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Topoisomerases and the regulation of neural function

https://doi.org/10.1038/nrn.2016.101

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/cne.20793openalex-snapshot

DNA topoisomerase I in the mouse central nervous system: Age and sex dependence

inferredcites →https://doi.org/10.1007/7050_2007_026openalex-snapshot

Spo11 and the Formation of DNA Double-Strand Breaks in Meiosis

inferredcites →https://doi.org/10.1007/s12035-008-8044-xopenalex-snapshot

Glutamate Regulates the Activity of Topoisomerase I in Mouse Cerebellum

inferredcites →https://doi.org/10.1016/j.cell.2014.12.023openalex-snapshot

Ligand-Dependent Enhancer Activation Regulated by Topoisomerase-I Activity

inferredcites →https://doi.org/10.1016/j.cell.2015.05.032openalex-snapshot

Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes

inferredcites →https://doi.org/10.1016/j.dnarep.2014.03.020openalex-snapshot

Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2)

inferredcites →https://doi.org/10.1016/j.molcel.2010.09.019openalex-snapshot

The DNA Damage Response: Making It Safe to Play with Knives

inferredcites →https://doi.org/10.1016/j.molcel.2010.11.024openalex-snapshot

TDRD3 Is an Effector Molecule for Arginine-Methylated Histone Marks

inferredcites →https://doi.org/10.1016/j.molcel.2012.03.001openalex-snapshot

Preventing Replication Stress to Maintain Genome Stability: Resolving Conflicts between Replication and Transcription

inferredcites →https://doi.org/10.1016/j.molcel.2012.04.009openalex-snapshot

R Loops: From Transcription Byproducts to Threats to Genome Stability

inferredcites →https://doi.org/10.1016/j.molcel.2014.01.011openalex-snapshot

Arginine Methylation Facilitates the Recruitment of TOP3B to Chromatin to Prevent R Loop Accumulation

inferredcites →https://doi.org/10.1016/j.neuron.2015.03.059openalex-snapshot

Gene Length Matters in Neurons

inferredcites →https://doi.org/10.1016/s0079-6603(06)81005-6openalex-snapshot

Repair of Topoisomerase I‐Mediated DNA Damage

inferredcites →https://doi.org/10.1038/35096590openalex-snapshot

DNA topoisomerase IIα is required for RNA polymerase II transcription on chromatin templates

inferredcites →https://doi.org/10.1038/emboj.2009.391openalex-snapshot

Positional dependence of transcriptional inhibition by DNA torsional stress in yeast chromosomes

inferredcites →https://doi.org/10.1038/nature03314openalex-snapshot

Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1

inferredcites →https://doi.org/10.1038/nature08444openalex-snapshot

A human 5′-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage

inferredcites →https://doi.org/10.1038/nature10726openalex-snapshot

Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons

inferredcites →https://doi.org/10.1038/nature11928openalex-snapshot

Circular RNAs are a large class of animal RNAs with regulatory potency

inferredcites →https://doi.org/10.1038/nature11993openalex-snapshot

Natural RNA circles function as efficient microRNA sponges

inferredcites →https://doi.org/10.1038/nature12504openalex-snapshot

Topoisomerases facilitate transcription of long genes linked to autism

inferredcites →https://doi.org/10.1038/nature14319openalex-snapshot

Disruption of DNA-methylation-dependent long gene repression in Rett syndrome

inferredcites →https://doi.org/10.1038/ncb1984openalex-snapshot

Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription

inferredcites →https://doi.org/10.1038/ncomms10191openalex-snapshot

Transcriptional elongation requires DNA break-induced signalling

inferredcites →https://doi.org/10.1038/ng.2929openalex-snapshot

TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function

inferredcites →https://doi.org/10.1038/ng987openalex-snapshot

Mutation of TDP1, encoding a topoisomerase I–dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy

inferredcites →https://doi.org/10.1038/nn.3479openalex-snapshot

Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation

inferredcites →https://doi.org/10.1038/nn.3484openalex-snapshot

Deletion of TOP3β, a component of FMRP-containing mRNPs, contributes to neurodevelopmental disorders

inferredcites →https://doi.org/10.1038/nn.3537openalex-snapshot

Maintaining genome stability in the nervous system

inferredcites →https://doi.org/10.1038/nn.3715openalex-snapshot

Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes

inferredcites →https://doi.org/10.1038/nrc2608openalex-snapshot

DNA topoisomerase II and its growing repertoire of biological functions

inferredcites →https://doi.org/10.1038/nrc3892openalex-snapshot

Topoisomerase-mediated chromosomal break repair: an emerging player in many games

inferredcites →https://doi.org/10.1038/nrg2380openalex-snapshot

Single-strand break repair and genetic disease

inferredcites →https://doi.org/10.1038/nrm3228openalex-snapshot

All tangled up: how cells direct, manage and exploit topoisomerase function

inferredcites →https://doi.org/10.1038/nrm3949openalex-snapshot

The selection and function of cell type-specific enhancers

inferredcites →https://doi.org/10.1038/nrm831openalex-snapshot

Cellular roles of DNA topoisomerases: a molecular perspective

inferredcites →https://doi.org/10.1038/nrn2559openalex-snapshot

DNA repair deficiency and neurological disease

inferredcites →https://doi.org/10.1046/j.1365-2443.2003.00643.xopenalex-snapshot

Enforced cytokinesis without complete nuclear division in embryonic cells depleting the activity of DNA topoisomerase IIα

inferredcites →https://doi.org/10.1073/pnas.080536597openalex-snapshot

SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage

inferredcites →https://doi.org/10.1073/pnas.101132498openalex-snapshot

Mice lacking DNA topoisomerase IIIβ develop to maturity but show a reduced mean lifespan

inferredcites →https://doi.org/10.1073/pnas.1119798109openalex-snapshot

Target genes of Topoisomerase IIβ regulate neuronal survival and are defined by their chromatin state

inferredcites →https://doi.org/10.1073/pnas.1232376100openalex-snapshot

Aberrant lamination in the cerebral cortex of mouse embryos lacking DNA topoisomerase IIβ

inferredcites →https://doi.org/10.1073/pnas.1305426110openalex-snapshot

R-loop formation at Snord116 mediates topotecan inhibition of Ube3a-antisense and allele-specific chromatin decondensation

inferredcites →https://doi.org/10.1073/pnas.1413204111openalex-snapshot

Topoisomerase 1 inhibition reversibly impairs synaptic function

inferredcites →https://doi.org/10.1073/pnas.1511016112openalex-snapshot

Lack of mitochondrial topoisomerase I ( TOP1mt ) impairs liver regeneration

inferredcites →https://doi.org/10.1073/pnas.191321998openalex-snapshot

Human mitochondrial topoisomerase I

inferredcites →https://doi.org/10.1073/pnas.192449499openalex-snapshot

Dual localization of human DNA topoisomerase IIIα to mitochondria and nucleus

inferredcites →https://doi.org/10.1073/pnas.85.4.1060openalex-snapshot

Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes.

inferredcites →https://doi.org/10.1073/pnas.89.23.11461openalex-snapshot

Positive supercoiling of DNA greatly diminishes mRNA synthesis in yeast.

inferredcites →https://doi.org/10.1073/pnas.95.3.1010openalex-snapshot

Mammalian DNA topoisomerase IIIα is essential in early embryogenesis

inferredcites →https://doi.org/10.1074/jbc.273.44.28553openalex-snapshot

Cloning of cDNA Encoding a Novel Mouse DNA Topoisomerase III (Topo IIIβ) Possessing Negatively Supercoiled DNA Relaxing Activity, Whose Message Is Highly Expressed in the Testis

inferredcites →https://doi.org/10.1074/jbc.m008517200openalex-snapshot

Involvement of DNA Topoisomerase IIβ in Neuronal Differentiation

inferredcites →https://doi.org/10.1074/jbc.m503320200openalex-snapshot

Human Topoisomerase IIα Rapidly Relaxes Positively Supercoiled DNA

inferredcites →https://doi.org/10.1074/jbc.m803493200openalex-snapshot

A Ubiquitin-Proteasome Pathway for the Repair of Topoisomerase I-DNA Covalent Complexes

inferredcites →https://doi.org/10.1093/nar/gkm102openalex-snapshot

C-Terminal regions of topoisomerase II and II determine isoform-specific functioning of the enzymes in vivo

inferredcites →https://doi.org/10.1093/nar/gku384openalex-snapshot

Increased negative supercoiling of mtDNA in TOP1mt knockout mice and presence of topoisomerases II and II in vertebrate mitochondria

inferredcites →https://doi.org/10.1101/gad.242990.114openalex-snapshot

A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expression

inferredcites →https://doi.org/10.1126/science.1127196openalex-snapshot

A Topoisomerase IIß-Mediated dsDNA Break Required for Regulated Transcription

inferredcites →https://doi.org/10.1126/science.287.5450.131openalex-snapshot

DNA Topoisomerase IIβ and Neural Development

inferredcites →https://doi.org/10.1126/science.aad7993openalex-snapshot

Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation

inferredcites →https://doi.org/10.1128/mcb.00617-06openalex-snapshot

Role of Topoisomerase IIβ in the Expression of Developmentally Regulated Genes

inferredcites →https://doi.org/10.1128/mcb.16.12.6804openalex-snapshot

Targeted Disruption of the Mouse Topoisomerase I Gene by Camptothecin Selection

inferredcites →https://doi.org/10.1146/annurev-biochem-061809-100002openalex-snapshot

New Mechanistic and Functional Insights into DNA Topoisomerases

inferredcites →https://doi.org/10.1146/annurev-neuro-060909-153138openalex-snapshot

The Pathophysiology of Fragile X (and What It Teaches Us about Synapses)

inferredcites →https://doi.org/10.1146/annurev-pathol-011811-132509openalex-snapshot

ATM and the Molecular Pathogenesis of Ataxia Telangiectasia

inferredcites →https://doi.org/10.1146/annurev.biochem.70.1.369openalex-snapshot

DNA Topoisomerases: Structure, Function, and Mechanism

inferredcites →https://doi.org/10.1242/bio.20146767openalex-snapshot

Topoisomerase IIbeta is required for proper retinal development and survival of postmitotic cells

inferredcites →https://doi.org/10.1261/rna.047126.114openalex-snapshot

Circular RNAs: diversity of form and function

inferredcites →https://doi.org/10.1371/journal.pgen.1003128openalex-snapshot

DNA Topoisomerases Maintain Promoters in a State Competent for Transcriptional Activation in Saccharomyces cerevisiae

inferredcites →https://doi.org/10.1371/journal.pgen.1003226openalex-snapshot

TDP2–Dependent Non-Homologous End-Joining Protects against Topoisomerase II–Induced DNA Breaks and Genome Instability in Cells and In Vivo

inferredcites →https://doi.org/10.1371/journal.pgen.1003370openalex-snapshot

Tdp2: A Means to Fixing the Ends

inferredcites →https://doi.org/10.1371/journal.pgen.1005098openalex-snapshot

Genome-Destabilizing Effects Associated with Top1 Loss or Accumulation of Top1 Cleavage Complexes in Yeast

inferredcites →https://doi.org/10.1371/journal.pone.0041094openalex-snapshot

Mitochondrial Topoisomerase I is Critical for Mitochondrial Integrity and Cellular Energy Metabolism

inferredcites →https://doi.org/10.1371/journal.pone.0156439openalex-snapshot

Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms

inferredcites →https://doi.org/10.1523/jneurosci.2674-14.2014openalex-snapshot

Cell-Type-Specific Repression by Methyl-CpG-Binding Protein 2 Is Biased toward Long Genes

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Delimiting the Ambit of Responsibility of Intermediary Publishers for Third Party Rights in European Data Protection: Towards a Synthetic Interpretation of the EU acquis

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Nano‐Biotechnology and Challenges of Drug Delivery System in Cancer Treatment Pathway: Review Article

inferred← citeshttps://doi.org/10.1002/med.21546openalex-snapshot

Topoisomerase 1B poisons: Over a half‐century of drug leads, clinical candidates, and serendipitous discoveries

inferred← citeshttps://doi.org/10.1007/7515_2021_38openalex-snapshot

HSF1 in RNA Polymerase II Promoter-Proximal Pausing and HSP70 Transcription

inferred← citeshttps://doi.org/10.1007/978-3-319-63953-6_6openalex-snapshot

Applications for Treatment of Neurodegenerative Diseases

inferred← citeshttps://doi.org/10.1007/s00018-022-04204-6openalex-snapshot

Defective repair of topoisomerase I induced chromosomal damage in Huntington’s disease

inferred← citeshttps://doi.org/10.1007/s42764-020-00026-7openalex-snapshot

Targeting DNA repair pathways: mechanisms and potential applications in cancer therapy

inferred← citeshttps://doi.org/10.1016/j.brainres.2023.148339openalex-snapshot

DNA Topoisomerase Top3β Is Impacted by Early Life Stress in the Developing Female and Male Rat Brain

inferred← citeshttps://doi.org/10.1016/j.ccell.2025.04.014openalex-snapshot

Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target

inferred← citeshttps://doi.org/10.1016/j.cell.2017.06.034openalex-snapshot

Genome Organization Drives Chromosome Fragility

inferred← citeshttps://doi.org/10.1016/j.celrep.2021.109802openalex-snapshot

NuMorph: Tools for cortical cellular phenotyping in tissue-cleared whole-brain images

inferred← citeshttps://doi.org/10.1016/j.dnarep.2017.06.005openalex-snapshot

The Top1 paradox: Friend and foe of the eukaryotic genome

inferred← citeshttps://doi.org/10.1016/j.dnarep.2019.102669openalex-snapshot

DNA repair and neurological disease: From molecular understanding to the development of diagnostics and model organisms

inferred← citeshttps://doi.org/10.1016/j.dnarep.2020.102837openalex-snapshot

Excision repair of topoisomerase DNA-protein crosslinks (TOP-DPC)

inferred← citeshttps://doi.org/10.1016/j.dnarep.2020.102849openalex-snapshot

Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs topoisomerase 1 DNA-protein crosslinks and 3′-blocking lesions in the absence of tyrosyl-DNA phosphodiesterase 1 (TDP1)

inferred← citeshttps://doi.org/10.1016/j.dnarep.2022.103277openalex-snapshot

Post-translational regulation of Tyrosyl-DNA phosphodiesterase (TDP1 and TDP2) for the repair of the trapped topoisomerase-DNA covalent complex

inferred← citeshttps://doi.org/10.1016/j.dnarep.2024.103629openalex-snapshot

Chromosomal single-strand break repair and neurological disease: Implications on transcription and emerging genomic tools

inferred← citeshttps://doi.org/10.1016/j.dnarep.2024.103699openalex-snapshot

Broken strands, broken minds: Exploring the nexus of DNA damage and neurodegeneration

inferred← citeshttps://doi.org/10.1016/j.ejcb.2017.09.003openalex-snapshot

RNA polymerase II pausing and transcriptional regulation of the HSP70 expression

inferred← citeshttps://doi.org/10.1016/j.ejmech.2017.11.011openalex-snapshot

Design, synthesis, and biological evaluation of 1,3-diarylisoquinolines as novel topoisomerase I catalytic inhibitors

inferred← citeshttps://doi.org/10.1016/j.ejmech.2026.119232openalex-snapshot

Integrated experimental and computational investigation of sophoridine derivatives reveals antitumor potential and Topo I-associated mechanisms

inferred← citeshttps://doi.org/10.1038/s10038-020-0800-4openalex-snapshot

Characterization of a novel loss-of-function variant in TDP2 in two adult patients with spinocerebellar ataxia autosomal recessive 23 (SCAR23)

inferred← citeshttps://doi.org/10.1038/s41467-020-16884-4openalex-snapshot

Topoisomerase 3β knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity

inferred← citeshttps://doi.org/10.1038/s41467-021-25252-9openalex-snapshot

PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation

inferred← citeshttps://doi.org/10.1038/s41467-023-44089-yopenalex-snapshot

ERK2-topoisomerase II regulatory axis is important for gene activation in immediate early genes

inferred← citeshttps://doi.org/10.1038/s41593-021-00923-4openalex-snapshot

Human ALS/FTD brain organoid slice cultures display distinct early astrocyte and targetable neuronal pathology

inferred← citeshttps://doi.org/10.1038/s42003-024-06552-4openalex-snapshot

Early oxidative stress and DNA damage in Aβ-burdened hippocampal neurons in an Alzheimer’s-like transgenic rat model

inferred← citeshttps://doi.org/10.1073/pnas.1914081116openalex-snapshot

Deletions associated with stabilization of the Top1 cleavage complex in yeast are products of the nonhomologous end-joining pathway

inferred← citeshttps://doi.org/10.1074/jbc.rev120.008286openalex-snapshot

The many lives of type IA topoisomerases

inferred← citeshttps://doi.org/10.1093/jimmun/vkae003openalex-snapshot

Topoisomerase 1 is required for the development and function of thymus

inferred← citeshttps://doi.org/10.1098/rstb.2016.0283openalex-snapshot

ATM-dependent pathways of chromatin remodelling and oxidative DNA damage responses

inferred← citeshttps://doi.org/10.1101/2020.09.11.293399openalex-snapshot

NuMorph: tools for cellular phenotyping in tissue cleared whole brain images

inferred← citeshttps://doi.org/10.1101/2020.12.10.419747openalex-snapshot

Epilepsy kinase CDKL5 is a DNA damage sensor which controls transcriptional activity at DNA breaks

inferred← citeshttps://doi.org/10.1101/2021.10.29.466366openalex-snapshot

Transcription disrupts DNA-scaffolded bacteriophage repressor complexes

inferred← citeshttps://doi.org/10.1101/2024.10.15.618281openalex-snapshot

Human Topoisomerase IIα Promotes Chromatin Condensation Via a Phase Transition

inferred← citeshttps://doi.org/10.1101/762500openalex-snapshot

FMRP binding to a ranked subset of long genes is revealed by coupled CLIP and TRAP in specific neuronal cell types

inferred← citeshttps://doi.org/10.1101/gad.301325.117openalex-snapshot

Genome integrity and disease prevention in the nervous system

inferred← citeshttps://doi.org/10.1111/acel.13554openalex-snapshot

Proper control of R‐loop homeostasis is required for maintenance of gene expression and neuronal function during aging

inferred← citeshttps://doi.org/10.1111/gtc.12993openalex-snapshot

Physiological concentrations of glucocorticoids induce pathological DNA double‐strand breaks

inferred← citeshttps://doi.org/10.1111/mmi.14997openalex-snapshot

Mechanistic insights from molecular microbiology into the production of immunological and neuronal diversity

inferred← citeshttps://doi.org/10.1126/sciadv.abg6363openalex-snapshot

Chromatin architecture at susceptible gene loci in cerebellar Purkinje cells characterizes DNA damage–induced neurodegeneration

inferred← citeshttps://doi.org/10.1186/s12906-023-04319-8openalex-snapshot

Flaxseed oil fraction reverses cardiac remodeling at a molecular level: improves cardiac function, decreases apoptosis, and suppresses miRNA-29b and miRNA 1 gene expression

inferred← citeshttps://doi.org/10.1186/s13287-018-0859-4openalex-snapshot

DNA topoisomerase IIβ stimulates neurite outgrowth in neural differentiated human mesenchymal stem cells through regulation of Rho-GTPases (RhoA/Rock2 pathway) and Nurr1 expression

inferred← citeshttps://doi.org/10.1242/dmm.031930openalex-snapshot

The central role of DNA damage and repair in CAG repeat diseases

inferred← citeshttps://doi.org/10.1242/jcs.263638openalex-snapshot

Mitochondrial topoisomerases, nucleoid architecture and mtDNA repair in human disease

inferred← citeshttps://doi.org/10.1371/journal.ppat.1009954openalex-snapshot

The Epstein-Barr virus deubiquitinating enzyme BPLF1 regulates the activity of topoisomerase II during productive infection

inferred← citeshttps://doi.org/10.1523/eneuro.0404-17.2017openalex-snapshot

Topoisomerase IIβ Selectively Regulates Motor Neuron Identity and Peripheral Connectivity through Hox/Pbx-Dependent Transcriptional Programs

inferred← citeshttps://doi.org/10.15252/embj.2021108271openalex-snapshot

CDKL5 kinase controls transcription‐coupled responses to DNA damage

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MECANISMOS DE REPARO AOS DANOS NO DNA NOS PONTOS DE CHECAGEM DO CICLO CELULAR

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Oncogenetic Function and Prognostic Value of DNA Topoisomerase II Alpha (TOP2A) in Human Malignances: A Pan-Cancer Analysis

inferred← citeshttps://doi.org/10.3233/jad-220203openalex-snapshot

DNA Damage Response-Associated Cell Cycle Re-Entry and Neuronal Senescence in Brain Aging and Alzheimer’s Disease

inferred← citeshttps://doi.org/10.3389/fgene.2019.01285openalex-snapshot

Higher Order Organization of the mtDNA: Beyond Mitochondrial Transcription Factor A

inferred← citeshttps://doi.org/10.3389/fgene.2022.856692openalex-snapshot

Oncogenetic Function and Prognostic Value of DNA Topoisomerase II Alpha in Human Malignances: A Pan-Cancer Analysis

inferred← citeshttps://doi.org/10.3389/fnagi.2017.00430openalex-snapshot

Role of Estrogen and Other Sex Hormones in Brain Aging. Neuroprotection and DNA Repair

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Topoisomerase-Mediated DNA Damage in Neurological Disorders

inferred← citeshttps://doi.org/10.3389/fncel.2022.836885openalex-snapshot

The Role of DNA Damage in Neural Plasticity in Physiology and Neurodegeneration

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Top2b-Regulated Genes and Pathways Linked to Retinal Homeostasis and Degeneration

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Leveraging Gene Expression Data for Drug Repurposing in Schizophrenia: A Signature Reversion Approach

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Type II DNA Topoisomerases Cause Spontaneous Double-Strand Breaks in Genomic DNA

inferred← citeshttps://doi.org/10.3390/ijms19113480openalex-snapshot

Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives

inferred← citeshttps://doi.org/10.3390/ijms21030751openalex-snapshot

Effect of Bortezomib on Global Gene Expression in PC12-Derived Nerve Cells

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Local Protein Translation and RNA Processing of Synaptic Proteins in Autism Spectrum Disorder

inferred← citeshttps://doi.org/10.3390/ijms222312806openalex-snapshot

Topoisomerase IIIβ Deficiency Induces Neuro-Behavioral Changes and Brain Connectivity Alterations in Mice

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SMC5 Plays Independent Roles in Congenital Heart Disease and Neurodevelopmental Disability

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From Infection to Tumor: Exploring the Therapeutic Potential of Ciprofloxacin Derivatives as Anticancer Agents

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Multidrug Resistance: Are We Still Afraid of the Big Bad Wolf

inferred← citeshttps://doi.org/10.3410/f.727745036.793565196openalex-snapshot

Faculty Opinions recommendation of The Top1 paradox: Friend and foe of the eukaryotic genome.

inferred← citeshttps://doi.org/10.3410/f.727835478.793556820openalex-snapshot

Faculty Opinions recommendation of Genome organization drives chromosome fragility.

inferred← citeshttps://doi.org/10.3410/f.727835478.793565203openalex-snapshot

Faculty Opinions recommendation of Genome organization drives chromosome fragility.

inferred← citeshttps://doi.org/10.4049/jimmunol.2200650openalex-snapshot

Topoisomerases in Immune Cell Development and Function

inferred← citeshttps://doi.org/10.6084/m9.figshare.24934229openalex-snapshot

Additional file 1 of Flaxseed oil fraction reverses cardiac remodeling at a molecular level: improves cardiac function, decreases apoptosis, and suppresses miRNA-29b and miRNA 1 gene expression

inferred← citeshttps://doi.org/10.64898/2025.12.08.693088openalex-snapshot

ALS/FTD-associated TDP-43 mutations promote fragility of genes governing excitatory neurotransmission via topoisomerase IIβ impairment

inferred← citeshttps://doi.org/10.70675/26791ff9zc628z4081zaf62zab7c02c91558openalex-snapshot

Caractérisation de la dynamique de l'ADN-glycosylase OGG1 et de résidus responsables de son interaction avec l'ADN en cellules vivantes

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Mécanisme d'action d'un nouveau composé organométallique inhibiteur des topoisomérases I d’adénocarcinomes

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