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Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/j.1460-2075.1996.tb00788.xopenalex-snapshot
Bcl‐2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types.
inferredcites →https://doi.org/10.1016/0020-711x(94)90021-3openalex-snapshot
Enzyme kinetics; behavior and analysis of rapid equilibrium and steady state enzyme systems
inferredcites →https://doi.org/10.1016/0092-8674(93)90509-oopenalex-snapshot
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
inferredcites →https://doi.org/10.1016/0968-0004(88)90219-8openalex-snapshot
Signal transduction by allosteric receptor oligomerization
inferredcites →https://doi.org/10.1016/s0021-9258(19)74386-5openalex-snapshot
Targeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence.
inferredcites →https://doi.org/10.1016/s0070-2161(08)60438-4openalex-snapshot
Kinetics of Movement in Narrow Channels
inferredcites →https://doi.org/10.1016/s0092-8674(00)80085-9openalex-snapshot
Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c
inferredcites →https://doi.org/10.1016/s0092-8674(00)80405-5openalex-snapshot
Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery
inferredcites →https://doi.org/10.1016/s0092-8674(00)80434-1openalex-snapshot
Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade
inferredcites →https://doi.org/10.1016/s0092-8674(00)80501-2openalex-snapshot
Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3
inferredcites →https://doi.org/10.1016/s0092-8674(00)80572-3openalex-snapshot
Solution Structure of BID, an Intracellular Amplifier of Apoptotic Signaling
inferredcites →https://doi.org/10.1016/s0092-8674(00)80573-5openalex-snapshot
Solution Structure of the Proapoptotic Molecule BID
inferredcites →https://doi.org/10.1016/s0092-8674(00)81182-4openalex-snapshot
The C. elegans Protein EGL-1 Is Required for Programmed Cell Death and Interacts with the Bcl-2–like Protein CED-9
inferredcites →https://doi.org/10.1016/s0092-8674(00)81382-3openalex-snapshot
Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL
inferredcites →https://doi.org/10.1016/s0092-8674(00)81589-5openalex-snapshot
Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors
inferredcites →https://doi.org/10.1016/s0092-8674(00)81590-1openalex-snapshot
Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis
inferredcites →https://doi.org/10.1016/s0962-8924(98)01321-xopenalex-snapshot
Bcl-2-family proteins: the role of the BH3 domain in apoptosis
inferredcites →https://doi.org/10.1016/s1097-2765(00)80307-xopenalex-snapshot
Bcl-xL Prevents Cell Death following Growth Factor Withdrawal by Facilitating Mitochondrial ATP/ADP Exchange
inferredcites →https://doi.org/10.1016/s1097-2765(00)80456-6openalex-snapshot
The Proapoptotic Activity of the Bcl-2 Family Member Bim Is Regulated by Interaction with the Dynein Motor Complex
inferredcites →https://doi.org/10.1016/s1097-2765(00)80469-4openalex-snapshot
Phosphorylation and Inactivation of BAD by Mitochondria-Anchored Protein Kinase A
inferredcites →https://doi.org/10.1038/20959openalex-snapshot
Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
inferredcites →https://doi.org/10.1038/23730openalex-snapshot
Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis
inferredcites →https://doi.org/10.1038/348334a0openalex-snapshot
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
inferredcites →https://doi.org/10.1038/35019596openalex-snapshot
BAX-dependent transport of cytochrome c reconstituted in pure liposomes
inferredcites →https://doi.org/10.1038/364806a0openalex-snapshot
Lethal effect of the anti-Fas antibody in mice
inferredcites →https://doi.org/10.1038/381335a0openalex-snapshot
X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death
inferredcites →https://doi.org/10.1038/385353a0openalex-snapshot
Bcl-xL forms an ion channel in synthetic lipid membranes
inferredcites →https://doi.org/10.1042/bj3450271openalex-snapshot
Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria
inferredcites →https://doi.org/10.1073/pnas.93.25.14559openalex-snapshot
BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases
inferredcites →https://doi.org/10.1073/pnas.94.21.11357openalex-snapshot
Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2
inferredcites →https://doi.org/10.1073/pnas.94.8.3668openalex-snapshot
Cytosol-to-membrane redistribution of Bax and Bcl-X L during apoptosis
inferredcites →https://doi.org/10.1073/pnas.96.10.5492openalex-snapshot
Bax, but not Bcl-x L , decreases the lifetime of planar phospholipid bilayer membranes at subnanomolar concentrations
inferredcites →https://doi.org/10.1074/jbc.272.21.13829openalex-snapshot
Nonionic Detergents Induce Dimerization among Members of the Bcl-2 Family
inferredcites →https://doi.org/10.1074/jbc.273.13.7770openalex-snapshot
The Overexpression of Bax Produces Cell Death upon Induction of the Mitochondrial Permeability Transition
inferredcites →https://doi.org/10.1074/jbc.274.17.11549openalex-snapshot
An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9
inferredcites →https://doi.org/10.1074/jbc.274.2.1156openalex-snapshot
Caspase Cleaved BID Targets Mitochondria and Is Required for Cytochrome c Release, while BCL-XL Prevents This Release but Not Tumor Necrosis Factor-R1/Fas Death
inferredcites →https://doi.org/10.1074/jbc.274.31.21932openalex-snapshot
Ion Channel Activity of the BH3 Only Bcl-2 Family Member, BID
inferredcites →https://doi.org/10.1074/jbc.274.4.2225openalex-snapshot
Bax-induced Caspase Activation and Apoptosis via Cytochromec Release from Mitochondria Is Inhibitable by Bcl-xL
inferredcites →https://doi.org/10.1083/jcb.139.5.1281openalex-snapshot
Movement of Bax from the Cytosol to Mitochondria during Apoptosis
inferredcites →https://doi.org/10.1083/jcb.143.1.207openalex-snapshot
Regulated Targeting of BAX to Mitochondria
inferredcites →https://doi.org/10.1083/jcb.144.5.891openalex-snapshot
Bid-induced Conformational Change of Bax Is Responsible for Mitochondrial Cytochrome c Release during Apoptosis
inferredcites →https://doi.org/10.1083/jcb.144.5.903openalex-snapshot
Cell Damage-induced Conformational Changes of the Pro-Apoptotic Protein Bak In Vivo Precede the Onset of Apoptosis
inferredcites →https://doi.org/10.1083/jcb.147.4.809openalex-snapshot
The Pro-Apoptotic Proteins, Bid and Bax, Cause a Limited Permeabilization of the Mitochondrial Outer Membrane That Is Enhanced by Cytosol
inferredcites →https://doi.org/10.1085/jgp.51.2.199openalex-snapshot
Pharmacological Modifications of the Sodium Channels of Frog Nerve
inferredcites →https://doi.org/10.1093/emboj/17.14.3878openalex-snapshot
Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis
inferredcites →https://doi.org/10.1101/gad.10.22.2859openalex-snapshot
BID: a novel BH3 domain-only death agonist.
inferredcites →https://doi.org/10.1101/gad.13.15.1899openalex-snapshot
BCL-2 family members and the mitochondria in apoptosis
inferredcites →https://doi.org/10.1101/gad.14.16.2060openalex-snapshot
tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c
inferredcites →https://doi.org/10.1126/science.277.5324.370openalex-snapshot
Inhibition of Bax Channel-Forming Activity by Bcl-2
inferredcites →https://doi.org/10.1126/science.278.5338.687openalex-snapshot
Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt
inferredcites →https://doi.org/10.1126/science.281.5381.1309openalex-snapshot
Mitochondria and Apoptosis
inferredcites →https://doi.org/10.1126/science.281.5381.1312openalex-snapshot
Caspases: Enemies Within
inferredcites →https://doi.org/10.1126/science.281.5381.1322openalex-snapshot
The Bcl-2 Protein Family: Arbiters of Cell Survival
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Effect of Low Temperature on the Testis of Largemouth Bass During Out-of-Season Breeding
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Pancreatic Adenocarcinoma
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Cell Death: Biological Mechanisms and Small Molecule Inhibitors
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Cancer and Cell Death
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Manganese in Neurodegeneration
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The role of CD95/CD95 Ligand Signaling in Apoptosis and Cancer
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tBid‐Mediated Genetic Ablation of Connective Tissue Cells Reveals Their Key Regulatory Function During Limb Regeneration in Axolotls
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Apoptosis in Parkinson's disease: Signals for neuronal degradation
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Mitochondrial membrane permeabilization: the sine qua non for cell death
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Redox regulation of mitochondrial permeability transition: Effects of uncoupler, lipoic acid and its positively charged analog LA‐plus and selenium
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BAK and BAX deletion using zinc‐finger nucleases yields apoptosis‐resistant CHO cells
inferred← citeshttps://doi.org/10.1002/bit.27269openalex-snapshot
Attenuating apoptosis in Chinese hamster ovary cells for improved biopharmaceutical production
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Mechanisms of apoptosis resistance and treatment strategies to overcome them in hormone‐refractory prostate cancer
inferred← citeshttps://doi.org/10.1002/cphy.c120020openalex-snapshot
Apoptosis and Necrosis in the Liver
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Baicalein Induces Caspase‐dependent Apoptosis Associated with the Generation of ROS and the Activation of AMPK in Human Lung Carcinoma A549 Cells
inferred← citeshttps://doi.org/10.1002/dvdy.20874openalex-snapshot
Developmental cell death during Xenopus metamorphosis involves BID cleavage and caspase 2 and 8 activation
inferred← citeshttps://doi.org/10.1002/glia.22645openalex-snapshot
Inhibition of cysteine cathepsin B and L activation in astrocytes contributes to neuroprotection against cerebral ischemia via blocking the tBid‐mitochondrial apoptotic signaling pathway
inferred← citeshttps://doi.org/10.1002/hed.24096openalex-snapshot
Convallaria keiskei as a novel therapeutic alternative for salivary gland cancer treatment by targeting myeloid cell leukemia‐1
inferred← citeshttps://doi.org/10.1002/hep.21062openalex-snapshot
Apoptosis and Necrosis in the Liver: A Tale of Two Deaths?
inferred← citeshttps://doi.org/10.1002/hep.510370432openalex-snapshot
Regulation of Apoptotic Signaling Pathways in Hepatocytes In Vivo
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Targeting and amplification of immune killing of tumor cells by pro‐Smac
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Cisplatin‐dependent upregulation of death receptors 4 and 5 augments induction of apoptosis by TNF‐related apoptosis‐inducing ligand against esophageal squamous cell carcinoma
inferred← citeshttps://doi.org/10.1002/ijc.22010openalex-snapshot
The major subtypes of human B‐cell lymphomas lack mutations in BCL‐2 family member BAD
inferred← citeshttps://doi.org/10.1002/ijc.22377openalex-snapshot
Enhancing dendritic cell vaccine potency by combining a BAK/BAX siRNA‐mediated antiapoptotic strategy to prolong dendritic cell life with an intracellular strategy to target antigen to lysosomal compartments
inferred← citeshttps://doi.org/10.1002/ijc.23378openalex-snapshot
Calpain‐mediated pathway dominates cisplatin‐induced apoptosis in human lung adenocarcinoma cells as determined by real‐time single cell analysis
inferred← citeshttps://doi.org/10.1002/ijc.23815openalex-snapshot
Identification of the regions of the HPV 5 E6 protein involved in Bak degradation and inhibition of apoptosis
inferred← citeshttps://doi.org/10.1002/ijc.27365openalex-snapshot
A new anticancer compound, Oblongifolin C, inhibits tumor growth and promotes apoptosis in HeLa cells through bax activation
inferred← citeshttps://doi.org/10.1002/ijc.34843openalex-snapshot
Novel chimeric antigen receptor‐expressing T cells targeting the malignant mesothelioma‐specific antigen sialylated HEG1
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Influence of cyclodextrins on the proliferation of HaCaT keratinocytes in vitro
inferred← citeshttps://doi.org/10.1002/jcb.20155openalex-snapshot
Daxx deletion mutant (amino acids 501–625)‐induced apoptosis occurs through the JNK/p38‐Bax‐dependent mitochondrial pathway
inferred← citeshttps://doi.org/10.1002/jcb.21243openalex-snapshot
Phosphorylation of mitochondrial phospholipid scramblase 3 by protein kinase C‐δ induces its activation and facilitates mitochondrial targeting of tBid
inferred← citeshttps://doi.org/10.1002/jcp.30329openalex-snapshot
Glucose deprivation‐induced endoplasmic reticulum stress response plays a pivotal role in enhancement of TRAIL cytotoxicity
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Mitochondrial isocitrate dehydrogenase protects human neuroblastoma SH‐SY5Y cells against oxidative stress
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C‐jun N‐terminal kinase regulates the interaction between 14‐3‐3 and Bad in ethanol‐induced cell death
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Sphingomyelin and phosphatidylcholine contrarily affect the induction of apoptosis in intestinal epithelial cells
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Tumour cell survival mechanisms in lethal metastatic prostate cancer differ between bone and soft tissue metastases
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MicroRNAs in non‐small cell lung cancer: Gene regulation, impact on cancer cellular processes, and therapeutic potential
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Amino acid sequence identification of goji berry cyclic peptides and anticervical carcinoma activity detection
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A systematic review on ethnomedicines of anti-cancer plants
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Mitochondrial aberrations in systemic lupus erythematosus pathogenesis: Insights and therapeutic implications
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Targeting mitochondria with folic acid and vitamin B12ameliorates nicotine mediated islet cell dysfunction
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Instrumental Activation of Bid by Caspase-1 in a Transgenic Mouse Model of ALS
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Lipid Metabolism and Release of Cytochrome c from Mitochondria
inferred← citeshttps://doi.org/10.1007/0-306-48412-9_19openalex-snapshot
Apoptosis Mechanisms Initiated by Oxidative Stress
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The Intrinsic (Mitochondrial) Death Pathway and New Cancer Therapeutics: Bcl-2 Family in Focus
inferred← citeshttps://doi.org/10.1007/1-4020-3302-8_15openalex-snapshot
Apoptosis-Inducing Anticancer Drugs in Clinical Trials
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The Effect of Structure and Mechanism of the Hsp70 Chaperone on the Ability to Identify Chemical Modulators and Therapeutics
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The Biology of Caspases in Central Nervous System Trauma
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Programmed Necrosis: A “New” Cell Death Outcome for Injured Adult Neurons?
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Single-Cell Profiling of the Intrinsic Apoptotic Pathway by Mass Cytometry (CyTOF)
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The Mitochondrial Death Pathway
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Molecular Pathways of Different Types of Cell Death: Many Roads to Death
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Permeabilization of the Outer Mitochondrial Membrane by Bcl-2 Proteins
inferred← citeshttps://doi.org/10.1007/978-1-4614-5847-0_1openalex-snapshot
Defective Apoptosis Signaling in Cancer
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Mitochondrial Calpains: Who, What, Where, When and Why?
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Structural Perspectives on BCL-2 Family of Proteins
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Bcl-2 Family and Their Therapeutic Potential
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Mitochondrial Regulation of Cell-Death
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Molecular and Cellular Biology of Neuroprotection in the CNS
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Neuronal Survival and Cell Death Signaling Pathways
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Roles of Apoptosis-Regulating Bcl-2 Family Genes in AML
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Bcl-2 Protein Interplay on the Outer Mitochondrial Membrane
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Targeting the Apoptotic Machinery as a Potential Antileukemic Strategy
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Neuronal and Schwann Cell Death in Diabetic Neuropathy
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Inhibitors of the Bcl-2 Protein Family as Sensitizers to Anticancer Agents
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Therapeutic Targeting of Apoptosis in Cancer
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Punching Holes in Membranes: How Oligomeric Pore-Forming Proteins and Lipids Cooperate to Form Aqueous Channels in Membranes
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Fungal Phytases: Biotechnological Applications in Food and Feed Industries
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Bile Acid Toxicity and Protein Kinases
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Manganese Neurotoxicity
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Primordial Cells Bridging the Gap Between Innate and Adaptive Immunity
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Methods of Permeabilization
inferred← citeshttps://doi.org/10.1007/978-3-319-53774-0_8openalex-snapshot
Cell Death in Ischemia-Reperfusion-Induced Liver Injury
inferred← citeshttps://doi.org/10.1007/978-3-319-55539-3_6openalex-snapshot
An Assessment of How VDAC Structures Have Impacted Our Understanding of Their Function
inferred← citeshttps://doi.org/10.1007/978-3-319-91439-8_11openalex-snapshot
Venetoclax: Targeting BCL2 in Hematological Cancers
inferred← citeshttps://doi.org/10.1007/978-88-470-2014-6_15openalex-snapshot
Experimental Treatment for Preservation of Mechanically Competent Cardiac Activity Following Cardiac Arrest
inferred← citeshttps://doi.org/10.1007/978-90-481-3381-9_11openalex-snapshot
Heat Shock Proteins and Post-Traumatic Stress Disorder
inferred← citeshttps://doi.org/10.1007/978-94-007-6211-4_9openalex-snapshot
BH3-Only Proteins in Cancer and Apoptosis
inferred← citeshttps://doi.org/10.1007/978-94-007-7500-8_7openalex-snapshot
Manganese in Health and Disease
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Caspases: Regulatory Mechanisms and Their Implications in Pathogenesis and Therapeutics
inferred← citeshttps://doi.org/10.1007/bf02975890openalex-snapshot
Apoptosis inducing effects of 6-Methoxydihydrosanguinarine in HT29 colon carcinoma cells
inferred← citeshttps://doi.org/10.1007/bf03040450openalex-snapshot
Cellular and molecular themes in apoptosis
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At the heart of mitochondrial quality control: many roads to the top
inferred← citeshttps://doi.org/10.1007/s00044-020-02574-9openalex-snapshot
Anticancer strategies by upregulating p53 through inhibition of its ubiquitination by MDM2
inferred← citeshttps://doi.org/10.1007/s00109-008-0434-zopenalex-snapshot
ARC is a critical cardiomyocyte survival switch in doxorubicin cardiotoxicity
inferred← citeshttps://doi.org/10.1007/s00204-005-0014-8openalex-snapshot
Berberine induces apoptosis through a mitochondria/caspases pathway in human hepatoma cells
inferred← citeshttps://doi.org/10.1007/s00204-014-1219-5openalex-snapshot
The Ca2+-calmodulin-Ca2+/calmodulin-dependent protein kinase II signaling pathway is involved in oxidative stress-induced mitochondrial permeability transition and apoptosis in isolated rat hepatocytes
inferred← citeshttps://doi.org/10.1007/s00210-013-0912-xopenalex-snapshot
Terfenadine induces anti-proliferative and apoptotic activities in human hormone-refractory prostate cancer through histamine receptor-independent Mcl-1 cleavage and Bak up-regulation
inferred← citeshttps://doi.org/10.1007/s00232-005-0799-7openalex-snapshot
Interactions of Bax and tBid with Lipid Monolayers
inferred← citeshttps://doi.org/10.1007/s00249-007-0149-zopenalex-snapshot
Monte Carlo simulations of tBid association with the mitochondrial outer membrane
inferred← citeshttps://doi.org/10.1007/s00253-012-3899-1openalex-snapshot
Understanding the mechanistic roles of 30Kc6 gene in apoptosis and specific productivity in antibody-producing Chinese hamster ovary cells
inferred← citeshttps://doi.org/10.1007/s00280-002-0522-7openalex-snapshot
Current status of the molecular mechanisms of anticancer drug-induced apoptosis
inferred← citeshttps://doi.org/10.1007/s00280-005-0111-7openalex-snapshot
Role of mitochondria as the gardens of cell death
inferred← citeshttps://doi.org/10.1007/s00395-009-0004-8openalex-snapshot
The mitochondrial permeability transition pore and ischemia-reperfusion injury
inferred← citeshttps://doi.org/10.1007/s00428-001-0568-7openalex-snapshot
Cell proliferation and apoptosis in human uterine leiomyomas and myometria
inferred← citeshttps://doi.org/10.1007/s00894-003-0152-yopenalex-snapshot
A multimeric model for murine anti-apoptotic protein Bcl-2 and structural insights for its regulation by post-translational modification.
inferred← citeshttps://doi.org/10.1007/s10238-013-0250-9openalex-snapshot
Association of overexpression of hexokinase II with chemoresistance in epithelial ovarian cancer
inferred← citeshttps://doi.org/10.1007/s10495-005-0887-2openalex-snapshot
Motexafin gadolinium induces mitochondriallymediated caspase-dependent apoptosis
inferred← citeshttps://doi.org/10.1007/s10495-005-6070-yopenalex-snapshot
Two mechanisms of caspase 9 processing in double-stranded RNA- and virus-triggered apoptosis
inferred← citeshttps://doi.org/10.1007/s10495-006-0330-3openalex-snapshot
Herpes simplex virus blocks apoptosis by precluding mitochondrial cytochrome c release independent of caspase activation in infected human epithelial cells
inferred← citeshttps://doi.org/10.1007/s10495-006-0484-zopenalex-snapshot
Rapid and profound potentiation of Apo2L/TRAIL-mediated cytotoxicity and apoptosis in thoracic cancer cells by the histone deacetylase inhibitor Trichostatin A: the essential role of the mitochondria-mediated caspase activation cascade
inferred← citeshttps://doi.org/10.1007/s10495-006-5541-0openalex-snapshot
Role of mitochondria in apoptosis induced by the 2‐5A system and mechanisms involved
inferred← citeshttps://doi.org/10.1007/s10495-006-7689-zopenalex-snapshot
The extrinsic and intrinsic apoptotic pathways are differentially affected by temperature upstream of mitochondrial damage
inferred← citeshttps://doi.org/10.1007/s10495-008-0184-yopenalex-snapshot
Bid truncation mediated by caspases-3 and -9 in vinorelbine-induced apoptosis
inferred← citeshttps://doi.org/10.1007/s10495-008-0240-7openalex-snapshot
JNK mediates UVB-induced apoptosis upstream lysosomal membrane permeabilization and Bcl-2 family proteins
inferred← citeshttps://doi.org/10.1007/s10495-010-0482-zopenalex-snapshot
α-Tocopheryl succinate causes mitochondrial permeabilization by preferential formation of Bak channels
inferred← citeshttps://doi.org/10.1007/s10495-011-0668-zopenalex-snapshot
Activation of apoptotic signalling events in human embryonic stem cells upon Coxsackievirus B3 infection
inferred← citeshttps://doi.org/10.1007/s10495-011-0684-zopenalex-snapshot
RNase MC2: a new Momordica charantia ribonuclease that induces apoptosis in breast cancer cells associated with activation of MAPKs and induction of caspase pathways
inferred← citeshttps://doi.org/10.1007/s10495-019-01540-0openalex-snapshot
Modulation of CD95-mediated signaling by post-translational modifications: towards understanding CD95 signaling networks
inferred← citeshttps://doi.org/10.1007/s10495-020-01634-0openalex-snapshot
Photodynamic therapy: apoptosis, paraptosis and beyond
inferred← citeshttps://doi.org/10.1007/s10495-026-02293-3openalex-snapshot
MUDENG, a component of adaptor complex 5, mediates TRAIL- and TMZ-triggered apoptosis in glioblastoma (GBM) via multiple pathways
inferred← citeshttps://doi.org/10.1007/s10529-016-2273-2openalex-snapshot
MicroRNA-190b confers radio-sensitivity through negative regulation of Bcl-2 in gastric cancer cells
inferred← citeshttps://doi.org/10.1007/s10565-016-9312-6openalex-snapshot
Molecular mechanism of apoptosis induction by Gaillardin, a sesquiterpene lactone, in breast cancer cell lines
inferred← citeshttps://doi.org/10.1007/s10620-008-0583-5openalex-snapshot
Overexpression of Mcl-1 Attenuates Liver Injury and Fibrosis in the Bile Duct–Ligated Mouse
inferred← citeshttps://doi.org/10.1007/s10637-008-9116-5openalex-snapshot
Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by a new series of substituted-1,3,4-oxadiazole derivatives
inferred← citeshttps://doi.org/10.1007/s10637-008-9134-3openalex-snapshot
Brazilian marine sponge Polymastia janeirensis induces apoptotic cell death in human U138MG glioma cell line, but not in a normal cell culture
inferred← citeshttps://doi.org/10.1007/s10637-008-9198-0openalex-snapshot
Extracts of marine sponge Polymastia janeirensis induce oxidative cell death through a caspase-9 apoptotic pathway in human U138MG glioma cell line
inferred← citeshttps://doi.org/10.1007/s10863-006-9055-9openalex-snapshot
The role of the mitochondria in mediating cytotoxicity of anti-cancer therapies
inferred← citeshttps://doi.org/10.1007/s10863-006-9060-zopenalex-snapshot
Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II
inferred← citeshttps://doi.org/10.1007/s10863-013-9527-7openalex-snapshot
Bcl-2 family in inter-organelle modulation of calcium signaling; roles in bioenergetics and cell survival
inferred← citeshttps://doi.org/10.1007/s10924-022-02654-4openalex-snapshot
Biodegradable PEG-PCL Nanoparticles for Co-delivery of MUC1 Inhibitor and Doxorubicin for the Confinement of Triple-Negative Breast Cancer
inferred← citeshttps://doi.org/10.1007/s11010-010-0709-xopenalex-snapshot
Role of Bcl-2 family proteins and caspases in the regulation of apoptosis
inferred← citeshttps://doi.org/10.1007/s11010-011-1192-8openalex-snapshot
Effects of phospholipids on the functional regulation of tBID in membranes
inferred← citeshttps://doi.org/10.1007/s11033-022-07921-0openalex-snapshot
Ketoprofen suppresses triple negative breast cancer cell growth by inducing apoptosis and inhibiting autophagy
inferred← citeshttps://doi.org/10.1007/s11060-014-1575-2openalex-snapshot
Co-administration of ABT-737 and SAHA induces apoptosis, mediated by Noxa upregulation, Bax activation and mitochondrial dysfunction in PTEN-intact malignant human glioma cell lines
inferred← citeshttps://doi.org/10.1007/s11064-008-9649-1openalex-snapshot
Hypoxia Ischemia-Mediated Cell Death in Neonatal Rat Brain
inferred← citeshttps://doi.org/10.1007/s11356-018-3406-zopenalex-snapshot
A mini review of fluoride-induced apoptotic pathways
inferred← citeshttps://doi.org/10.1007/s11356-022-20858-yopenalex-snapshot
The antiproliferative and apoptotic potential of Clinacanthus nutans against human breast cancer cells through targeted apoptosis pathway
inferred← citeshttps://doi.org/10.1007/s11418-026-02032-7openalex-snapshot
Apoptosis- and ferroptosis-inducing activity of triptolide in SBC-3 human small-cell lung cancer cells
inferred← citeshttps://doi.org/10.1007/s11655-015-2050-4openalex-snapshot
Xuezhikang (血脂康) reduced renal cell apoptosis in streptozocin-induced diabetic rats through regulation of Bcl-2 family
inferred← citeshttps://doi.org/10.1007/s11655-016-2251-5openalex-snapshot
Molecular Pathway of Psoralidin-Induced Apoptosis in HepG2 Cell Line
inferred← citeshttps://doi.org/10.1007/s11882-003-0070-1openalex-snapshot
Immune disorders caused by defects in the caspase cascade
inferred← citeshttps://doi.org/10.1007/s11912-020-0881-4openalex-snapshot
Revolution of Chronic Lymphocytic Leukemia Therapy: the Chemo-Free Treatment Paradigm
inferred← citeshttps://doi.org/10.1007/s11926-022-01063-9openalex-snapshot
Mitochondria in the Pathogenesis of Systemic Lupus Erythematosus
inferred← citeshttps://doi.org/10.1007/s12011-013-9649-0openalex-snapshot
Effects of Selenium Intervention on Chronic Fluorosis-Induced Renal Cell Apoptosis in Rats
inferred← citeshttps://doi.org/10.1007/s12011-020-02348-9openalex-snapshot
Zinc Modulates the Response to Apoptosis in an In Vitro Model with High Glucose and Inflammatory Stimuli in C2C12 Cells
inferred← citeshttps://doi.org/10.1007/s12013-016-0736-7openalex-snapshot
Oleanolic Acid Inhibits High Salt-Induced Exaggeration of Warburg-like Metabolism in Breast Cancer Cells
inferred← citeshttps://doi.org/10.1007/s12031-008-9111-5openalex-snapshot
Interactions of PACAP and Ceramides in the Control of Granule Cell Apoptosis During Cerebellar Development
inferred← citeshttps://doi.org/10.1007/s12035-012-8289-2openalex-snapshot
Driving Apoptosis-relevant Proteins Toward Neural Differentiation
inferred← citeshttps://doi.org/10.1007/s12035-016-0117-7openalex-snapshot
A Mitocentric View of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1007/s12038-011-9170-6openalex-snapshot
Cytotoxic effects of the novel isoflavone, phenoxodiol, on prostate cancer cell lines
inferred← citeshttps://doi.org/10.1007/s12185-022-03358-0openalex-snapshot
Hexokinase II expression as a prognostic marker in diffuse large B-cell lymphoma: pre- and post-rituximab era
inferred← citeshttps://doi.org/10.1007/s12257-009-0154-4openalex-snapshot
Widdrol from Juniperus chinensis induces apoptosis in human colon adenocarcinoma HT29 Cells
inferred← citeshttps://doi.org/10.1007/s12272-009-2218-6openalex-snapshot
Magnolol induces apoptosis via activation of both mitochondrial and death receptor pathways in A375-S2 cells
inferred← citeshttps://doi.org/10.1007/s12602-025-10650-yopenalex-snapshot
Alginate Oligosaccharide Alleviates Salmonella Typhimurium-Induced Liver Injury by Regulating Oxidative Stress, Apoptosis, and Inflammatory Signaling Pathway
inferred← citeshttps://doi.org/10.1007/s13205-025-04392-5openalex-snapshot
Dose-dependent apoptotic effect of Woodfordia fruticosa on hepatocellular carcinoma (HepG2) cells by upregulating bax and caspase-9
inferred← citeshttps://doi.org/10.1007/s13365-013-0189-3openalex-snapshot
Immunological control of herpes simplex virus infections
inferred← citeshttps://doi.org/10.1007/s13365-015-0361-zopenalex-snapshot
The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) protects cells against cold-shock-induced apoptosis by maintaining phosphorylation of protein kinase B (AKT)
inferred← citeshttps://doi.org/10.1007/s40495-025-00431-0openalex-snapshot
Mitochondrial Dynamics in Blood Cancer Development and Progression
inferred← citeshttps://doi.org/10.1007/s43032-023-01184-1openalex-snapshot
Drastic Loss of Antral Follicles Due to Gene Expression Dysregulation Occurs on the First Day After Subcutaneous Ovarian Transplantation
inferred← citeshttps://doi.org/10.1016/b0-44-306600-0/50050-xopenalex-snapshot
Apoptosis in Cerebral Ischemia
inferred← citeshttps://doi.org/10.1016/b978-0-08-046884-6.01106-4openalex-snapshot
The Sertoli Cell as a Target for Toxicants
inferred← citeshttps://doi.org/10.1016/b978-0-08-100601-6.02137-2openalex-snapshot
The Sertoli Cell as a Target for Toxicants
inferred← citeshttps://doi.org/10.1016/b978-0-12-374279-7.11016-1openalex-snapshot
TNF Receptor Superfamily Signaling Pathways in Immune Cells
inferred← citeshttps://doi.org/10.1016/b978-0-12-381510-1.00031-4openalex-snapshot
Programmed Cardiomyocyte Death in Heart Disease
inferred← citeshttps://doi.org/10.1016/b978-0-12-394306-4.00010-1openalex-snapshot
New Insights into the Mechanisms for Photodynamic Therapy-Induced Cancer Cell Death
inferred← citeshttps://doi.org/10.1016/b978-0-12-801238-3.02137-1openalex-snapshot
The Sertoli Cell as a Target for Toxicants ☆
inferred← citeshttps://doi.org/10.1016/b978-0-12-811752-1.00002-xopenalex-snapshot
Mitochondria as Signaling Platforms
inferred← citeshttps://doi.org/10.1016/b978-0-12-813814-4.00002-xopenalex-snapshot
Hormones of Programmed Cell Death
inferred← citeshttps://doi.org/10.1016/b978-0-12-821618-7.00141-3openalex-snapshot
The BCL-2 Family Proteins: Insights Into Their Mechanism of Action and Therapeutic Potential
inferred← citeshttps://doi.org/10.1016/b978-0-12-822416-8.00004-xopenalex-snapshot
Mitochondrial contribution to cell death
inferred← citeshttps://doi.org/10.1016/b978-0-323-95488-4.00241-2openalex-snapshot
The Sertoli Cell as a Target for Toxicants
inferred← citeshttps://doi.org/10.1016/b978-0-444-64046-8.00030-6openalex-snapshot
Apoptosis: The Signaling Pathways and Their Control
inferred← citeshttps://doi.org/10.1016/b978-0-7216-9654-6.50011-4openalex-snapshot
Apoptosis and Necrosis
inferred← citeshttps://doi.org/10.1016/b978-012689663-3/50042-9openalex-snapshot
CD95L/FasL and its receptor CD95 (APO-1/Fas)
inferred← citeshttps://doi.org/10.1016/b978-1-4160-3479-7.10009-6openalex-snapshot
Apoptotic Cell Death
inferred← citeshttps://doi.org/10.1016/b978-1-4160-5478-8.10007-7openalex-snapshot
Apoptosis and Related Mechanisms in Cerebral Ischemia
inferred← citeshttps://doi.org/10.1016/bs.apcsb.2021.02.007openalex-snapshot
Apoptotic signals at the endoplasmic reticulum-mitochondria interface
inferred← citeshttps://doi.org/10.1016/j.abb.2008.02.004openalex-snapshot
Insight into the apoptosis-inducing action of α-bisabolol towards malignant tumor cells: Involvement of lipid rafts and Bid
inferred← citeshttps://doi.org/10.1016/j.abb.2020.108665openalex-snapshot
Cellular compartments challenged by membrane photo-oxidation
inferred← citeshttps://doi.org/10.1016/j.aquaculture.2026.744493openalex-snapshot
High CO2 at stable pH disrupts olfactory homeostasis and function in largemouth bass
inferred← citeshttps://doi.org/10.1016/j.archoralbio.2016.05.013openalex-snapshot
Apoptosis-associated protein expression in human salivary gland morphogenesis
inferred← citeshttps://doi.org/10.1016/j.bbabio.2006.04.011openalex-snapshot
Proapoptotic BCL-2 family members and mitochondrial dysfunction during ischemia/reperfusion injury, a study employing cardiac HL-1 cells and GFP biosensors
inferred← citeshttps://doi.org/10.1016/j.bbabio.2008.08.002openalex-snapshot
Oligomeric BAX induces mitochondrial permeability transition and complete cytochrome c release without oxidative stress
inferred← citeshttps://doi.org/10.1016/j.bbabio.2010.07.006openalex-snapshot
BAX insertion, oligomerization, and outer membrane permeabilization in brain mitochondria: Role of permeability transition and SH-redox regulation
inferred← citeshttps://doi.org/10.1016/j.bbadis.2005.07.001openalex-snapshot
The relevance of mitochondrial membrane topology to mitochondrial function
inferred← citeshttps://doi.org/10.1016/j.bbadis.2013.02.002openalex-snapshot
Inhibition of calpain-regulated p35/cdk5 plays a central role in sildenafil-induced protection against chemical hypoxia produced by malonate
inferred← citeshttps://doi.org/10.1016/j.bbadis.2014.02.009openalex-snapshot
Role of mitochondria in mutant SOD1 linked amyotrophic lateral sclerosis
inferred← citeshttps://doi.org/10.1016/j.bbadis.2015.06.004openalex-snapshot
C/EBP homologous protein (CHOP) gene deficiency attenuates renal ischemia/reperfusion injury in mice
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2003.08.011openalex-snapshot
Control of mitochondrial integrity by Bcl-2 family members and caspase-independent cell death
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2004.02.008openalex-snapshot
Regulation of Bcl-2 proteins during anoikis and amorphosis
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2006.02.006openalex-snapshot
Mitochondrial membrane dynamics, cristae remodelling and apoptosis
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2010.10.008openalex-snapshot
Mitochondrial involvement in cell death of non-mammalian eukaryotes
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2011.02.011openalex-snapshot
Dimerization of Smac is crucial for its mitochondrial retention by XIAP subsequent to mitochondrial outer membrane permeabilization
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2016.04.020openalex-snapshot
VDAC2-specific cellular functions and the underlying structure
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2021.118997openalex-snapshot
The role of Bcl-2 proteins in modulating neuronal Ca2+ signaling in health and in Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2022.119317openalex-snapshot
Pro-apoptotic complexes of BAX and BAK on the outer mitochondrial membrane
inferred← citeshttps://doi.org/10.1016/j.bbamem.2008.12.008openalex-snapshot
The role of membrane cholesterol in determining bile acid cytotoxicity and cytoprotection of ursodeoxycholic acid
inferred← citeshttps://doi.org/10.1016/j.bbamem.2017.12.009openalex-snapshot
New limits of sensitivity of site-directed spin labeling electron paramagnetic resonance for membrane proteins
inferred← citeshttps://doi.org/10.1016/j.bbamem.2018.10.007openalex-snapshot
Oxidatively stressed mitochondria-mimicking membranes: A molecular insight into their organization during apoptosis
inferred← citeshttps://doi.org/10.1016/j.bbcan.2020.188357openalex-snapshot
Caspase-8: The double-edged sword
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