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Intra-islet lesions and lobular variations in β-cell mass expansion in ob/ob mice revealed by 3D imaging of intact pancreas

https://doi.org/10.1038/srep34885
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/j.1550-8528.1996.tb00519.xopenalex-snapshot
OBESE, A NEW MUTATION IN THE HOUSE MOUSE*
inferredcites →https://doi.org/10.1007/978-90-481-3271-3_20openalex-snapshot
β-Cell Function in Obese-Hyperglycemic Mice [ob/ob Mice]
inferredcites →https://doi.org/10.1007/bf01219435openalex-snapshot
Development of the obese-hyperglycaemic syndrome in mice
inferredcites →https://doi.org/10.1007/bf01221856openalex-snapshot
The influence of genetic background on the expression of the obese (ob) gene in the mouse
inferredcites →https://doi.org/10.1007/s00464-015-4236-4openalex-snapshot
Sleeve gastrectomy, but not duodenojejunostomy, preserves total beta-cell mass in Goto-Kakizaki rats evaluated by three-dimensional optical projection tomography
inferredcites →https://doi.org/10.1016/0024-3205(76)90112-0openalex-snapshot
Pancreatic polypeptide and glucagon: Non-random distribution in pancreatic islets
inferredcites →https://doi.org/10.1016/0026-0495(95)90244-9openalex-snapshot
Development of insulin secretory function in young obese hyperglycemic mice (Umeå )
inferredcites →https://doi.org/10.1016/b978-0-12-800043-4.00006-3openalex-snapshot
The Pancreas
inferredcites →https://doi.org/10.1016/j.yexcr.2005.05.024openalex-snapshot
Fibronectin fragmentation promotes α4β1 integrin-mediated contraction of a fibrin–fibronectin provisional matrix
inferredcites →https://doi.org/10.1038/cddis.2013.52openalex-snapshot
Neurogenin 3+ cells contribute to β-cell neogenesis and proliferation in injured adult mouse pancreas
inferredcites →https://doi.org/10.1038/nmeth985openalex-snapshot
Tomographic molecular imaging and 3D quantification within adult mouse organs
inferredcites →https://doi.org/10.1073/pnas.1313696110openalex-snapshot
Reporter islets in the eye reveal the plasticity of the endocrine pancreas
inferredcites →https://doi.org/10.1093/oxfordjournals.jhered.a106073openalex-snapshot
OBESE, A NEW MUTATION IN THE HOUSE MOUSE*
inferredcites →https://doi.org/10.1097/00006676-199205000-00015openalex-snapshot
Pancreatic Islets of Obese Hyperglycemic Mice (ob/ob)
inferredcites →https://doi.org/10.1097/00006676-199904000-00008openalex-snapshot
Islet Amyloid Polypeptide and Insulin Relationship in a Longitudinal Study of the Genetically Obese (oblob) Mouse
inferredcites →https://doi.org/10.1100/tsw.2007.117openalex-snapshot
The Physiology of Obese-Hyperglycemic Mice [ob/obMice]
inferredcites →https://doi.org/10.1126/science.1068206openalex-snapshot
Optical Projection Tomography as a Tool for 3D Microscopy and Gene Expression Studies
inferredcites →https://doi.org/10.1146/annurev.biochem.67.1.395openalex-snapshot
BIOCHEMISTRY AND GENETICS OF VON WILLEBRAND FACTOR
inferredcites →https://doi.org/10.1152/ajpendo.1998.274.6.e1034openalex-snapshot
Vagotomy in young obese hyperglycemic mice: effects on syndrome development and islet proliferation
inferredcites →https://doi.org/10.1152/ajpendo.1998.275.4.e594openalex-snapshot
Influence of age, hyperglycemia, leptin, and NPY on islet blood flow in obese-hyperglycemic mice
inferredcites →https://doi.org/10.1172/jci110464openalex-snapshot
Functional differences between rat islets of ventral and dorsal pancreatic origin.
inferredcites →https://doi.org/10.1210/en.140.2.778openalex-snapshot
Initiation of Increased Pancreatic Islet Growth in Young Normoglycemic Mice (Umea +/?)
inferredcites →https://doi.org/10.1371/journal.pone.0021753openalex-snapshot
Impaired Spleen Formation Perturbs Morphogenesis of the Gastric Lobe of the Pancreas
inferredcites →https://doi.org/10.1371/journal.pone.0027445openalex-snapshot
Altered Islet Composition and Disproportionate Loss of Large Islets in Patients with Type 2 Diabetes
inferredcites →https://doi.org/10.1371/journal.pone.0056922openalex-snapshot
Topologically Heterogeneous Beta Cell Adaptation in Response to High-Fat Diet in Mice
inferredcites →https://doi.org/10.1371/journal.pone.0106693openalex-snapshot
Non-Invasive Bioluminescence Imaging of β-Cell Function in Obese-Hyperglycemic [ob/ob] Mice
inferredcites →https://doi.org/10.2337/db09-1400openalex-snapshot
Quantification and Three-Dimensional Imaging of the Insulitis-Induced Destruction of β-Cells in Murine Type 1 Diabetes
inferredcites →https://doi.org/10.2337/db12-1657openalex-snapshot
Pancreatic Islet Vasculature Adapts to Insulin Resistance Through Dilation and Not Angiogenesis
inferredcites →https://doi.org/10.2337/diabetes.52.7.1716openalex-snapshot
Increased Islet Volume but Unchanged Islet Number in ob/ob Mice
inferredcites →https://doi.org/10.2337/diabetes.54.1.133openalex-snapshot
Genetic Background Determines the Size and Structure of the Endocrine Pancreas
inferredcites →https://doi.org/10.3791/50238openalex-snapshot
Near Infrared Optical Projection Tomography for Assessments of β-cell Mass Distribution in Diabetes Research
inferredcites →https://doi.org/10.4161/isl.1.2.9480openalex-snapshot
Islet architecture: A comparative study
inferredcites →https://doi.org/10.4161/isl.3.1.14132openalex-snapshot
Low insulin content of large islet population is present in situ and in isolated islets
inferredcites →https://doi.org/10.4161/isl.3.4.16417openalex-snapshot
An improved protocol for optical projection tomography imaging reveals lobular heterogeneities in pancreatic islet and β-cell mass distribution
inferredcites →https://doi.org/10.4161/org.28351openalex-snapshot
In vitro reconstitution of pancreatic islets

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4789208openalex-extracted
Unlocking Regenerative Potential: Beta-Cell Neogenesis and Novel Myokines Involved in Adaptation to Insulin Resistance in Mice
inferred← citeshttps://doi.org/10.1007/978-1-0716-2807-2_1openalex-snapshot
3D Optical Molecular Imaging of the Rodent Pancreas by OPT and LSFM
inferred← citeshttps://doi.org/10.1007/s00125-017-4512-zopenalex-snapshot
Early deficits in insulin secretion, beta cell mass and islet blood perfusion precede onset of autoimmune type 1 diabetes in BioBreeding rats
inferred← citeshttps://doi.org/10.1007/s00592-019-01420-8openalex-snapshot
On the dynamics of the human endocrine pancreas and potential consequences for the development of type 1 diabetes
inferred← citeshttps://doi.org/10.1007/s11306-024-02151-wopenalex-snapshot
Kiphynet: an online network simulation tool connecting cellular kinetics and physiological transport
inferred← citeshttps://doi.org/10.1016/j.bbrc.2025.152409openalex-snapshot
DA-9701 (Motilitone®) improves glucose homeostasis by protecting STZ-induced β-cells death
inferred← citeshttps://doi.org/10.1016/j.celrep.2025.116283openalex-snapshot
Beta-cell adaptation unveiled: The role of myokines in insulin-resistant mice
inferred← citeshttps://doi.org/10.1016/j.jmb.2019.10.032openalex-snapshot
The Role of the Islet Niche on Beta Cell Structure and Function
inferred← citeshttps://doi.org/10.1038/s41467-024-47686-7openalex-snapshot
Illuminating the complete ß-cell mass of the human pancreas- signifying a new view on the islets of Langerhans
inferred← citeshttps://doi.org/10.1038/s41597-022-01546-5openalex-snapshot
Quantitative 3D OPT and LSFM datasets of pancreata from mice with streptozotocin-induced diabetes
inferred← citeshttps://doi.org/10.1038/s41598-017-12124-wopenalex-snapshot
Kinetics of functional beta cell mass decay in a diphtheria toxin receptor mouse model of diabetes
inferred← citeshttps://doi.org/10.1038/s41598-019-43130-9openalex-snapshot
3D analysis of the whole subcutaneous adipose tissue reveals a complex spatial network of interconnected lobules with heterogeneous browning ability
inferred← citeshttps://doi.org/10.1038/s41598-020-74616-6openalex-snapshot
Mesoscopic 3D imaging of pancreatic cancer and Langerhans islets based on tissue autofluorescence
inferred← citeshttps://doi.org/10.1038/s42003-020-01243-2openalex-snapshot
Topologically selective islet vulnerability and self-sustained downregulation of markers for β-cell maturity in streptozotocin-induced diabetes
inferred← citeshttps://doi.org/10.1038/s42003-021-02589-xopenalex-snapshot
3D imaging of human organs with micrometer resolution - applied to the endocrine pancreas
inferred← citeshttps://doi.org/10.1038/sdata.2017.31openalex-snapshot
Spatial and quantitative datasets of the pancreatic β-cell mass distribution in lean and obese mice
inferred← citeshttps://doi.org/10.1101/2023.01.09.523222openalex-snapshot
Insulin resistance-driven beta-cell adaptation in mice: Mechanistic characterization and 3D analysis
inferred← citeshttps://doi.org/10.1111/jdi.14002openalex-snapshot
Signaling pathways that regulate adaptive β‐cell proliferation for the treatment of diabetes
inferred← citeshttps://doi.org/10.1126/sciadv.aaz9124openalex-snapshot
A 3D atlas of the dynamic and regional variation of pancreatic innervation in diabetes
inferred← citeshttps://doi.org/10.1155/2024/7747599openalex-snapshot
Long-Term Administration of Omeprazole-Induced Hypergastrinemia and Changed Glucose Homeostasis and Expression of Metabolism-Related Genes
inferred← citeshttps://doi.org/10.14739/2310-1237.2022.1.254173openalex-snapshot
Optimization of endocrine pancreas fluorescence analysis using machine methods
inferred← citeshttps://doi.org/10.14739/2409-2932.2022.3.259868openalex-snapshot
Features of the planimetric organization of the endocrine part of the pancreas in hypertensive rats of the SHR line
inferred← citeshttps://doi.org/10.2337/db21-0310openalex-snapshot
Developmental Timing of High-Fat Diet Exposure Impacts Glucose Homeostasis in Mice in a Sex-Specific Manner
inferred← citeshttps://doi.org/10.3389/fendo.2021.633063openalex-snapshot
Mesoscopic Optical Imaging of the Pancreas—Revisiting Pancreatic Anatomy and Pathophysiology
inferred← citeshttps://doi.org/10.3389/fendo.2021.652853openalex-snapshot
The Eye as a Transplantation Site to Monitor Pancreatic Islet Cell Plasticity
inferred← citeshttps://doi.org/10.3389/fnetp.2021.802881openalex-snapshot
A Graph-Based Framework for Multiscale Modeling of Physiological Transport
inferred← citeshttps://doi.org/10.3390/ijms23179798openalex-snapshot
Investigating the Expression and Function of the Glucose Transporter GLUT6 in Obesity
inferred← citeshttps://doi.org/10.70675/b3b53f33z46ecz484dzaa28z2f877c52af60openalex-snapshot
De l'imagerie tissu entier à la modélisation in silico du réseau vasculaire du tissu adipeux
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