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DGIdb: mining the druggable genome
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1016/s1359-6446(05)03666-4openalex-snapshot
The druggable genome: an update
inferredcites →https://doi.org/10.1038/75556openalex-snapshot
Gene Ontology: tool for the unification of biology
inferredcites →https://doi.org/10.1038/msb.2009.98openalex-snapshot
A side effect resource to capture phenotypic effects of drugs
inferredcites →https://doi.org/10.1038/nature09208openalex-snapshot
Diverse somatic mutation patterns and pathway alterations in human cancers
inferredcites →https://doi.org/10.1038/nature10933openalex-snapshot
The clonal and mutational evolution spectrum of primary triple-negative breast cancers
inferredcites →https://doi.org/10.1038/nature11003openalex-snapshot
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
inferredcites →https://doi.org/10.1038/nature11017openalex-snapshot
The landscape of cancer genes and mutational processes in breast cancer
inferredcites →https://doi.org/10.1038/nature11154openalex-snapshot
Sequence analysis of mutations and translocations across breast cancer subtypes
inferredcites →https://doi.org/10.1038/nature11159openalex-snapshot
Large-scale prediction and testing of drug activity on side-effect targets
inferredcites →https://doi.org/10.1038/nature11412openalex-snapshot
Comprehensive molecular portraits of human breast tumours
inferredcites →https://doi.org/10.1038/nrd3478openalex-snapshot
Trends in the exploitation of novel drug targets
inferredcites →https://doi.org/10.1093/nar/30.1.276openalex-snapshot
The Pfam Protein Families Database
inferredcites →https://doi.org/10.1093/nar/gkl999openalex-snapshot
BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities
inferredcites →https://doi.org/10.1093/nar/gkp1014openalex-snapshot
Update of TTD: Therapeutic Target Database
inferredcites →https://doi.org/10.1093/nar/gkp934openalex-snapshot
T3DB: a comprehensively annotated database of common toxins and their targets
inferredcites →https://doi.org/10.1093/nar/gkp970openalex-snapshot
SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions
inferredcites →https://doi.org/10.1093/nar/gkq1037openalex-snapshot
PROMISCUOUS: a database for network-based drug-repositioning
inferredcites →https://doi.org/10.1093/nar/gkq1126openalex-snapshot
DrugBank 3.0: a comprehensive resource for 'Omics' research on drugs
inferredcites →https://doi.org/10.1093/nar/gkq1237openalex-snapshot
Entrez Gene: gene-centered information at NCBI
inferredcites →https://doi.org/10.1093/nar/gkr1011openalex-snapshot
STITCH 3: zooming in on protein-chemical interactions
inferredcites →https://doi.org/10.1093/nar/gkr1065openalex-snapshot
The Pfam protein families database
inferredcites →https://doi.org/10.1093/nar/gkr777openalex-snapshot
ChEMBL: a large-scale bioactivity database for drug discovery
inferredcites →https://doi.org/10.1093/nar/gkr912openalex-snapshot
SuperTarget goes quantitative: update on drug-target interactions
inferredcites →https://doi.org/10.1093/nar/gkr948openalex-snapshot
InterPro in 2011: new developments in the family and domain prediction database
inferredcites →https://doi.org/10.1093/nar/gks1111openalex-snapshot
Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells
inferredcites →https://doi.org/10.1093/nar/gks994openalex-snapshot
The Comparative Toxicogenomics Database: update 2013
inferredcites →https://doi.org/10.1097/01.jto.0000407557.30793.a6openalex-snapshot
Molecular Targeted Agents and Biologic Therapies for Lung Cancer
inferredcites →https://doi.org/10.1126/science.1075762openalex-snapshot
The Protein Kinase Complement of the Human Genome
inferredcites →https://doi.org/10.1126/science.1132939openalex-snapshot
The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease
inferredcites →https://doi.org/10.1158/1078-0432.ccr-12-1894openalex-snapshot
DNA-Mutation Inventory to Refine and Enhance Cancer Treatment (DIRECT): A Catalog of Clinically Relevant Cancer Mutations to Enable Genome-Directed Anticancer Therapy
inferredcites →https://doi.org/10.1158/2159-8290.cd-12-0349openalex-snapshot
Activating HER2 Mutations in HER2 Gene Amplification Negative Breast Cancer
inferredcites →https://doi.org/10.1186/1471-2105-9-104openalex-snapshot
PDTD: a web-accessible protein database for drug target identification
inferredcites →https://doi.org/10.1371/journal.pone.0067980openalex-snapshot
Prioritizing Potentially Druggable Mutations with dGene: An Annotation Tool for Cancer Genome Sequencing Data
inferredcites →https://doi.org/10.1517/14728222.8.6.587openalex-snapshot
The promise of genomics to identify novel therapeutic targets
inferredcites →https://doi.org/10.2217/bmm.11.94openalex-snapshot
From Pharmacogenomic Knowledge Acquisition to Clinical Applications: The PharmGKB as a Clinical Pharmacogenomic Biomarker Resource
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In-silico network-based analysis of drugs used against COVID-19: Human well-being study
inferred← citeshttps://doi.org/10.1016/j.sjbs.2021.07.068openalex-snapshot
Identifying key genes and screening therapeutic agents associated with diabetes mellitus and HCV-related hepatocellular carcinoma by bioinformatics analysis
inferred← citeshttps://doi.org/10.1016/j.surg.2016.06.064openalex-snapshot
Identification of novel therapeutic targets in anaplastic thyroid carcinoma using functional genomic mRNA-profiling: Paving the way for new avenues?
inferred← citeshttps://doi.org/10.1016/j.tem.2018.11.005openalex-snapshot
Identifying Potential Ageing-Modulating Drugs In Silico
inferred← citeshttps://doi.org/10.1016/j.tibs.2015.07.004openalex-snapshot
Targeting disordered proteins with small molecules using entropy
inferred← citeshttps://doi.org/10.1016/j.tips.2017.08.006openalex-snapshot
Evidence-Based Precision Oncology with the Cancer Targetome
inferred← citeshttps://doi.org/10.1016/j.trsl.2024.05.008openalex-snapshot
Potential applications of dual haptoglobin expression in the reclassification and treatment of hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1016/j.tube.2024.102538openalex-snapshot
Identification of host immune-related biomarkers in active tuberculosis: A comprehensive analysis of differentially expressed genes
inferred← citeshttps://doi.org/10.1016/j.urolonc.2016.05.012openalex-snapshot
Using the neoadjuvant chemotherapy paradigm to develop precision therapy for muscle-invasive bladder cancer
inferred← citeshttps://doi.org/10.1016/j.xhgg.2022.100100openalex-snapshot
From pharmacogenetics to pharmaco-omics: Milestones and future directions
inferred← citeshttps://doi.org/10.1016/j.ygeno.2024.110834openalex-snapshot
Boosting edgeR (Robust) by dealing with missing observations and gene-specific outliers in RNA-Seq profiles and its application to explore biomarker genes for diagnosis and therapies of ovarian cancer
inferred← citeshttps://doi.org/10.1016/j.ygeno.2025.111097openalex-snapshot
Multi-omics dissection of super-enhancer heterogeneity reveals subtype-specific transcriptional drivers in triple-negative breast cancer
inferred← citeshttps://doi.org/10.1016/j.ymeth.2023.12.001openalex-snapshot
Using TransR to enhance drug repurposing knowledge graph for COVID-19 and its complications
inferred← citeshttps://doi.org/10.1021/acs.jcim.5c03216openalex-snapshot
CrossLinker: Aligning Relational and Sequential Contexts for Drug-Target Interaction Prediction in Cold-Start and Few-Shot Scenarios
inferred← citeshttps://doi.org/10.1021/acssynbio.8b00237openalex-snapshot
Network-Based Combinatorial CRISPR-Cas9 Screens Identify Synergistic Modules in Human Cells
inferred← citeshttps://doi.org/10.1021/cb5001839openalex-snapshot
A Screening Pattern Recognition Method Finds New and Divergent Targets for Drugs and Natural Products
inferred← citeshttps://doi.org/10.1038/bcj.2015.24openalex-snapshot
BRAF V600E mutation in early-stage multiple myeloma: good response to broad acting drugs and no relation to prognosis
inferred← citeshttps://doi.org/10.1038/modpathol.2017.34openalex-snapshot
Genomic analysis of follicular dendritic cell sarcoma by molecular inversion probe array reveals tumor suppressor-driven biology
inferred← citeshttps://doi.org/10.1038/mp.2015.28openalex-snapshot
Targeting the schizophrenia genome: a fast track strategy from GWAS to clinic
inferred← citeshttps://doi.org/10.1038/nature16478openalex-snapshot
Divergent clonal selection dominates medulloblastoma at recurrence
inferred← citeshttps://doi.org/10.1038/nature25169openalex-snapshot
Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling
inferred← citeshttps://doi.org/10.1038/nbt.3183openalex-snapshot
Opportunities for drug repositioning from phenome-wide association studies
inferred← citeshttps://doi.org/10.1038/ncomms15290openalex-snapshot
Genomic analysis of oesophageal squamous-cell carcinoma identifies alcohol drinking-related mutation signature and genomic alterations
inferred← citeshttps://doi.org/10.1038/ncomms15580openalex-snapshot
Systematic discovery of mutation-specific synthetic lethals by mining pan-cancer human primary tumor data
inferred← citeshttps://doi.org/10.1038/ncomms9019openalex-snapshot
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways
inferred← citeshttps://doi.org/10.1038/ng.3838openalex-snapshot
Spatial heterogeneity in medulloblastoma
inferred← citeshttps://doi.org/10.1038/ni.2787openalex-snapshot
Unifying immunology with informatics and multiscale biology
inferred← citeshttps://doi.org/10.1038/nm.3984openalex-snapshot
Pan-cancer analysis of the extent and consequences of intratumor heterogeneity
inferred← citeshttps://doi.org/10.1038/nmeth.3505openalex-snapshot
SpeedSeq: ultra-fast personal genome analysis and interpretation
inferred← citeshttps://doi.org/10.1038/s12276-022-00876-zopenalex-snapshot
WNK3 inhibition elicits antitumor immunity by suppressing PD-L1 expression on tumor cells and activating T-cell function
inferred← citeshttps://doi.org/10.1038/s41380-021-01104-2openalex-snapshot
Altered network and rescue of human neurons derived from individuals with early-onset genetic epilepsy
inferred← citeshttps://doi.org/10.1038/s41380-021-01335-3openalex-snapshot
Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry
inferred← citeshttps://doi.org/10.1038/s41388-021-01882-7openalex-snapshot
CRISPR screens identify cholesterol biosynthesis as a therapeutic target on stemness and drug resistance of colon cancer
inferred← citeshttps://doi.org/10.1038/s41398-019-0652-xopenalex-snapshot
Evidence that genes involved in hedgehog signaling are associated with both bipolar disorder and high BMI
inferred← citeshttps://doi.org/10.1038/s41398-025-03243-4openalex-snapshot
Systematic dissection of pleiotropic loci and critical regulons in excitatory neurons and microglia relevant to neuropsychiatric and ocular diseases
inferred← citeshttps://doi.org/10.1038/s41398-025-03351-1openalex-snapshot
Spatial and functional profiles distinguish target sets of Parkinson’s disease and antipsychotic drugs with different clinical effects
inferred← citeshttps://doi.org/10.1038/s41419-021-04202-9openalex-snapshot
p53-dependent induction of P2X7 on hematopoietic stem and progenitor cells regulates hematopoietic response to genotoxic stress
inferred← citeshttps://doi.org/10.1038/s41467-018-05914-xopenalex-snapshot
The prognostic effects of somatic mutations in ER-positive breast cancer
inferred← citeshttps://doi.org/10.1038/s41467-018-06132-1openalex-snapshot
Contribution of allelic imbalance to colorectal cancer
inferred← citeshttps://doi.org/10.1038/s41467-020-15220-0openalex-snapshot
Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML
inferred← citeshttps://doi.org/10.1038/s41467-021-24813-2openalex-snapshot
Oncogenic enhancers drive esophageal squamous cell carcinogenesis and metastasis
inferred← citeshttps://doi.org/10.1038/s41467-021-27651-4openalex-snapshot
Prediction of biomarkers and therapeutic combinations for anti-PD-1 immunotherapy using the global gene network association
inferred← citeshttps://doi.org/10.1038/s41467-022-28378-6openalex-snapshot
In vivo CRISPR screens reveal a HIF-1α-mTOR-network regulates T follicular helper versus Th1 cells
inferred← citeshttps://doi.org/10.1038/s41467-023-38335-6openalex-snapshot
NetBID2 provides comprehensive hidden driver analysis
inferred← citeshttps://doi.org/10.1038/s41467-023-42233-2openalex-snapshot
Expanding PROTACtable genome universe of E3 ligases
inferred← citeshttps://doi.org/10.1038/s41467-024-47581-1openalex-snapshot
Integrated proteogenomic and metabolomic characterization of papillary thyroid cancer with different recurrence risks
inferred← citeshttps://doi.org/10.1038/s41467-025-59620-6openalex-snapshot
scMINER: a mutual information-based framework for clustering and hidden driver inference from single-cell transcriptomics data
inferred← citeshttps://doi.org/10.1038/s41525-022-00290-4openalex-snapshot
The druggable schizophrenia genome: from repurposing opportunities to unexplored drug targets
inferred← citeshttps://doi.org/10.1038/s41537-025-00559-4openalex-snapshot
Exploring genetic associations and drug targets for mitochondrial proteins and schizophrenia risk
inferred← citeshttps://doi.org/10.1038/s41537-025-00670-6openalex-snapshot
The shared genetic architecture between schizophrenia and common peripheral organ imaging phenotypes
inferred← citeshttps://doi.org/10.1038/s41562-024-02040-1openalex-snapshot
A multi-omics Mendelian randomization study identifies new therapeutic targets for alcohol use disorder and problem drinking
inferred← citeshttps://doi.org/10.1038/s41569-020-00477-1openalex-snapshot
Systems biology in cardiovascular disease: a multiomics approach
inferred← citeshttps://doi.org/10.1038/s41573-019-0046-zopenalex-snapshot
Synthetic lethality as an engine for cancer drug target discovery
inferred← citeshttps://doi.org/10.1038/s41586-024-07950-8openalex-snapshot
Targeted protein relocalization via protein transport coupling
inferred← citeshttps://doi.org/10.1038/s41586-025-08980-6openalex-snapshot
Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis
inferred← citeshttps://doi.org/10.1038/s41588-018-0102-3openalex-snapshot
Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity
inferred← citeshttps://doi.org/10.1038/s41588-018-0151-7openalex-snapshot
Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways
inferred← citeshttps://doi.org/10.1038/s41588-018-0176-yopenalex-snapshot
Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma
inferred← citeshttps://doi.org/10.1038/s41588-018-0209-6openalex-snapshot
Pharmacogenomic landscape of patient-derived tumor cells informs precision oncology therapy
inferred← citeshttps://doi.org/10.1038/s41589-018-0205-2openalex-snapshot
Combined chemosensitivity and chromatin profiling prioritizes drug combinations in CLL
inferred← citeshttps://doi.org/10.1038/s41593-018-0326-7openalex-snapshot
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions
inferred← citeshttps://doi.org/10.1038/s41598-017-00122-xopenalex-snapshot
A c-Myc-regulated stem cell-like signature in high-risk neuroblastoma: A systematic discovery (Target neuroblastoma ESC-like signature)
inferred← citeshttps://doi.org/10.1038/s41598-017-10928-4openalex-snapshot
A genomic exploration identifies mechanisms that may explain adverse cardiovascular effects of COX-2 inhibitors
inferred← citeshttps://doi.org/10.1038/s41598-018-24005-xopenalex-snapshot
Epigenetic alterations to Polycomb targets precede malignant transition in a mouse model of breast cancer
inferred← citeshttps://doi.org/10.1038/s41598-018-26453-xopenalex-snapshot
Blood lipid-related low-frequency variants in LDLR and PCSK9 are associated with onset age and risk of myocardial infarction in Japanese
inferred← citeshttps://doi.org/10.1038/s41598-021-93346-xopenalex-snapshot
Untangling the genetic link between type 1 and type 2 diabetes using functional genomics
inferred← citeshttps://doi.org/10.1038/s41598-022-13159-4openalex-snapshot
Analysis of multiple databases identifies crucial genes correlated with prognosis of hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1038/s41598-024-79906-xopenalex-snapshot
Novel candidate plasma proteins for the pathogenesis and treatment of atopic dermatitis revealed by proteome-wide association study
inferred← citeshttps://doi.org/10.1038/s41598-024-84362-8openalex-snapshot
Tryptophan metabolism-related gene CYP1B1 serves as a shared biomarker for both Parkinson’s disease and insomnia
inferred← citeshttps://doi.org/10.1038/s41598-025-15977-8openalex-snapshot
Druggable genome-wide Mendelian randomization integrating GWAS and eQTL/pQTL data identifies targets for lung squamous cell carcinoma
inferred← citeshttps://doi.org/10.1038/s41698-022-00257-9openalex-snapshot
Multi-site desmoplastic small round cell tumors are genetically related and immune-cold
inferred← citeshttps://doi.org/10.1038/s41698-025-00813-zopenalex-snapshot
Personalized prediction of anticancer potential of non-oncology drugs through learning from genome derived molecular pathways
inferred← citeshttps://doi.org/10.1038/s42003-019-0736-4openalex-snapshot
Diversity spectrum analysis identifies mutation-specific effects of cancer driver genes
inferred← citeshttps://doi.org/10.1038/s43587-023-00455-5openalex-snapshot
Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging
inferred← citeshttps://doi.org/10.1038/s44161-025-00757-4openalex-snapshot
A multimodal vision knowledge graph of cardiovascular disease
inferred← citeshttps://doi.org/10.1038/s44321-024-00060-yopenalex-snapshot
Genome-wide CRISPR screens identify PKMYT1 as a therapeutic target in pancreatic ductal adenocarcinoma
inferred← citeshttps://doi.org/10.1038/s44321-024-00169-0openalex-snapshot
Diagnosis and prognosis prediction of gastric cancer by high-performance serum lipidome fingerprints
inferred← citeshttps://doi.org/10.1038/srep11966openalex-snapshot
Identification of a multi-cancer gene expression biomarker for cancer clinical outcomes using a network-based algorithm
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