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Zscan4 transiently reactivates early embryonic genes during the generation of induced pluripotent stem cells

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1016/0378-1119(91)90434-dopenalex-snapshot

Efficient selection for high-expression transfectants with a novel eukaryotic vector

inferredcites →https://doi.org/10.1016/j.cell.2006.07.024openalex-snapshot

Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors

inferredcites →https://doi.org/10.1016/j.cell.2009.01.001openalex-snapshot

Role of the Murine Reprogramming Factors in the Induction of Pluripotency

inferredcites →https://doi.org/10.1016/j.cell.2009.07.039openalex-snapshot

Nanog Is the Gateway to the Pluripotent Ground State

inferredcites →https://doi.org/10.1016/j.cell.2010.10.008openalex-snapshot

Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues

inferredcites →https://doi.org/10.1016/j.cub.2009.06.065openalex-snapshot

Reprogramming after Chromosome Transfer into Mouse Blastomeres

inferredcites →https://doi.org/10.1016/j.gep.2009.08.002openalex-snapshot

Trim43a, Trim43b, and Trim43c: Novel mouse genes expressed specifically in mouse preimplantation embryos

inferredcites →https://doi.org/10.1016/j.stem.2008.01.004openalex-snapshot

Sequential Expression of Pluripotency Markers during Direct Reprogramming of Mouse Somatic Cells

inferredcites →https://doi.org/10.1016/j.stem.2009.07.012openalex-snapshot

Uncovering Early Response of Gene Regulatory Networks in ESCs by Systematic Induction of Transcription Factors

inferredcites →https://doi.org/10.1016/j.stem.2010.04.015openalex-snapshot

Functional Genomics Reveals a BMP-Driven Mesenchymal-to-Epithelial Transition in the Initiation of Somatic Cell Reprogramming

inferredcites →https://doi.org/10.1016/j.stem.2010.07.017openalex-snapshot

Identification and Classification of Chromosomal Aberrations in Human Induced Pluripotent Stem Cells

inferredcites →https://doi.org/10.1016/j.stem.2010.12.001openalex-snapshot

Reprogramming Factor Expression Initiates Widespread Targeted Chromatin Remodeling

inferredcites →https://doi.org/10.1016/j.stem.2010.12.003openalex-snapshot

Dynamic Changes in the Copy Number of Pluripotency and Cell Proliferation Genes in Human ESCs and iPSCs during Reprogramming and Time in Culture

inferredcites →https://doi.org/10.1016/j.ydbio.2007.05.003openalex-snapshot

Zscan4: A novel gene expressed exclusively in late 2-cell embryos and embryonic stem cells

inferredcites →https://doi.org/10.1016/s0076-6879(06)11009-5openalex-snapshot

[9] TM4 Microarray Software Suite

inferredcites →https://doi.org/10.1038/182064a0openalex-snapshot

Sexually Mature Individuals of Xenopus laevis from the Transplantation of Single Somatic Nuclei

inferredcites →https://doi.org/10.1038/28615openalex-snapshot

Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei

inferredcites →https://doi.org/10.1038/385810a0openalex-snapshot

Viable offspring derived from fetal and adult mammalian cells

inferredcites →https://doi.org/10.1038/471046aopenalex-snapshot

The dark side of induced pluripotency

inferredcites →https://doi.org/10.1038/nature07863openalex-snapshot

piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells

inferredcites →https://doi.org/10.1038/nature07864openalex-snapshot

Virus-free induction of pluripotency and subsequent excision of reprogramming factors

inferredcites →https://doi.org/10.1038/nature08592openalex-snapshot

Direct cell reprogramming is a stochastic process amenable to acceleration

inferredcites →https://doi.org/10.1038/nature08882openalex-snapshot

Zscan4 regulates telomere elongation and genomic stability in ES cells

inferredcites →https://doi.org/10.1038/nature09342openalex-snapshot

Epigenetic memory in induced pluripotent stem cells

inferredcites →https://doi.org/10.1038/nature09798openalex-snapshot

Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells

inferredcites →https://doi.org/10.1038/nature09805openalex-snapshot

Somatic coding mutations in human induced pluripotent stem cells

inferredcites →https://doi.org/10.1038/nature09871openalex-snapshot

Copy number variation and selection during reprogramming to pluripotency

inferredcites →https://doi.org/10.1038/nature10106openalex-snapshot

Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1

inferredcites →https://doi.org/10.1038/nbt1483openalex-snapshot

A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types

inferredcites →https://doi.org/10.1038/ncomms1503openalex-snapshot

Reprogramming within hours following nuclear transfer into mouse but not human zygotes

inferredcites →https://doi.org/10.1038/nrg2937openalex-snapshot

Methods for making induced pluripotent stem cells: reprogramming à la carte

inferredcites →https://doi.org/10.1038/nrg2955openalex-snapshot

Progress in understanding reprogramming to the induced pluripotent state

inferredcites →https://doi.org/10.1073/pnas.012025199openalex-snapshot

Large-scale analysis of the human and mouse transcriptomes

inferredcites →https://doi.org/10.1073/pnas.0801017105openalex-snapshot

Chromosomal transposition of PiggyBac in mouse embryonic stem cells

inferredcites →https://doi.org/10.1073/pnas.1009374107openalex-snapshot

Promotion of direct reprogramming by transformation-deficient Myc

inferredcites →https://doi.org/10.1073/pnas.101118898openalex-snapshot

Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation

inferredcites →https://doi.org/10.1073/pnas.93.20.10887openalex-snapshot

Ligand-activated site-specific recombination in mice.

inferredcites →https://doi.org/10.1084/jem.20101866openalex-snapshot

p53 connects tumorigenesis and reprogramming to pluripotency

inferredcites →https://doi.org/10.1093/bioinformatics/bti343openalex-snapshot

A web-based tool for principal component and significance analysis of microarray data

inferredcites →https://doi.org/10.1093/nar/gkn294openalex-snapshot

QUMA: quantification tool for methylation analysis

inferredcites →https://doi.org/10.1101/gad.1963910openalex-snapshot

Induced pluripotency: history, mechanisms, and applications

inferredcites →https://doi.org/10.1101/gr.749203openalex-snapshot

A Highly Efficient Recombineering-Based Method for Generating Conditional Knockout Mutations

inferredcites →https://doi.org/10.1186/1471-2164-12-102openalex-snapshot

Responsiveness of genes to manipulation of transcription factors in ES cells is associated with histone modifications and tissue specificity

inferredcites →https://doi.org/10.1186/gb-2005-6-7-r61openalex-snapshot

Transcript copy number estimation using a mouse whole-genome oligonucleotide microarray

inferredcites →https://doi.org/10.1242/dev.110.3.815openalex-snapshot

Embryonic stem cells alone are able to support fetal development in the mouse

inferredcites →https://doi.org/10.1242/dev.127.8.1737openalex-snapshot

Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.3367197openalex-extracted

Minor Splicing Factors Zrsr1 and Zrsr2 Essential for Gametogenesis, Early Embryo Development and Conversion of Stem Cells into 2C-Like

inferred← citeshttps://doi.org/10.1002/bies.202200029openalex-snapshot

Genome architecture and totipotency: An intertwined relation during early embryonic development

inferred← citeshttps://doi.org/10.1002/jcp.24980openalex-snapshot

Roles for Histone Acetylation in Regulation of Telomere Elongation and Two‐cell State in Mouse ES Cells

inferred← citeshttps://doi.org/10.1002/stem.1303openalex-snapshot

Induction of Pluripotent Stem Cells from Primordial Germ Cells by Single Reprogramming Factors

inferred← citeshttps://doi.org/10.1007/5584_2025_853openalex-snapshot

Genes as Genome Stabilizers in Pluripotent Stem Cells

inferred← citeshttps://doi.org/10.1007/7651_2015_279openalex-snapshot

Computational Biology Methods for Characterization of Pluripotent Cells

inferred← citeshttps://doi.org/10.1007/978-1-4939-0787-8_5openalex-snapshot

Advances in Pluripotent and Adult Stem Cells for Eye Research

inferred← citeshttps://doi.org/10.1007/s00109-017-1509-5openalex-snapshot

Totipotency in the mouse

inferred← citeshttps://doi.org/10.1007/s00412-017-0656-3openalex-snapshot

Telomere chromatin establishment and its maintenance during mammalian development

inferred← citeshttps://doi.org/10.1007/s11626-016-0096-zopenalex-snapshot

Zscan4 is expressed specifically during late meiotic prophase in both spermatogenesis and oogenesis

inferred← citeshttps://doi.org/10.1007/s11626-016-0097-yopenalex-snapshot

Expression analysis of the endogenous Zscan4 locus and its coding proteins in mouse ES cells and preimplantation embryos

inferred← citeshttps://doi.org/10.1007/s12015-022-10412-1openalex-snapshot

A Comprehensive Review on the Role of ZSCAN4 in Embryonic Development, Stem Cells, and Cancer

inferred← citeshttps://doi.org/10.1007/s13238-019-0651-yopenalex-snapshot

The role of telomere-binding modulators in pluripotent stem cells

inferred← citeshttps://doi.org/10.1016/b978-0-12-386541-0.00038-2openalex-snapshot

Role of iPSC-Producing Factors in Pre-Implantation Embryos

inferred← citeshttps://doi.org/10.1016/b978-0-323-90059-1.00007-5openalex-snapshot

Auxiliary pluripotency-associated genes and their contributions in the generation of induced pluripotent stem cells

inferred← citeshttps://doi.org/10.1016/bs.ctdb.2015.10.014openalex-snapshot

Lineage Segregation in the Totipotent Embryo

inferred← citeshttps://doi.org/10.1016/bs.ctdb.2016.04.004openalex-snapshot

Zygotic Genome Activation Revisited

inferred← citeshttps://doi.org/10.1016/j.arr.2025.102773openalex-snapshot

Telomeres as hallmarks of iPSC aging: A review on telomere dynamics during stemness and cellular reprogramming

inferred← citeshttps://doi.org/10.1016/j.bbrc.2015.09.107openalex-snapshot

ZSCAN4 and TRF1: A functionally indirect interaction in cancer cells independent of telomerase activity

inferred← citeshttps://doi.org/10.1016/j.bbrc.2018.02.155openalex-snapshot

ZSCAN4 is negatively regulated by the ubiquitin-proteasome system and the E3 ubiquitin ligase RNF20

inferred← citeshttps://doi.org/10.1016/j.bbrc.2019.11.114openalex-snapshot

H3.3 impedes zygotic transcriptional program activated by Dux

inferred← citeshttps://doi.org/10.1016/j.biomaterials.2014.10.055openalex-snapshot

Generation of induced pluripotent stem cells without genetic defects by small molecules

inferred← citeshttps://doi.org/10.1016/j.celrep.2014.10.052openalex-snapshot

Telomere Elongation and Naive Pluripotent Stem Cells Achieved from Telomerase Haplo-Insufficient Cells by Somatic Cell Nuclear Transfer

inferred← citeshttps://doi.org/10.1016/j.celrep.2016.08.087openalex-snapshot

MERVL/Zscan4 Network Activation Results in Transient Genome-wide DNA Demethylation of mESCs

inferred← citeshttps://doi.org/10.1016/j.celrep.2017.07.070openalex-snapshot

Zscan4 Inhibits Maintenance DNA Methylation to Facilitate Telomere Elongation in Mouse Embryonic Stem Cells

inferred← citeshttps://doi.org/10.1016/j.celrep.2019.11.080openalex-snapshot

Functional Oocytes Derived from Granulosa Cells

inferred← citeshttps://doi.org/10.1016/j.celrep.2019.12.010openalex-snapshot

SETDB1-Mediated Cell Fate Transition between 2C-Like and Pluripotent States

inferred← citeshttps://doi.org/10.1016/j.celrep.2020.107877openalex-snapshot

The Zscan4-Tet2 Transcription Nexus Regulates Metabolic Rewiring and Enhances Proteostasis to Promote Reprogramming

inferred← citeshttps://doi.org/10.1016/j.celrep.2025.116654openalex-snapshot

The exit of naive pluripotency contains a metabolism-induced checkpoint for telomere homeostasis

inferred← citeshttps://doi.org/10.1016/j.gde.2013.06.005openalex-snapshot

Epigenetics of cellular reprogramming

inferred← citeshttps://doi.org/10.1016/j.mcpro.2025.101077openalex-snapshot

Zscan4 as a Candidate Conveyor of Early Developmental Defects in O-GlcNAc Transferase Intellectual Disability

inferred← citeshttps://doi.org/10.1016/j.stem.2013.07.001openalex-snapshot

Genetic and Epigenetic Variations in iPSCs: Potential Causes and Implications for Application

inferred← citeshttps://doi.org/10.1016/j.stem.2016.12.004openalex-snapshot

New Insights into Early Human Development: Lessons for Stem Cell Derivation and Differentiation

inferred← citeshttps://doi.org/10.1016/j.stemcr.2014.01.014openalex-snapshot

Platform for Induction and Maintenance of Transgene-free hiPSCs Resembling Ground State Pluripotent Stem Cells

inferred← citeshttps://doi.org/10.1016/j.stemcr.2016.02.010openalex-snapshot

Zscan4 Is Activated after Telomere Shortening in Mouse Embryonic Stem Cells

inferred← citeshttps://doi.org/10.1016/j.stemcr.2016.07.009openalex-snapshot

Embryonic Stem Cell Culture Conditions Support Distinct States Associated with Different Developmental Stages and Potency

inferred← citeshttps://doi.org/10.1016/j.stemcr.2018.05.003openalex-snapshot

Dynamics of Telomere Rejuvenation during Chemical Induction to Pluripotent Stem Cells

inferred← citeshttps://doi.org/10.1016/j.tcb.2014.09.006openalex-snapshot

Reprogramming the genome to totipotency in mouse embryos

inferred← citeshttps://doi.org/10.1016/j.tig.2016.10.007openalex-snapshot

Linking Telomere Regulation to Stem Cell Pluripotency

inferred← citeshttps://doi.org/10.1038/cr.2012.157openalex-snapshot

Zscan4 promotes genomic stability during reprogramming and dramatically improves the quality of iPS cells as demonstrated by tetraploid complementation

inferred← citeshttps://doi.org/10.1038/jhg.2012.74openalex-snapshot

Deciphering transcription dysregulation in FSH muscular dystrophy

inferred← citeshttps://doi.org/10.1038/nature11244openalex-snapshot

Embryonic stem cell potency fluctuates with endogenous retrovirus activity

inferred← citeshttps://doi.org/10.1038/ncomms2966openalex-snapshot

Zscan4 restores the developmental potency of embryonic stem cells

inferred← citeshttps://doi.org/10.1038/ncomms9207openalex-snapshot

Novel PRD-like homeodomain transcription factors and retrotransposon elements in early human development

inferred← citeshttps://doi.org/10.1038/s41388-020-1333-1openalex-snapshot

ZSCAN4 facilitates chromatin remodeling and promotes the cancer stem cell phenotype

inferred← citeshttps://doi.org/10.1038/s41467-018-04818-0openalex-snapshot

Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a

inferred← citeshttps://doi.org/10.1038/s41467-021-25072-xopenalex-snapshot

CTCF is a barrier for 2C-like reprogramming

inferred← citeshttps://doi.org/10.1038/s41588-017-0016-5openalex-snapshot

A molecular roadmap for the emergence of early-embryonic-like cells in culture

inferred← citeshttps://doi.org/10.1038/s42003-023-05148-8openalex-snapshot

Zfp296 knockout enhances chromatin accessibility and induces a unique state of pluripotency in embryonic stem cells

inferred← citeshttps://doi.org/10.1038/s44321-024-00097-zopenalex-snapshot

DiPRO1 distinctly reprograms muscle and mesenchymal cancer cells

inferred← citeshttps://doi.org/10.1038/srep03492openalex-snapshot

Roles for Tbx3 in regulation of two-cell state and telomere elongation in mouse ES cells

inferred← citeshttps://doi.org/10.1042/bcj20210646openalex-snapshot

An ERK5–KLF2 signalling module regulates early embryonic gene expression and telomere rejuvenation in stem cells

inferred← citeshttps://doi.org/10.1074/jbc.ra120.014598openalex-snapshot

The nuclear factor CECR2 promotes somatic cell reprogramming by reorganizing the chromatin structure

inferred← citeshttps://doi.org/10.1093/dnares/dsad029openalex-snapshot

ZSCAN4-binding motif—TGCACAC is conserved and enriched in CA/TG microsatellites in both mouse and human genomes

inferred← citeshttps://doi.org/10.1093/dnares/dst018openalex-snapshot

Repression of Global Protein Synthesis by Eif1a-Like Genes That Are Expressed Specifically in the Two-Cell Embryos and the Transient Zscan4-Positive State of Embryonic Stem Cells

inferred← citeshttps://doi.org/10.1093/dnares/dsv016openalex-snapshot

Correction of Down syndrome and Edwards syndrome aneuploidies in human cell cultures

inferred← citeshttps://doi.org/10.1093/nar/gkz594openalex-snapshot

Zscan4c activates endogenous retrovirus MERVL and cleavage embryo genes

inferred← citeshttps://doi.org/10.1096/fj.202200586ropenalex-snapshot

Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F‐actin in zygotes and leads to cognitive and social disorders in offspring mice

inferred← citeshttps://doi.org/10.1098/rspb.2017.1357openalex-snapshot

Novel and divergent genes in the evolution of placental mammals

inferred← citeshttps://doi.org/10.1101/079921openalex-snapshot

Exploratory bioinformatics analysis reveals importance of “junk” DNA in early embryo development

inferred← citeshttps://doi.org/10.1101/431890openalex-snapshot

Dppa2 and Dppa4 directly regulate the Dux driven zygotic transcriptional programme

inferred← citeshttps://doi.org/10.1101/gad.227926.113openalex-snapshot

Inferring the choreography of parental genomes during fertilization from ultralarge-scale whole-transcriptome analysis

inferred← citeshttps://doi.org/10.1101/gad.321174.118openalex-snapshot

Dppa2 and Dppa4 directly regulate the Dux-driven zygotic transcriptional program

inferred← citeshttps://doi.org/10.1101/gad.325696.119openalex-snapshot

GADD45 promotes locus-specific DNA demethylation and 2C cycling in embryonic stem cells

inferred← citeshttps://doi.org/10.1111/cpr.12162openalex-snapshot

Inducing pluripotency in vitro: recent advances and highlights in induced pluripotent stem cells generation and pluripotency reprogramming

inferred← citeshttps://doi.org/10.1152/ajpgi.00299.2012openalex-snapshot

Inflammation increases cells expressing ZSCAN4 and progenitor cell markers in the adult pancreas

inferred← citeshttps://doi.org/10.1155/2021/1624669openalex-snapshot

Transposable Element Dynamics and Regulation during Zygotic Genome Activation in Mammalian Embryos and Embryonic Stem Cell Model Systems

inferred← citeshttps://doi.org/10.1186/2045-9769-3-7openalex-snapshot

Role of Oct4 in the early embryo development

inferred← citeshttps://doi.org/10.1186/s12864-017-3566-0openalex-snapshot

Exploratory bioinformatics investigation reveals importance of “junk” DNA in early embryo development

inferred← citeshttps://doi.org/10.1262/jrd.2019-039openalex-snapshot

The necessity of ZSCAN4 for preimplantation development and gene expression of bovine embryos

inferred← citeshttps://doi.org/10.1262/jrd.2021-065openalex-snapshot

Cleavage-embryo genes and transposable elements are regulated by histone variant H2A.X

inferred← citeshttps://doi.org/10.1371/journal.pgen.1004038openalex-snapshot

Zfp322a Regulates Mouse ES Cell Pluripotency and Enhances Reprogramming Efficiency

inferred← citeshttps://doi.org/10.1371/journal.pone.0059908openalex-snapshot

Few Single Nucleotide Variations in Exomes of Human Cord Blood Induced Pluripotent Stem Cells

inferred← citeshttps://doi.org/10.1371/journal.pone.0089821openalex-snapshot

Zscan4 Is Regulated by PI3-Kinase and DNA-Damaging Agents and Directly Interacts with the Transcriptional Repressors LSD1 and CtBP2 in Mouse Embryonic Stem Cells

inferred← citeshttps://doi.org/10.15252/embr.201948354openalex-snapshot

A distinct metabolic state arises during the emergence of 2‐cell‐like cells

inferred← citeshttps://doi.org/10.21775/cimb.035.085openalex-snapshot

The Role of Ubiquitination and SUMOylation in Telomere Biology

inferred← citeshttps://doi.org/10.32469/10355/66732openalex-snapshot

Metabolic programming of a Warburg effect-like phenotype in donor fibroblasts prior to somatic cell nuclear transfer

inferred← citeshttps://doi.org/10.3390/biomedicines1010049openalex-snapshot

Decoding the Pluripotency Network: The Emergence of New Transcription Factors

inferred← citeshttps://doi.org/10.3390/ijms151120948openalex-snapshot

Stem Cells: The Pursuit of Genomic Stability

inferred← citeshttps://doi.org/10.3390/ijms241512121openalex-snapshot

ZSCAN4 Regulates Zygotic Genome Activation and Telomere Elongation in Porcine Parthenogenetic Embryos

inferred← citeshttps://doi.org/10.3390/ijms25073898openalex-snapshot

Reprogramming Chromosome Ends by Functional Histone Acetylation

inferred← citeshttps://doi.org/10.3727/215517912x658918openalex-snapshot

Human Decidua-Derived Mesenchymal Cells Are a Promising Source for the Generation and Cell Banking of Human Induced Pluripotent Stem Cells

inferred← citeshttps://doi.org/10.4161/cbt.29220openalex-snapshot

Zscan4 interacts directly with human Rap1 in cancer cells regardless of telomerase status

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