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TDP2–Dependent Non-Homologous End-Joining Protects against Topoisomerase II–Induced DNA Breaks and Genome Instability in Cells and In Vivo

https://doi.org/10.1371/journal.pgen.1003226

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Potential role for DNA topoisomerase II poisons in the generation of t(11;20)(p15;q11) translocations

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inferredcites →https://doi.org/10.1002/gcc.20685openalex-snapshot

Rearrangements of the MLL gene are influenced by DNA secondary structure, potentially mediated by topoisomerase II binding

inferredcites →https://doi.org/10.1002/gcc.20848openalex-snapshot

Microhomologies and topoisomerase II consensus sequences identified near the breakpoint junctions of the recurrent t(7;21)(p22;q22) translocation in acute myeloid leukemia

inferredcites →https://doi.org/10.1002/gcc.2870020110openalex-snapshot

Implication of prior treatment with drug combinations including inhibitors of topoisomerase II in therapy‐related monocytic leukemia with a 9;11 translocation

inferredcites →https://doi.org/10.1007/978-3-540-71021-9_8openalex-snapshot

Sister chromatid recombination

inferredcites →https://doi.org/10.1016/0027-5107(94)90048-5openalex-snapshot

Mutagenicity and carcinogenicity of topoisomerase-interactive agents

inferredcites →https://doi.org/10.1016/j.dnarep.2006.05.016openalex-snapshot

Biochemical mechanisms of chromosomal translocations resulting from DNA double-strand breaks

inferredcites →https://doi.org/10.1016/j.dnarep.2006.05.031openalex-snapshot

Topoisomerase II and the etiology of chromosomal translocations

inferredcites →https://doi.org/10.1016/s1097-2765(00)80108-2openalex-snapshot

Ku70

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Repair of DNA Covalently Linked to Protein

inferredcites →https://doi.org/10.1038/cr.2007.111openalex-snapshot

Regulation of DNA double-strand break repair pathway choice

inferredcites →https://doi.org/10.1038/emboj.2009.276openalex-snapshot

ATM and Artemis promote homologous recombination of radiation‐induced DNA double‐strand breaks in G2

inferredcites →https://doi.org/10.1038/nature06337openalex-snapshot

Human CtIP promotes DNA end resection

inferredcites →https://doi.org/10.1038/nature08444openalex-snapshot

A human 5′-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage

inferredcites →https://doi.org/10.1038/ng.613openalex-snapshot

Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements

inferredcites →https://doi.org/10.1038/nrc2607openalex-snapshot

Targeting DNA topoisomerase II in cancer chemotherapy

inferredcites →https://doi.org/10.1038/nrc2608openalex-snapshot

DNA topoisomerase II and its growing repertoire of biological functions

inferredcites →https://doi.org/10.1038/nrm831openalex-snapshot

Cellular roles of DNA topoisomerases: a molecular perspective

inferredcites →https://doi.org/10.1038/nsmb.1710openalex-snapshot

DNA resection in eukaryotes: deciding how to fix the break

inferredcites →https://doi.org/10.1038/onc.2011.94openalex-snapshot

Oncogenic role of EAPII in lung cancer development and its activation of the MAPK–ERK pathway

inferredcites →https://doi.org/10.1038/sj.onc.1206374openalex-snapshot

EAPII interacts with ETS1 and modulates its transcriptional function

inferredcites →https://doi.org/10.1038/sj.onc.1207052openalex-snapshot

Reciprocal DNA topoisomerase II cleavage events at 5′-TATTA-3′ sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and der(9) genomic breakpoint junctions in treatment-related AML without further processing

inferredcites →https://doi.org/10.1038/sj.onc.1210075openalex-snapshot

XRCC4 in G1 suppresses homologous recombination in S/G2, in G1 checkpoint-defective cells

inferredcites →https://doi.org/10.1046/j.1365-2141.2001.03000.xopenalex-snapshot

Therapy‐related acute lymphoblastic leukaemia with MLL rearrangements following DNA topoisomerase II inhibitors, an increasing problem: report on two new cases and review of the literature since 1992

inferredcites →https://doi.org/10.1056/nejmoa042715openalex-snapshot

DNA Topoisomerase II in Therapy-Related Acute Promyelocytic Leukemia

inferredcites →https://doi.org/10.1073/pnas.0400726101openalex-snapshot

DNA end joining becomes less efficient and more error-prone during cellular senescence

inferredcites →https://doi.org/10.1073/pnas.0603455103openalex-snapshot

Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage

inferredcites →https://doi.org/10.1073/pnas.171309898openalex-snapshot

Near-precise interchromosomal recombination and functional DNA topoisomerase II cleavage sites at MLL and AF-4 genomic breakpoints in treatment-related acute lymphoblastic leukemia with t(4;11) translocation

inferredcites →https://doi.org/10.1073/pnas.95.24.14066openalex-snapshot

DNA end-joining catalyzed by human cell-free extracts

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TTRAP, a Novel Protein That Associates with CD40, Tumor Necrosis Factor (TNF) Receptor-75 and TNF Receptor-associated Factors (TRAFs), and That Inhibits Nuclear Factor-κB Activation

inferredcites →https://doi.org/10.1074/jbc.m110.181016openalex-snapshot

TDP2/TTRAP Is the Major 5′-Tyrosyl DNA Phosphodiesterase Activity in Vertebrate Cells and Is Critical for Cellular Resistance to Topoisomerase II-induced DNA Damage

inferredcites →https://doi.org/10.1074/jbc.m111.333963openalex-snapshot

Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Repairs DNA Damage Induced by Topoisomerases I and II and Base Alkylation in Vertebrate Cells

inferredcites →https://doi.org/10.1074/jbc.m405042200openalex-snapshot

TDP1 Overexpression in Human Cells Counteracts DNA Damage Mediated by Topoisomerases I and II

inferredcites →https://doi.org/10.1086/507791openalex-snapshot

Nucleotide-Resolution Mapping of Topoisomerase-Mediated and Apoptotic DNA Strand Scissions at or near an MLL Translocation Hotspot

inferredcites →https://doi.org/10.1089/dna.2007.0649openalex-snapshot

The Requirement of Artemis in Double-Strand Break Repair Depends on the Type of DNA Damage

inferredcites →https://doi.org/10.1093/emboj/17.18.5497openalex-snapshot

Homologous recombination and non‐homologous end‐joining pathways of DNA double‐strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

inferredcites →https://doi.org/10.1093/nar/gkn937openalex-snapshot

The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing

inferredcites →https://doi.org/10.1093/nar/gkq1175openalex-snapshot

CtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1

inferredcites →https://doi.org/10.1093/nar/gks622openalex-snapshot

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1

inferredcites →https://doi.org/10.1101/gad.181685.111openalex-snapshot

Mutant p53 cooperates with ETS2 to promote etoposide resistance

inferredcites →https://doi.org/10.1101/gad.946401openalex-snapshot

Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells

inferredcites →https://doi.org/10.1128/mcb.19.7.5166openalex-snapshot

Sister Chromatid Exchanges Are Mediated by Homologous Recombination in Vertebrate Cells

inferredcites →https://doi.org/10.1146/annurev-genet-110410-132435openalex-snapshot

Double-Strand Break End Resection and Repair Pathway Choice

inferredcites →https://doi.org/10.1146/annurev.biochem.70.1.369openalex-snapshot

DNA Topoisomerases: Structure, Function, and Mechanism

inferredcites →https://doi.org/10.1200/jco.2008.19.0892openalex-snapshot

High-Dose Etoposide: From Phase I to a Component of Curative Therapy

inferredcites →https://doi.org/10.1371/journal.pone.0012541openalex-snapshot

Topoisomerase II-Mediated DNA Damage Is Differently Repaired during the Cell Cycle by Non-Homologous End Joining and Homologous Recombination

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inferredcites →https://doi.org/10.4161/cc.10.19.17763openalex-snapshot

Pleiotropic functions of EAPII/TTRAP/TDP2

inferredcites →https://doi.org/10.4161/cc.9.4.10764openalex-snapshot

γH2AX foci analysis for monitoring DNA double-strand break repair: Strengths, limitations and optimization

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1016/j.celrep.2017.08.091openalex-snapshot

DNA Ligase IV Guides End-Processing Choice during Nonhomologous End Joining

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DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks

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Polθ promotes the repair of 5′-DNA-protein crosslinks by microhomology-mediated end-joining

inferred← citeshttps://doi.org/10.1016/j.celrep.2021.108977openalex-snapshot

Topoisomerase IIα represses transcription by enforcing promoter-proximal pausing

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ATM suppresses c-Myc overexpression in the mammary epithelium in response to estrogen

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ARID1A stabilizes non-homologous end joining factors at DNA breaks induced by the G4 ligand pyridostatin

inferred← citeshttps://doi.org/10.1016/j.devcel.2019.11.006openalex-snapshot

GCNA Interacts with Spartan and Topoisomerase II to Regulate Genome Stability

inferred← citeshttps://doi.org/10.1016/j.dnarep.2014.02.008openalex-snapshot

Nonhomologous end joining: A good solution for bad ends

inferred← citeshttps://doi.org/10.1016/j.dnarep.2014.03.009openalex-snapshot

Inter-individual variation in DNA repair capacity: A need for multi-pathway functional assays to promote translational DNA repair research

inferred← citeshttps://doi.org/10.1016/j.dnarep.2014.03.020openalex-snapshot

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Influence of nucleotide excision repair on mitoxantrone cytotoxicity

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Depletion of tyrosyl DNA phosphodiesterase 2 activity enhances etoposide-mediated double-strand break formation and cell killing

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Repair of DNA-protein crosslinks in plants

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Excision repair of topoisomerase DNA-protein crosslinks (TOP-DPC)

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Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs topoisomerase 1 DNA-protein crosslinks and 3′-blocking lesions in the absence of tyrosyl-DNA phosphodiesterase 1 (TDP1)

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Untangling trapped topoisomerases with tyrosyl-DNA phosphodiesterases

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Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity

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Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations

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A Mechanism to Minimize Errors during Non-homologous End Joining

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Two distinct long-range synaptic complexes promote different aspects of end processing prior to repair of DNA breaks by non-homologous end joining

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Tyrosyl-DNA-phosphodiesterase I (TDP1) participates in the removal and repair of stabilized-Top2α cleavage complexes in human cells

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Bioflavonoids cause DNA double-strand breaks and chromosomal translocations through topoisomerase II-dependent and -independent mechanisms

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DNA–Protein Crosslink Proteolysis Repair

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Etoposide Quinone Is a Covalent Poison of Human Topoisomerase IIβ

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ATM specifically mediates repair of double-strand breaks with blocked DNA ends

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Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway

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TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function

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Mdm2 selectively suppresses DNA damage arising from inhibition of topoisomerase II independent of p53

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Characterization of a novel loss-of-function variant in TDP2 in two adult patients with spinocerebellar ataxia autosomal recessive 23 (SCAR23)

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GSE4 peptide suppresses oxidative and telomere deficiencies in ataxia telangiectasia patient cells

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NBS1 is required for SPO11-linked DNA double-strand break repair in male meiosis

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Inhibition of topoisomerase IIA (Top2α) induces telomeric DNA damage and T cell dysfunction during chronic viral infection

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H263A and SCAN1/H493R mutant TDP1 block TOP1-induced double-strand break repair during gene transcription in quiescent cells and promote cell death

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TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription

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Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency

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End processing in NHEJ by Polymerase λ and PNKP is coordinated during short-range synapsis

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Human topoisomerases and their roles in genome stability and organization

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Mechanisms and regulation of DNA end resection in the maintenance of genome stability

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Confined migration induces non-lethal DNA damage in developing neurons

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Release of paused RNA polymerase II at specific loci favors DNA double-strand-break formation and promotes cancer translocations

inferred← citeshttps://doi.org/10.1038/s41598-023-39649-7openalex-snapshot

DNA-PK inhibition extends the therapeutic effects of Top2 poisoning to non-proliferating cells, increasing activity at a cost

inferred← citeshttps://doi.org/10.1038/srep36804openalex-snapshot

Contribution of sleep to the repair of neuronal DNA double-strand breaks: evidence from flies and mice

inferred← citeshttps://doi.org/10.1039/d1dt03700eopenalex-snapshot

Platinum complexes as inhibitors of DNA repair protein Ku70 and topoisomerase IIα in cancer cells

inferred← citeshttps://doi.org/10.1074/jbc.ra118.006269openalex-snapshot

An internal ribosome entry site in the coding region of tyrosyl-DNA phosphodiesterase 2 drives alternative translation start

inferred← citeshttps://doi.org/10.1080/15257770.2019.1674332openalex-snapshot

Repair of trapped topoisomerase II covalent cleavage complexes: Novel proteasome-independent mechanisms

inferred← citeshttps://doi.org/10.1093/nar/gkaa318openalex-snapshot

Ubiquitin stimulated reversal of topoisomerase 2 DNA-protein crosslinks by TDP2

inferred← citeshttps://doi.org/10.1093/nar/gkaa483openalex-snapshot

Topoisomerase II contributes to DNA secondary structure-mediated double-stranded breaks

inferred← citeshttps://doi.org/10.1093/nar/gkaa640openalex-snapshot

Canonical non-homologous end-joining promotes genome mutagenesis and translocations induced by transcription-associated DNA topoisomerase 2 activity

inferred← citeshttps://doi.org/10.1093/nar/gkv969openalex-snapshot

DNA double-strand breaks with 5′ adducts are efficiently channeled to the DNA2-mediated resection pathway

inferred← citeshttps://doi.org/10.1093/nar/gkw228openalex-snapshot

Reversal of DNA damage induced Topoisomerase 2 DNA–protein crosslinks by Tdp2

inferred← citeshttps://doi.org/10.1093/nar/gkx1219openalex-snapshot

Tyrosyl–DNA phosphodiesterases: rescuing the genome from the risks of relaxation

inferred← citeshttps://doi.org/10.1093/narcan/zcae016openalex-snapshot

TDP2 is a regulator of estrogen-responsive oncogene expression

inferred← citeshttps://doi.org/10.1093/plcell/koab228openalex-snapshot

The repair of topoisomerase 2 cleavage complexes in Arabidopsis

inferred← citeshttps://doi.org/10.1101/2020.02.18.953851openalex-snapshot

Transcription-associated topoisomerase activities control DNA-breaks production by G-quadruplex ligands

inferred← citeshttps://doi.org/10.1101/2020.05.12.091058openalex-snapshot

Control of RNA Polymerase II Promoter-Proximal Pausing by DNA Supercoiling

inferred← citeshttps://doi.org/10.1101/2020.09.03.280669openalex-snapshot

The genetic sequences prone to copy number variation and single nucleotide polymorphism are linked to the repair of the poisoned DNA topoisomerase II

inferred← citeshttps://doi.org/10.1101/gad.353693.126openalex-snapshot

MRE11 suppresses germline mutagenesis at meiotic double-strand breaks in mice

inferred← citeshttps://doi.org/10.1111/gtc.12770openalex-snapshot

TDP2 suppresses genomic instability induced by androgens in the epithelial cells of prostate glands

inferred← citeshttps://doi.org/10.1111/gtc.70076openalex-snapshot

Processing of DNA Topoisomerase II – DNA –Protein Crosslinks Associated With Anticancer Drugs

inferred← citeshttps://doi.org/10.1124/molpharm.121.000374openalex-snapshot

Mechanisms to Repair Stalled Topoisomerase II-DNA Covalent Complexes

inferred← citeshttps://doi.org/10.1126/sciadv.adl2108openalex-snapshot

RAD54L2 counters TOP2-DNA adducts to promote genome stability

inferred← citeshttps://doi.org/10.1136/gutjnl-2015-309809openalex-snapshot

HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B

inferred← citeshttps://doi.org/10.1146/annurev-biochem-032620-105820openalex-snapshot

DNA–Protein Crosslinks and Their Resolution

inferred← citeshttps://doi.org/10.1155/2017/6439169openalex-snapshot

Physiological Roles of DNA Double-Strand Breaks

inferred← citeshttps://doi.org/10.11575/prism/25052openalex-snapshot

A Tale of a ‘Tail’ – Understanding the Role of Ku80 C-terminal Region in Non-Homologous End Joining

inferred← citeshttps://doi.org/10.1158/1535-7163.mct-16-0767openalex-snapshot

The DNA-Binding Polyamine Moiety in the Vectorized DNA Topoisomerase II Inhibitor F14512 Alters Reparability of the Consequent Enzyme-Linked DNA Double-Strand Breaks

inferred← citeshttps://doi.org/10.1158/1535-7163.mct-19-1064openalex-snapshot

The Indenoisoquinoline LMP517: A Novel Antitumor Agent Targeting both TOP1 and TOP2

inferred← citeshttps://doi.org/10.1186/s12864-019-6436-0openalex-snapshot

CNCC: an analysis tool to determine genome-wide DNA break end structure at single-nucleotide resolution

inferred← citeshttps://doi.org/10.1186/s13059-026-04080-4openalex-snapshot

The SMARCA4 subunit of the SWI/SNF complex prevents genome instability at G quadruplexes

inferred← citeshttps://doi.org/10.1186/s13071-019-3792-1openalex-snapshot

DNA damage response and repair in perspective: Aedes aegypti, Drosophila melanogaster and Homo sapiens

inferred← citeshttps://doi.org/10.1186/s13578-019-0366-zopenalex-snapshot

DNA–protein cross-link repair: what do we know now?

inferred← citeshttps://doi.org/10.1212/nxg.0000000000000262openalex-snapshot

Confirming TDP2 mutation in spinocerebellar ataxia autosomal recessive 23 (SCAR23)

inferred← citeshttps://doi.org/10.1371/journal.pgen.1003370openalex-snapshot

Tdp2: A Means to Fixing the Ends

inferred← citeshttps://doi.org/10.1371/journal.pgen.1006891openalex-snapshot

Natural variation in a single amino acid substitution underlies physiological responses to topoisomerase II poisons

inferred← citeshttps://doi.org/10.1371/journal.pone.0108483openalex-snapshot

MRE11-Deficiency Associated with Improved Long-Term Disease Free Survival and Overall Survival in a Subset of Stage III Colon Cancer Patients in Randomized CALGB 89803 Trial

inferred← citeshttps://doi.org/10.1371/journal.pone.0244790openalex-snapshot

Tyrosyl-DNA phosphodiesterases are involved in mutagenic events at a ribonucleotide embedded into DNA in human cells

inferred← citeshttps://doi.org/10.1371/journal.ppat.1009954openalex-snapshot

The Epstein-Barr virus deubiquitinating enzyme BPLF1 regulates the activity of topoisomerase II during productive infection

inferred← citeshttps://doi.org/10.17615/jhtj-pn93openalex-snapshot

Characterizing Ku’s Role as an AP lyase in Nonhomologous End Joining

inferred← citeshttps://doi.org/10.2147/ijn.s181732openalex-snapshot

Gold nanoparticles – an optical biosensor for RNA quantification for cancer and neurologic disorders diagnosis

inferred← citeshttps://doi.org/10.2174/0113895575370547250526062144openalex-snapshot

Topoisomerase II Inhibition in Cancer: A Focus on Metal Complexes

inferred← citeshttps://doi.org/10.3389/fcell.2024.1394531openalex-snapshot

Tyrosyl-DNA phosphodiesterase 2 (Tdp2) repairs DNA-protein crosslinks and protects against double strand breaks in vivo

inferred← citeshttps://doi.org/10.3389/fimmu.2022.982870openalex-snapshot

Topoisomerase 2β and DNA topology during B cell development

inferred← citeshttps://doi.org/10.3389/fmolb.2019.00141openalex-snapshot

DNA Double Strand Breaks and Chromosomal Translocations Induced by DNA Topoisomerase II

inferred← citeshttps://doi.org/10.3389/fmolb.2022.944775openalex-snapshot

Targeting DNA-Protein Crosslinks via Post-Translational Modifications

inferred← citeshttps://doi.org/10.3389/fnagi.2021.751742openalex-snapshot

Topoisomerase-Mediated DNA Damage in Neurological Disorders

inferred← citeshttps://doi.org/10.3390/cancers13102315openalex-snapshot

High Temperature Drives Topoisomerase Mediated Chromosomal Break Repair Pathway Choice

inferred← citeshttps://doi.org/10.3390/genes10100791openalex-snapshot

Broken by the Cut: A Journey into the Role of Topoisomerase II in DNA Fragility

inferred← citeshttps://doi.org/10.3390/genes10110868openalex-snapshot

Type II DNA Topoisomerases Cause Spontaneous Double-Strand Breaks in Genomic DNA

inferred← citeshttps://doi.org/10.3390/genes14101931openalex-snapshot

Usnic Acid Derivatives Inhibit DNA Repair Enzymes Tyrosyl-DNA Phosphodiesterases 1 and 2 and Act as Potential Anticancer Agents

inferred← citeshttps://doi.org/10.3390/genes15010085openalex-snapshot

Enzymatic Processing of DNA–Protein Crosslinks

inferred← citeshttps://doi.org/10.3390/genes7070032openalex-snapshot

Collision of Trapped Topoisomerase 2 with Transcription and Replication: Generation and Repair of DNA Double-Strand Breaks with 5′ Adducts

inferred← citeshttps://doi.org/10.3390/genes9120581openalex-snapshot

The Emerging Role of Cohesin in the DNA Damage Response

inferred← citeshttps://doi.org/10.3390/ijms19072056openalex-snapshot

Effect of TDP2 on the Level of TOP2-DNA Complexes and SUMOylated TOP2-DNA Complexes

inferred← citeshttps://doi.org/10.3390/ijms20123015openalex-snapshot

Mammalian Tyrosyl-DNA Phosphodiesterases in the Context of Mitochondrial DNA Repair

inferred← citeshttps://doi.org/10.3390/ijms222111336openalex-snapshot

New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1

inferred← citeshttps://doi.org/10.4103/jrcr.jrcr_60_20openalex-snapshot

DNA-Dependent protein kinase in DNA damage response: Three decades and beyond

inferred← citeshttps://doi.org/10.4161/15476286.2014.992283openalex-snapshot

Ribonucleotide triggered DNA damage and RNA-DNA damage responses

inferred← citeshttps://doi.org/10.5772/intechopen.95453openalex-snapshot

DNA Damage and Repair Mechanisms Triggered by Exposure to Bioflavonoids and Natural Compounds

inferred← citeshttps://doi.org/10.64898/2026.07.14.738426openalex-snapshot

ZATT/ZNF451 promotes release of stalled TOP2 cleavage complexes

inferred← citeshttps://doi.org/10.70675/8177333az76a6z4204z808az958753142cafopenalex-snapshot

Regulation of alternative splicing and polyadenylation by genotoxic anti-cancer agents

inferred← citeshttps://doi.org/10.70675/82bac603zacf0z4b15z9075z79c992d95421openalex-snapshot

Etudes des G-quadruplexes : impact de la stabilisation par des ligands en tant qu'agents anti-cancéreux et identification des protéines associées régulant leur métabolisme

inferred← citeshttps://doi.org/10.7554/elife.53447openalex-snapshot

Suppressing proteasome mediated processing of topoisomerase II DNA-protein complexes preserves genome integrity

inferred← citeshttps://doi.org/10.7554/elife.65184openalex-snapshot

Transcription-associated topoisomerase 2α (TOP2A) activity is a major effector of cytotoxicity induced by G-quadruplex ligands

inferred← citeshttps://doi.org/10.7554/elife.91304.1openalex-snapshot

Topological stress triggers difficult-to-repair DNA lesions in ribosomal DNA with ensuing formation of PML-nucleolar compartment

inferred← citeshttps://doi.org/10.7554/elife.91304.1.sa0openalex-snapshot

Reviewer #3 (Public Review): Topological stress triggers difficult-to-repair DNA lesions in ribosomal DNA with ensuing formation of PML-nucleolar compartment

inferred← citeshttps://doi.org/10.7554/elife.91304.1.sa2openalex-snapshot

Reviewer #1 (Public Review): Topological stress triggers difficult-to-repair DNA lesions in ribosomal DNA with ensuing formation of PML-nucleolar compartment

inferred← citeshttps://doi.org/10.7554/elife.91304.1.sa4openalex-snapshot

Author Response: Topological stress triggers difficult-to-repair DNA lesions in ribosomal DNA with ensuing formation of PML-nucleolar compartment

inferred← citeshttps://doi.org/10.7554/elife.91304.3openalex-snapshot

Topological stress triggers persistent DNA lesions in ribosomal DNA with ensuing formation of PML-nucleolar compartment

Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.