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Induction of KLF4 in basal keratinocytes blocks the proliferation–differentiation switch and initiates squamous epithelial dysplasia

https://doi.org/10.1038/sj.onc.1208307
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Signal transduction by transforming growth factor-β: A cooperative paradigm with extensive negative regulation
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Conditional gene expression in secretory tissues and skin of transgenic mice using the MMTV‐LTR and the tetracycline responsive system
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Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
inferredcites →https://doi.org/10.1007/bf00665795openalex-snapshot
Transgenic mice and squamous multistage skin carcinogenesis
inferredcites →https://doi.org/10.1007/bf01642554openalex-snapshot
Cytokeratin and vimentin expression in normal epithelium and squamous cell carcinomas of the larynx
inferredcites →https://doi.org/10.1016/0003-2697(87)90021-2openalex-snapshot
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
inferredcites →https://doi.org/10.1016/0076-6879(95)54003-2openalex-snapshot
[1] Isolation and utilization of epidermal keratinocytes for oncogene research
inferredcites →https://doi.org/10.1016/0092-8674(90)90077-ropenalex-snapshot
Development of mammary hyperplasia and neoplasia in MMTV-TGFα transgenic mice
inferredcites →https://doi.org/10.1016/0092-8674(93)90461-xopenalex-snapshot
Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors
inferredcites →https://doi.org/10.1016/0922-3371(90)90071-4openalex-snapshot
Comparison of epidermal patch size in X-chromosome-linked mosaic and dizygotic chimeric mice
inferredcites →https://doi.org/10.1016/j.ceb.2003.10.012openalex-snapshot
Live and let die in the intestinal epithelium
inferredcites →https://doi.org/10.1016/s0014-5793(97)01465-8openalex-snapshot
Expression of the gut‐enriched Krüppel‐like factor gene during development and intestinal tumorigenesis
inferredcites →https://doi.org/10.1016/s0092-8674(00)81683-9openalex-snapshot
The Hallmarks of Cancer
inferredcites →https://doi.org/10.1016/s0092-8674(02)01014-0openalex-snapshot
The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells
inferredcites →https://doi.org/10.1016/s0092-8674(03)01075-4openalex-snapshot
Principles of Tumor Suppression
inferredcites →https://doi.org/10.1016/s0955-0674(00)00283-0openalex-snapshot
Building ‘validated’ mouse models of human cancer
inferredcites →https://doi.org/10.1016/s0962-8924(01)02127-4openalex-snapshot
Mouse models for multistep tumorigenesis
inferredcites →https://doi.org/10.1016/s0962-8924(01)82000-6openalex-snapshot
Mouse models for multistep tumorigenesis
inferredcites →https://doi.org/10.1016/s1535-6108(03)00052-7openalex-snapshot
Notch and cancer: Best to avoid the ups and downs
inferredcites →https://doi.org/10.1016/s1535-6108(03)00273-3openalex-snapshot
Progressive vascular changes in a transgenic mouse model of squamous cell carcinoma
inferredcites →https://doi.org/10.1016/s1535-6108(03)00308-8openalex-snapshot
p21Waf1/Cip1 as a therapeutic target in breast and other cancers
inferredcites →https://doi.org/10.1016/s1535-6108(04)00090-xopenalex-snapshot
Focus on head and neck cancer
inferredcites →https://doi.org/10.1038/11926openalex-snapshot
Klf4 is a transcription factor required for establishing the barrier function of the skin
inferredcites →https://doi.org/10.1038/35074129openalex-snapshot
Somatic activation of the K-ras oncogene causes early onset lung cancer in mice
inferredcites →https://doi.org/10.1038/35077219openalex-snapshot
The Hedgehog and Wnt signalling pathways in cancer
inferredcites →https://doi.org/10.1038/352345a0openalex-snapshot
Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
inferredcites →https://doi.org/10.1038/356215a0openalex-snapshot
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
inferredcites →https://doi.org/10.1038/372773a0openalex-snapshot
Sunburn and p53 in the onset of skin cancer
inferredcites →https://doi.org/10.1038/386761a0openalex-snapshot
Gatekeepers and caretakers
inferredcites →https://doi.org/10.1038/ng747openalex-snapshot
Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer
inferredcites →https://doi.org/10.1038/sj.onc.1202673openalex-snapshot
Conditional expression of the ErbB2 oncogene elicits reversible hyperplasia in stratified epithelia and up-regulation of TGFα expression in transgenic mice
inferredcites →https://doi.org/10.1038/sj.onc.1206413openalex-snapshot
Overexpression of Krüppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity
inferredcites →https://doi.org/10.1038/sj.onc.1207067openalex-snapshot
Identification of Krüppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer
inferredcites →https://doi.org/10.1046/j.1523-1747.2002.01778.xopenalex-snapshot
Rapid Compensation for Glycosylphosphatidylinositol Anchor Deficient Keratinocytes after Birth: Visualization of Glycosylphosphatidylinositol-Anchored Proteins in situ
inferredcites →https://doi.org/10.1056/nejmra001375openalex-snapshot
Head and Neck Cancer
inferredcites →https://doi.org/10.1073/pnas.93.24.14025openalex-snapshot
Frequent clones of p53-mutated keratinocytes in normal human skin
inferredcites →https://doi.org/10.1074/jbc.271.33.20009openalex-snapshot
Identification and Characterization of a Gene Encoding a Gut-enriched Krüppel-like Factor Expressed during Growth Arrest
inferredcites →https://doi.org/10.1074/jbc.271.49.31384openalex-snapshot
A Gene for a Novel Zinc-finger Protein Expressed in Differentiated Epithelial Cells and Transiently in Certain Mesenchymal Cells
inferredcites →https://doi.org/10.1074/jbc.273.17.10747openalex-snapshot
Transactivation of the Human Keratin 4 and Epstein-Barr Virus ED-L2 Promoters by Gut-enriched Krüppel-like Factor
inferredcites →https://doi.org/10.1074/jbc.273.28.17917openalex-snapshot
The Gut-enriched Krüppel-like Factor Suppresses the Activity of the CYP1A1 Promoter in an Sp1-dependent Fashion
inferredcites →https://doi.org/10.1074/jbc.c000062200openalex-snapshot
The Gut-enriched Krüppel-like Factor (Krüppel-like Factor 4) Mediates the Transactivating Effect of p53 on the p21 Promoter
inferredcites →https://doi.org/10.1074/jbc.c100275200openalex-snapshot
Squamous Cell Tumors in Mice Heterozygous for a Null Allele of Atp2a2, Encoding the Sarco(endo)plasmic Reticulum Ca2+-ATPase Isoform 2 Ca2+Pump
inferredcites →https://doi.org/10.1074/jbc.m006323200openalex-snapshot
Positive- and Negative-acting Krüppel-like Transcription Factors Bind a Transforming Growth Factor β Control Element Required for Expression of the Smooth Muscle Cell Differentiation Marker SM22α in Vivo
inferredcites →https://doi.org/10.1074/jbc.m211337200openalex-snapshot
Krüppel-like Factor 4 (KLF4/GKLF) Is a Target of Bone Morphogenetic Proteins and Transforming Growth Factor β1 in the Regulation of Vascular Smooth Muscle Cell Phenotype
inferredcites →https://doi.org/10.1083/jcb.143.2.469openalex-snapshot
Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages during Skin Development
inferredcites →https://doi.org/10.1093/nar/23.10.1686openalex-snapshot
A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins
inferredcites →https://doi.org/10.1093/nar/27.23.4562openalex-snapshot
Characterization of the structure and regulation of the murine gene encoding gut-enriched Kruppel-like factor (Kruppel-like factor 4)
inferredcites →https://doi.org/10.1093/nar/28.15.2969openalex-snapshot
Gut-enriched Kruppel-like factor represses cyclin D1 promoter activity through Sp1 motif
inferredcites →https://doi.org/10.1126/science.272.5268.1621openalex-snapshot
Sending and Receiving the Hedgehog Signal: Control by the Drosophila Gli Protein Cubitus interruptus
inferredcites →https://doi.org/10.1126/science.272.5268.1668openalex-snapshot
Human Homolog of patched , a Candidate Gene for the Basal Cell Nevus Syndrome
inferredcites →https://doi.org/10.1128/jvi.68.7.4358-4368.1994openalex-snapshot
Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic mice
inferredcites →https://doi.org/10.1152/ajpgi.00203.2003openalex-snapshot
Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Krüppel-like factor
inferredcites →https://doi.org/10.1158/1078-0432.ccr-03-0484openalex-snapshot
Nuclear Localization of KLF4 Is Associated with an Aggressive Phenotype in Early-Stage Breast Cancer
inferredcites →https://doi.org/10.1158/1078-0432.ccr-03-0527openalex-snapshot
Phosphorylation/Cytoplasmic Localization of p21Cip1/WAF1 Is Associated with HER2/ neu Overexpression and Provides a Novel Combination Predictor for Poor Prognosis in Breast Cancer Patients
inferredcites →https://doi.org/10.1242/dev.00477openalex-snapshot
Ectopic expression of Kruppel like factor 4(Klf4)accelerates formation of the epidermal permeability barrier
inferredcites →https://doi.org/10.1242/dev.129.11.2619openalex-snapshot
The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon
inferredcites →https://doi.org/10.1242/jcs.88.3.305openalex-snapshot
Clonal origin of chemically induced papillomas: Separate analysis of epidermal and dermal components

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Krüppel‐like factor 4 functions as a tumor suppressor in cervical carcinoma
inferred← citeshttps://doi.org/10.1002/ijc.21533openalex-snapshot
KLF5 promotes cell proliferation and tumorigenesis through gene regulationin the TSU-Pr1 human bladder cancer cell line
inferred← citeshttps://doi.org/10.1002/ijc.27963openalex-snapshot
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Genome modification in human embryonic stem cells
inferred← citeshttps://doi.org/10.1002/mc.22161openalex-snapshot
Oxidative DNA damage causes premature senescence in mouse embryonic fibroblasts deficient for Krüppel‐like factor 4
inferred← citeshttps://doi.org/10.1002/stem.1016openalex-snapshot
Differentiation Efficiency of Induced Pluripotent Stem Cells Depends on the Number of Reprogramming Factors
inferred← citeshttps://doi.org/10.1002/stem.477openalex-snapshot
Krüppel-Like Transcription Factor 4 Contributes to Maintenance of Telomerase Activity in Stem Cells
inferred← citeshttps://doi.org/10.1007/978-1-4939-8570-8_14openalex-snapshot
Modulation of Lung Epithelial Cell Function Using Conditional and Inducible Transgenic Approaches
inferred← citeshttps://doi.org/10.1007/978-1-60761-860-7_24openalex-snapshot
Keratinocyte-Induced Pluripotent Stem Cells: From Hair to Where?
inferred← citeshttps://doi.org/10.1007/978-4-431-87775-2openalex-snapshot
The Biology of Krüppel-like Factors
inferred← citeshttps://doi.org/10.1007/978-4-431-87775-2_1openalex-snapshot
Krüppel-like Factors: Ingenious Three Fingers Directing Biology and Pathobiology
inferred← citeshttps://doi.org/10.1007/978-4-431-87775-2_16openalex-snapshot
Krüppel-like Factors in Cancers
inferred← citeshttps://doi.org/10.1007/bf03346681openalex-snapshot
Krüppel-like factor 4 mediates anti-proliferative effects of progesterone with G0/G1 arrest in human endometrial epithelial cells
inferred← citeshttps://doi.org/10.1007/s00018-013-1376-3openalex-snapshot
RETRACTED ARTICLE: Regulation of estrogen receptor signaling in breast carcinogenesis and breast cancer therapy
inferred← citeshttps://doi.org/10.1007/s00018-016-2312-0openalex-snapshot
Genetically modified laboratory mice with sebaceous glands abnormalities
inferred← citeshttps://doi.org/10.1007/s00204-017-1945-6openalex-snapshot
A miRNA signature for an environmental heterocyclic amine defined by a multi-organ carcinogenicity bioassay in the rat
inferred← citeshttps://doi.org/10.1007/s00280-011-1708-7openalex-snapshot
Inhibition of glutathione synthesis reverses Krüppel-like factor 4-mediated cisplatin resistance
inferred← citeshttps://doi.org/10.1007/s00403-010-1101-0openalex-snapshot
The role of KLF4 in UVB-induced murine skin tumor development and its correlation with cyclin D1, p53, and p21Waf1/Cip1 in epithelial tumors of the human skin
inferred← citeshttps://doi.org/10.1007/s00432-010-0955-zopenalex-snapshot
Induced pluripotent cancer cells: progress and application
inferred← citeshttps://doi.org/10.1007/s10495-009-0368-0openalex-snapshot
KLF4 suppresses HDACi induced caspase activation and the SAPK pathway by targeting p57Kip2
inferred← citeshttps://doi.org/10.1007/s11515-016-1396-0openalex-snapshot
Chemical-only reprogramming to pluripotency
inferred← citeshttps://doi.org/10.1007/s12015-010-9123-8openalex-snapshot
Advances in Reprogramming Somatic Cells to Induced Pluripotent Stem Cells
inferred← citeshttps://doi.org/10.1007/s12015-013-9487-7openalex-snapshot
The Current Status of iPS Cells in Cardiac Research and Their Potential for Tissue Engineering and Regenerative Medicine
inferred← citeshttps://doi.org/10.1007/s12033-010-9252-yopenalex-snapshot
Progenitor Cells for Regenerative Medicine and Consequences of ART and Cloning-Associated Epimutations
inferred← citeshttps://doi.org/10.1007/s12192-008-0033-5openalex-snapshot
Upregulation of the constitutively expressed HSC70 by KLF4
inferred← citeshttps://doi.org/10.1007/s12272-012-0208-6openalex-snapshot
Chemical biology in stem cell research
inferred← citeshttps://doi.org/10.1007/s12282-016-0708-1openalex-snapshot
KLF4 and NANOG are prognostic biomarkers for triple-negative breast cancer
inferred← citeshttps://doi.org/10.1007/s13277-013-1321-yopenalex-snapshot
Embryonic stem cell-specific signature in cervical cancer
inferred← citeshttps://doi.org/10.1007/s40944-022-00605-4openalex-snapshot
The Role of Krüppel-like Factor 4 (KLF4) Gene in Breast Cancer Tissue Samples: A Systematic Review and Meta-analysis
inferred← citeshttps://doi.org/10.1016/b978-0-12-804280-9.00006-8openalex-snapshot
Molecular genetics of meningiomas
inferred← citeshttps://doi.org/10.1016/j.arr.2010.03.001openalex-snapshot
How far are induced pluripotent stem cells from the clinic?
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2017.04.017openalex-snapshot
Transdifferentiation and reprogramming: Overview of the processes, their similarities and differences
inferred← citeshttps://doi.org/10.1016/j.bbrc.2009.02.156openalex-snapshot
Embryonic stem cell markers expression in cancers
inferred← citeshttps://doi.org/10.1016/j.bbrc.2019.07.011openalex-snapshot
KLF4 suppresses the tumor activity of cutaneous squamous cell carcinoma (SCC) cells via the regulation of SMAD signaling and SOX2 expression
inferred← citeshttps://doi.org/10.1016/j.brainres.2008.11.013openalex-snapshot
Glutamatergic stimulation triggers rapid Krüpple-like factor 4 expression in neurons and the overexpression of KLF4 sensitizes neurons to NMDA-induced caspase-3 activity
inferred← citeshttps://doi.org/10.1016/j.canlet.2018.09.005openalex-snapshot
Context-dependent functions of KLF4 in cancers: Could alternative splicing isoforms be the key?
inferred← citeshttps://doi.org/10.1016/j.cej.2020.128130openalex-snapshot
2D and 3D co-spatial compartmentalized patch to enhance the therapeutic efficacy of keratinocytes for wound closure
inferred← citeshttps://doi.org/10.1016/j.copbio.2009.09.005openalex-snapshot
New strategies to generate induced pluripotent stem cells
inferred← citeshttps://doi.org/10.1016/j.diff.2013.06.002openalex-snapshot
Generation of induced pluripotent stem cells from human foetal fibroblasts using the Sleeping Beauty transposon gene delivery system
inferred← citeshttps://doi.org/10.1016/j.heliyon.2019.e02257openalex-snapshot
Cancer stem cell subpopulations in moderately differentiated head and neck cutaneous squamous cell carcinoma
inferred← citeshttps://doi.org/10.1016/j.humpath.2011.09.003openalex-snapshot
Loss of nuclear expression of Krüppel-like factor 4 is associated with poor prognosis in patients with oral cancer
inferred← citeshttps://doi.org/10.1016/j.jbo.2016.02.002openalex-snapshot
MiR-367 negatively regulates apoptosis induced by adriamycin in osteosarcoma cells by targeting KLF4
inferred← citeshttps://doi.org/10.1016/j.jmb.2016.09.023openalex-snapshot
KATapulting toward Pluripotency and Cancer
inferred← citeshttps://doi.org/10.1016/j.juro.2013.08.087openalex-snapshot
Epigenetic Inactivation of KLF4 is Associated with Urothelial Cancer Progression and Early Recurrence
inferred← citeshttps://doi.org/10.1016/j.mce.2015.05.015openalex-snapshot
Glucocorticoid receptor and Klf4 co-regulate anti-inflammatory genes in keratinocytes
inferred← citeshttps://doi.org/10.1016/j.pneurobio.2015.09.009openalex-snapshot
Human induced pluripotent stem cells in Parkinson's disease: A novel cell source of cell therapy and disease modeling
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Strategies and New Developments in the Generation of Patient-Specific Pluripotent Stem Cells
inferred← citeshttps://doi.org/10.1016/j.stemcr.2015.01.006openalex-snapshot
Long-Term Safety Issues of iPSC-Based Cell Therapy in a Spinal Cord Injury Model: Oncogenic Transformation with Epithelial-Mesenchymal Transition
inferred← citeshttps://doi.org/10.1016/j.ydbio.2006.12.015openalex-snapshot
Tough beginnings: Alterations in the transcriptome of cloned embryos during the first two cell cycles
inferred← citeshttps://doi.org/10.1016/j.ydbio.2007.12.018openalex-snapshot
Krüppel-like factor 4 is involved in functional differentiation of testicular Sertoli cells
inferred← citeshttps://doi.org/10.1016/j.yjmcc.2007.06.001openalex-snapshot
Induction of p53 by GKLF is essential for inhibition of proliferation of vascular smooth muscle cells
inferred← citeshttps://doi.org/10.1016/j.yjmcc.2022.11.009openalex-snapshot
Klf4 deficiency exacerbates myocardial ischemia/reperfusion injury in mice via enhancing ROCK1/DRP1 pathway-dependent mitochondrial fission
inferred← citeshttps://doi.org/10.1016/s0973-6883(11)60114-xopenalex-snapshot
Use of Stem Cells for Liver Diseases—Current Scenario
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.0c00618openalex-snapshot
Nanomedicine-Based Approaches for mRNA Delivery
inferred← citeshttps://doi.org/10.1038/cdd.2012.125openalex-snapshot
p53 Counteracts reprogramming by inhibiting mesenchymal-to-epithelial transition
inferred← citeshttps://doi.org/10.1038/nature07864openalex-snapshot
Virus-free induction of pluripotency and subsequent excision of reprogramming factors
inferred← citeshttps://doi.org/10.1038/ncb1314openalex-snapshot
The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene
inferred← citeshttps://doi.org/10.1038/ncomms9419openalex-snapshot
Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis
inferred← citeshttps://doi.org/10.1038/nm.3866openalex-snapshot
KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis
inferred← citeshttps://doi.org/10.1038/nm0216-217aopenalex-snapshot
Erratum: Corrigendum: KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis
inferred← citeshttps://doi.org/10.1038/nmeth.1323openalex-snapshot
Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon
inferred← citeshttps://doi.org/10.1038/nrc1780openalex-snapshot
KLF4, p21 and context-dependent opposing forces in cancer
inferred← citeshttps://doi.org/10.1038/nrc3582openalex-snapshot
Krüppel-like factors in cancer
inferred← citeshttps://doi.org/10.1038/onc.2010.474openalex-snapshot
Mutant p53 subverts p63 control over KLF4 expression in keratinocytes
inferred← citeshttps://doi.org/10.1038/onc.2010.591openalex-snapshot
Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion
inferred← citeshttps://doi.org/10.1038/onc.2012.437openalex-snapshot
Krüppel-like factor 4 (KLF4) suppresses neuroblastoma cell growth and determines non-tumorigenic lineage differentiation
inferred← citeshttps://doi.org/10.1038/onc.2016.349openalex-snapshot
Impairment of DYRK2 augments stem-like traits by promoting KLF4 expression in breast cancer
inferred← citeshttps://doi.org/10.1038/onc.2016.479openalex-snapshot
FBXO32 suppresses breast cancer tumorigenesis through targeting KLF4 to proteasomal degradation
inferred← citeshttps://doi.org/10.1038/onc.2016.481openalex-snapshot
KLF4 is regulated by RAS/RAF/MEK/ERK signaling through E2F1 and promotes melanoma cell growth
inferred← citeshttps://doi.org/10.1038/oncsis.2015.8openalex-snapshot
Kruppel-like factor 4 signals through microRNA-206 to promote tumor initiation and cell survival
inferred← citeshttps://doi.org/10.1038/s41388-018-0370-5openalex-snapshot
A SIRT1-centered circuitry regulates breast cancer stemness and metastasis
inferred← citeshttps://doi.org/10.1038/s41388-019-0990-4openalex-snapshot
Reactivation of super-enhancers by KLF4 in human Head and Neck Squamous Cell Carcinoma
inferred← citeshttps://doi.org/10.1038/s41419-019-1541-1openalex-snapshot
Monomethyltransferase SET8 facilitates hepatocellular carcinoma growth by enhancing aerobic glycolysis
inferred← citeshttps://doi.org/10.1038/s41586-021-03562-8openalex-snapshot
PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism
inferred← citeshttps://doi.org/10.1038/sj.onc.1209077openalex-snapshot
Snail induction is an early response to Gli1 that determines the efficiency of epithelial transformation
inferred← citeshttps://doi.org/10.1038/sj.onc.1210022openalex-snapshot
Krüppel-like factor 4 exhibits antiapoptotic activity following γ-radiation-induced DNA damage
inferred← citeshttps://doi.org/10.1038/srep04361openalex-snapshot
Partial Somatic to Stem Cell Transformations Induced By Cell-Permeable Reprogramming Factors
inferred← citeshttps://doi.org/10.1053/j.gastro.2010.03.048openalex-snapshot
Esophageal Squamous Cell Dysplasia and Delayed Differentiation With Deletion of Krüppel-Like Factor 4 in Murine Esophagus
inferred← citeshttps://doi.org/10.1053/j.gastro.2010.08.048openalex-snapshot
Klf4 Overexpression Activates Epithelial Cytokines and Inflammation-Mediated Esophageal Squamous Cell Cancer in Mice
inferred← citeshttps://doi.org/10.1073/pnas.0903860106openalex-snapshot
Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4
inferred← citeshttps://doi.org/10.1074/jbc.m110.179952openalex-snapshot
Regulation of Krüppel-like Factor 4 by the Anaphase Promoting Complex Pathway Is Involved in TGF-β Signaling
inferred← citeshttps://doi.org/10.1074/jbc.m111.236737openalex-snapshot
Krüppel-like Factor 4 (KLF4) Activates the Transcription of the Gene for the Platelet Isoform of Phosphofructokinase (PFKP) in Breast Cancer
inferred← citeshttps://doi.org/10.1074/jbc.m112.343566openalex-snapshot
Novel Insight into KLF4 Proteolytic Regulation in Estrogen Receptor Signaling and Breast Carcinogenesis
inferred← citeshttps://doi.org/10.1074/jbc.m113.476861openalex-snapshot
Defining the Communication between Agonist and Coactivator Binding in the Retinoid X Receptor α Ligand Binding Domain
inferred← citeshttps://doi.org/10.1074/jbc.m602712200openalex-snapshot
Inhibition of JNK Promotes Differentiation of Epidermal Keratinocytes
inferred← citeshttps://doi.org/10.1089/cell.2013.0077openalex-snapshot
Posttranslational Modifications of Defined Embryonic Reprogramming Transcription Factors
inferred← citeshttps://doi.org/10.1089/scd.2008.0062openalex-snapshot
iPS Cells: A More Critical Review
inferred← citeshttps://doi.org/10.1089/ten.tea.2017.0444openalex-snapshot
Messenger RNA Delivery for Tissue Engineering and Regenerative Medicine Applications
inferred← citeshttps://doi.org/10.1093/carcin/bgi243openalex-snapshot
Emerging role of KLF4 in human gastrointestinal cancer
inferred← citeshttps://doi.org/10.1093/carcin/bgs143openalex-snapshot
Deficiency of the Kruppel-like factor KLF4 correlates with increased cell proliferation and enhanced skin tumorigenesis
inferred← citeshttps://doi.org/10.1093/carcin/bgt349openalex-snapshot
Impairing squamous differentiation by Klf4 deletion is sufficient to initiate tongue carcinoma development upon K- Ras activation in mice
inferred← citeshttps://doi.org/10.1097/01.mog.0000239864.73962.dbopenalex-snapshot
Key role of Krüppel-like factor proteins in pancreatic cancer and other gastrointestinal neoplasias
inferred← citeshttps://doi.org/10.1098/rstb.2008.2261openalex-snapshot
Pluripotency and nuclear reprogramming
inferred← citeshttps://doi.org/10.1101/019455openalex-snapshot
Engineering Cell Fate: The Roles of iPSC Transcription Factors, Chemicals, Barriers and Enhancing Factors in Reprogramming and Transdifferentiation
inferred← citeshttps://doi.org/10.1111/eos.12866openalex-snapshot
The prognostic role of combining Krüppel‐like factor 4 score and grade of inflammation in a Norwegian cohort of oral tongue squamous cell carcinomas
inferred← citeshttps://doi.org/10.1111/j.1745-7270.2008.00439.xopenalex-snapshot
Roles of Krüppel-like factor 4 in normal homeostasis, cancer and stem cells
inferred← citeshttps://doi.org/10.1111/jcmm.16194openalex-snapshot
The preventive and therapeutic effects of AAV1‐KLF4‐shRNA in cigarette smoke‐induced pulmonary hypertension
inferred← citeshttps://doi.org/10.1128/mcb.00480-14openalex-snapshot
MicroRNAs 206 and 21 Cooperate To Promote RAS–Extracellular Signal-Regulated Kinase Signaling by Suppressing the Translation of RASA1 and SPRED1
inferred← citeshttps://doi.org/10.1128/mcb.00838-12openalex-snapshot
Role of Krüppel-Like Factor 4 in Neurogenesis and Radial Neuronal Migration in the Developing Cerebral Cortex
inferred← citeshttps://doi.org/10.1128/mcb.01189-10openalex-snapshot
A KLF4–miRNA-206 Autoregulatory Feedback Loop Can Promote or Inhibit Protein Translation Depending upon Cell Context
inferred← citeshttps://doi.org/10.1128/mcb.01456-10openalex-snapshot
Cooperative Transcriptional Activation by Klf4, Meis2, and Pbx1
inferred← citeshttps://doi.org/10.1152/physrev.00058.2009openalex-snapshot
Mammalian Krüppel-Like Factors in Health and Diseases
inferred← citeshttps://doi.org/10.1155/2016/4736159openalex-snapshot
Factor‐Reduced Human Induced Pluripotent Stem Cells Efficiently Differentiate into Neurons Independent of the Number of Reprogramming Factors
inferred← citeshttps://doi.org/10.1155/2016/6439864openalex-snapshot
Endothelial Transdifferentiation of Tumor Cells Triggered by the Twist1‐Jagged1‐KLF4 Axis: Relationship between Cancer Stemness and Angiogenesis
inferred← citeshttps://doi.org/10.1158/0008-5472.can-05-2059openalex-snapshot
Destabilization of Kruppel-Like Factor 4 Protein in Response to Serum Stimulation Involves the Ubiquitin-Proteasome Pathway
inferred← citeshttps://doi.org/10.1158/0008-5472.can-10-2414openalex-snapshot
Prognostic Value and Function of KLF4 in Prostate Cancer: RNAa and Vector-Mediated Overexpression Identify KLF4 as an Inhibitor of Tumor Cell Growth and Migration
inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-09-0310openalex-snapshot
Putative Tumor-Suppressive Function of Krüppel-Like Factor 4 in Primary Lung Carcinoma
inferred← citeshttps://doi.org/10.11606/d.17.2014.tde-30102014-110439openalex-snapshot
Avaliação do Papel da Via Canônica e Não Canônica de NFB na Manutenção da Pluripotência e na Diferenciação, por Meio da Técnica de Imunoprecipitação de Cromatina
inferred← citeshttps://doi.org/10.11606/d.46.2017.tde-11042017-082202openalex-snapshot
O papel da quinase Aurora A na biologia das células iniciadoras de turmor pulmonares com mutação em KRAS
inferred← citeshttps://doi.org/10.1165/rcmb.2006-0043ocopenalex-snapshot
Gut-Enriched Krüppel-Like Factor Interaction with Smad3 Inhibits Myofibroblast Differentiation
inferred← citeshttps://doi.org/10.1167/iovs.17-21826openalex-snapshot
KLF4 Plays an Essential Role in Corneal Epithelial Homeostasis by Promoting Epithelial Cell Fate and Suppressing Epithelial–Mesenchymal Transition
inferred← citeshttps://doi.org/10.1182/blood-2006-03-011106openalex-snapshot
KLF4 suppresses transformation of pre-B cells by ABL oncogenes
inferred← citeshttps://doi.org/10.1186/1476-4598-12-89openalex-snapshot
Krüppel-like factor 4 regulates genetic stability in mouse embryonic fibroblasts
inferred← citeshttps://doi.org/10.1186/1477-7819-9-121openalex-snapshot
Comprehensive analysis of clinical significance of stem-cell related factors in renal cell cancer
inferred← citeshttps://doi.org/10.1186/1756-9966-29-135openalex-snapshot
An embryo-specific expressing TGF-β family protein, growth-differentiation factor 3 (GDF3), augments progression of B16 melanoma
inferred← citeshttps://doi.org/10.1186/1756-9966-30-9openalex-snapshot
Stem cells in clinical practice: applications and warnings
inferred← citeshttps://doi.org/10.1186/s12885-022-09198-9openalex-snapshot
Prognostic significance of KLF4 in solid tumours: an updated meta-analysis
inferred← citeshttps://doi.org/10.1186/s12943-015-0373-6openalex-snapshot
Impaired autophagy in mouse embryonic fibroblasts null for Krüppel-like Factor 4 promotes DNA damage and increases apoptosis upon serum starvation
inferred← citeshttps://doi.org/10.1186/scrt102openalex-snapshot
Progress on stem cell research towards the treatment of Parkinson's disease
inferred← citeshttps://doi.org/10.1242/jcs.03070openalex-snapshot
Epidermal and craniofacial defects in mice overexpressing Klf5 in the basal layer of the epidermis
inferred← citeshttps://doi.org/10.1242/jcs.108910openalex-snapshot
Krüppel-like factor 4 is involved in cell scattering induced by hepatocyte growth factor
inferred← citeshttps://doi.org/10.1371/annotation/121b04a1-0cbb-4e24-8a63-fc9cdd31ec76openalex-snapshot
Correction: Klf4 Is a Transcriptional Regulator of Genes Critical for EMT, Including Jnk1 (Mapk8)
inferred← citeshttps://doi.org/10.1371/annotation/af3b480b-2a5a-4483-a98d-82476b314ec1openalex-snapshot
Correction: Krüppel-Like Factor 4, a Tumor Suppressor in Hepatocellular Carcinoma Cells Reverts Epithelial Mesenchymal Transition by Suppressing Slug Expression
inferred← citeshttps://doi.org/10.1371/journal.pone.0010369openalex-snapshot
Differential Control of Notch1 Gene Transcription by Klf4 and Sp3 Transcription Factors in Normal versus Cancer-Derived Keratinocytes
inferred← citeshttps://doi.org/10.1371/journal.pone.0035362openalex-snapshot
Local Microenvironment Provides Important Cues for Cell Differentiation in Lingual Epithelia
inferred← citeshttps://doi.org/10.1371/journal.pone.0043593openalex-snapshot
Krüppel-Like Factor 4, a Tumor Suppressor in Hepatocellular Carcinoma Cells Reverts Epithelial Mesenchymal Transition by Suppressing Slug Expression
inferred← citeshttps://doi.org/10.1371/journal.pone.0045546openalex-snapshot
Keratinocyte-Targeted Expression of Human Laminin γ2 Rescues Skin Blistering and Early Lethality of Laminin γ2 Deficient Mice
inferred← citeshttps://doi.org/10.1371/journal.pone.0057329openalex-snapshot
Klf4 Is a Transcriptional Regulator of Genes Critical for EMT, Including Jnk1 (Mapk8)
inferred← citeshttps://doi.org/10.1371/journal.pone.0067758openalex-snapshot
Attenuation of Krüppel-Like Factor 4 Facilitates Carcinogenesis by Inducing G1/S Phase Arrest in Clear Cell Renal Cell Carcinoma
inferred← citeshttps://doi.org/10.1371/journal.pone.0124283openalex-snapshot
High EMT Signature Score of Invasive Non-Small Cell Lung Cancer (NSCLC) Cells Correlates with NFκB Driven Colony-Stimulating Factor 2 (CSF2/GM-CSF) Secretion by Neighboring Stromal Fibroblasts
inferred← citeshttps://doi.org/10.1371/journal.pone.0166944openalex-snapshot
Transcriptomic Analysis Shows Decreased Cortical Expression of NR4A1, NR4A2 and RXRB in Schizophrenia and Provides Evidence for Nuclear Receptor Dysregulation
inferred← citeshttps://doi.org/10.1371/journal.pone.0257977openalex-snapshot
Transcription factors Krüppel-like factor 4 and paired box 5 regulate the expression of the Grainyhead-like genes
inferred← citeshttps://doi.org/10.1371/journal.ppat.1005195openalex-snapshot
Differentiation-Dependent KLF4 Expression Promotes Lytic Epstein-Barr Virus Infection in Epithelial Cells
inferred← citeshttps://doi.org/10.1371/journal.ppat.1005747openalex-snapshot
Post-Transcriptional Regulation of KLF4 by High-Risk Human Papillomaviruses Is Necessary for the Differentiation-Dependent Viral Life Cycle
inferred← citeshttps://doi.org/10.1379/csc-210.1openalex-snapshot
Induction of KLF4 in response to heat stress
inferred← citeshttps://doi.org/10.14288/1.0072497openalex-snapshot
Factors in glutamate excitotoxicity, inflammation and epilepsy
inferred← citeshttps://doi.org/10.14670/hh-24.1343openalex-snapshot
The role of Krüppel-like factors in the reprogramming of somatic cells to induced pluripotent stem cells.
inferred← citeshttps://doi.org/10.1515/bc.2009.060openalex-snapshot
Krüppel-like factor 4 represses transcription of the survivin gene in esophageal cancer cell lines
inferred← citeshttps://doi.org/10.1517/14712598.2012.684875openalex-snapshot
Recent developments in transposon-mediated gene therapy
inferred← citeshttps://doi.org/10.15252/emmm.202012391openalex-snapshot
New insight into the significance of KLF4 PARylation in genome stability, carcinogenesis, and therapy
inferred← citeshttps://doi.org/10.18632/oncotarget.10058openalex-snapshot
KLF4α stimulates breast cancer cell proliferation by acting as a KLF4 antagonist
inferred← citeshttps://doi.org/10.18632/oncotarget.19231openalex-snapshot
Morusin inhibits cell proliferation and tumor growth by down-regulating c-Myc in human gastric cancer
inferred← citeshttps://doi.org/10.19106/jmedsci005301202109openalex-snapshot
Induced pluripotent stem cells and genome editing technology as therapeutic strategies for Duchenne muscular dystrophy
inferred← citeshttps://doi.org/10.2147/ott.s199615openalex-snapshot
Identification of candidate biomarkers correlated with the diagnosis and prognosis of cervical cancer via integrated bioinformatics analysis
inferred← citeshttps://doi.org/10.2147/ott.s68340openalex-snapshot
The transcription factor KLF4 as an independent predictive marker for pathologic complete remission in breast cancer neoadjuvant chemotherapy: a case–control study
inferred← citeshttps://doi.org/10.2174/138920209788921010openalex-snapshot
Expression and Function of Kruppel Like-Factors (KLF) in Carcinogenesis
inferred← citeshttps://doi.org/10.2174/138920209789503932openalex-snapshot
Kruppel-Like Factors 4 and 5: Unity in Diversity
inferred← citeshttps://doi.org/10.2741/s349openalex-snapshot
Endogenous anticancer mechanism differentiation
inferred← citeshttps://doi.org/10.31390/gradschool_dissertations.3709openalex-snapshot
Identification of genes responsible for maintenance of differentiation capability in dental pulp stem cells
inferred← citeshttps://doi.org/10.3389/fonc.2020.01091openalex-snapshot
Cancer Stem Cell Subpopulations Are Present Within Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma
inferred← citeshttps://doi.org/10.3389/fsurg.2014.00005openalex-snapshot
Induced Pluripotent Stem Cell Potential in Medicine, Specifically Focused on Reproductive Medicine
inferred← citeshttps://doi.org/10.3389/fsurg.2016.00021openalex-snapshot
Cancer Stem Cell Hierarchy in Glioblastoma Multiforme
inferred← citeshttps://doi.org/10.33915/etd.5581openalex-snapshot
The Diverse Relationship of Kruppel-Like Factors 4 and 5 in Breast Cancer
inferred← citeshttps://doi.org/10.33915/etd.6619openalex-snapshot
Kruppel-like factor 4 (KLF4) regulates protumorigenic signaling in triple-negative breast cancer (TNBC) cells
inferred← citeshttps://doi.org/10.33915/etd.6863openalex-snapshot
Regulation and Function of the Cancer Stem Cell Transcription Factors GLI1 and Kruppel-like Factor 4
inferred← citeshttps://doi.org/10.3724/sp.j.1005.2012.00260openalex-snapshot
The genetic safety of induced pluripotent stem (iPS) cells
inferred← citeshttps://doi.org/10.37867/te140189openalex-snapshot
CANCER STEM CELLS: THE GREATEST MENACE IN CONQUERING CANCER MANAGEMENT
inferred← citeshttps://doi.org/10.3824/stembook.1.24.1openalex-snapshot
The pluripotent transcriptome
inferred← citeshttps://doi.org/10.3892/etm.2017.4262openalex-snapshot
Expression of Krüppel-like factor 4 in breast cancer tissues and its effects on the proliferation of breast cancer MDA-MB-231 cells
inferred← citeshttps://doi.org/10.3892/mco.2016.883openalex-snapshot
Krüppel-like factor 4: A new potential biomarker of lung cancer
inferred← citeshttps://doi.org/10.3892/ol.2013.1151openalex-snapshot
The clinical and prognostic implications of pluripotent stem cell gene expression in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.4081/jnai.2010.1625openalex-snapshot
Induced pluripotent stem cells: the long-expected revolution in medical science and practice?
inferred← citeshttps://doi.org/10.4081/jnai.2010.e1openalex-snapshot
Induced pluripotent stem cells: the long-expected revolution in medical science and practice?
inferred← citeshttps://doi.org/10.4161/cbt.4.12.2355openalex-snapshot
KLF4 and PCNA identify stages of tumor initiation in a conditional model of cutaneous squamous epithelial neoplasia
inferred← citeshttps://doi.org/10.4161/cbt.7.5.5768openalex-snapshot
Nuclear Krüppel-like factor 4 expression is associated with human skin squamous cell carcinoma progression and metastasis
inferred← citeshttps://doi.org/10.4161/cbt.7.5.6110openalex-snapshot
Bad things happen in the basal layer: KLF4 and squamous cell carcinoma
inferred← citeshttps://doi.org/10.4161/cbt.8.3.7486openalex-snapshot
Prevention of KLF4-mediated tumor initiation and malignant transformation by UAB30 rexinoid
inferred← citeshttps://doi.org/10.4161/cc.22265openalex-snapshot
p53 mutation alters the effect of the esophageal tumor suppressor KLF5 on keratinocyte proliferation
inferred← citeshttps://doi.org/10.4172/2572-4118.1000110openalex-snapshot
KLF4 Improve Prognosis of Triple-negative Breast Cancer by Suppression of Epithelial-mesenchymal Transition
inferred← citeshttps://doi.org/10.4238/2015.october.2.6openalex-snapshot
Screening of crucial long non-coding RNAs in oral epithelial dysplasia by serial analysis of gene expression
inferred← citeshttps://doi.org/10.4267/2042/44555openalex-snapshot
KLF4 (Kruppel-like factor 4 (gut))
inferred← citeshttps://doi.org/10.5430/jst.v5n1p49openalex-snapshot
KLF4 Genome: A double edged sword
inferred← citeshttps://doi.org/10.5772/19315openalex-snapshot
Cancer Initiating Cells in Head and Neck Squamous Cell Carcinoma
inferred← citeshttps://doi.org/10.5772/52527openalex-snapshot
Transposons for Non-Viral Gene Transfer
inferred← citeshttps://doi.org/10.5772/57614openalex-snapshot
Embryonic Stem Cells and Oncogenes
inferred← citeshttps://doi.org/10.5772/intechopen.89151openalex-snapshot
KLF4-Mediated Plasticity of Myeloid-Derived Suppressor Cells (MDSCs)
inferred← citeshttps://doi.org/10.5897/ajb12.1074openalex-snapshot
Amniotic fluid-derived mesenchymal stem cells as a novel therapeutic approach in the treatment of fulminant hepatic failure in rats
inferred← citeshttps://doi.org/10.5966/sctm.2013-0179openalex-snapshot
Removal of Reprogramming Transgenes Improves the Tissue Reconstitution Potential of Keratinocytes Generated From Human Induced Pluripotent Stem Cells
inferred← citeshttps://doi.org/10.6323/jocrp.2011.27.5.1openalex-snapshot
The Role of Gut-Enriched Krüppel-Like Factor (GKLF)/ KLF4 in Gastrointestinal Tract-Related Cancers
inferred← citeshttps://doi.org/10.70675/3b65f04aze7bbz4435z98bfz04ce04593fd1openalex-snapshot
Contrôle de l’expansion ex vivo de précurseurs kératinocytaires humains fonctionnels : implication des facteurs de transcription KLF4 et MAD4
inferred← citeshttps://doi.org/10.7150/jca.21241openalex-snapshot
Restoration of KLF4 Inhibits Invasion and Metastases of Lung Adenocarcinoma through Suppressing MMP2
inferred← citeshttps://doi.org/10.7150/thno.32908openalex-snapshot
Polo-Like Kinase 1 phosphorylates and stabilizes KLF4 to promote tumorigenesis in nasopharyngeal carcinoma
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