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Adipose- and muscle-derived Wnts trigger pancreatic β-cell adaptation to systemic insulin resistance
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1 of the 36 references listed on this page is in the Retraction Watch database as retracted (export 2026-11-04): 10.2337/db07-0847 (notice 2017-03-29).
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1007/978-90-481-3271-3_17openalex-snapshot
Wnt Signaling in Pancreatic Islets
inferredcites →https://doi.org/10.1007/s00018-007-7045-7openalex-snapshot
Glycogen synthase kinase 3: A key regulator of cellular fate
inferredcites →https://doi.org/10.1007/s00125-007-0848-0openalex-snapshot
Regulation of insulin secretion, glucokinase gene transcription and beta cell proliferation by adipocyte-derived Wnt signalling molecules
inferredcites →https://doi.org/10.1016/j.biocel.2014.08.005openalex-snapshot
Stearoyl-CoA desaturase regulates inflammatory gene expression by changing DNA methylation level in 3T3 adipocytes
inferredcites →https://doi.org/10.1016/j.cell.2006.04.009openalex-snapshot
Secretion of Wnt Ligands Requires Evi, a Conserved Transmembrane Protein
inferredcites →https://doi.org/10.1016/j.cellsig.2014.12.012openalex-snapshot
Acute Wnt pathway activation positively regulates leptin gene expression in mature adipocytes
inferredcites →https://doi.org/10.1016/j.cld.2013.09.012openalex-snapshot
Adipose Tissue as an Endocrine Organ
inferredcites →https://doi.org/10.1016/j.cmet.2006.07.001openalex-snapshot
Transcriptional control of adipocyte formation
inferredcites →https://doi.org/10.1016/j.devcel.2014.03.016openalex-snapshot
WLS Retrograde Transport to the Endoplasmic Reticulum during Wnt Secretion
inferredcites →https://doi.org/10.1016/j.tcb.2012.07.008openalex-snapshot
Wnt signaling in myogenesis
inferredcites →https://doi.org/10.1016/j.transproceed.2007.01.039openalex-snapshot
The Use of Iodixanol for the Purification of Rat Pancreatic Islets
inferredcites →https://doi.org/10.1038/cr.2008.47openalex-snapshot
Wnt signaling and stem cell control
inferredcites →https://doi.org/10.1038/ng1732openalex-snapshot
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
inferredcites →https://doi.org/10.1042/bc20070072openalex-snapshot
Wnt4 inhibits β‐catenin/TCF signalling by redirecting β‐catenin to the cell membrane
inferredcites →https://doi.org/10.1042/bst0360357openalex-snapshot
TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic β-cells
inferredcites →https://doi.org/10.1073/pnas.0133792100openalex-snapshot
Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion
inferredcites →https://doi.org/10.1073/pnas.0701509104openalex-snapshot
Wnt signaling regulates pancreatic β cell proliferation
inferredcites →https://doi.org/10.1074/jbc.m110.102855openalex-snapshot
Activation of Canonical Wingless-type MMTV Integration Site Family (Wnt) Signaling in Mature Adipocytes Increases β-Catenin Levels and Leads to Cell Dedifferentiation and Insulin Resistance
inferredcites →https://doi.org/10.1074/jbc.m402937200openalex-snapshot
Wnt10b Inhibits Development of White and Brown Adipose Tissues
inferredcites →https://doi.org/10.1093/hmg/ddu553openalex-snapshot
Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass
inferredcites →https://doi.org/10.1101/gr.563703openalex-snapshot
Haplotype Structure, LD Blocks, and Uneven Recombination Within the LRP5 Gene
inferredcites →https://doi.org/10.1126/science.1136370openalex-snapshot
LRP6 Mutation in a Family with Early Coronary Disease and Metabolic Risk Factors
inferredcites →https://doi.org/10.1126/science.289.5481.950openalex-snapshot
Inhibition of Adipogenesis by Wnt Signaling
inferredcites →https://doi.org/10.1136/jmg.2006.041715openalex-snapshot
Polymorphisms of the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with obesity phenotypes in a large family-based association study
inferredcites →https://doi.org/10.1146/annurev.cellbio.20.010403.113126openalex-snapshot
THE WNT SIGNALING PATHWAY IN DEVELOPMENT AND DISEASE
inferredcites →https://doi.org/10.1172/jci10830openalex-snapshot
Insights into insulin resistance and type 2 diabetes from knockout mouse models
inferredcites →https://doi.org/10.1172/jci200421845openalex-snapshot
PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance
inferredcites →https://doi.org/10.1186/1750-2187-6-12openalex-snapshot
Canonical Wnt signaling is involved in switching from cell proliferation to myogenic differentiation of mouse myoblast cells
inferredcites →https://doi.org/10.1210/endo.142.1.7863openalex-snapshot
Free Fatty Acid-Induced Inhibition of Glucose and Insulin-Like Growth Factor I-Induced Deoxyribonucleic Acid Synthesis in the Pancreatic β-Cell Line INS-11
inferredcites →https://doi.org/10.1242/dev.02366openalex-snapshot
Stabilization of β-catenin impacts pancreas growth
inferredcites →https://doi.org/10.1371/journal.pone.0008509openalex-snapshot
Activation of Wnt/β-Catenin Signaling Increases Insulin Sensitivity through a Reciprocal Regulation of Wnt10b and SREBP-1c in Skeletal Muscle Cells
inferredcites →https://doi.org/10.2337/db06-0474openalex-snapshot
Transcription Factor TCF7L2 Genetic Study in the French Population
inferredcites →https://doi.org/10.2337/db07-0847openalex-snapshot
Transcription Factor 7-Like 2 Regulates β-Cell Survival and Function in Human Pancreatic Islets
inferredcites →https://doi.org/10.2337/db08-1221openalex-snapshot
A Functional Melanocortin System May Be Required for Chronic CNS-Mediated Antidiabetic and Cardiovascular Actions of Leptin
inferredcites →https://doi.org/10.2337/diabetes.52.1.102openalex-snapshot
β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
inferredcites →https://doi.org/10.2337/diacare.27.5.1047openalex-snapshot
Global Prevalence of Diabetes
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4789208openalex-extracted
Unlocking Regenerative Potential: Beta-Cell Neogenesis and Novel Myokines Involved in Adaptation to Insulin Resistance in Mice
inferred← citeshttps://doi.org/10.1002/jbm4.10573openalex-snapshot
Androgen Deprivation Therapy Differentially Impacts Bone and Muscle in the Short Term in Physically Active Men With Prostate Cancer
inferred← citeshttps://doi.org/10.1002/jcp.28584openalex-snapshot
Islet cells are the source of Wnts that can induce beta‐cell proliferation in vitro
inferred← citeshttps://doi.org/10.1002/mco2.283openalex-snapshot
Signaling pathways and intervention for therapy of type 2 diabetes mellitus
inferred← citeshttps://doi.org/10.1002/rco2.27openalex-snapshot
Skeletal muscle‐specific over‐expression of the nuclear sirtuin SIRT6 blocks cancer‐associated cachexia by regulating multiple targets
inferred← citeshttps://doi.org/10.1007/978-3-662-67753-7_8openalex-snapshot
Muskulatur: „peripheres mechanisch- und Signalstoff-gestütztes Zentrum der Gesundheit“
inferred← citeshttps://doi.org/10.1007/s12035-025-05047-5openalex-snapshot
Voglibose Attenuates Amyloid Beta–Induced Memory Deficits in a Rodent Model: A Potential Alzheimer’s Therapy via Wnt Signaling Modulation
inferred← citeshttps://doi.org/10.1016/b978-0-12-820472-6.00050-5openalex-snapshot
Targeting Islet GPCRs to Improve Insulin Secretion
inferred← citeshttps://doi.org/10.1016/j.bbadis.2019.06.018openalex-snapshot
Oleic acid increases the transcriptional activity of FoxO1 by promoting its nuclear translocation and β-catenin binding in pancreatic β-cells
inferred← citeshttps://doi.org/10.1016/j.bbrc.2016.09.130openalex-snapshot
Wnt4 antagonises Wnt3a mediated increases in growth and glucose stimulated insulin secretion in the pancreatic beta-cell line, INS-1
inferred← citeshttps://doi.org/10.1016/j.bbrc.2022.04.047openalex-snapshot
Differential expression of regulators of the canonical Wnt pathway during the compensatory beta-cell hyperplasia in prediabetic mice
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2020.111154openalex-snapshot
Maternal exposure to Di-n-butyl phthalate (DBP) aggravate gestational diabetes mellitus via FoxM1 suppression by pSTAT1 signalling
inferred← citeshttps://doi.org/10.1016/j.ejphar.2023.175606openalex-snapshot
Modulation of transcription factors by small molecules in β-cell development and differentiation
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.129634openalex-snapshot
Insights on effects of Wnt pathway modulation on insulin signaling and glucose homeostasis for the treatment of type 2 diabetes mellitus: Wnt activation or Wnt inhibition?
inferred← citeshttps://doi.org/10.1016/j.isci.2024.111064openalex-snapshot
RETRACTED: Complement C3 promotes islet β-cell dedifferentiation by activating Wnt/β-catenin pathway
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2021.107928openalex-snapshot
Obesity-induced changes in human islet G protein-coupled receptor expression: Implications for metabolic regulation
inferred← citeshttps://doi.org/10.1055/a-0879-1846openalex-snapshot
ICAT acts as a Coactivator in Regulating PPARγ Transcriptional Activity in Mesangial Cells
inferred← citeshttps://doi.org/10.1080/07391102.2021.1930583openalex-snapshot
Repositioning of antidiabetic drugs for Alzheimer’s disease: possibility of Wnt signaling modulation by targeting LRP6 an in silico based study
inferred← citeshttps://doi.org/10.1096/fj.202100009ropenalex-snapshot
Transcriptome analysis of islets from diabetes‐resistant and diabetes‐prone obese mice reveals novel gene regulatory networks involved in beta‐cell compensation and failure
inferred← citeshttps://doi.org/10.1097/mol.0000000000000445openalex-snapshot
Wnt signaling in cardiovascular disease: opportunities and challenges
inferred← citeshttps://doi.org/10.1111/jcmm.16663openalex-snapshot
The complex role of Wnt ligands in type 2 diabetes mellitus and related complications
inferred← citeshttps://doi.org/10.1152/ajpendo.00353.2017openalex-snapshot
Do skeletal muscle-secreted factors influence the function of pancreatic β-cells?
inferred← citeshttps://doi.org/10.1152/physrev.00034.2016openalex-snapshot
(Re)generating Human Beta Cells: Status, Pitfalls, and Perspectives
inferred← citeshttps://doi.org/10.1159/000543145openalex-snapshot
The Role of Wnt3a/β-Catenin/TCF7L2 Pathway in Diabetes and Cardiorenal Complications
inferred← citeshttps://doi.org/10.1186/s13287-017-0640-0openalex-snapshot
Mesenchymal stromal cells ameliorate oxidative stress-induced islet endothelium apoptosis and functional impairment via Wnt4-β-catenin signaling
inferred← citeshttps://doi.org/10.1186/s43094-024-00751-wopenalex-snapshot
Repurposing dapagliflozin for Alzheimer's disease: a mechanistic exploration
inferred← citeshttps://doi.org/10.1210/clinem/dgac221openalex-snapshot
Extreme Variations in Muscle Fiber Composition Enable Detection of Insulin Resistance and Excessive Insulin Secretion
inferred← citeshttps://doi.org/10.1210/clinem/dgad164openalex-snapshot
Human Placental LRP5 and Sclerostin are Increased in Gestational Diabetes Mellitus Pregnancies
inferred← citeshttps://doi.org/10.18388/pb.2018_126openalex-snapshot
Epigenetyczna regulacja ekspresji genów â nowy mechanizm łączący otyłość z rozwojem cukrzycy typu 2
inferred← citeshttps://doi.org/10.3389/fbinf.2026.1885995openalex-snapshot
Computational identification of candidate biomarkers and compounds associated with skeletal muscle insulin sensitivity improvement mediated by physical activity: an integrative multi-omics and computational chemistry study
inferred← citeshttps://doi.org/10.3389/fendo.2019.00741openalex-snapshot
A Comparative Peptidomic Characterization of Cultured Skeletal Muscle Tissues Derived From db/db Mice
inferred← citeshttps://doi.org/10.3389/fphys.2019.01608openalex-snapshot
Myokine Regulation of Insulin Secretion: Impact of Inflammation and Type 2 Diabetes
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