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Mitogen-activated protein kinases in innate immunity

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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/art.22869openalex-snapshot

Central role of the MEK/ERK MAP kinase pathway in a mouse model of rheumatoid arthritis: Potential proinflammatory mechanisms

inferredcites →https://doi.org/10.1002/art.24266openalex-snapshot

Evaluation of the efficacy and safety of pamapimod, a p38 MAP kinase inhibitor, in a double‐blind, methotrexate‐controlled study of patients with active rheumatoid arthritis

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Efficacy, pharmacodynamics, and safety of VX‐702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: Results of two randomized, double‐blind, placebo‐controlled clinical studies

inferredcites →https://doi.org/10.1002/art.34489openalex-snapshot

Antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: Advantages of targeting upstream kinases MKK‐3 or MKK‐6

inferredcites →https://doi.org/10.1002/eji.200526192openalex-snapshot

Control of dual‐specificity phosphatase‐1 expression in activated macrophages by IL‐10

inferredcites →https://doi.org/10.1002/emmm.201000103openalex-snapshot

Regulation of the severity of neuroinflammation and demyelination by TLR‐ASK1‐p38 pathway

inferredcites →https://doi.org/10.1007/s00436-011-2348-xopenalex-snapshot

An evolutionary analysis of trypanosomatid GP63 proteases

inferredcites →https://doi.org/10.1016/j.ceb.2009.01.010openalex-snapshot

Cell structure and dynamics

inferredcites →https://doi.org/10.1016/j.ceb.2009.01.015openalex-snapshot

Targeting protein kinases for the development of anti-inflammatory drugs

inferredcites →https://doi.org/10.1016/j.cell.2007.07.009openalex-snapshot

NF-κB Is a Negative Regulator of IL-1β Secretion as Revealed by Genetic and Pharmacological Inhibition of IKKβ

inferredcites →https://doi.org/10.1016/j.cell.2009.03.007openalex-snapshot

Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-κB Activation

inferredcites →https://doi.org/10.1016/j.cellsig.2011.03.006openalex-snapshot

Shigella flexneri type III secreted effector OspF reveals new crosstalks of proinflammatory signaling pathways during bacterial infection

inferredcites →https://doi.org/10.1016/j.chembiol.2011.11.010openalex-snapshot

Discovery of Potent and Selective Covalent Inhibitors of JNK

inferredcites →https://doi.org/10.1016/j.chom.2008.02.016openalex-snapshot

Salmonella AvrA Coordinates Suppression of Host Immune and Apoptotic Defenses via JNK Pathway Blockade

inferredcites →https://doi.org/10.1016/j.chom.2012.09.011openalex-snapshot

The Salmonella Kinase SteC Targets the MAP Kinase MEK to Regulate the Host Actin Cytoskeleton

inferredcites →https://doi.org/10.1016/j.ejpain.2011.04.005openalex-snapshot

Clinical trial of the p38 MAP kinase inhibitor dilmapimod in neuropathic pain following nerve injury

inferredcites →https://doi.org/10.1016/j.febslet.2006.12.012openalex-snapshot

Differential requirement of MKK4 and MKK7 in JNK activation by distinct scaffold proteins

inferredcites →https://doi.org/10.1016/j.immuni.2011.04.015openalex-snapshot

Anthrax Toxin Induces Macrophage Death by p38 MAPK Inhibition but Leads to Inflammasome Activation via ATP Leakage

inferredcites →https://doi.org/10.1016/j.immuni.2011.12.010openalex-snapshot

TAK1 Negatively Regulates NF-κB and p38 MAP Kinase Activation in Gr-1+CD11b+ Neutrophils

inferredcites →https://doi.org/10.1016/j.immuni.2012.01.001openalex-snapshot

NK Cell Genesis: A Trick of the Trail

inferredcites →https://doi.org/10.1016/j.intimp.2010.06.023openalex-snapshot

Critical role for apoptosis signal-regulating kinase 1 in the development of inflammatory K/BxN serum-induced arthritis

inferredcites →https://doi.org/10.1016/j.it.2005.11.007openalex-snapshot

MAP kinase kinase kinases and innate immunity

inferredcites →https://doi.org/10.1016/j.lfs.2008.09.003openalex-snapshot

The role of MAP kinase phosphatase-1 in the protective mechanism of dexamethasone against endotoxemia

inferredcites →https://doi.org/10.1016/j.molcel.2007.11.011openalex-snapshot

Structural Insights into the Enzymatic Mechanism of the Pathogenic MAPK Phosphothreonine Lyase

inferredcites →https://doi.org/10.1016/j.molimm.2008.01.011openalex-snapshot

The tyrosine kinase Syk promotes phagocytosis of Francisella through the activation of Erk

inferredcites →https://doi.org/10.1016/j.tibs.2008.11.005openalex-snapshot

Eliminylation: a post-translational modification catalyzed by phosphothreonine lyases

inferredcites →https://doi.org/10.1016/j.tips.2012.06.007openalex-snapshot

Targeting of TAK1 in inflammatory disorders and cancer

inferredcites →https://doi.org/10.1016/j.yexcr.2011.03.022openalex-snapshot

GSK-3β-induced ASK1 stabilization is crucial in LPS-induced endotoxin shock

inferredcites →https://doi.org/10.1016/s0014-5793(98)00578-xopenalex-snapshot

Role of MAP kinase cascades in inducing arginine transporters and nitric oxide synthetase in RAW264 macrophages

inferredcites →https://doi.org/10.1016/s0092-8674(00)00210-5openalex-snapshot

TNF-α Induction by LPS Is Regulated Posttranscriptionally via a Tpl2/ERK-Dependent Pathway

inferredcites →https://doi.org/10.1016/s0898-6568(99)00018-2openalex-snapshot

Involvement of Mitogen-Activated Protein Kinase Homologues in the Regulation of Lipopolysaccharide-Mediated Induction of Cyclo-oxygenase-2 but not Nitric Oxide Synthase in RAW 264.7 Macrophages

inferredcites →https://doi.org/10.1016/s1074-7613(00)80038-2openalex-snapshot

Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements

inferredcites →https://doi.org/10.1016/s1097-2765(03)00070-4openalex-snapshot

NF-κB1/p105 Regulates Lipopolysaccharide-Stimulated MAP Kinase Signaling by Governing the Stability and Function of the Tpl2 Kinase

inferredcites →https://doi.org/10.1021/jm9012906openalex-snapshot

Selective p38α Inhibitors Clinically Evaluated for the Treatment of Chronic Inflammatory Disorders

inferredcites →https://doi.org/10.1038/10061openalex-snapshot

MAPKAP kinase 2 is essential for LPS-induced TNF-α biosynthesis

inferredcites →https://doi.org/10.1038/35085597openalex-snapshot

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

inferredcites →https://doi.org/10.1038/emboj.2009.234openalex-snapshot

A non‐redundant role for MKP5 in limiting ROS production and preventing LPS‐induced vascular injury

inferredcites →https://doi.org/10.1038/jid.2012.373openalex-snapshot

Glutamine Suppresses DNFB-Induced Contact Dermatitis by Deactivating p38 Mitogen–Activated Protein Kinase via Induction of MAPK Phosphatase-1

inferredcites →https://doi.org/10.1038/nature02764openalex-snapshot

Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5

inferredcites →https://doi.org/10.1038/ni.1640openalex-snapshot

The kinase p38α serves cell type–specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression

inferredcites →https://doi.org/10.1038/ni.1644openalex-snapshot

The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling

inferredcites →https://doi.org/10.1038/ni.1819openalex-snapshot

Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

inferredcites →https://doi.org/10.1038/ni.1863openalex-snapshot

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

inferredcites →https://doi.org/10.1038/ni1014openalex-snapshot

Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3

inferredcites →https://doi.org/10.1038/ni1200openalex-snapshot

ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity

inferredcites →https://doi.org/10.1038/ni1255openalex-snapshot

Essential function for the kinase TAK1 in innate and adaptive immune responses

inferredcites →https://doi.org/10.1038/ni1310openalex-snapshot

Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1

inferredcites →https://doi.org/10.1038/ni1517openalex-snapshot

The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways

inferredcites →https://doi.org/10.1038/ni1528openalex-snapshot

Pathogen subversion of cell-intrinsic innate immunity

inferredcites →https://doi.org/10.1038/nri2035openalex-snapshot

MAPK phosphatases — regulating the immune response

inferredcites →https://doi.org/10.1038/nri2634openalex-snapshot

Transcriptional control of the inflammatory response

inferredcites →https://doi.org/10.1038/nri2711openalex-snapshot

The regulation of IL-10 production by immune cells

inferredcites →https://doi.org/10.1038/sj.onc.1210411openalex-snapshot

Scaffold proteins of MAP-kinase modules

inferredcites →https://doi.org/10.1042/0264-6021:3520145openalex-snapshot

Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7

inferredcites →https://doi.org/10.1042/bj20061891openalex-snapshot

Manipulation of host signalling pathways by anthrax toxins

inferredcites →https://doi.org/10.1042/bj20071149openalex-snapshot

Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex

inferredcites →https://doi.org/10.1042/bj20091062openalex-snapshot

MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophages

inferredcites →https://doi.org/10.1042/bst0340837openalex-snapshot

Mechanisms of MAPK signalling specificity

inferredcites →https://doi.org/10.1046/j.1365-2567.1999.00747.xopenalex-snapshot

Involvement of p38 mitogen‐activated protein kinase in lipopolysaccharide‐induced iNOS and COX‐2 expression in J774 macrophages

inferredcites →https://doi.org/10.1046/j.1462-5822.2003.00263.xopenalex-snapshot

Macrophage signalling upon mycobacterial infection: the MAP kinases lead the way

inferredcites →https://doi.org/10.1056/nejmoa1203421openalex-snapshot

Improved Survival with MEK Inhibition in BRAF-Mutated Melanoma

inferredcites →https://doi.org/10.1073/pnas.0608995103openalex-snapshot

Acetylation of MEK2 and IκB kinase (IKK) activation loop residues by YopJ inhibits signaling

inferredcites →https://doi.org/10.1073/pnas.0610731104openalex-snapshot

MicroRNA-155 is induced during the macrophage inflammatory response

inferredcites →https://doi.org/10.1073/pnas.0909133107openalex-snapshot

Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents

inferredcites →https://doi.org/10.1073/pnas.1008203109openalex-snapshot

Serine/threonine acetylation of TGFβ-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling

inferredcites →https://doi.org/10.1073/pnas.1107577108openalex-snapshot

Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses

inferredcites →https://doi.org/10.1073/pnas.1116188109openalex-snapshot

Epithelial transforming growth factor β-activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species

inferredcites →https://doi.org/10.1073/pnas.1120251109openalex-snapshot

Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation of DUSP16/MKP-7

inferredcites →https://doi.org/10.1073/pnas.1207290109openalex-snapshot

p38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation

inferredcites →https://doi.org/10.1074/jbc.m109.065102openalex-snapshot

PB1 Domain Interaction of p62/Sequestosome 1 and MEKK3 Regulates NF-κB Activation

inferredcites →https://doi.org/10.1074/jbc.m112.345405openalex-snapshot

Essential Role for IKKβ in Production of Type 1 Interferons by Plasmacytoid Dendritic Cells

inferredcites →https://doi.org/10.1074/jbc.m112.359489openalex-snapshot

ERK5 Protein Promotes, whereas MEK1 Protein Differentially Regulates, the Toll-like Receptor 2 Protein-dependent Activation of Human Endothelial Cells and Monocytes

inferredcites →https://doi.org/10.1074/jbc.m207453200openalex-snapshot

A Resorcylic Acid Lactone, 5Z-7-Oxozeaenol, Prevents Inflammation by Inhibiting the Catalytic Activity of TAK1 MAPK Kinase Kinase

inferredcites →https://doi.org/10.1074/jbc.m506771200openalex-snapshot

Recruitment of Tumor Necrosis Factor Receptor-associated Factor Family Proteins to Apoptosis Signal-regulating Kinase 1 Signalosome Is Essential for Oxidative Stress-induced Cell Death

inferredcites →https://doi.org/10.1074/jbc.m508720200openalex-snapshot

Cooperation of ERK and SCFSkp2 for MKP-1 Destruction Provides a Positive Feedback Regulation of Proliferating Signaling

inferredcites →https://doi.org/10.1074/jbc.m704236200openalex-snapshot

Chemical Genetics Define the Roles of p38α and p38β in Acute and Chronic Inflammation

inferredcites →https://doi.org/10.1074/jbc.m706970200openalex-snapshot

VopA Inhibits ATP Binding by Acetylating the Catalytic Loop of MAPK Kinases

inferredcites →https://doi.org/10.1074/jbc.m805861200openalex-snapshot

The Leishmania Surface Protease GP63 Cleaves Multiple Intracellular Proteins and Actively Participates in p38 Mitogen-activated Protein Kinase Inactivation

inferredcites →https://doi.org/10.1084/jem.20020281openalex-snapshot

Genetic Dissection of the Cellular Pathways and Signaling Mechanisms in Modeled Tumor Necrosis Factor–induced Crohn's-like Inflammatory Bowel Disease

inferredcites →https://doi.org/10.1084/jem.20060336openalex-snapshot

Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1

inferredcites →https://doi.org/10.1084/jem.20071728openalex-snapshot

Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling

inferredcites →https://doi.org/10.1084/jem.20091059openalex-snapshot

TPL-2 negatively regulates interferon-β production in macrophages and myeloid dendritic cells

inferredcites →https://doi.org/10.1093/emboj/cdg552openalex-snapshot

Feedback control of the protein kinase TAK1 by SAPK2a/p38α

inferredcites →https://doi.org/10.1093/nar/gkq1178openalex-snapshot

Stress induced gene expression: a direct role for MAPKAP kinases in transcriptional activation of immediate early genes

inferredcites →https://doi.org/10.1099/mic.0.058115-0openalex-snapshot

Functions of the Salmonella pathogenicity island 2 (SPI-2) type III secretion system effectors

inferredcites →https://doi.org/10.1101/cshperspect.a006049openalex-snapshot

Signaling in Innate Immunity and Inflammation

inferredcites →https://doi.org/10.1101/gad.1360605openalex-snapshot

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

inferredcites →https://doi.org/10.1101/gad.888501openalex-snapshot

MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines

inferredcites →https://doi.org/10.1111/j.1365-2567.2006.02495.xopenalex-snapshot

MEKK3 is essential for lipopolysaccharide‐induced interleukin‐6 and granulocyte–macrophage colony‐stimulating factor production in macrophages

inferredcites →https://doi.org/10.1111/j.1365-2567.2010.03313.xopenalex-snapshot

Increased inflammation and lethality of Dusp1−/− mice in polymicrobial peritonitis models

inferredcites →https://doi.org/10.1111/j.1365-2605.2012.01284.xopenalex-snapshot

The role of male chromosomal polymorphism played in spermatogenesis and the outcome of IVF/ICSI‐ET treatment

inferredcites →https://doi.org/10.1111/j.1365-2958.2008.06134.xopenalex-snapshot

SpvC is a Salmonella effector with phosphothreonine lyase activity on host mitogen‐activated protein kinases

inferredcites →https://doi.org/10.1111/j.1462-5822.2007.01109.xopenalex-snapshot

Yersinia outer proteins: Yops

inferredcites →https://doi.org/10.1111/j.1600-065x.2008.00744.xopenalex-snapshot

Regulation of the immune response by stress‐activated protein kinases

inferredcites →https://doi.org/10.1111/j.1600-065x.2012.01104.xopenalex-snapshot

IκB kinase regulation of the TPL‐2/ERK MAPK pathway

inferredcites →https://doi.org/10.1111/j.1742-4658.2012.08716.xopenalex-snapshot

Dual‐specificity MAP kinase phosphatases (MKPs)

inferredcites →https://doi.org/10.1124/jpet.110.166173openalex-snapshot

A Benzothiophene Inhibitor of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Inhibits Tumor Necrosis Factor α Production and Has Oral Anti-Inflammatory Efficacy in Acute and Chronic Models of Inflammation

inferredcites →https://doi.org/10.1126/science.1096158openalex-snapshot

Regulation of Phagosome Maturation by Signals from Toll-Like Receptors

inferredcites →https://doi.org/10.1126/science.1126867openalex-snapshot

Yersinia YopJ Acetylates and Inhibits Kinase Activation by Blocking Phosphorylation

inferredcites →https://doi.org/10.1126/science.1138960openalex-snapshot

The Phosphothreonine Lyase Activity of a Bacterial Type III Effector Family

inferredcites →https://doi.org/10.1126/science.1183021openalex-snapshot

Regulation of Adaptive Immunity by the Innate Immune System

inferredcites →https://doi.org/10.1126/science.1227568openalex-snapshot

JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation

inferredcites →https://doi.org/10.1126/science.286.5449.2514openalex-snapshot

Reduced MAP Kinase Phosphatase-1 Degradation After p42/p44 MAPK -Dependent Phosphorylation

inferredcites →https://doi.org/10.1126/scisignal.2002010openalex-snapshot

Large-Scale Discovery of ERK2 Substrates Identifies ERK-Mediated Transcriptional Regulation by ETV3

inferredcites →https://doi.org/10.1126/scisignal.2002187openalex-snapshot

The Emerging Role of Linear Ubiquitination in Cell Signaling

inferredcites →https://doi.org/10.1128/iai.00018-10openalex-snapshot

Mitogen-Activated Protein Kinase Phosphatase 2 Regulates the Inflammatory Response in Sepsis

inferredcites →https://doi.org/10.1128/iai.69.4.2001-2010.2001openalex-snapshot

Induction of Inducible Nitric Oxide Synthase-NO· by Lipoarabinomannan ofMycobacterium tuberculosisIs Mediated by MEK1-ERK, MKK7-JNK, and NF-κB Signaling Pathways

inferredcites →https://doi.org/10.1128/mcb.00227-07openalex-snapshot

Thioredoxin and TRAF Family Proteins Regulate Reactive Oxygen Species-Dependent Activation of ASK1 through Reciprocal Modulation of the N-Terminal Homophilic Interaction of ASK1

inferredcites →https://doi.org/10.1128/mcb.00301-07openalex-snapshot

Phosphorylation of TPL-2 on Serine 400 Is Essential for Lipopolysaccharide Activation of Extracellular Signal-Regulated Kinase in Macrophages

inferredcites →https://doi.org/10.1128/mcb.00564-12openalex-snapshot

Coordinate Regulation of TPL-2 and NF-κB Signaling in Macrophages by NF-κB1 p105

inferredcites →https://doi.org/10.1128/mcb.01065-12openalex-snapshot

IκB Kinase 2 Regulates TPL-2 Activation of Extracellular Signal-Regulated Kinases 1 and 2 by Direct Phosphorylation of TPL-2 Serine 400

inferredcites →https://doi.org/10.1128/mcb.01456-06openalex-snapshot

The Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinases MK2 and MK3 Cooperate in Stimulation of Tumor Necrosis Factor Biosynthesis and Stabilization of p38 MAPK

inferredcites →https://doi.org/10.1128/mcb.01690-12openalex-snapshot

MSK1 and MSK2 Inhibit Lipopolysaccharide-Induced Prostaglandin Production via an Interleukin-10 Feedback Loop

inferredcites →https://doi.org/10.1128/mcb.23.14.4739-4752.2003openalex-snapshot

NF-κB1 p105 Negatively Regulates TPL-2 MEK Kinase Activity

inferredcites →https://doi.org/10.1128/mcb.24.21.9658-9667.2004openalex-snapshot

Lipopolysaccharide Activation of the TPL-2/MEK/Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Cascade Is Regulated by IκB Kinase-Induced Proteolysis of NF-κB1 p105

inferredcites →https://doi.org/10.1128/mcb.25.23.10454-10464.2005openalex-snapshot

Generation and Characterization of p38β (MAPK11) Gene-Targeted Mice

inferredcites →https://doi.org/10.1128/mcb.26.6.2399-2407.2006openalex-snapshot

Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Regulates Tumor Necrosis Factor mRNA Stability and Translation Mainly by Altering Tristetraprolin Expression, Stability, and Binding to Adenine/Uridine-Rich Element

inferredcites →https://doi.org/10.1128/mcb.26.6.2408-2418.2006openalex-snapshot

Posttranslational Regulation of Tristetraprolin Subcellular Localization and Protein Stability by p38 Mitogen-Activated Protein Kinase and Extracellular Signal-Regulated Kinase Pathways

inferredcites →https://doi.org/10.1128/mmbr.00031-10openalex-snapshot

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

inferredcites →https://doi.org/10.1146/annurev-biochem-090308-173656openalex-snapshot

The Evolution of Protein Kinase Inhibitors from Antagonists to Agonists of Cellular Signaling

inferredcites →https://doi.org/10.1146/annurev-pathol-011110-130138openalex-snapshot

Alternative Macrophage Activation and Metabolism

inferredcites →https://doi.org/10.1146/annurev.immunol.021908.132532openalex-snapshot

Alternative Activation of Macrophages: An Immunologic Functional Perspective

inferredcites →https://doi.org/10.1152/physrev.00044.2005openalex-snapshot

The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology

inferredcites →https://doi.org/10.1158/1078-0432.ccr-08-0333openalex-snapshot

Advances in the Development of Cancer Therapeutics Directed against the RAS-Mitogen-Activated Protein Kinase Pathway

inferredcites →https://doi.org/10.1172/jci119649openalex-snapshot

Bone marrow transplantation reproduces the tristetraprolin-deficiency syndrome in recombination activating gene-2 (-/-) mice. Evidence that monocyte/macrophage progenitors may be responsible for TNFalpha overproduction.

inferredcites →https://doi.org/10.1172/jci27544openalex-snapshot

A specific p47phox -serine phosphorylated by convergent MAPKs mediates neutrophil NADPH oxidase priming at inflammatory sites

inferredcites →https://doi.org/10.1172/jci65124openalex-snapshot

Eukaryotic elongation factor 2 controls TNF-α translation in LPS-induced hepatitis

inferredcites →https://doi.org/10.1177/0091270010397050openalex-snapshot

An Oral Inhibitor of p38 MAP Kinase Reduces Plasma Fibrinogen in Patients With Chronic Obstructive Pulmonary Disease

inferredcites →https://doi.org/10.1182/blood-2007-11-123604openalex-snapshot

IFN-γ–mediated inhibition of MAPK phosphatase expression results in prolonged MAPK activity in response to M-CSF and inhibition of proliferation

inferredcites →https://doi.org/10.1189/jlb.0210083openalex-snapshot

Increased inflammation and impaired resistance to Chlamydophila pneumoniae infection in Dusp1-/- mice: critical role of IL-6

inferredcites →https://doi.org/10.1189/jlb.0309151openalex-snapshot

Macrophage differentiation of myeloid progenitor cells in response to M-CSF is regulated by the dual-specificity phosphatase DUSP5

inferredcites →https://doi.org/10.1210/me.2007-0067openalex-snapshot

Dual Specificity Phosphatase 1 Knockout Mice Show Enhanced Susceptibility to Anaphylaxis but Are Sensitive to Glucocorticoids

inferredcites →https://doi.org/10.1371/journal.pgen.1002977openalex-snapshot

The p38/MK2-Driven Exchange between Tristetraprolin and HuR Regulates AU–Rich Element–Dependent Translation

inferredcites →https://doi.org/10.1371/journal.pone.0031550openalex-snapshot

Myeloid Takl Acts as a Negative Regulator of the LPS Response and Mediates Resistance to Endotoxemia

inferredcites →https://doi.org/10.1371/journal.ppat.1001192openalex-snapshot

MAP Kinase Phosphatase-2 Plays a Critical Role in Response to Infection by Leishmania mexicana

inferredcites →https://doi.org/10.2174/156802609789007345openalex-snapshot

Cot/Tpl-2 Protein Kinase as a Target for the Treatment of Inflammatory Disease

inferredcites →https://doi.org/10.3858/emm.2009.41.4.058openalex-snapshot

p47phox, the phagocyte NADPH oxidase/NOX2 organizer: structure, phosphorylation and implication in diseases

inferredcites →https://doi.org/10.3899/jrheum.100602openalex-snapshot

A 24-Week, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study of the Efficacy of Oral SCIO-469, a p38 Mitogen-activated Protein Kinase Inhibitor, in Patients with Active Rheumatoid Arthritis

inferredcites →https://doi.org/10.4049/jimmunol.0804343openalex-snapshot

Increased Inflammation, Impaired Bacterial Clearance, and Metabolic Disruption after Gram-Negative Sepsis in Mkp-1 -Deficient Mice

inferredcites →https://doi.org/10.4049/jimmunol.0900043openalex-snapshot

Glutamine Protects Mice from Lethal Endotoxic Shock via a Rapid Induction of MAPK Phosphatase-1

inferredcites →https://doi.org/10.4049/jimmunol.0900312openalex-snapshot

The Induction of IL-10 by Zymosan in Dendritic Cells Depends on CREB Activation by the Coactivators CREB-Binding Protein and TORC2 and Autocrine PGE2

inferredcites →https://doi.org/10.4049/jimmunol.0901026openalex-snapshot

The α-Isoform of p38 MAPK Specifically Regulates Arthritic Bone Loss

inferredcites →https://doi.org/10.4049/jimmunol.0901336openalex-snapshot

Tumor Progression Locus 2 (Map3k8) Is Critical for Host Defense against Listeria monocytogenes and IL-1β Production

inferredcites →https://doi.org/10.4049/jimmunol.1103700openalex-snapshot

Myeloid-Specific Tristetraprolin Deficiency in Mice Results in Extreme Lipopolysaccharide Sensitivity in an Otherwise Minimal Phenotype

inferredcites →https://doi.org/10.4049/jimmunol.1201599openalex-snapshot

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inferredcites →https://doi.org/10.4049/jimmunol.1202462openalex-snapshot

PGE2 Induces Macrophage IL-10 Production and a Regulatory-like Phenotype via a Protein Kinase A–SIK–CRTC3 Pathway

inferredcites →https://doi.org/10.4049/jimmunol.1300173openalex-snapshot

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inferredcites →https://doi.org/10.4049/jimmunol.175.9.5596openalex-snapshot

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inferredcites →https://doi.org/10.4049/jimmunol.177.3.1913openalex-snapshot

MAPKAP Kinase 2-Deficient Mice Are Resistant to Collagen-Induced Arthritis

inferredcites →https://doi.org/10.4049/jimmunol.178.8.5312openalex-snapshot

Knockout of Mkp-1 Enhances the Host Inflammatory Responses to Gram-Positive Bacteria

inferredcites →https://doi.org/10.4049/jimmunol.180.7.5075openalex-snapshot

Macrophage Deletion of p38α Partially Impairs Lipopolysaccharide-Induced Cellular Activation

inferredcites →https://doi.org/10.5167/uzh-63198openalex-snapshot

Improved survival with MEK Inhibition in BRAF-mutated melanoma for the METRIC Study Group

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Ginseng-DF ameliorates intestinal mucosal barrier injury and enhances immunity in immunosuppressed mice by regulating MAPK/NF-κB signaling pathways

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Activation of Toll-like receptor 3 increases mouse aortic vascular smooth muscle cell contractility through ERK1/2 pathway

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inferred← citeshttps://doi.org/10.1007/s10311-021-01280-1openalex-snapshot

Methods to evaluate the toxicity of engineered nanomaterials for biomedical applications: a review

inferred← citeshttps://doi.org/10.1007/s10499-026-02606-yopenalex-snapshot

Transcriptomic analysis reveals organ-specific adaptations in the gut-liver axis during diet domestication of mandarin fish (Siniperca chuatsi)

inferred← citeshttps://doi.org/10.1007/s10528-023-10390-0openalex-snapshot

Exploration of the Shared Hub Genes and Biological Mechanism in Osteoporosis and Type 2 Diabetes Mellitus based on Machine Learning

inferred← citeshttps://doi.org/10.1007/s10529-020-03045-2openalex-snapshot

miR-19a mitigates hypoxia/reoxygenation-induced injury by depressing CCL20 and inactivating MAPK pathway in human embryonic cardiomyocytes

inferred← citeshttps://doi.org/10.1007/s10549-019-05166-3openalex-snapshot

Anti-tumor and anti-metastasis efficacy of E6201, a MEK1 inhibitor, in preclinical models of triple-negative breast cancer

inferred← citeshttps://doi.org/10.1007/s10753-017-0600-yopenalex-snapshot

Andrographolide Benefits Rheumatoid Arthritis via Inhibiting MAPK Pathways

inferred← citeshttps://doi.org/10.1007/s10753-017-0636-zopenalex-snapshot

Roburic Acid Suppresses NO and IL-6 Production via Targeting NF-κB and MAPK Pathway in RAW264.7 Cells

inferred← citeshttps://doi.org/10.1007/s10753-019-01056-4openalex-snapshot

Inhibition of Fibroblast Growth Factor Receptor by AZD4547 Protects Against Inflammation in Septic Mice

inferred← citeshttps://doi.org/10.1007/s10753-021-01439-6openalex-snapshot

The Signaling Pathways Regulating NLRP3 Inflammasome Activation

inferred← citeshttps://doi.org/10.1007/s10753-021-01464-5openalex-snapshot

Induction of Exaggerated Cytokine Production in Human Peripheral Blood Mononuclear Cells by a Recombinant SARS-CoV-2 Spike Glycoprotein S1 and Its Inhibition by Dexamethasone

inferred← citeshttps://doi.org/10.1007/s10753-024-02080-9openalex-snapshot

A Pair of Epimers of Lignan Alleviate Neuroinflammatory Effects by Modulating iNOS/COX-2 and MAPK/NF-κB Signaling Pathways

inferred← citeshttps://doi.org/10.1007/s10753-026-02493-8openalex-snapshot

Mogroside V Alleviates Concanavalin A-induced Acute Liver Injury by Inhibiting Inflammatory Responses and M1 Macrophage Polarization

inferred← citeshttps://doi.org/10.1007/s10787-019-00593-6openalex-snapshot

Evaluation of the therapeutic potential of the selective p38 MAPK inhibitor Skepinone-L and the dual p38/JNK 3 inhibitor LN 950 in experimental K/BxN serum transfer arthritis

inferred← citeshttps://doi.org/10.1007/s10787-020-00698-3openalex-snapshot

Cellular signalling pathways mediating the pathogenesis of chronic inflammatory respiratory diseases: an update

inferred← citeshttps://doi.org/10.1007/s10787-024-01525-9openalex-snapshot

Taming the storm: potential anti-inflammatory compounds targeting SARS-CoV-2 MPro

inferred← citeshttps://doi.org/10.1007/s10787-026-02270-xopenalex-snapshot

2-Butanone 4-glucopyranoside 6′-O-gallate isolated from Memecylon scutellatum exhibits anti-inflammatory activity via modulation of the NF-κB and MAPK signaling pathways in LPS-stimulated RAW 264.7 macrophages

inferred← citeshttps://doi.org/10.1007/s10811-025-03773-wopenalex-snapshot

Anti-inflammatory effect of a Capsosiphon fulvescens (Chlorophyta) extract obtained by subcritical water extraction on lipopolysaccharide-induced RAW 264.7 cells

inferred← citeshttps://doi.org/10.1007/s10875-024-01732-7openalex-snapshot

A Novel Frameshift Variant of the ELF4 Gene in a Patient with Autoinflammatory Disease: Clinical Features, Transcriptomic Profiling and Functional Studies

inferred← citeshttps://doi.org/10.1007/s11010-017-2978-0openalex-snapshot

Ubiquitin-specific protease 14 regulates LPS-induced inflammation by increasing ERK1/2 phosphorylation and NF-κB activation

inferred← citeshttps://doi.org/10.1007/s11010-017-3041-xopenalex-snapshot

Rotundarpene inhibits TNF-α-induced activation of the Akt, mTOR, and NF-κB pathways, and the JNK and p38 associated with production of reactive oxygen species

inferred← citeshttps://doi.org/10.1007/s11033-018-4531-yopenalex-snapshot

Sodium selenite protects from 3-nitropropionic acid-induced oxidative stress in cultured primary cortical neurons

inferred← citeshttps://doi.org/10.1007/s11033-021-06752-9openalex-snapshot

Harnessing the immune system against cancer: current immunotherapy approaches and therapeutic targets

inferred← citeshttps://doi.org/10.1007/s11033-023-08244-4openalex-snapshot

Evaluation of both expression and serum protein levels of caspase-8 and mitogen-activated protein kinase 1 genes in patients with different severities of COVID-19 infection

inferred← citeshttps://doi.org/10.1007/s11033-023-09077-xopenalex-snapshot

Integrative function of histone deacetylase 3 in inflammation

inferred← citeshttps://doi.org/10.1007/s11033-024-10038-1openalex-snapshot

TLR-4: a promising target for chemotherapy-induced peripheral neuropathy

inferred← citeshttps://doi.org/10.1007/s11033-025-10692-zopenalex-snapshot

Curcumin and acute myeloid leukemia: a golden hope, updated insights

inferred← citeshttps://doi.org/10.1007/s11046-017-0187-8openalex-snapshot

Inflammation Induced by Candida parapsilosis in THP-1 Cells and Human Peripheral Blood Mononuclear Cells (PBMCs)

inferred← citeshttps://doi.org/10.1007/s11064-018-2661-1openalex-snapshot

A Novel and Selective p38 Mitogen-Activated Protein Kinase Inhibitor Attenuates LPS-Induced Neuroinflammation in BV2 Microglia and a Mouse Model

inferred← citeshttps://doi.org/10.1007/s11064-021-03360-8openalex-snapshot

Spata2 Knockdown Exacerbates Brain Inflammation via NF-κB/P38MAPK Signaling and NLRP3 Inflammasome Activation in Cerebral Ischemia/Reperfusion Rats

inferred← citeshttps://doi.org/10.1007/s11064-022-03674-1openalex-snapshot

Melatonin Alters the miRNA Transcriptome of Inflammasome Activation in Murine Microglial Cells

inferred← citeshttps://doi.org/10.1007/s11101-024-09955-7openalex-snapshot

Plant-derived bioactive compounds as key players in the modulation of immune-related conditions

inferred← citeshttps://doi.org/10.1007/s11130-024-01231-5openalex-snapshot

Anti-inflammatory Effect of Symplocos prunifolia Extract in an In Vitro Model of Acute Pneumonia

inferred← citeshttps://doi.org/10.1007/s11255-017-1728-2openalex-snapshot

Collectins in urinary tract and kidney diseases

inferred← citeshttps://doi.org/10.1007/s11356-018-1337-3openalex-snapshot

In type 2 diabetes induced by cigarette smoking, activation of p38 MAPK is involved in pancreatic β-cell apoptosis

inferred← citeshttps://doi.org/10.1007/s11418-020-01452-3openalex-snapshot

Shenyan Kangfu tablet alleviates diabetic kidney disease through attenuating inflammation and modulating the gut microbiota

inferred← citeshttps://doi.org/10.1007/s11427-020-1720-9openalex-snapshot

MAP3K2 augments Th1 cell differentiation via IL-18 to promote T cell-mediated colitis

inferred← citeshttps://doi.org/10.1007/s11481-014-9543-3openalex-snapshot

Target Engagement Analysis and Link to Pharmacodynamic Endpoint for a Novel Class of CNS-penetrant and Efficacious p38α MAPK Inhibitors

inferred← citeshttps://doi.org/10.1007/s11596-024-2830-1openalex-snapshot

Jianpi Qinghua Formula Alleviates Diabetic Myocardial Injury Through Inhibiting JunB/c-Fos Expression

inferred← citeshttps://doi.org/10.1007/s12011-022-03171-0openalex-snapshot

The Dysregulation of Inflammatory Pathways Triggered by Copper Exposure

inferred← citeshttps://doi.org/10.1007/s12013-025-01911-2openalex-snapshot

TNF-α-Induced Upregulation of ADAMTS-8 Expression in SW480 Cells: Implications for Intracellular Signaling Pathways and Transcription Factor Activity

inferred← citeshttps://doi.org/10.1007/s12013-026-02131-yopenalex-snapshot

Ferroptosis–Inflammation Crosstalk: Mechanistic Insights and Emerging Drug Targets

inferred← citeshttps://doi.org/10.1007/s12016-025-09097-4openalex-snapshot

Targeting IL-4/IL-13 Signaling Pathways in Chronic Rhinosinusitis with Nasal Polyps: From Mechanisms to Therapies

inferred← citeshttps://doi.org/10.1007/s12031-020-01622-8openalex-snapshot

Cronobacter sakazakii Infection in Early Postnatal Rats Impaired Contextual-Associated Learning: a Putative Role of C5a-Mediated NF-κβ and ASK1 Pathways

inferred← citeshttps://doi.org/10.1007/s12032-022-01945-zopenalex-snapshot

NLRP3 inflammasome activation By 17β-estradiol is a potential therapeutic target in hepatocellular carcinoma treatment

inferred← citeshttps://doi.org/10.1007/s12035-023-03558-7openalex-snapshot

The Role of Resveratrol on Spinal Cord Injury: from Bench to Bedside

inferred← citeshttps://doi.org/10.1007/s12325-019-01026-0openalex-snapshot

The Proteins of Keratoconus: a Literature Review Exploring Their Contribution to the Pathophysiology of the Disease

inferred← citeshttps://doi.org/10.1007/s12602-020-09663-6openalex-snapshot

Hepatoprotective Effect of Probiotic Lactic Acid Bacteria on Thioacetamide-Induced Liver Fibrosis in Rats

inferred← citeshttps://doi.org/10.1007/s12602-023-10093-3openalex-snapshot

Studies of the Impact of the Bifidobacterium Species on Inducible Nitric Oxide Synthase Expression and Nitric Oxide Production in Murine Macrophages of the BMDM Cell Line

inferred← citeshttps://doi.org/10.1007/s12602-024-10297-1openalex-snapshot

The Therapeutic Effects of Probiotic on Systemic Lupus Erythematosus in Lupus Mice Models: A Systematic Review

inferred← citeshttps://doi.org/10.1007/s12672-026-04646-5openalex-snapshot

Bioinformatic analysis and experimental validation of the function of mitogen-activated protein kinase in esophageal cancer

inferred← citeshttps://doi.org/10.1007/s13238-018-0599-3openalex-snapshot

Transcriptional mechanism of IRF8 and PU.1 governs microglial activation in neurodegenerative condition

inferred← citeshttps://doi.org/10.1007/s13238-019-0653-9openalex-snapshot

JMJD3 in the regulation of human diseases

inferred← citeshttps://doi.org/10.1007/s13258-026-01769-5openalex-snapshot

Anti-inflammatory activity and antioxidant capacity of Clerodendrum japonicum (Thunb.) sweet extract in LPS-stimulated macrophages

inferred← citeshttps://doi.org/10.1007/s13577-022-00822-1openalex-snapshot

Cl-amidine attenuates lipopolysaccharide-induced inflammation in human gingival fibroblasts via the JNK/MAPK, NF-κB, and Nrf2 signalling pathways

inferred← citeshttps://doi.org/10.1007/s15010-024-02325-7openalex-snapshot

Activation of the MAPK network provides a survival advantage during the course of COVID-19-induced sepsis: a real-world evidence analysis of a multicenter COVID-19 Sepsis Cohort

inferred← citeshttps://doi.org/10.1007/s40265-014-0193-9openalex-snapshot

Spleen Tyrosine Kinase Inhibitors for Rheumatoid Arthritis: Where Are We Now?

inferred← citeshttps://doi.org/10.1007/s40618-023-02161-wopenalex-snapshot

Combined evaluation of prolactin-induced peptide (PIP) and extracellular signal-regulated kinase (ERK) as new sperm biomarkers of FSH treatment efficacy in normogonadotropic idiopathic infertile men

inferred← citeshttps://doi.org/10.1007/s40820-024-01455-9openalex-snapshot

Nanomaterial-Based Repurposing of Macrophage Metabolism and Its Applications

inferred← citeshttps://doi.org/10.1007/s42452-025-07214-8openalex-snapshot

Mechanistic insight into potential toxic effects of microplastics and nanoplastics on human health

inferred← citeshttps://doi.org/10.1016/b978-0-08-100596-5.22358-5openalex-snapshot

Tocopherols and Tocotrienols: Sources, Analytical Methods, and Effects in Food and Biological Systems

inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.12458-8openalex-snapshot

Medicinal Chemistry Case History: Structure-Based Drug Design of Oral and Inhaled p38 MAP Kinase Inhibitors as Clinical Candidates

inferred← citeshttps://doi.org/10.1016/b978-0-12-417186-2.00012-1openalex-snapshot

Mucosal immunity in mollusks

inferred← citeshttps://doi.org/10.1016/b978-0-12-801238-3.04062-9openalex-snapshot

Signaling Through Mitogen-Activated Protein (MAP) Kinases☆

inferred← citeshttps://doi.org/10.1016/b978-0-12-801238-3.98742-7openalex-snapshot

MAP Kinase Modules in Signaling☆

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