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The developability of heteroaromatic and heteroaliphatic rings – do some have a better pedigree as potential drug molecules than others?
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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A Comprehensive Listing of Bioactivation Pathways of Organic Functional Groups
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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inferred← citeshttps://doi.org/10.1021/acs.joc.9b03003openalex-snapshot
Switchable Ring-Contractive Extrusion Reactions of 2,5-Dihydro-1,4,5-thiadiazepine S-Oxides: Entries to Pyridazines or Pyrazoles
inferred← citeshttps://doi.org/10.1021/acs.orglett.0c00006openalex-snapshot
Cu-Mediated Expeditious Annulation of Alkyl 3-Aminoacrylates with Aryldiazonium Salts: Access to Alkyl N2-Aryl 1,2,3-Triazole-carboxylates for Druglike Molecular Synthesis
inferred← citeshttps://doi.org/10.1021/acs.orglett.0c03064openalex-snapshot
Asymmetric Transfer Hydrogenation of Densely Functionalized Diheteroaryl and Diaryl Ketones by a Ru-Catalyst of Minimal Stereogenicity
inferred← citeshttps://doi.org/10.1021/acs.orglett.1c00026openalex-snapshot
TBAI/K2S2O8-Promoted [4 + 2] Annulation of Ketene N,S-Acetals and N-Tosylhydrazones toward Pyridazines
inferred← citeshttps://doi.org/10.1021/acs.orglett.1c00226openalex-snapshot
Metal-Free α-C(sp 3 )–H Aroylation of Amines via a Photoredox Catalytic Radical–Radical Cross-Coupling Process
inferred← citeshttps://doi.org/10.1021/acs.orglett.2c00831openalex-snapshot
Visible-Light-Induced α,γ-C(sp3)–H Difunctionalization of Piperidines
inferred← citeshttps://doi.org/10.1021/acs.orglett.3c00206openalex-snapshot
Copper-Catalyzed Trifluoromethylation of (Hetero)aryl Boronic Acid Pinacol Esters with YlideFluor
inferred← citeshttps://doi.org/10.1021/acs.orglett.5b01370openalex-snapshot
Modular, Concise, and Efficient Synthesis of Highly Functionalized 5-Fluoropyridazines by a [2 + 1]/[3 + 2]-Cycloaddition Sequence
inferred← citeshttps://doi.org/10.1021/acs.orglett.5b02079openalex-snapshot
Facile Synthesis of 3-N-Alkyl Pyrimidin-2,4-diones from N-Sulfonyloxy Maleimides and Amines
inferred← citeshttps://doi.org/10.1021/acs.orglett.6b01099openalex-snapshot
SnAP-eX Reagents for the Synthesis of Exocyclic 3-Amino- and 3-Alkoxypyrrolidines and Piperidines from Aldehydes
inferred← citeshttps://doi.org/10.1021/acs.orglett.6b01551openalex-snapshot
Fluoride-Assisted Synthesis of 1,4,5,6-Tetrahydropyridazines via [4 + 2] Cyclodimerization of in Situ-Generated Azoalkenes Followed by a C–N Bond Cleavage
inferred← citeshttps://doi.org/10.1021/acs.orglett.6c00059openalex-snapshot
Exploring γ-Nitroketones as 1,4-Dicarbonyl Precursors for Annulation to Pyridazines through Interrupted Nef Reaction
inferred← citeshttps://doi.org/10.1021/acs.orglett.8b01212openalex-snapshot
Synthesis of α-(4-Oxazolyl)amino Esters via Brønsted Acid Catalyzed Tandem Reaction
inferred← citeshttps://doi.org/10.1021/acscatal.2c03672openalex-snapshot
Visible Light-Mediated, Diastereoselective Epimerization of Morpholines and Piperazines to More Stable Isomers
inferred← citeshttps://doi.org/10.1021/acscatal.4c07840openalex-snapshot
Sulfonium Ylide Enabled, Copper-Catalyzed Difluoromethylation, Monofluoromethylation, and Monofluoroalkylation of Lithium Aryl nButyl Borates
inferred← citeshttps://doi.org/10.1021/acscombsci.6b00103openalex-snapshot
Expanding Synthesizable Space of Disubstituted 1,2,4-Oxadiazoles
inferred← citeshttps://doi.org/10.1021/acsinfecdis.4c00137openalex-snapshot
Synthesis and Anti-Chagas Activity Profile of a Redox-Active Lead 3-Benzylmenadione Revealed by High-Content Imaging
inferred← citeshttps://doi.org/10.1021/acsinfecdis.4c00808openalex-snapshot
Identification of a Series Containing a Pentafluorophenyl Moiety That Targets Pks13 to Inhibit Growth of Mycobacterium tuberculosis
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.6b00018openalex-snapshot
Core Replacements in a Potent Series of VEGFR-2 Inhibitors and Their Impact on Potency, Solubility, and hERG
inferred← citeshttps://doi.org/10.1021/acsomega.1c00104openalex-snapshot
Physicochemical Profiling and Comparison of Research Antiplasmodials and Advanced Stage Antimalarials with Oral Drugs
inferred← citeshttps://doi.org/10.1021/acsorginorgau.4c00028openalex-snapshot
Parallel Minisci Reaction of gem -Difluorocycloalkyl Building Blocks
inferred← citeshttps://doi.org/10.1021/ja4055492openalex-snapshot
Pd(II)-Catalyzed C–H Iodination Using Molecular I 2 as the Sole Oxidant
inferred← citeshttps://doi.org/10.1021/ja507704bopenalex-snapshot
Cu(II)-Mediated Ortho C–H Alkynylation of (Hetero)Arenes with Terminal Alkynes
inferred← citeshttps://doi.org/10.1021/jacs.8b08145openalex-snapshot
Electrochemical Aminoxyl-Mediated α-Cyanation of Secondary Piperidines for Pharmaceutical Building Block Diversification
inferred← citeshttps://doi.org/10.1021/jm500066bopenalex-snapshot
Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N-Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (LELP)
inferred← citeshttps://doi.org/10.1021/jo400989qopenalex-snapshot
Strategy for the Synthesis of Pyridazine Heterocycles and Their Derivatives
inferred← citeshttps://doi.org/10.1021/jo501930sopenalex-snapshot
Access to 4-Alkylaminopyridazine Derivatives via Nitrogen-Assisted Regioselective Pd-Catalyzed Reactions
inferred← citeshttps://doi.org/10.1021/ml3003007openalex-snapshot
Discovery of a Highly Selective, Brain-Penetrant Aminopyrazole LRRK2 Inhibitor
inferred← citeshttps://doi.org/10.1021/ol500655kopenalex-snapshot
Copper-Catalyzed α-Methylenation of Benzylpyridines Using Dimethylacetamide as One-Carbon Source
inferred← citeshttps://doi.org/10.1039/c3dt52090kopenalex-snapshot
Synthesis and evaluation of new polynuclear organometallic Ru( ii ), Rh( iii ) and Ir( iii ) pyridyl ester complexes as in vitro antiparasitic and antitumor agents
inferred← citeshttps://doi.org/10.1039/c3md00003fopenalex-snapshot
Increasing small molecule drug developability in sub-optimal chemical space
inferred← citeshttps://doi.org/10.1039/c3md00226hopenalex-snapshot
Development and evaluation of selective, reversible LSD1 inhibitors derived from fragments
inferred← citeshttps://doi.org/10.1039/c3ob40263kopenalex-snapshot
An efficient coupling of N-tosylhydrazones with 2-halopyridines: synthesis of 2-α-styrylpyridines endowed with antitumor activity
inferred← citeshttps://doi.org/10.1039/c3ob40413gopenalex-snapshot
Synthesis of 2-amino-imidazo[4,5-b]pyridines
inferred← citeshttps://doi.org/10.1039/c4sc02155jopenalex-snapshot
Amine α-heteroarylation via photoredox catalysis: a homolytic aromatic substitution pathway
inferred← citeshttps://doi.org/10.1039/c5md00241aopenalex-snapshot
Discovery of high affinity inhibitors of Leishmania donovani N -myristoyltransferase
inferred← citeshttps://doi.org/10.1039/c7cc02601copenalex-snapshot
Coordination strategy-induced selective C–H amination of 8-aminoquinolines
inferred← citeshttps://doi.org/10.1039/c7ob02682jopenalex-snapshot
Negishi cross-couplings in the synthesis of amino acids
inferred← citeshttps://doi.org/10.1039/c7sc03612dopenalex-snapshot
A practical and scalable system for heteroaryl amino acid synthesis
inferred← citeshttps://doi.org/10.1039/c9cc09337kopenalex-snapshot
SnAP reagents for the synthesis of selenomorpholines and 1,4-selenazepanes and their biological evaluation
inferred← citeshttps://doi.org/10.1039/c9ra02712bopenalex-snapshot
Synthesis of 1,4,5,6-tetrahydropyridazines and pyridazines via transition-metal-free (4 + 2) cycloaddition of alkoxyallenes with 1,2-diaza-1,3-dienes
inferred← citeshttps://doi.org/10.1039/d0cc04471gopenalex-snapshot
SLAP reagents for the photocatalytic synthesis of C3/C5-substituted, N-unprotected selenomorpholines and 1,4-selenazepanes
inferred← citeshttps://doi.org/10.1039/d0ob01265copenalex-snapshot
Transition-metal-catalyzed C–H functionalization of pyrazoles
inferred← citeshttps://doi.org/10.1039/d4cc00608aopenalex-snapshot
Photo-induced phosphorylation/cyclization of N -homoallyl and N -allyl aldehyde hydrazones to access phosphorylated tetrahydropyridazines and dihydropyrazoles
inferred← citeshttps://doi.org/10.1039/d4cc06716aopenalex-snapshot
Palladium-catalysed alleneamination of γ,δ-unsaturated hydrazones with propargylic acetates: access to tetrahydropyridazines bearing allenes
inferred← citeshttps://doi.org/10.1039/d6cc03612kopenalex-snapshot
Annulation of α-carbonyl vinyl sulfoxonium ylides with hypervalent iodine diazo compounds
inferred← citeshttps://doi.org/10.1055/a-2092-9205openalex-snapshot
Synthesis of 2,2-Disubstituted and 2,2,3-Trisubstituted 1,4-Dioxane-Derived Building Blocks
inferred← citeshttps://doi.org/10.1055/a-2114-7673openalex-snapshot
A New One-Pot Synthesis of 3,6-Disubstituted Pyridazines Starting from β-Nitro-β,γ-Unsaturated Ketones
inferred← citeshttps://doi.org/10.1055/a-2445-1338openalex-snapshot
Concise Synthesis of Tetrasubstituted 1,6-Dihydropyridazine and Pyridazine Derivatives
inferred← citeshttps://doi.org/10.1071/ch13280openalex-snapshot
Design and Evaluation of the Performance of an NMR Screening Fragment Library
inferred← citeshttps://doi.org/10.1080/00397911.2020.1781185openalex-snapshot
Rh-catalyzed C–N coupling of N-sulfonyl-1,2,3-trizales with secondary amines for regioselective synthesis of phenylvinyl-1,2-diamines
inferred← citeshttps://doi.org/10.1080/14756366.2020.1806259openalex-snapshot
Discovery of 3,6-disubstituted pyridazines as a novel class of anticancer agents targeting cyclin-dependent kinase 2: synthesis, biological evaluation and in silico insights
inferred← citeshttps://doi.org/10.1080/17460441.2024.2368743openalex-snapshot
Unveiling dynamics of nitrogen content and selected nitrogen heterocycles in thrombin inhibitors: a ceteris paribus approach
inferred← citeshttps://doi.org/10.1126/science.aac9895openalex-snapshot
Site-selective arene C-H amination via photoredox catalysis
inferred← citeshttps://doi.org/10.11606/t.60.2019.tde-27052019-111337openalex-snapshot
Síntese, funcionalização e prospecção biológica de fragmentos heterocíclicos baseados em núcleos heteroaromáticos subexplorados
inferred← citeshttps://doi.org/10.1371/journal.pone.0170150openalex-snapshot
Experimental and In-Silico Investigation of Anti-Microbial Activity of 1-Chloro-2-Isocyanatoethane Derivatives of Thiomorpholine, Piperazine and Morpholine
inferred← citeshttps://doi.org/10.1515/9783111739601-014openalex-snapshot
49513 Negishi coupling reactions
inferred← citeshttps://doi.org/10.1517/17460441.2014.932346openalex-snapshot
What does the aromatic ring number mean for drug design?
inferred← citeshttps://doi.org/10.2147/dddt.s484310openalex-snapshot
Effects of Food on the Pharmacokinetics and Safety of HA121-28 Tablet, a Novel Multi-Targeting Tyrosine Kinase Inhibitor, in Healthy Chinese Subjects: A Phase I Clinical Trial
inferred← citeshttps://doi.org/10.26434/chemrxiv-2024-3lt8bopenalex-snapshot
Synthesis and anti-Chagas activity profile of a novel redox-active lead 3-benzylmenadione revealed by high-content imaging
inferred← citeshttps://doi.org/10.3390/ijms24065406openalex-snapshot
Room Temperature Synthesis of Bioactive 1,2,4-Oxadiazoles
inferred← citeshttps://doi.org/10.3390/inorganics10120247openalex-snapshot
Palladium(II) and Platinum(II) Deprotonated Diaminocarbene Complexes Based on N-(2-Pyridyl)ureas with Oxadiazole Periphery
inferred← citeshttps://doi.org/10.3390/molecules21010075openalex-snapshot
Chemical Structure-Related Drug-Like Criteria of Global Approved Drugs
inferred← citeshttps://doi.org/10.3390/molecules26082341openalex-snapshot
A One-Pot Approach to Novel Pyridazine C-Nucleosides
inferred← citeshttps://doi.org/10.3762/bjoc.13.162openalex-snapshot
Oxidative dehydrogenation of C–C and C–N bonds: A convenient approach to access diverse (dihydro)heteroaromatic compounds
inferred← citeshttps://doi.org/10.3987/com-13-s(s)30openalex-snapshot
N,N-Bond Formation in Intramolecular Cobalt-Catalyzed [2+2+2] Cyclizations of Alkynyl-Linked Bisnitriles, and the Preparation of Annulated Pyridazines
inferred← citeshttps://doi.org/10.3998/ark.5550190.p009.629openalex-snapshot
New heteroatom-rich ring systems from N,N-dialkyl-N’-chlorosulfonyl chloroformamidines
inferred← citeshttps://doi.org/10.6023/cjoc202507030openalex-snapshot
Photocatalytic Radical-Mediated Synthesis of Unnatural α -Amino Acids from Heteroaryl Aldehydes
inferred← citeshttps://doi.org/10.70675/54b7e590z8928z4bccz9bc0z7152dce42f35openalex-snapshot
Synthesis of trifluoromethylated nitrogen-containing heterocycles
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