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Chemical approaches to the discovery and development of cancer therapies
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Goodman and Gilman's The Pharmacological Basis of Therapeutics
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Calculation of ligand‐nucleic acid binding free energies with the generalized‐born model in DOCK
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Molecular characterization of the hdm2-p53 interaction 1 1Edited by J. Karn
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Enzyme-Prodrug Strategies for Cancer Therapy
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Anticancer Drug Development Guide
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GENE-DIRECTED ENZYME PRODRUG THERAPY
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Predictive ADMET studies, the challenges and the opportunities
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The Process of Structure-Based Drug Design
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High-throughput X-ray crystallography for drug discovery
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Receptor-mediated and enzyme-dependent targeting of cytotoxic anticancer drugs
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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1
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Selective activation of anticancer prodrugs by monoclonal antibody–enzyme conjugates
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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
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Prodrug strategies in cancer therapy
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Chemoinformatics – predicting the physicochemical properties of 'drug-like' molecules
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Recognition of the DNA minor groove by pyrrole-imidazole polyamides
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High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications
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Property Distributions: Differences between Drugs, Natural Products, and Molecules from Combinatorial Chemistry
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Isolation and Structure Elucidation of Chlorofusin, a Novel p53-MDM2 Antagonist from a Fusarium sp.
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Simple Selection Criteria for Drug-like Chemical Matter
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Characteristic Physical Properties and Structural Fragments of Marketed Oral Drugs
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Assessing Scoring Functions for Protein−Ligand Interactions
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Development of Natural Product-Derived Receptor Tyrosine Kinase Inhibitors Based on Conservation of Protein Domain Fold
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Trisubstituted Acridine Derivatives as Potent and Selective Telomerase Inhibitors
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inferredcites →https://doi.org/10.1021/jm034182uopenalex-snapshot
A Nonpeptidic Sulfonamide Inhibits the p53−mdm2 Interaction and Activates p53-Dependent Transcription in mdm2-Overexpressing Cells
inferredcites →https://doi.org/10.1021/jm049486aopenalex-snapshot
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inferredcites →https://doi.org/10.1021/jm0497803openalex-snapshot
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inferredcites →https://doi.org/10.1021/ol036083gopenalex-snapshot
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inferredcites →https://doi.org/10.1021/ol0360849openalex-snapshot
Solid-Phase Synthesis of the Cyclic Peptide Portion of Chlorofusin, an Inhibitor of p53-MDM2 Interactions
inferredcites →https://doi.org/10.1038/13495openalex-snapshot
Inhibition of telomerase limits the growth of human cancer cells
inferredcites →https://doi.org/10.1038/205698a0openalex-snapshot
Inhibition of Cell Division in Escherichia coli by Electrolysis Products from a Platinum Electrode
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inferredcites →https://doi.org/10.1038/35038557openalex-snapshot
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inferredcites →https://doi.org/10.1039/b211889kopenalex-snapshot
Binding of an inhibitor of the p53/MDM2 Interaction to MDM2
inferredcites →https://doi.org/10.1054/bjoc.2001.1843openalex-snapshot
Measurement of the critical DNA lesions produced by antibody-directed enzyme prodrug therapy (ADEPT) in vitro, in vivo and in clinical material
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Synthesis of the thapsigargins
inferredcites →https://doi.org/10.1073/pnas.052698099openalex-snapshot
Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands
inferredcites →https://doi.org/10.1073/pnas.081560598openalex-snapshot
Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors
inferredcites →https://doi.org/10.1073/pnas.1337088100openalex-snapshot
Systematic discovery of multicomponent therapeutics
inferredcites →https://doi.org/10.1073/pnas.2035074100openalex-snapshot
Nuclear localization of pyrrole–imidazole polyamide–fluorescein conjugates in cell culture
inferredcites →https://doi.org/10.1073/pnas.96.25.14276openalex-snapshot
Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death
inferredcites →https://doi.org/10.1074/jbc.m403319200openalex-snapshot
Structural Basis for the Autoinhibition and STI-571 Inhibition of c-Kit Tyrosine Kinase
inferredcites →https://doi.org/10.1093/milmed/151.1.386openalex-snapshot
Goodman and Gilman's the Pharmacological Basis of Therapeutics
inferredcites →https://doi.org/10.1093/nar/gkg215openalex-snapshot
DNA crosslinking and biological activity of a hairpin polyamide-chlorambucil conjugate
inferredcites →https://doi.org/10.1126/science.1089946openalex-snapshot
Generating Diverse Skeletons of Small Molecules Combinatorially
inferredcites →https://doi.org/10.1126/science.1092472openalex-snapshot
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
inferredcites →https://doi.org/10.1126/science.1095920openalex-snapshot
Protein Kinase Inhibitors: Insights into Drug Design from Structure
inferredcites →https://doi.org/10.1126/science.1099480openalex-snapshot
Overriding Imatinib Resistance with a Novel ABL Kinase Inhibitor
inferredcites →https://doi.org/10.1126/science.1099736openalex-snapshot
Crystal Structures of Human Cytochrome P450 3A4 Bound to Metyrapone and Progesterone
inferredcites →https://doi.org/10.1126/science.274.5289.948openalex-snapshot
Structure of the MDM2 Oncoprotein Bound to the p53 Tumor Suppressor Transactivation Domain
inferredcites →https://doi.org/10.1126/science.7605428openalex-snapshot
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
inferredcites →https://doi.org/10.1158/0008-5472.can-03-2941openalex-snapshot
SJG-136 (NSC 694501), a Novel Rationally Designed DNA Minor Groove Interstrand Cross-Linking Agent with Potent and Broad Spectrum Antitumor Activity
inferredcites →https://doi.org/10.1158/0008-5472.can-03-2942openalex-snapshot
SJG-136 (NSC 694501), A Novel Rationally Designed DNA Minor Groove Interstrand Cross-Linking Agent with Potent and Broad Spectrum Antitumor Activity
inferredcites →https://doi.org/10.1158/0008-5472.can-04-1713openalex-snapshot
The Novel Sequence-Specific DNA Cross-Linking Agent SJG-136 (NSC 694501) Has Potent and Selective In vitro Cytotoxicity in Human B-Cell Chronic Lymphocytic Leukemia Cells with Evidence of a p53-Independent Mechanism of Cell Kill
inferredcites →https://doi.org/10.1158/0008-5472.can-04-2910openalex-snapshot
The G-Quadruplex-Interactive Molecule BRACO-19 Inhibits Tumor Growth, Consistent with Telomere Targeting and Interference with Telomerase Function
inferredcites →https://doi.org/10.1158/1535-7163.1201.3.10openalex-snapshot
A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells
inferredcites →https://doi.org/10.1182/blood.v96.3.925openalex-snapshot
Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor
inferredcites →https://doi.org/10.1517/13543784.8.2.161openalex-snapshot
Targeting enzymes to cancers - new developments
inferredcites →https://doi.org/10.2174/1568011033353605openalex-snapshot
Chemical and Biological Profile of Dual Cdk1 and Cdk2 Inhibitors
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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inferred← citeshttps://doi.org/10.1016/j.bmcl.2012.04.090openalex-snapshot
Chromatin structure determines accessibility of a hairpin polyamide–chlorambucil conjugate at histone H4 genes in pancreatic cancer cells
inferred← citeshttps://doi.org/10.1016/j.bmcl.2014.11.077openalex-snapshot
Development of constrained tamoxifen mimics and their antiproliferative properties against breast cancer cells
inferred← citeshttps://doi.org/10.1016/j.bpc.2007.12.003openalex-snapshot
Study by optical spectroscopy and molecular dynamics of the interaction of acridine–spermine conjugate with DNA
inferred← citeshttps://doi.org/10.1016/j.ccr.2013.02.023openalex-snapshot
DNA-binding of nickel(II), copper(II) and zinc(II) complexes: Structure–affinity relationships
inferred← citeshttps://doi.org/10.1016/j.colsurfb.2006.09.020openalex-snapshot
Effect of the cell type and cell density on the binding of living cells to a silica particle: An atomic force microscope study
inferred← citeshttps://doi.org/10.1016/j.drudis.2007.06.009openalex-snapshot
Seeding drug discovery: integrating telomerase cancer biology and cellular senescence to uncover new therapeutic opportunities in targeting cancer stem cells
inferred← citeshttps://doi.org/10.1016/j.ejmech.2010.07.051openalex-snapshot
Synthesis of the steroidal glycoside (25R)-3β,16β-diacetoxy-12,22-dioxo-5α-cholestan-26-yl β-d-glucopyranoside and its anti-cancer properties on cervicouterine HeLa, CaSki, and ViBo cells
inferred← citeshttps://doi.org/10.1016/j.ejmech.2013.05.042openalex-snapshot
Resonance light scattering technique as a new tool to determine the binding mode of anticancer drug oridonin to DNA
inferred← citeshttps://doi.org/10.1016/j.ejmech.2014.10.050openalex-snapshot
Investigation of podophyllotoxin esters as potential anticancer agents: Synthesis, biological studies and tubulin inhibition properties
inferred← citeshttps://doi.org/10.1016/j.ejmech.2017.12.029openalex-snapshot
Colchicine prodrugs and codrugs: Chemistry and bioactivities
inferred← citeshttps://doi.org/10.1016/j.ejmech.2018.10.058openalex-snapshot
Novel 3-(2,6,9-trisubstituted-9H-purine)-8-chalcone derivatives as potent anti-gastric cancer agents: Design, synthesis and structural optimization
inferred← citeshttps://doi.org/10.1016/j.fitote.2010.06.024openalex-snapshot
Distinct G-quadruplex structures of human telomeric DNA formed by the induction of sanguinarine and nitidine under salt-deficient condition
inferred← citeshttps://doi.org/10.1016/j.gene.2021.145445openalex-snapshot
Molecular biological investigation of temozolomide and KC7F2 combination in U87MG glioma cell line
inferred← citeshttps://doi.org/10.1016/j.gene.2022.146975openalex-snapshot
Discovery of a potent Guanidine derivative that selectively binds and stabilizes the human BCL-2 G-quadruplex DNA and downregulates the transcription
inferred← citeshttps://doi.org/10.1016/j.heliyon.2023.e13111openalex-snapshot
Convenient synthesis, characterization and biological evaluation of novel 1-phenylcyclopropane carboxamide derivatives
inferred← citeshttps://doi.org/10.1016/j.ijantimicag.2007.01.005openalex-snapshot
Interactions of pyrrolobenzodiazepine dimers and duplex DNA from methicillin-resistant Staphylococcus aureus
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2019.01.031openalex-snapshot
Radiation induced DNA damage and its protection by a gadolinium(III) complex: Spectroscopic, molecular docking and gel electrophoretic studies
inferred← citeshttps://doi.org/10.1016/j.jddst.2024.105957openalex-snapshot
Exosomes improved the in vitro anti-melanoma efficacy of dihydroartemisinin
inferred← citeshttps://doi.org/10.1016/j.jlumin.2012.06.035openalex-snapshot
Characterizing the interaction between oridonin and bovine serum albumin by a hybrid spectroscopic approach
inferred← citeshttps://doi.org/10.1016/j.jlumin.2014.12.021openalex-snapshot
Interaction and sonodynamic damage activity of acridine red (AD-R) to bovine serum albumin (BSA)
inferred← citeshttps://doi.org/10.1016/j.jphotochem.2018.05.046openalex-snapshot
Investigation of photophysical properties of 1,8-naphthalimides with an extended conjugation on naphthalene moiety via Suzuki coupling reaction
inferred← citeshttps://doi.org/10.1016/j.jscs.2021.101323openalex-snapshot
Molecular docking analysis and spectroscopic investigations of zinc(II), nickel(II) N-phthaloyl-β-alanine complexes for DNA binding: Evaluation of antibacterial and antitumor activities
inferred← citeshttps://doi.org/10.1016/j.molliq.2024.126813openalex-snapshot
Synthesis of some new arylazo-coumarin derivatives and their comparative biological activity studies: Cytotoxicity, gene expression, DNA binding, BSA binding, and in silico analysis
inferred← citeshttps://doi.org/10.1016/j.molstruc.2016.03.008openalex-snapshot
Synthesis, characterization, biological and electrochemical evaluation of novel ether based ON donor bidentate Schiff bases
inferred← citeshttps://doi.org/10.1016/j.molstruc.2016.11.074openalex-snapshot
Antitumor activity of 3,4-ethylenedioxythiophene derivatives and quantitative structure-activity relationship analysis
inferred← citeshttps://doi.org/10.1016/j.molstruc.2024.140764openalex-snapshot
Investigation of the anticancer potential of newly synthesized N4-substituted thiosemicarbazones: In silico and in vitro biological approaches
inferred← citeshttps://doi.org/10.1016/j.molstruc.2025.145013openalex-snapshot
Synthesis of Co(II), Ni(II) and Cu(II) Chelates of Novel Schiff base as Promising Antibacterial, Antioxidant and Anticancer Agents: Spectroscopic, DFT and Molecular Docking Studies
inferred← citeshttps://doi.org/10.1016/j.nantod.2022.101732openalex-snapshot
Amphiphilic porphyrin-based supramolecular self-assembly for photochemotherapy: From molecular design to application
inferred← citeshttps://doi.org/10.1016/j.nexres.2025.100344openalex-snapshot
Cyperus Kyllingia leaf extract mediated biosynthesis of silver nanoparticles: Assessment of their anticancer, photocatalytic activity and interaction with human serum albumin
inferred← citeshttps://doi.org/10.1016/j.nucmedbio.2009.07.007openalex-snapshot
Direct detection and quantification of abasic sites for in vivo studies of DNA damage and repair
inferred← citeshttps://doi.org/10.1016/j.phpro.2015.09.160openalex-snapshot
Multifunctional Nanoprobes for Cancer Cell Targeting, Imaging and Anticancer Drug Delivery
inferred← citeshttps://doi.org/10.1016/j.phrs.2007.07.009openalex-snapshot
Synthesis, in vitro activity and in vivo toxicity of the new 2,3-dinitrobutadiene derivative (1E,3E)-1,4-bis(2-naphthyl)-2,3-dinitro-1,3-butadiene
inferred← citeshttps://doi.org/10.1016/j.poly.2017.05.046openalex-snapshot
Pharmacological, electrochemical and drug–DNA interaction aspects of tridentate Schiff bases and their triphenylphosphine nickel(II) complexes
inferred← citeshttps://doi.org/10.1016/j.saa.2007.06.008openalex-snapshot
Effect of spermine conjugation on the interaction of acridine with alternating purine–pyrimidine oligodeoxyribonucleotides studied by CD, fluorescence and absorption spectroscopies
inferred← citeshttps://doi.org/10.1016/j.saa.2016.05.001openalex-snapshot
A colorimetric and fluorescence enhancement anion probe based on coumarin compounds
inferred← citeshttps://doi.org/10.1016/j.saa.2020.119318openalex-snapshot
New 2,9-disubstituted-1,10-phenanthroline derivatives with anticancer activity by selective targeting of telomeric G-quadruplex DNA
inferred← citeshttps://doi.org/10.1016/j.steroids.2014.09.007openalex-snapshot
Synthesis and biological evaluation of novel sarsasapogenin derivatives as potential anti-tumor agents
inferred← citeshttps://doi.org/10.1016/j.tet.2009.06.058openalex-snapshot
Synthesis-driven mapping of the dictyodendrin alkaloids
inferred← citeshttps://doi.org/10.1016/j.toxlet.2015.09.010openalex-snapshot
Sulfur and nitrogen mustards induce characteristic poly(ADP-ribosyl)ation responses in HaCaT keratinocytes with distinctive cellular consequences
inferred← citeshttps://doi.org/10.1016/j.toxlet.2020.01.024openalex-snapshot
NAD+ in sulfur mustard toxicity
inferred← citeshttps://doi.org/10.1016/s0213-9251(08)70979-1openalex-snapshot
Perspectivas de futuro en el diseño y el desarrollo de un fármaco
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.6b00079openalex-snapshot
Linking of Antitumor trans NHC-Pt(II) Complexes to G-Quadruplex DNA Ligand for Telomeric Targeting
inferred← citeshttps://doi.org/10.1021/acs.orglett.7b02511openalex-snapshot
A Unified Modular Synthetic Strategy for Dictyodendrins F, H, I, and G
inferred← citeshttps://doi.org/10.1021/acsabm.3c00297openalex-snapshot
Small Molecule Interactions with Biomacromolecules: DNA Binding Interactions of a Manganese(III) Schiff Base Complex with Potential Anticancer Activities
inferred← citeshttps://doi.org/10.1021/ci600500vopenalex-snapshot
DNA Minor Groove Pharmacophores Describing Sequence Specific Properties
inferred← citeshttps://doi.org/10.1021/ci800455fopenalex-snapshot
Hydrogen-Bonding Patterns of Minor Groove-Binder−DNA Complexes Reveal Criteria for Discovery of New Scaffolds
inferred← citeshttps://doi.org/10.1021/ja0665951openalex-snapshot
Depurinating Acylfulvene−DNA Adducts: Characterizing Cellular Chemical Reactions of a Selective Antitumor Agent
inferred← citeshttps://doi.org/10.1021/jm060035vopenalex-snapshot
Synthesis, Biological Activity, and DNA-Damage Profile of Platinum-Threading Intercalator Conjugates Designed To Target Adenine
inferred← citeshttps://doi.org/10.1021/jm7011408openalex-snapshot
Histone Deacetylase Inhibitors: From Bench to Clinic
inferred← citeshttps://doi.org/10.1021/jm900627vopenalex-snapshot
Benzothiopyranoindole-Based Antiproliferative Agents: Synthesis, Cytotoxicity, Nucleic Acids Interaction, and Topoisomerases Inhibition Properties
inferred← citeshttps://doi.org/10.1021/jo060501oopenalex-snapshot
Efficient Synthesis of Achiral seco-Cyclopropylbenz[2,3-e]indoline Analogues: [4-Amino-2-(5,6,7-trimethoxyindole-2-carboxamido)naphthalen-1-yl]ethyl Chloride and [4-Hydroxy-2-(5,6,7-trimethoxyindole-2-carboxamido)naphthalen-1-yl]ethyl Chloride
inferred← citeshttps://doi.org/10.1021/jo300351gopenalex-snapshot
The Mechanism of Guanine Alkylation by Nitrogen Mustards: A Computational Study
inferred← citeshttps://doi.org/10.1021/jo500696nopenalex-snapshot
Regiospecific C–N Photocyclization of 2-Styrylquinolines
inferred← citeshttps://doi.org/10.1021/ol302791xopenalex-snapshot
An Efficient and Practical Radiosynthesis of [11C]Temozolomide
inferred← citeshttps://doi.org/10.1021/ol400195dopenalex-snapshot
An Efficient and Practical Radiosynthesis of [11C]Temozolomide
inferred← citeshttps://doi.org/10.1038/ncomms10437openalex-snapshot
Temperature-feedback upconversion nanocomposite for accurate photothermal therapy at facile temperature
inferred← citeshttps://doi.org/10.1038/s41598-017-03906-3openalex-snapshot
Structural insight for the recognition of G-quadruplex structure at human c-myc promoter sequence by flavonoid Quercetin
inferred← citeshttps://doi.org/10.1038/srep23793openalex-snapshot
Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1)
inferred← citeshttps://doi.org/10.1038/srep42629openalex-snapshot
A selective and label-free strategy for rapid screening of telomere-binding Ligands via fluorescence regulation of DNA/silver nanocluster
inferred← citeshttps://doi.org/10.1039/9781837671328-00477openalex-snapshot
Reversible Small Molecule–Nucleic Acid Interactions
inferred← citeshttps://doi.org/10.1039/b514814fopenalex-snapshot
3D structure and the drug-discovery process
inferred← citeshttps://doi.org/10.1039/b516378aopenalex-snapshot
Neomycin-capped aromatic platforms: quadruplex DNA recognition and telomerase inhibition
inferred← citeshttps://doi.org/10.1039/b708635kopenalex-snapshot
The importance of metal geometry in the recognition of G-quadruplex-DNA by metal-terpyridine complexes
inferred← citeshttps://doi.org/10.1039/b714772bopenalex-snapshot
A hitchhiker's guide to G-quadruplex ligands
inferred← citeshttps://doi.org/10.1039/b801920gopenalex-snapshot
Targeting transcription factors for therapeutic benefit
inferred← citeshttps://doi.org/10.1039/b909153jopenalex-snapshot
Synthesis and DNA-binding affinity studies of glycosylated intercalators designed as functional mimics of the anthracycline antibiotics
inferred← citeshttps://doi.org/10.1039/c2cs35467eopenalex-snapshot
Recent advances in the development of 1,8-naphthalimide based DNA targeting binders, anticancer and fluorescent cellular imaging agents
inferred← citeshttps://doi.org/10.1039/c2ob06898bopenalex-snapshot
Synthesis and photophysical evaluation of a pyridinium 4-amino-1,8-naphthalimide derivative that upon intercalation displays preference for AT-rich double-stranded DNA
inferred← citeshttps://doi.org/10.1039/c3an01024dopenalex-snapshot
A label-free and colorimetric turn-on assay for coralyne based on coralyne-induced formation of peroxidase-mimicking split DNAzyme
inferred← citeshttps://doi.org/10.1039/c3ob40370jopenalex-snapshot
The effect of the 4-amino functionality on the photophysical and DNA binding properties of alkyl-pyridinium derived 1,8-naphthalimides
inferred← citeshttps://doi.org/10.1039/c5ra00925aopenalex-snapshot
Synthesis, in vitro evaluation and DNA interaction studies of N-allyl naphthalimide analogues as anticancer agents
inferred← citeshttps://doi.org/10.1039/c6cc01996jopenalex-snapshot
One-step gene delivery into the cytoplasm in a fusion-dependent manner based on a new membrane fusogenic lipid
inferred← citeshttps://doi.org/10.1039/c6nj03904aopenalex-snapshot
The effects of structural changes on the anti-microbial and anti-proliferative activities of diimidazolium salts
inferred← citeshttps://doi.org/10.1039/c6ob00527fopenalex-snapshot
Antiproliferative activity of bicyclic benzimidazole nucleosides: synthesis, DNA-binding and cell cycle analysis
inferred← citeshttps://doi.org/10.1039/c7cc06246jopenalex-snapshot
A modular design for minor groove binding and recognition of mixed base pair sequences of DNA
inferred← citeshttps://doi.org/10.1039/c7cp06058kopenalex-snapshot
Characterization of the binding interactions between EvaGreen dye and dsDNA
inferred← citeshttps://doi.org/10.1039/c7ob02433aopenalex-snapshot
Tetrazolylpyrene unnatural nucleoside as a human telomeric multimeric G-quadruplex selective switch-on fluorescent sensor
inferred← citeshttps://doi.org/10.1039/c7ra06580aopenalex-snapshot
The in vivo anti-tumor effect of curcumin derivative (2E,6E)-2,6-bis(4-hydroxy-3-methoxybenzylidene)cyclohexanone (BHMC) on 4T1 breast cancer cells
inferred← citeshttps://doi.org/10.1039/d0nj03712eopenalex-snapshot
Oxalato bridged coordination polymer of manganese( iii ) involving unconventional O⋯π-hole(nitrile) and antiparallel nitrile⋯nitrile contacts: antiproliferative evaluation and theoretical studies
inferred← citeshttps://doi.org/10.1039/d0ob02298eopenalex-snapshot
Synthesis, DNA-binding and antiproliferative properties of diarylquinolizinium derivatives
inferred← citeshttps://doi.org/10.1039/d1nj02696hopenalex-snapshot
Synthesis, structural characterization, protein binding, DNA cleavage and anticancer activity of fluorophore labelled copper( ii ) complexes based on 1,8-naphthalimide conjugates
inferred← citeshttps://doi.org/10.1039/d2tb02121hopenalex-snapshot
NOAEL cancer therapy: a tumor targetable docetaxel–inorganic polymer nanohybrid prevents drug-induced neutropenia
inferred← citeshttps://doi.org/10.1073/pnas.0609699104openalex-snapshot
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
inferred← citeshttps://doi.org/10.1080/07391102.2012.742246openalex-snapshot
Novel G-quadruplex stabilizing agents: in-silico approach and dynamics
inferred← citeshttps://doi.org/10.1080/07391102.2018.1512420openalex-snapshot
Supramolecular complex binding to G-quadruplex DNA: Berberine encapsulated by a planar side arm–tethered β-cyclodextrin
inferred← citeshttps://doi.org/10.1080/08927022.2014.913098openalex-snapshot
Theoretical studies on interaction of anticancer drugs (dacarbazine, procarbazine and triethylenemelamine) with normal (AT and GC) and mismatch (GG, CC, AA and TT) base pairs
inferred← citeshttps://doi.org/10.1080/10406638.2025.2538877openalex-snapshot
A Novel Phenoxyquinoline-Pyrimidine Hybrids: Synthesis, In Silico ADME Studies, Molecular Docking and in Vitro Cytotoxic Activity
inferred← citeshttps://doi.org/10.1080/10426507.2022.2116707openalex-snapshot
Phenothiazine derivatives of 1,8-naphthalic anhydride: Synthesis, characterization and antimicrobial studies
inferred← citeshttps://doi.org/10.1088/1478-3975/6/3/036013openalex-snapshot
Modeling the entropic structural transition of DNA complexes formed with intercalating drugs
inferred← citeshttps://doi.org/10.1093/nar/gki726openalex-snapshot
Intercalator conjugates of pyrimidine locked nucleic acid-modified triplex-forming oligonucleotides: improving DNA binding properties and reaching cellular activities
inferred← citeshttps://doi.org/10.1093/nar/gki782openalex-snapshot
Not so crystal clear: the structure of the human telomere G-quadruplex in solution differs from that present in a crystal
inferred← citeshttps://doi.org/10.1093/nar/gkm1069openalex-snapshot
A novel G-quadruplex-forming GGA repeat region in the c-myb promoter is a critical regulator of promoter activity
inferred← citeshttps://doi.org/10.1093/nar/gnj012openalex-snapshot
Sequence- and structural-selective nucleic acid binding revealed by the melting of mixtures
inferred← citeshttps://doi.org/10.1097/cad.0b013e3283324d0aopenalex-snapshot
NSC746364, NSC746365, and NSC746366: the spectra of cytotoxicity and molecular correlates of response to telomerase activity
inferred← citeshttps://doi.org/10.1107/s1600536810023482openalex-snapshot
Ethyl 1,6-dimethyl-2-oxo-4-(quinolin-4-yl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate
inferred← citeshttps://doi.org/10.1111/cbdd.13492openalex-snapshot
Synthesis and antitumor activity of 2‐isocamphanyl thiosemicarbazone derivatives via ROS‐enhanced mitochondrial damage
inferred← citeshttps://doi.org/10.1111/j.1349-7006.2011.02103.xopenalex-snapshot
QS‐ZYX‐1‐61 induces apoptosis through topoisomerase II in human non‐small‐cell lung cancer A549 cells
inferred← citeshttps://doi.org/10.1111/jphp.12168openalex-snapshot
DLJ14, a novel chemo-sensitization agent, enhances therapeutic effects of adriamycin against MCF-7/A cells both in vitro and in vivo
inferred← citeshttps://doi.org/10.1134/s1070328414050091openalex-snapshot
Coordination chemistry of Schiff base tin complexes
inferred← citeshttps://doi.org/10.1158/1535-7163.c.6530937openalex-snapshot
Data from Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia
inferred← citeshttps://doi.org/10.1158/1535-7163.c.6530937.v1openalex-snapshot
Data from Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia
inferred← citeshttps://doi.org/10.1158/1535-7163.mct-08-0130openalex-snapshot
Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia
inferred← citeshttps://doi.org/10.1159/000486911openalex-snapshot
Chlormethine Hydrochloride is Not Inferior to Tacrolimus in Treating Steroid-Resistant Nephrotic Syndrome
inferred← citeshttps://doi.org/10.1159/000543427openalex-snapshot
Temozolomide Treatment in Refractory Pituitary Adenomas and Pituitary Carcinomas
inferred← citeshttps://doi.org/10.1186/s11671-020-3295-1openalex-snapshot
Novel Chemo-Photothermal Therapy in Breast Cancer Using Methotrexate-Loaded Folic Acid Conjugated Au@SiO2 Nanoparticles
inferred← citeshttps://doi.org/10.1371/journal.pone.0060253openalex-snapshot
Re-Directing an Alkylating Agent to Mitochondria Alters Drug Target and Cell Death Mechanism
inferred← citeshttps://doi.org/10.1371/journal.pone.0062351openalex-snapshot
Early Chk1 Phosphorylation Is Driven by Temozolomide-Induced, DNA Double Strand Break- and Mismatch Repair-Independent DNA Damage
inferred← citeshttps://doi.org/10.1371/journal.pone.0136669openalex-snapshot
A New Epigenetic Mechanism of Temozolomide Action in Glioma Cells
inferred← citeshttps://doi.org/10.1517/14712598.6.3.257openalex-snapshot
Antiprotease therapy in cancer: hot or not?
inferred← citeshttps://doi.org/10.1529/biophysj.106.082420openalex-snapshot
Atomic Force Microscopy Study of the Specific Adhesion between a Colloid Particle and a Living Melanoma Cell: Effect of the Charge and the Hydrophobicity of the Particle Surface
inferred← citeshttps://doi.org/10.1530/erc-18-0015openalex-snapshot
65 YEARS OF THE DOUBLE HELIX: Treatment of pituitary tumors with temozolomide: an update
inferred← citeshttps://doi.org/10.18388/abp.2016_1338openalex-snapshot
Searching for anti-glioma activity. Ribonucleoside analogues with modifications in nucleobase and sugar moieties.
inferred← citeshttps://doi.org/10.2174/0113895575390561251121044125openalex-snapshot
Recent Developments in Heterocyclic Derivatives as Novel Cancer Therapeutics: From 2020-2024
inferred← citeshttps://doi.org/10.2174/092986712799945021openalex-snapshot
Molecular Property Filters Describing Pharmacokinetics and Drug Binding
inferred← citeshttps://doi.org/10.2174/138161210791209009openalex-snapshot
Novel Metals and Metal Complexes as Platforms for Cancer Therapy
inferred← citeshttps://doi.org/10.2174/1385272823666191029114830openalex-snapshot
A Review of Cationic Arylfurans and Their Isosteres: Synthesis and Biological Importance
inferred← citeshttps://doi.org/10.2174/1570179419666220216091422openalex-snapshot
Ligands for Abasic Site-containing DNA and their Use as Fluorescent Probes
inferred← citeshttps://doi.org/10.2174/157018009787158472openalex-snapshot
DNA Binders: 1. Evaluation of DNA-Interactive Ability, Design, and Synthesis of Novel Intercalating Agents
inferred← citeshttps://doi.org/10.2174/157018010791526296openalex-snapshot
Synthesis and Evaluation of Haloacetyl, α-Bromoacryloyl and Nitrooxyacetyl Benzo[b]furan and Benzo[b]thiophene Derivatives as Potent Antiproliferative Agents Against Leukemia L1210 and K562 Cells
inferred← citeshttps://doi.org/10.2174/187152009787047743openalex-snapshot
Pyrrolo[2,1-c][1,4]benzodiazepine as a Scaffold for the Design and Synthesis of Anti- Tumour Drugs
inferred← citeshttps://doi.org/10.2174/1871520619666191112114340openalex-snapshot
Anticancer Activity of Platinum (II) Complex with 2-Benzoylpyridine by Induction of DNA Damage, S-Phase Arrest, and Apoptosis
inferred← citeshttps://doi.org/10.22533/at.ed.756242712openalex-snapshot
Farmácia: limites na investigação e inovação
inferred← citeshttps://doi.org/10.22533/at.ed.7562427121openalex-snapshot
EFEITO DOS HIPNÓTICOS EM IDOSOS: NOVAS POSSIBILIDADES DE TRATAMENTO E A IMPORTÂNCIA DO CICLO DO SONO
inferred← citeshttps://doi.org/10.22533/at.ed.7562427122openalex-snapshot
ANTICONCEPCIONAIS HORMONAIS E SEUS EFEITOS NO ORGANISMO FEMININO
inferred← citeshttps://doi.org/10.22533/at.ed.7562427123openalex-snapshot
BENEFÍCIOS DO UXI AMARELO (Endopleura uchi) EM MULHERES COM MIOMA: UMA REVISÃO DA LITERATURA
inferred← citeshttps://doi.org/10.2298/aoo1304118bopenalex-snapshot
Insights of potential G-quadruplex sequences in telomeres and proto-oncogenes
inferred← citeshttps://doi.org/10.3109/07357907.2013.775293openalex-snapshot
Aggressive Silent GH Pituitary Tumor Resistant to Multiple Treatments, Including Temozolomide
inferred← citeshttps://doi.org/10.3109/09687688.2010.521200openalex-snapshot
Receptor-targeted nanocarriers for therapeutic delivery to cancer
inferred← citeshttps://doi.org/10.3109/10715762.2014.886328openalex-snapshot
Mechanism of the malabaricone C-induced toxicity to the MCF-7 cell line
inferred← citeshttps://doi.org/10.32657/10220/47708openalex-snapshot
Development and application of NMR spectroscopy in G-quadruplexes : structure, dynamics and formation in biofilm
inferred← citeshttps://doi.org/10.3389/fendo.2018.00318openalex-snapshot
Temozolomide and Pituitary Tumors: Current Understanding, Unresolved Issues, and Future Directions
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