttps://doi.org/10.1017/cts.2021.803openalex-snapshot
Zebrafish larvae as experimental model to expedite the search for new biomarkers and treatments for neonatal sepsis
inferred← citeshttps://doi.org/10.1080/03602532.2021.1922435openalex-snapshot
Recent developments in in vitro and in vivo models for improved translation of preclinical pharmacokinetics and pharmacodynamics data
inferred← citeshttps://doi.org/10.1242/dmm.049145openalex-snapshot
An anti-tuberculosis compound screen using a zebrafish infection model identifies an aspartyl-tRNA synthetase inhibitor
inferred← citeshttps://doi.org/10.3389/fphar.2026.1785275openalex-snapshot
Zebrafish as a translational platform for investigating multi-organ pharmacological interactions of traditional Chinese medicine
inferred← citeshttps://doi.org/10.3390/pathogens14090908openalex-snapshot
Mycobacterium marinum Immune Evasion in Zebrafish
inferred← citeshttps://doi.org/10.3390/pharmaceutics15020344openalex-snapshot
Scaling Pharmacodynamics from Rats to Humans to Support Erythropoietin and Romiplostim Combination Therapy to Treat Erythropoietin-Resistant Anemia
inferred← citeshttps://doi.org/10.64898/2026.05.29.728504openalex-snapshot
Accelerating drug development in infectious diseases using zebrafish disease models supported by pharmacokinetic-pharmacodynamic modeling as new approach methodology (NAM)
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