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Astragaloside IV ameliorates 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis implicating regulation of energy metabolism

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/ibd.20997openalex-snapshot
Importance of mucosal healing in ulcerative colitis
inferredcites →https://doi.org/10.1002/ibd.21379openalex-snapshot
Function of the intestinal epithelium and its dysregulation in inflammatory bowel disease
inferredcites →https://doi.org/10.1002/ibd.21403openalex-snapshot
Importance of disrupted intestinal barrier in inflammatory bowel diseases
inferredcites →https://doi.org/10.1016/j.cgh.2010.12.028openalex-snapshot
Mucosal Healing Predicts Late Outcomes After the First Course of Corticosteroids for Newly Diagnosed Ulcerative Colitis
inferredcites →https://doi.org/10.1016/j.ijdevneu.2009.09.004openalex-snapshot
ATP controls cell cycle and induces proliferation in the mouse developing retina
inferredcites →https://doi.org/10.1016/j.jep.2011.01.030openalex-snapshot
In vitro growth stimulatory and in vivo wound healing studies on cycloartane-type saponins of Astragalus genus
inferredcites →https://doi.org/10.1016/j.jep.2012.02.025openalex-snapshot
Synergistic interaction between Astragali Radix and Rehmanniae Radix in a Chinese herbal formula to promote diabetic wound healing
inferredcites →https://doi.org/10.1016/j.stem.2012.09.009openalex-snapshot
Identifying the Stem Cell of the Intestinal Crypt: Strategies and Pitfalls
inferredcites →https://doi.org/10.1016/j.stem.2013.09.015openalex-snapshot
Transplantation of Expanded Fetal Intestinal Progenitors Contributes to Colon Regeneration after Injury
inferredcites →https://doi.org/10.1016/j.tibtech.2008.11.007openalex-snapshot
Tipping the balance: modulating the Wnt pathway for tissue repair
inferredcites →https://doi.org/10.1021/pr060433mopenalex-snapshot
Differential Protein Expression Profile in the Intestinal Epithelium from Patients with Inflammatory Bowel Disease
inferredcites →https://doi.org/10.1038/347095a0openalex-snapshot
Effect of ATP on actin filament stiffness
inferredcites →https://doi.org/10.1038/cddis.2011.49openalex-snapshot
Differentiation of hematopoietic stem cell and myeloid populations by ATP is modulated by cytokines
inferredcites →https://doi.org/10.1038/nature06196openalex-snapshot
Identification of stem cells in small intestine and colon by marker gene Lgr5
inferredcites →https://doi.org/10.1038/ncb3165openalex-snapshot
ATP synthase promotes germ cell differentiation independent of oxidative phosphorylation
inferredcites →https://doi.org/10.1038/nm.2695openalex-snapshot
Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell
inferredcites →https://doi.org/10.1053/j.gastro.2012.04.054openalex-snapshot
Incidence and Mortality of Colorectal Adenocarcinoma in Persons With Inflammatory Bowel Disease From 1998 to 2010
inferredcites →https://doi.org/10.1053/j.gastro.2013.07.015openalex-snapshot
Mitochondrial Gene Polymorphisms That Protect Mice From Colitis
inferredcites →https://doi.org/10.1056/nejm199110033251406openalex-snapshot
Inflammatory Bowel Disease
inferredcites →https://doi.org/10.1056/nejmra020831openalex-snapshot
Inflammatory Bowel Disease
inferredcites →https://doi.org/10.1073/pnas.1017640108openalex-snapshot
Heterologous down-regulation of angiotensin type 1 receptors by purinergic P2Y 2 receptor stimulation through S-nitrosylation of NF-κB
inferredcites →https://doi.org/10.1084/jem.20040446openalex-snapshot
RIP Links TLR4 to Akt and Is Essential for Cell Survival in Response to LPS Stimulation
inferredcites →https://doi.org/10.1091/mbc.e04-12-1089openalex-snapshot
Actin Depolymerization Disrupts Tight Junctions via Caveolae-mediated Endocytosis
inferredcites →https://doi.org/10.1111/1753-0407.12117openalex-snapshot
Healing effect of a two‐herb recipe ( NF3 ) on foot ulcers in C hinese patients with diabetes: A randomized double‐blind placebo‐controlled study (包含两种草本中药的配方(NF3)对中国糖尿病患者足部溃疡的治疗作用:一项随机双盲安慰剂对照的研究)
inferredcites →https://doi.org/10.1111/micc.12074openalex-snapshot
Astragaloside IV Protects Heart from Ischemia and Reperfusion Injury via Energy Regulation Mechanisms
inferredcites →https://doi.org/10.1136/gut.2009.203554openalex-snapshot
Targeting the proteasome: partial inhibition of the proteasome by bortezomib or deletion of the immunosubunit LMP7 attenuates experimental colitis
inferredcites →https://doi.org/10.1136/gut.38.4.568openalex-snapshot
Butyrate enema therapy stimulates mucosal repair in experimental colitis in the rat.
inferredcites →https://doi.org/10.1136/gutjnl-2012-302830openalex-snapshot
Mucosal healing in inflammatory bowel diseases: a systematic review
inferredcites →https://doi.org/10.1155/2013/574629openalex-snapshot
Huang Qi Jian Zhong Pellet Attenuates TNBS-Induced Colitis in Rats via Mechanisms Involving Improvement of Energy Metabolism
inferredcites →https://doi.org/10.1242/jcs.03311openalex-snapshot
Rac-WAVE-mediated actin reorganization is required for organization and maintenance of cell-cell adhesion
inferredcites →https://doi.org/10.1358/mf.2009.31.2.1353846openalex-snapshot
Wound-healing activity of Astragali radix in rats
inferredcites →https://doi.org/10.3892/mmr.2011.716openalex-snapshot
Pro-angiogenic activity of astragaloside IV in HUVECs in vitro and zebrafish in vivo
inferredcites →https://doi.org/10.3892/mmr.2012.744openalex-snapshot
Expression of immunoglobulin-like transcript (ILT)2 and ILT3 in human gastric cancer and its clinical significance

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4764792openalex-extracted
Astragaloside IV Exhibited Antidiabetic Effects by Improving Glucose Metabolism, Repairing Damaged Gut Barrier and Regulating Intestinal Microbiota
inferred← citeshttps://doi.org/10.1002/ptr.70205openalex-snapshot
Astragaloside IV Exhibited Antidiabetic Effects by Improving Glucose Metabolism, Repairing Damaged Gut Barrier and Regulating Intestinal Microbiota
inferred← citeshttps://doi.org/10.1007/s11101-019-09626-yopenalex-snapshot
Chemical diversity and biological activities of the saponins isolated from Astragalus genus: focus on Astragaloside IV
inferred← citeshttps://doi.org/10.1007/s11655-018-2943-5openalex-snapshot
Role of Chinese Herbal Medicines in Regulation of Energy Metabolism in Treating Cardiovascular Diseases
inferred← citeshttps://doi.org/10.1007/s11655-024-4101-1openalex-snapshot
Advancements of Macrophages Involvement in Pathological Progression of Colitis-Associated Colorectal Cancer and Associated Pharmacological Interventions
inferred← citeshttps://doi.org/10.1016/j.biopha.2021.111881openalex-snapshot
Suppression of plasmacytoid dendritic cell migration to colonic isolated lymphoid follicles abrogates the development of colitis
inferred← citeshttps://doi.org/10.1016/j.biopha.2024.117580openalex-snapshot
Pharmacological potential of natural medicine Astragali Radix in treating intestinal diseases
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e33102openalex-snapshot
Network pharmacology and experimental validation to explore the mechanism of Changji'an formula against irritable bowel syndrome with predominant diarrhea
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.137394openalex-snapshot
Super Astragalus polysaccharide in specific gut microbiota metabolism alleviates chronic unpredictable mild stress-induced cognitive deficits mice
inferred← citeshttps://doi.org/10.1016/j.intimp.2020.107290openalex-snapshot
Astragaloside IV alleviates PM2.5-induced lung injury in rats by modulating TLR4/MyD88/NF-κB signalling pathway
inferred← citeshttps://doi.org/10.1016/j.intimp.2024.112281openalex-snapshot
Astragaloside IV ameliorates indomethacin-induced intestinal inflammation in rats through inhibiting the activation of NLRP3 inflammasome
inferred← citeshttps://doi.org/10.1016/j.intimp.2025.116135openalex-snapshot
Astragaloside IV alleviates ulcerative colitis via gut microbiota - butyrate metabolism axis to reshape Th17/Treg balance
inferred← citeshttps://doi.org/10.1016/j.phrs.2019.04.010openalex-snapshot
Saponins regulate intestinal inflammation in colon cancer and IBD
inferred← citeshttps://doi.org/10.1016/j.phymed.2022.154287openalex-snapshot
Astragaloside Ⅳ alleviates ulcerative colitis by regulating the balance of Th17/Treg cells
inferred← citeshttps://doi.org/10.1038/s41401-018-0082-yopenalex-snapshot
Astragaloside IV attenuates myocardial ischemia/reperfusion injury in rats via inhibition of calcium-sensing receptor-mediated apoptotic signaling pathways
inferred← citeshttps://doi.org/10.1038/s41598-018-19564-yopenalex-snapshot
Thyroid Dysfunction, Neurological Disorder and Immunosuppression as the Consequences of Long-term Combined Stress
inferred← citeshttps://doi.org/10.1080/10408398.2026.2731837openalex-snapshot
Dietary bioactive compounds modulate intestinal stem cells to alleviate colorectal lesions
inferred← citeshttps://doi.org/10.1080/1061186x.2020.1864741openalex-snapshot
Advancements of compounds targeting Wnt and Notch signalling pathways in the treatment of inflammatory bowel disease and colon cancer
inferred← citeshttps://doi.org/10.1089/jmf.2020.4712openalex-snapshot
Nutritional Interventions Using Functional Foods and Nutraceuticals to Improve Inflammatory Bowel Disease
inferred← citeshttps://doi.org/10.1142/s0192415x23500684openalex-snapshot
Astragalus membranaceus as a Drug Candidate for Inflammatory Bowel Disease: The Preclinical Evidence
inferred← citeshttps://doi.org/10.1142/s0192415x25500405openalex-snapshot
Astragaloside IV: A Promising Drug to Prevent the Transition from Colitis to Colorectal Cancer
inferred← citeshttps://doi.org/10.1186/s12951-024-03007-0openalex-snapshot
Oral creatine-modified selenium-based hyaluronic acid nanogel mediated mitochondrial energy recovery to drive the treatment of inflammatory bowel disease
inferred← citeshttps://doi.org/10.1186/s13020-022-00673-wopenalex-snapshot
Understanding the tonifying and the detoxifying properties of Chinese medicines from their impacts on gut microbiota and host metabolism: a case study with four medicinal herbs in experimental colitis rat model
inferred← citeshttps://doi.org/10.12659/msm.916030openalex-snapshot
Astragaloside IV Alleviates the Myocardial Damage Induced by Lipopolysaccharide via the Toll-Like Receptor 4 (TLR4)/Nuclear Factor kappa B (NF-κB)/Proliferator-Activated Receptor α (PPARα) Signaling Pathway
inferred← citeshttps://doi.org/10.1590/1414-431x2021e11877openalex-snapshot
Rectal roflumilast improves trinitrobenzenesulfonic acid-induced chronic colitis in rats
inferred← citeshttps://doi.org/10.21203/rs.3.rs-1941258/v1openalex-snapshot
Understanding the tonifying and the detoxifying properties of Chinese medicines from their impacts on gut microbiota and host metabolism: a case study with four medicinal herbs in experimental colitis rat model
inferred← citeshttps://doi.org/10.3389/fimmu.2021.740565openalex-snapshot
Astragaloside IV Alleviates the Experimental DSS-Induced Colitis by Remodeling Macrophage Polarization Through STAT Signaling
inferred← citeshttps://doi.org/10.3389/fimmu.2022.981917openalex-snapshot
Enhancement of liver mitochondrial complex I and energy metabolism induced by enteritis: The key role of gut microbiota derived endotoxins
inferred← citeshttps://doi.org/10.3389/fmed.2024.1502849openalex-snapshot
T helper cell 17/regulatory T cell balance regulates ulcerative colitis and the therapeutic role of natural plant components: a review
inferred← citeshttps://doi.org/10.3389/fphar.2018.01163openalex-snapshot
Calcium Sensing Receptor-Related Pathway Contributes to Cardiac Injury and the Mechanism of Astragaloside IV on Cardioprotection
inferred← citeshttps://doi.org/10.3389/fphar.2020.01337openalex-snapshot
Systematic Investigation of the Efficacy of Sinitang Decoction Against Ulcerative Colitis
inferred← citeshttps://doi.org/10.3389/fphar.2022.873150openalex-snapshot
Astragaloside IV Alleviates Intestinal Barrier Dysfunction via the AKT-GSK3β-β-Catenin Pathway in Peritoneal Dialysis
inferred← citeshttps://doi.org/10.3389/fphar.2022.892790openalex-snapshot
Traditional Chinese Medicine and Natural Products: Potential Approaches for Inflammatory Bowel Disease
inferred← citeshttps://doi.org/10.3389/fphar.2026.1851055openalex-snapshot
Targeting mitochondrial dysfunction with traditional Chinese medicine for inflammatory bowel disease: a comprehensive review
inferred← citeshttps://doi.org/10.3389/fphys.2018.00389openalex-snapshot
The Contribution of Different Components in QiShenYiQi Pills® to Its Potential to Modulate Energy Metabolism in Protection of Ischemic Myocardial Injury
inferred← citeshttps://doi.org/10.3892/etm.2019.7907openalex-snapshot
Astragaloside IV alleviates the symptoms of experimental ulcerative colitis in vitro and in vivo
inferred← citeshttps://doi.org/10.3892/mmr.2021.11883openalex-snapshot
Astragaloside IV improves angiogenesis under hypoxic conditions by enhancing hypoxia‑inducible factor‑1α SUMOylation
inferred← citeshttps://doi.org/10.6084/m9.figshare.21273882openalex-snapshot
Additional file 1 of Understanding the tonifying and the detoxifying properties of Chinese medicines from their impacts on gut microbiota and host metabolism: a case study with four medicinal herbs in experimental colitis rat model
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